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Fusion gene ID: 42260 |
FusionGeneSummary for XYLT1_FAM86A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: XYLT1_FAM86A | Fusion gene ID: 42260 | Hgene | Tgene | Gene symbol | XYLT1 | FAM86A | Gene ID | 64131 | 196483 |
| Gene name | xylosyltransferase 1 | eukaryotic elongation factor 2 lysine methyltransferase | |
| Synonyms | DBQD2|PXYLT1|XT-I|XT1|XTI|XYLTI|xylT-I | EFM3|FAM86A|SB153|eEF2-KMT | |
| Cytomap | 16p12.3 | 16p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | xylosyltransferase 1beta-D-xylosyltransferase 1peptide O-xylosyltransferase 1xylosyltransferase Ixylosyltransferase iota | protein-lysine N-methyltransferase EEF2KMTeEF2-lysine methyltransferasefamily with sequence similarity 86, member Aprotein FAM86Aputative protein N-methyltransferase FAM86A | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q86Y38 | ||
| Ensembl transtripts involved in fusion gene | ENST00000261381, ENST00000568226, | ENST00000458008, ENST00000427587, ENST00000587133, | |
| Fusion gene scores | * DoF score | 7 X 4 X 4=112 | 2 X 2 X 2=8 |
| # samples | 6 | 2 | |
| ** MAII score | log2(6/112*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: XYLT1 [Title/Abstract] AND FAM86A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | FAM86A | GO:0018023 | peptidyl-lysine trimethylation | 25231979 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-QC-A6FX-01A | XYLT1 | chr16 | 17564291 | - | FAM86A | chr16 | 5145515 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000261381 | ENST00000458008 | XYLT1 | chr16 | 17564291 | - | FAM86A | chr16 | 5145515 | - |
| In-frame | ENST00000261381 | ENST00000427587 | XYLT1 | chr16 | 17564291 | - | FAM86A | chr16 | 5145515 | - |
| In-frame | ENST00000261381 | ENST00000587133 | XYLT1 | chr16 | 17564291 | - | FAM86A | chr16 | 5145515 | - |
| intron-3CDS | ENST00000568226 | ENST00000458008 | XYLT1 | chr16 | 17564291 | - | FAM86A | chr16 | 5145515 | - |
| intron-3CDS | ENST00000568226 | ENST00000427587 | XYLT1 | chr16 | 17564291 | - | FAM86A | chr16 | 5145515 | - |
