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Fusion gene ID: 42262 |
FusionGeneSummary for XYLT1_HS3ST4 |
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Fusion gene information | Fusion gene name: XYLT1_HS3ST4 | Fusion gene ID: 42262 | Hgene | Tgene | Gene symbol | XYLT1 | HS3ST4 | Gene ID | 64131 | 9951 |
Gene name | xylosyltransferase 1 | heparan sulfate-glucosamine 3-sulfotransferase 4 | |
Synonyms | DBQD2|PXYLT1|XT-I|XT1|XTI|XYLTI|xylT-I | 3-OST-4|30ST4|3OST4|h3-OST-4 | |
Cytomap | 16p12.3 | 16p12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | xylosyltransferase 1beta-D-xylosyltransferase 1peptide O-xylosyltransferase 1xylosyltransferase Ixylosyltransferase iota | heparan sulfate glucosamine 3-O-sulfotransferase 4heparan sulfate (glucosamine) 3-O-sulfotransferase 4heparan sulfate 3-O-sulfotransferase 4heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4 | |
Modification date | 20180519 | 20180329 | |
UniProtAcc | Q86Y38 | Q9Y661 | |
Ensembl transtripts involved in fusion gene | ENST00000261381, ENST00000568226, | ENST00000331351, ENST00000475436, | |
Fusion gene scores | * DoF score | 7 X 4 X 4=112 | 6 X 2 X 5=60 |
# samples | 6 | 6 | |
** MAII score | log2(6/112*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/60*10)=0 | |
Context | PubMed: XYLT1 [Title/Abstract] AND HS3ST4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-FS-A4F4-06A | XYLT1 | chr16 | 17292069 | - | HS3ST4 | chr16 | 26146933 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000261381 | ENST00000331351 | XYLT1 | chr16 | 17292069 | - | HS3ST4 | chr16 | 26146933 | + |
5CDS-3UTR | ENST00000261381 | ENST00000475436 | XYLT1 | chr16 | 17292069 | - | HS3ST4 | chr16 | 26146933 | + |
intron-3CDS | ENST00000568226 | ENST00000331351 | XYLT1 | chr16 | 17292069 | - | HS3ST4 | chr16 | 26146933 | + |
intron-3UTR | ENST00000568226 | ENST00000475436 | XYLT1 | chr16 | 17292069 | - | HS3ST4 | chr16 | 26146933 | + |
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FusionProtFeatures for XYLT1_HS3ST4 |
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Hgene | Tgene |
XYLT1 | HS3ST4 |
Catalyzes the first step in the biosynthesis ofchondroitin sulfate and dermatan sulfate proteoglycans, such asDCN. Transfers D-xylose from UDP-D-xylose to specific serineresidues of the core protein (PubMed:15461586, PubMed:17189265,PubMed:24581741, PubMed:23982343). Required for normal embryonicand postnatal skeleton development, especially of the long bones(PubMed:24581741, PubMed:23982343). Required for normal maturationof chondrocytes during bone development, and normal onset ofossification (By similarity). {ECO:0000250|UniProtKB:Q811B1,ECO:0000269|PubMed:15461586, ECO:0000269|PubMed:17189265,ECO:0000269|PubMed:23982343, ECO:0000269|PubMed:24581741}. | Sulfotransferase that utilizes 3'-phospho-5'-adenylylsulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid uniton heparan sulfate. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (Bysimilarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for XYLT1_HS3ST4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for XYLT1_HS3ST4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
XYLT1 | MYC, ADH1C, MEF2A | HS3ST4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for XYLT1_HS3ST4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for XYLT1_HS3ST4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | XYLT1 | C4014294 | DESBUQUOIS DYSPLASIA 2 | 2 | UNIPROT |
Hgene | XYLT1 | C0033847 | Pseudoxanthoma Elasticum | 1 | CTD_human;UNIPROT |
Hgene | XYLT1 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
Tgene | HS3ST4 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |