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Fusion gene ID: 4227 |
FusionGeneSummary for BMP1_MALL |
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Fusion gene information | Fusion gene name: BMP1_MALL | Fusion gene ID: 4227 | Hgene | Tgene | Gene symbol | BMP1 | MALL | Gene ID | 649 | 7851 |
Gene name | bone morphogenetic protein 1 | mal, T cell differentiation protein like | |
Synonyms | OI13|PCOLC|PCP|PCP2|TLD | BENE | |
Cytomap | 8p21.3 | 2q13 | |
Type of gene | protein-coding | protein-coding | |
Description | bone morphogenetic protein 1mammalian tolloid proteinprocollagen C-endopeptidaseprocollagen C-proteinase 3 | MAL-like protein | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P13497 | Q13021 | |
Ensembl transtripts involved in fusion gene | ENST00000306385, ENST00000354870, ENST00000397816, ENST00000306349, ENST00000397814, ENST00000523849, | ENST00000272462, ENST00000427178, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 4 X 4 X 2=32 |
# samples | 3 | 4 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: BMP1 [Title/Abstract] AND MALL [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | BMP1 | GO:0006508 | proteolysis | 16824737 |
Hgene | BMP1 | GO:0061036 | positive regulation of cartilage development | 3201241 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF737796 | BMP1 | chr8 | 22037967 | - | MALL | chr2 | 110841958 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000306385 | ENST00000272462 | BMP1 | chr8 | 22037967 | - | MALL | chr2 | 110841958 | + |
5CDS-intron | ENST00000306385 | ENST00000427178 | BMP1 | chr8 | 22037967 | - | MALL | chr2 | 110841958 | + |
3UTR-3UTR | ENST00000354870 | ENST00000272462 | BMP1 | chr8 | 22037967 | - | MALL | chr2 | 110841958 | + |
3UTR-intron | ENST00000354870 | ENST00000427178 | BMP1 | chr8 | 22037967 | - | MALL | chr2 | 110841958 | + |
5CDS-3UTR | ENST00000397816 | ENST00000272462 | BMP1 | chr8 | 22037967 | - | MALL | chr2 | 110841958 | + |
5CDS-intron | ENST00000397816 | ENST00000427178 | BMP1 | chr8 | 22037967 | - | MALL | chr2 | 110841958 | + |
5CDS-3UTR | ENST00000306349 | ENST00000272462 | BMP1 | chr8 | 22037967 | - | MALL | chr2 | 110841958 | + |
5CDS-intron | ENST00000306349 | ENST00000427178 | BMP1 | chr8 | 22037967 | - | MALL | chr2 | 110841958 | + |
5CDS-3UTR | ENST00000397814 | ENST00000272462 | BMP1 | chr8 | 22037967 | - | MALL | chr2 | 110841958 | + |
5CDS-intron | ENST00000397814 | ENST00000427178 | BMP1 | chr8 | 22037967 | - | MALL | chr2 | 110841958 | + |
intron-3UTR | ENST00000523849 | ENST00000272462 | BMP1 | chr8 | 22037967 | - | MALL | chr2 | 110841958 | + |
intron-intron | ENST00000523849 | ENST00000427178 | BMP1 | chr8 | 22037967 | - | MALL | chr2 | 110841958 | + |
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FusionProtFeatures for BMP1_MALL |
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Hgene | Tgene |
BMP1 | MALL |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BMP1_MALL |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BMP1_MALL |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BMP1_MALL |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BMP1_MALL |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | BMP1 | C3553887 | OSTEOGENESIS IMPERFECTA, TYPE XIII | 3 | UNIPROT |