| intron-3CDS | ENST00000568226 | ENST00000587133 | XYLT1 | chr16 | 17564291 | - | FAM86A | chr16 | 5145515 | - |
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FusionProtFeatures for XYLT1_FAM86A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| XYLT1 | FAM86A |
| Catalyzes the first step in the biosynthesis ofchondroitin sulfate and dermatan sulfate proteoglycans, such asDCN. Transfers D-xylose from UDP-D-xylose to specific serineresidues of the core protein (PubMed:15461586, PubMed:17189265,PubMed:24581741, PubMed:23982343). Required for normal embryonicand postnatal skeleton development, especially of the long bones(PubMed:24581741, PubMed:23982343). Required for normal maturationof chondrocytes during bone development, and normal onset ofossification (By similarity). {ECO:0000250|UniProtKB:Q811B1,ECO:0000269|PubMed:15461586, ECO:0000269|PubMed:17189265,ECO:0000269|PubMed:23982343, ECO:0000269|PubMed:24581741}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | XYLT1 | chr16:17564291 | chr16:5145515 | ENST00000261381 | - | 1 | 12 | 1_17 | 121 | 960 | Topological domain | Cytoplasmic |
| Hgene | XYLT1 | chr16:17564291 | chr16:5145515 | ENST00000261381 | - | 1 | 12 | 18_38 | 121 | 960 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Tgene | >FAM86A | chr16:17564291 | chr16:5145515 | ENST00000427587 | - | 0 | 8 | 165_167 | 32 | 331 | Region | S-adenosyl-L-methionine binding |
| Tgene | >FAM86A | chr16:17564291 | chr16:5145515 | ENST00000458008 | - | 0 | 7 | 165_167 | 32 | 297 | Region | S-adenosyl-L-methionine binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >XYLT1 | chr16:17564291 | chr16:5145515 | ENST00000261381 | - | 1 | 12 | 390_392 | 121 | 960 | Region | UDP-xylose binding |
| Hgene | >XYLT1 | chr16:17564291 | chr16:5145515 | ENST00000261381 | - | 1 | 12 | 494_495 | 121 | 960 | Region | UDP-xylose binding |
| Hgene | >XYLT1 | chr16:17564291 | chr16:5145515 | ENST00000261381 | - | 1 | 12 | 598_599 | 121 | 960 | Region | UDP-xylose binding |
| Hgene | >XYLT1 | chr16:17564291 | chr16:5145515 | ENST00000261381 | - | 1 | 12 | 39_959 | 121 | 960 | Topological domain | Lumenal |
