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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4228

FusionGeneSummary for BMP2K_ANXA3

check button Fusion gene summary
Fusion gene informationFusion gene name: BMP2K_ANXA3
Fusion gene ID: 4228
HgeneTgene
Gene symbol

BMP2K

ANXA3

Gene ID

55589

306

Gene nameBMP2 inducible kinaseannexin A3
SynonymsBIKE|HRIHFB2017ANX3
Cytomap

4q21.21

4q21.21

Type of geneprotein-codingprotein-coding
DescriptionBMP-2-inducible protein kinaseannexin A335-alpha calcimedinAnnexin III (lipocortin III)PAP-IIIannexin III (lipocortin III, 1,2-cyclic-inositol-phosphate phosphodiesterase, placental anticoagulant protein III, calcimedin 35-alpha)annexin-3calcimedin 35-alphainositol 1,2-cyclic p
Modification date2018052320180519
UniProtAcc

Q9NSY1

P12429

Ensembl transtripts involved in fusion geneENST00000335016, ENST00000502871, 
ENST00000264908, ENST00000512884, 
ENST00000503570, 
Fusion gene scores* DoF score5 X 3 X 4=602 X 2 X 2=8
# samples 52
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: BMP2K [Title/Abstract] AND ANXA3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneANXA3

GO:0006909

phagocytosis

9497492

TgeneANXA3

GO:0010595

positive regulation of endothelial cell migration

16236264

TgeneANXA3

GO:0042742

defense response to bacterium

9497492

TgeneANXA3

GO:0043312

neutrophil degranulation

9550422

TgeneANXA3

GO:0045766

positive regulation of angiogenesis

16236264

TgeneANXA3

GO:0051091

positive regulation of DNA binding transcription factor activity

16236264


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-PG-A914-01ABMP2Kchr4

79697875

+ANXA3chr4

79494334

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000335016ENST00000264908BMP2Kchr4

79697875

+ANXA3chr4

79494334

+
5CDS-intronENST00000335016ENST00000512884BMP2Kchr4

79697875

+ANXA3chr4

79494334

+
5CDS-5UTRENST00000335016ENST00000503570BMP2Kchr4

79697875

+ANXA3chr4

79494334

+
Frame-shiftENST00000502871ENST00000264908BMP2Kchr4

79697875

+ANXA3chr4

79494334

+
5CDS-intronENST00000502871ENST00000512884BMP2Kchr4

79697875

+ANXA3chr4

79494334

+
5CDS-5UTRENST00000502871ENST00000503570BMP2Kchr4

79697875

+ANXA3chr4

79494334

+

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FusionProtFeatures for BMP2K_ANXA3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BMP2K

Q9NSY1

ANXA3

P12429

May be involved in osteoblast differentiation. Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol1,2-cyclic phosphate to form inositol 1-phosphate.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BMP2K_ANXA3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BMP2K_ANXA3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BMP2KKDM5B, TERF1, TERF2, ABL1, EPS15, AP2M1, FN1, SLC25A41, LIMS1, XPO1, CAPZA2, CDK2, CLTB, CLTC, DBN1, FLNA, GAK, GBA, MYH9, PPP1CB, PICALM, IQGAP1, PDLIM7, SEC16A, SYNPO, LIMA1, GTSE1, ANLN, MYO19, MYO18A, AP2S1, CLINT1, REPS1, STAMBP, STAMBPL1, RALBP1, INTS4, RUNDC3AANXA3IGSF21, TP53, UBR1, UNC119, ISG15, STX4, ANXA11, STXBP2, ANXA4, SNAP23, ATF2, PPP2R4, SSNA1, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BMP2K_ANXA3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneANXA3P12429DB09095DifluocortoloneAnnexin A3small moleculeapproved|investigational|withdrawn

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RelatedDiseases for BMP2K_ANXA3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneANXA3C0003873Rheumatoid Arthritis1CTD_human
TgeneANXA3C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneANXA3C0024141Lupus Erythematosus, Systemic1CTD_human
TgeneANXA3C0033578Prostatic Neoplasms1CTD_human
TgeneANXA3C0919267ovarian neoplasm1CTD_human