FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 42262

FusionGeneSummary for XYLT1_HS3ST4

check button Fusion gene summary
Fusion gene informationFusion gene name: XYLT1_HS3ST4
Fusion gene ID: 42262
HgeneTgene
Gene symbol

XYLT1

HS3ST4

Gene ID

64131

9951

Gene namexylosyltransferase 1heparan sulfate-glucosamine 3-sulfotransferase 4
SynonymsDBQD2|PXYLT1|XT-I|XT1|XTI|XYLTI|xylT-I3-OST-4|30ST4|3OST4|h3-OST-4
Cytomap

16p12.3

16p12.1

Type of geneprotein-codingprotein-coding
Descriptionxylosyltransferase 1beta-D-xylosyltransferase 1peptide O-xylosyltransferase 1xylosyltransferase Ixylosyltransferase iotaheparan sulfate glucosamine 3-O-sulfotransferase 4heparan sulfate (glucosamine) 3-O-sulfotransferase 4heparan sulfate 3-O-sulfotransferase 4heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4
Modification date2018051920180329
UniProtAcc

Q86Y38

Q9Y661

Ensembl transtripts involved in fusion geneENST00000261381, ENST00000568226, 
ENST00000331351, ENST00000475436, 
Fusion gene scores* DoF score7 X 4 X 4=1126 X 2 X 5=60
# samples 66
** MAII scorelog2(6/112*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/60*10)=0
Context

PubMed: XYLT1 [Title/Abstract] AND HS3ST4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-FS-A4F4-06AXYLT1chr16

17292069

-HS3ST4chr16

26146933

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000261381ENST00000331351XYLT1chr16

17292069

-HS3ST4chr16

26146933

+
5CDS-3UTRENST00000261381ENST00000475436XYLT1chr16

17292069

-HS3ST4chr16

26146933

+
intron-3CDSENST00000568226ENST00000331351XYLT1chr16

17292069

-HS3ST4chr16

26146933

+
intron-3UTRENST00000568226ENST00000475436XYLT1chr16

17292069

-HS3ST4chr16

26146933

+

Top

FusionProtFeatures for XYLT1_HS3ST4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
XYLT1

Q86Y38

HS3ST4

Q9Y661

Catalyzes the first step in the biosynthesis ofchondroitin sulfate and dermatan sulfate proteoglycans, such asDCN. Transfers D-xylose from UDP-D-xylose to specific serineresidues of the core protein (PubMed:15461586, PubMed:17189265,PubMed:24581741, PubMed:23982343). Required for normal embryonicand postnatal skeleton development, especially of the long bones(PubMed:24581741, PubMed:23982343). Required for normal maturationof chondrocytes during bone development, and normal onset ofossification (By similarity). {ECO:0000250|UniProtKB:Q811B1,ECO:0000269|PubMed:15461586, ECO:0000269|PubMed:17189265,ECO:0000269|PubMed:23982343, ECO:0000269|PubMed:24581741}. Sulfotransferase that utilizes 3'-phospho-5'-adenylylsulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid uniton heparan sulfate. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for XYLT1_HS3ST4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for XYLT1_HS3ST4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
XYLT1MYC, ADH1C, MEF2AHS3ST4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for XYLT1_HS3ST4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for XYLT1_HS3ST4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneXYLT1C4014294DESBUQUOIS DYSPLASIA 22UNIPROT
HgeneXYLT1C0033847Pseudoxanthoma Elasticum1CTD_human;UNIPROT
HgeneXYLT1C0236969Substance-Related Disorders1CTD_human
TgeneHS3ST4C0236733Amphetamine-Related Disorders1CTD_human