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FusionGeneSequence for XYLT1_FAM86A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_XYLT1_ENST00000261381_chr16_17564291_-_FAM86A_ENST00000458008_chr16_5145515_-_386aa MVAAPCARRLARRSHSALLAALTVLLLQTLVVWNFSSLDSGAGERRGGAAVGGGEQPPPAPAPRRERRDLPAEPAAARGGGGGGGGGGGG RGPQARARGGGPGEPRGQQPASRGALPARALSLEAKLRDSSDSELLRDILHKTVKHPVCVKHPPSVKYARCFLSELIKKPSGGSVTLSES TAIISYGTTGLVTWDAALYLAEWAIENPAVFTNRTVLELGSGAGLTGLAICKMCRPRAYIFSDCHSRVLEQLRGNVLLNGLSLEADITAK LDSPRVTVAQLDWDVATVHQLSAFQPDVVIAADVLYCPEAIMSLVGVLRRLAACREHQRAPEVYVAFTVRNPETCQLFTTELGRAGIRWE >In-frame_XYLT1_ENST00000261381_chr16_17564291_-_FAM86A_ENST00000427587_chr16_5145515_-_420aa MVAAPCARRLARRSHSALLAALTVLLLQTLVVWNFSSLDSGAGERRGGAAVGGGEQPPPAPAPRRERRDLPAEPAAARGGGGGGGGGGGG RGPQARARGGGPGEPRGQQPASRGALPARALSLEAKLRDSSDSELLRDILHKTVKHPVCVKHPPSVKYARCFLSELIKKHEAVHTEPLDE LYEALAETLMAKESTQGHRSYLLPSGGSVTLSESTAIISYGTTGLVTWDAALYLAEWAIENPAVFTNRTVLELGSGAGLTGLAICKMCRP RAYIFSDCHSRVLEQLRGNVLLNGLSLEADITAKLDSPRVTVAQLDWDVATVHQLSAFQPDVVIAADVLYCPEAIMSLVGVLRRLAACRE >In-frame_XYLT1_ENST00000261381_chr16_17564291_-_FAM86A_ENST00000587133_chr16_5145515_-_359aa MVAAPCARRLARRSHSALLAALTVLLLQTLVVWNFSSLDSGAGERRGGAAVGGGEQPPPAPAPRRERRDLPAEPAAARGGGGGGGGGGGG RGPQARARGGGPGEPRGQQPASRGALPARALSLEAKLRDSSDSELLRDILHKPSGGSVTLSESTAIISYGTTGLVTWDAALYLAEWAIEN PAVFTNRTVLELGSGAGLTGLAICKMCRPRAYIFSDCHSRVLEQLRGNVLLNGLSLEADITAKLDSPRVTVAQLDWDVATVHQLSAFQPD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_XYLT1_ENST00000261381_chr16_17564291_-_FAM86A_ENST00000458008_chr16_5145515_-_1158nt ATGGTGGCGGCGCCGTGCGCCCGGAGGCTGGCCCGGCGCTCGCACTCGGCGCTGCTCGCGGCGCTCACGGTGCTGCTGCTGCAGACGCTG GTCGTGTGGAATTTCAGCAGCCTCGACTCCGGGGCCGGGGAGCGCCGCGGGGGCGCAGCGGTCGGCGGCGGGGAGCAGCCGCCCCCGGCC CCGGCCCCGCGCCGGGAGCGCCGGGACCTGCCCGCCGAGCCGGCTGCAGCCCGAGGAGGAGGAGGAGGCGGCGGCGGAGGAGGAGGAGGA CGGGGGCCCCAGGCGCGGGCGCGGGGAGGCGGCCCCGGAGAACCGCGGGGACAGCAGCCGGCCAGCCGGGGGGCACTGCCCGCCCGGGCT CTGAGCTTAGAAGCAAAGTTAAGAGACTCATCAGATTCTGAGCTGCTGCGGGATATTTTGCACAAGACTGTGAAGCATCCTGTGTGTGTG AAGCACCCGCCGTCCGTCAAATATGCCCGGTGCTTTCTCTCAGAACTCATCAAAAAGCCCTCGGGAGGCTCGGTCACACTCTCCGAGAGC