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Fusion gene ID: 4228 |
FusionGeneSummary for BMP2K_ANXA3 |
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Fusion gene information | Fusion gene name: BMP2K_ANXA3 | Fusion gene ID: 4228 | Hgene | Tgene | Gene symbol | BMP2K | ANXA3 | Gene ID | 55589 | 306 |
Gene name | BMP2 inducible kinase | annexin A3 | |
Synonyms | BIKE|HRIHFB2017 | ANX3 | |
Cytomap | 4q21.21 | 4q21.21 | |
Type of gene | protein-coding | protein-coding | |
Description | BMP-2-inducible protein kinase | annexin A335-alpha calcimedinAnnexin III (lipocortin III)PAP-IIIannexin III (lipocortin III, 1,2-cyclic-inositol-phosphate phosphodiesterase, placental anticoagulant protein III, calcimedin 35-alpha)annexin-3calcimedin 35-alphainositol 1,2-cyclic p | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9NSY1 | P12429 | |
Ensembl transtripts involved in fusion gene | ENST00000335016, ENST00000502871, | ENST00000264908, ENST00000512884, ENST00000503570, | |
Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 2 X 2 X 2=8 |
# samples | 5 | 2 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: BMP2K [Title/Abstract] AND ANXA3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ANXA3 | GO:0006909 | phagocytosis | 9497492 |
Tgene | ANXA3 | GO:0010595 | positive regulation of endothelial cell migration | 16236264 |
Tgene | ANXA3 | GO:0042742 | defense response to bacterium | 9497492 |
Tgene | ANXA3 | GO:0043312 | neutrophil degranulation | 9550422 |
Tgene | ANXA3 | GO:0045766 | positive regulation of angiogenesis | 16236264 |
Tgene | ANXA3 | GO:0051091 | positive regulation of DNA binding transcription factor activity | 16236264 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | UCEC | TCGA-PG-A914-01A | BMP2K | chr4 | 79697875 | + | ANXA3 | chr4 | 79494334 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000335016 | ENST00000264908 | BMP2K | chr4 | 79697875 | + | ANXA3 | chr4 | 79494334 | + |
5CDS-intron | ENST00000335016 | ENST00000512884 | BMP2K | chr4 | 79697875 | + | ANXA3 | chr4 | 79494334 | + |
5CDS-5UTR | ENST00000335016 | ENST00000503570 | BMP2K | chr4 | 79697875 | + | ANXA3 | chr4 | 79494334 | + |
Frame-shift | ENST00000502871 | ENST00000264908 | BMP2K | chr4 | 79697875 | + | ANXA3 | chr4 | 79494334 | + |
5CDS-intron | ENST00000502871 | ENST00000512884 | BMP2K | chr4 | 79697875 | + | ANXA3 | chr4 | 79494334 | + |
5CDS-5UTR | ENST00000502871 | ENST00000503570 | BMP2K | chr4 | 79697875 | + | ANXA3 | chr4 | 79494334 | + |
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FusionProtFeatures for BMP2K_ANXA3 |
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Hgene | Tgene |
BMP2K | ANXA3 |
May be involved in osteoblast differentiation. | Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol1,2-cyclic phosphate to form inositol 1-phosphate. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BMP2K_ANXA3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BMP2K_ANXA3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
BMP2K | KDM5B, TERF1, TERF2, ABL1, EPS15, AP2M1, FN1, SLC25A41, LIMS1, XPO1, CAPZA2, CDK2, CLTB, CLTC, DBN1, FLNA, GAK, GBA, MYH9, PPP1CB, PICALM, IQGAP1, PDLIM7, SEC16A, SYNPO, LIMA1, GTSE1, ANLN, MYO19, MYO18A, AP2S1, CLINT1, REPS1, STAMBP, STAMBPL1, RALBP1, INTS4, RUNDC3A | ANXA3 | IGSF21, TP53, UBR1, UNC119, ISG15, STX4, ANXA11, STXBP2, ANXA4, SNAP23, ATF2, PPP2R4, SSNA1, TES |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BMP2K_ANXA3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | ANXA3 | P12429 | DB09095 | Difluocortolone | Annexin A3 | small molecule | approved|investigational|withdrawn |
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RelatedDiseases for BMP2K_ANXA3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ANXA3 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
Tgene | ANXA3 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | ANXA3 | C0024141 | Lupus Erythematosus, Systemic | 1 | CTD_human |
Tgene | ANXA3 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | ANXA3 | C0919267 | ovarian neoplasm | 1 | CTD_human |