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Fusion gene ID: 42285 |
FusionGeneSummary for YARS_ANKRD17 |
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Fusion gene information | Fusion gene name: YARS_ANKRD17 | Fusion gene ID: 42285 | Hgene | Tgene | Gene symbol | YARS | ANKRD17 | Gene ID | 8565 | 26057 |
Gene name | tyrosyl-tRNA synthetase | ankyrin repeat domain 17 | |
Synonyms | CMTDIC|TYRRS|YRS|YTS | GTAR|MASK2|NY-BR-16 | |
Cytomap | 1p35.1 | 4q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | tyrosine--tRNA ligase, cytoplasmictyrosine tRNA ligase 1, cytoplasmictyrosyl--tRNA ligasetyrosyl-tRNA synthetase, cytoplasmic | ankyrin repeat domain-containing protein 17gene trap ankyrin repeat proteinserologically defined breast cancer antigen NY-BR-16 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P54577 | O75179 | |
Ensembl transtripts involved in fusion gene | ENST00000469100, ENST00000373477, | ENST00000358602, ENST00000509867, ENST00000330838, ENST00000514252, | |
Fusion gene scores | * DoF score | 7 X 8 X 7=392 | 8 X 14 X 3=336 |
# samples | 10 | 18 | |
** MAII score | log2(10/392*10)=-1.97085365434048 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(18/336*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: YARS [Title/Abstract] AND ANKRD17 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ANKRD17 | GO:0042742 | defense response to bacterium | 23711367 |
Tgene | ANKRD17 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 22328336 |
Tgene | ANKRD17 | GO:0045087 | innate immune response | 23711367 |
Tgene | ANKRD17 | GO:1900245 | positive regulation of MDA-5 signaling pathway | 22328336 |
Tgene | ANKRD17 | GO:1900246 | positive regulation of RIG-I signaling pathway | 22328336 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-DX-A48P-01A | YARS | chr1 | 33263364 | - | ANKRD17 | chr4 | 73944607 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000469100 | ENST00000358602 | YARS | chr1 | 33263364 | - | ANKRD17 | chr4 | 73944607 | - |
intron-3CDS | ENST00000469100 | ENST00000509867 | YARS | chr1 | 33263364 | - | ANKRD17 | chr4 | 73944607 | - |
intron-3CDS | ENST00000469100 | ENST00000330838 | YARS | chr1 | 33263364 | - | ANKRD17 | chr4 | 73944607 | - |
intron-intron | ENST00000469100 | ENST00000514252 | YARS | chr1 | 33263364 | - | ANKRD17 | chr4 | 73944607 | - |
Frame-shift | ENST00000373477 | ENST00000358602 | YARS | chr1 | 33263364 | - | ANKRD17 | chr4 | 73944607 | - |
Frame-shift | ENST00000373477 | ENST00000509867 | YARS | chr1 | 33263364 | - | ANKRD17 | chr4 | 73944607 | - |
Frame-shift | ENST00000373477 | ENST00000330838 | YARS | chr1 | 33263364 | - | ANKRD17 | chr4 | 73944607 | - |
5CDS-intron | ENST00000373477 | ENST00000514252 | YARS | chr1 | 33263364 | - | ANKRD17 | chr4 | 73944607 | - |
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FusionProtFeatures for YARS_ANKRD17 |
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Hgene | Tgene |
YARS | ANKRD17 |
Catalyzes the attachment of tyrosine to tRNA(Tyr) in atwo-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for YARS_ANKRD17 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for YARS_ANKRD17 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
YARS | ARF6, SAP18, EIF1B, EIF6, CDK2, DYNC1H1, METTL16, XRCC5, FN1, VCAM1, ITGA4, NRD1, SARNP, HSPA8, ENO1, SHMT2, MOV10, NXF1, EGFR, ESR1, DDB1, G3BP2, HNRNPH2, NAA10, NAA15, PROSC, TATDN1, ACTB, ACTG1, AHNAK, CLUH, CPOX, EEF1A1, SNRPA, WDR48, YARS2, NTRK1, PPP2R2A, SORT1, FOXB1, FOXH1, FOXI2, FOXL1, FOXL2, FOXQ1, MCM2, TRIM5, GTF2E2, DLD, G3BP1 | ANKRD17 | BAP1, APC, ITSN2, SIRT7, KIAA0368, ITGA4, ADH6, MDM2, AURKB, CDKN1A, HOXC4, MAGEA1, ZC3H3, FOSL2, SFRP4, LHX9, RBM23, MSH6, NTRK1, FGFR1OP, CAPN1, RPL10, CREB1, FOS, AKAP17A, FGF3, FGF8, STX11, TRIM41, TCEANC2, TGIF2LY, ZNF263, IRF9, CDX1, SIX2, ZNF414, TRMT2A, HOXD4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for YARS_ANKRD17 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for YARS_ANKRD17 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | YARS | C1842237 | Charcot-Marie-Tooth Disease, Dominant Intermediate C | 1 | CTD_human;ORPHANET;UNIPROT |