ACGGCCATCATCTCCTACGGTACCACAGGCCTGGTCACATGGGACGCCGCCCTCTACCTTGCAGAATGGGCCATCGAGAACCCGGCAGTC TTCACTAACAGGACTGTCCTAGAGCTTGGCAGTGGTGCTGGCCTCACAGGCCTGGCCATCTGCAAGATGTGCCGCCCCCGGGCATACATC TTCAGCGACTGTCACAGCCGGGTCCTTGAGCAGCTCCGAGGGAATGTCCTTCTCAATGGCCTCTCATTAGAGGCAGACATCACTGCCAAG TTAGACAGCCCCAGGGTGACAGTGGCCCAGCTGGACTGGGACGTCGCGACGGTCCATCAGCTCTCTGCCTTCCAGCCAGATGTTGTCATT GCAGCAGATGTGCTGTATTGCCCAGAAGCCATCATGTCGCTGGTCGGGGTCCTGCGGAGGCTGGCTGCCTGCCGGGAGCACCAGCGGGCT CCTGAGGTCTACGTGGCCTTTACCGTCCGCAACCCAGAGACGTGCCAGCTGTTCACCACCGAGCTAGGCCGGGCCGGGATCAGATGGGAA >In-frame_XYLT1_ENST00000261381_chr16_17564291_-_FAM86A_ENST00000427587_chr16_5145515_-_1260nt ATGGTGGCGGCGCCGTGCGCCCGGAGGCTGGCCCGGCGCTCGCACTCGGCGCTGCTCGCGGCGCTCACGGTGCTGCTGCTGCAGACGCTG GTCGTGTGGAATTTCAGCAGCCTCGACTCCGGGGCCGGGGAGCGCCGCGGGGGCGCAGCGGTCGGCGGCGGGGAGCAGCCGCCCCCGGCC CCGGCCCCGCGCCGGGAGCGCCGGGACCTGCCCGCCGAGCCGGCTGCAGCCCGAGGAGGAGGAGGAGGCGGCGGCGGAGGAGGAGGAGGA CGGGGGCCCCAGGCGCGGGCGCGGGGAGGCGGCCCCGGAGAACCGCGGGGACAGCAGCCGGCCAGCCGGGGGGCACTGCCCGCCCGGGCT CTGAGCTTAGAAGCAAAGTTAAGAGACTCATCAGATTCTGAGCTGCTGCGGGATATTTTGCACAAGACTGTGAAGCATCCTGTGTGTGTG AAGCACCCGCCGTCCGTCAAATATGCCCGGTGCTTTCTCTCAGAACTCATCAAAAAGCACGAGGCTGTCCACACAGAGCCTTTGGACGAG CTGTATGAAGCGCTGGCGGAGACCCTGATGGCCAAGGAGTCCACCCAGGGCCACCGGAGCTATTTGCTGCCCTCGGGAGGCTCGGTCACA CTCTCCGAGAGCACGGCCATCATCTCCTACGGTACCACAGGCCTGGTCACATGGGACGCCGCCCTCTACCTTGCAGAATGGGCCATCGAG AACCCGGCAGTCTTCACTAACAGGACTGTCCTAGAGCTTGGCAGTGGTGCTGGCCTCACAGGCCTGGCCATCTGCAAGATGTGCCGCCCC CGGGCATACATCTTCAGCGACTGTCACAGCCGGGTCCTTGAGCAGCTCCGAGGGAATGTCCTTCTCAATGGCCTCTCATTAGAGGCAGAC ATCACTGCCAAGTTAGACAGCCCCAGGGTGACAGTGGCCCAGCTGGACTGGGACGTCGCGACGGTCCATCAGCTCTCTGCCTTCCAGCCA GATGTTGTCATTGCAGCAGATGTGCTGTATTGCCCAGAAGCCATCATGTCGCTGGTCGGGGTCCTGCGGAGGCTGGCTGCCTGCCGGGAG CACCAGCGGGCTCCTGAGGTCTACGTGGCCTTTACCGTCCGCAACCCAGAGACGTGCCAGCTGTTCACCACCGAGCTAGGCCGGGCCGGG ATCAGATGGGAAGTGGAACCTCGTCATGAGCAGAAACTGTTTCCCTACGAAGAGCACTTGGAGATGGCAATGCTGAATCTCACCCTGTAG >In-frame_XYLT1_ENST00000261381_chr16_17564291_-_FAM86A_ENST00000587133_chr16_5145515_-_1077nt ATGGTGGCGGCGCCGTGCGCCCGGAGGCTGGCCCGGCGCTCGCACTCGGCGCTGCTCGCGGCGCTCACGGTGCTGCTGCTGCAGACGCTG GTCGTGTGGAATTTCAGCAGCCTCGACTCCGGGGCCGGGGAGCGCCGCGGGGGCGCAGCGGTCGGCGGCGGGGAGCAGCCGCCCCCGGCC CCGGCCCCGCGCCGGGAGCGCCGGGACCTGCCCGCCGAGCCGGCTGCAGCCCGAGGAGGAGGAGGAGGCGGCGGCGGAGGAGGAGGAGGA CGGGGGCCCCAGGCGCGGGCGCGGGGAGGCGGCCCCGGAGAACCGCGGGGACAGCAGCCGGCCAGCCGGGGGGCACTGCCCGCCCGGGCT CTGAGCTTAGAAGCAAAGTTAAGAGACTCATCAGATTCTGAGCTGCTGCGGGATATTTTGCACAAGCCCTCGGGAGGCTCGGTCACACTC TCCGAGAGCACGGCCATCATCTCCTACGGTACCACAGGCCTGGTCACATGGGACGCCGCCCTCTACCTTGCAGAATGGGCCATCGAGAAC CCGGCAGTCTTCACTAACAGGACTGTCCTAGAGCTTGGCAGTGGTGCTGGCCTCACAGGCCTGGCCATCTGCAAGATGTGCCGCCCCCGG GCATACATCTTCAGCGACTGTCACAGCCGGGTCCTTGAGCAGCTCCGAGGGAATGTCCTTCTCAATGGCCTCTCATTAGAGGCAGACATC ACTGCCAAGTTAGACAGCCCCAGGGTGACAGTGGCCCAGCTGGACTGGGACGTCGCGACGGTCCATCAGCTCTCTGCCTTCCAGCCAGAT GTTGTCATTGCAGCAGATGTGCTGTATTGCCCAGAAGCCATCATGTCGCTGGTCGGGGTCCTGCGGAGGCTGGCTGCCTGCCGGGAGCAC CAGCGGGCTCCTGAGGTCTACGTGGCCTTTACCGTCCGCAACCCAGAGACGTGCCAGCTGTTCACCACCGAGCTAGGCCGGGCCGGGATC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_XYLT1_ENST00000261381_chr16_17564291_-_FAM86A_ENST00000458008_chr16_5145515_-_2571nt GCGGCCGCGGGAGCTGCGGGGAGCGCGGGGGCGGCCCGGAGCGTGCCGGGGTCCCCGCGCCTCGCTCGCCGGCCGCGCTCCGAAGATGGT GGCGGCGCCGTGCGCCCGGAGGCTGGCCCGGCGCTCGCACTCGGCGCTGCTCGCGGCGCTCACGGTGCTGCTGCTGCAGACGCTGGTCGT GTGGAATTTCAGCAGCCTCGACTCCGGGGCCGGGGAGCGCCGCGGGGGCGCAGCGGTCGGCGGCGGGGAGCAGCCGCCCCCGGCCCCGGC CCCGCGCCGGGAGCGCCGGGACCTGCCCGCCGAGCCGGCTGCAGCCCGAGGAGGAGGAGGAGGCGGCGGCGGAGGAGGAGGAGGACGGGG GCCCCAGGCGCGGGCGCGGGGAGGCGGCCCCGGAGAACCGCGGGGACAGCAGCCGGCCAGCCGGGGGGCACTGCCCGCCCGGGCTCTGAG CTTAGAAGCAAAGTTAAGAGACTCATCAGATTCTGAGCTGCTGCGGGATATTTTGCACAAGACTGTGAAGCATCCTGTGTGTGTGAAGCA CCCGCCGTCCGTCAAATATGCCCGGTGCTTTCTCTCAGAACTCATCAAAAAGCCCTCGGGAGGCTCGGTCACACTCTCCGAGAGCACGGC CATCATCTCCTACGGTACCACAGGCCTGGTCACATGGGACGCCGCCCTCTACCTTGCAGAATGGGCCATCGAGAACCCGGCAGTCTTCAC TAACAGGACTGTCCTAGAGCTTGGCAGTGGTGCTGGCCTCACAGGCCTGGCCATCTGCAAGATGTGCCGCCCCCGGGCATACATCTTCAG CGACTGTCACAGCCGGGTCCTTGAGCAGCTCCGAGGGAATGTCCTTCTCAATGGCCTCTCATTAGAGGCAGACATCACTGCCAAGTTAGA CAGCCCCAGGGTGACAGTGGCCCAGCTGGACTGGGACGTCGCGACGGTCCATCAGCTCTCTGCCTTCCAGCCAGATGTTGTCATTGCAGC AGATGTGCTGTATTGCCCAGAAGCCATCATGTCGCTGGTCGGGGTCCTGCGGAGGCTGGCTGCCTGCCGGGAGCACCAGCGGGCTCCTGA GGTCTACGTGGCCTTTACCGTCCGCAACCCAGAGACGTGCCAGCTGTTCACCACCGAGCTAGGCCGGGCCGGGATCAGATGGGAAGTGGA ACCTCGTCATGAGCAGAAACTGTTTCCCTACGAAGAGCACTTGGAGATGGCAATGCTGAATCTCACCCTGTAGGACTCACACACGACTCC AACGGGATTGTGAGAATCAAGTCACTCTCATGGGAAGAATTTTTATATGGGAAAGCGGATAAAACTTTCATTGGACTGGAATGTTTGGAG AATGTTAATTTCCAAATCAGGAACCACAAACTGCCCTCTAATAAGACATCGGCTATCTAAGCGTGTGGGTGCCCCCTTTCTGCCAGCAGT TCTGGTTCTTAAGAAAATCACCATAAATCAGACATGAAAATTCTGGCTCCAAAAATAGCATTTTCTTTGTGCAAATAAAAACGTGTGTAT CAAGTATGATGTTCCCCCAACGTGGACACACTCAGTTCCTCACAAAGCCAAGCCCACTGCAGCTGCCACATCCCTGGGCTTACGGTGCAG CAGGTGCTTTTTTCAAGACAGGAATCAAAATGTTAGGAACACGGCAGAAAGGGGACACCTGGAGACCAAACGCAGGATGAGGAGTTCTGC AGAGGTCACAGGGAAGTCACAGAACAGTAATACGCTAGCAGGGGCATGGGGCGTGAAGAACAGAAGAAGAGAGGAAGCGTTTCCAAGCCT CCAGAGAAGAAATCAAGGCCAACCAAAGCTTCCCGGGTCACAGAACCAATTCTTTTACCAGGCAGTACCACTGCTGTCATTTCAGCTTCT GGCCACTGGGAGGTGCTGCTCGAAAGGGTTTGCCCTGAGACTCCAAGAAGAAGCTGCGGGAAGGACAGCAGGGGTCCTGGGGTTTTAGCC TCTGGCCCAGGAGTTATGTGTCCATAACCAAAGGGAGCACAGTCTGCACCCAGCTCTCATCCCATCGGAGCTGCTGCGACTCCCGCAGGT TCTTCCGGAACTGGTTTAGCTTGCCCGCAGGATCAGGAAAGTTTGAGAAAAGCATCTGCAAAAAAATAAAGAGCAGAGCTTACCTCATTG CCTGTCCCCACCCCATCCCAGGTCACCACCTGGCTGACCCCAGGTCCCCGACCCAACAACAACCCCTCCCAAGTCCCTAACTCCCTCACT TGGACTCGAGACCCTTCACACCCCAGCAGCACTCCGCCTCCAACTTGACATCACAGTTTCTGGAAACTTCCCCGCATGTCCCACTTTCCC ACACTTGGTGCCCTGGAGCACCTCCCGGCCTCTACGTGCTGCCCATTCCCCTGTGAGCACCCTCCTCTCGGCCTCTGGCCAACGCAGTCT CACCCATCTGTGGGTAACAAGGGGGTGTCGGTGTTCTTTGCAGCCTTGCTAAACTGTCTGAATCAAGGATCACAAACTACAGCCTGCAGG >In-frame_XYLT1_ENST00000261381_chr16_17564291_-_FAM86A_ENST00000427587_chr16_5145515_-_2673nt GCGGCCGCGGGAGCTGCGGGGAGCGCGGGGGCGGCCCGGAGCGTGCCGGGGTCCCCGCGCCTCGCTCGCCGGCCGCGCTCCGAAGATGGT GGCGGCGCCGTGCGCCCGGAGGCTGGCCCGGCGCTCGCACTCGGCGCTGCTCGCGGCGCTCACGGTGCTGCTGCTGCAGACGCTGGTCGT GTGGAATTTCAGCAGCCTCGACTCCGGGGCCGGGGAGCGCCGCGGGGGCGCAGCGGTCGGCGGCGGGGAGCAGCCGCCCCCGGCCCCGGC CCCGCGCCGGGAGCGCCGGGACCTGCCCGCCGAGCCGGCTGCAGCCCGAGGAGGAGGAGGAGGCGGCGGCGGAGGAGGAGGAGGACGGGG GCCCCAGGCGCGGGCGCGGGGAGGCGGCCCCGGAGAACCGCGGGGACAGCAGCCGGCCAGCCGGGGGGCACTGCCCGCCCGGGCTCTGAG CTTAGAAGCAAAGTTAAGAGACTCATCAGATTCTGAGCTGCTGCGGGATATTTTGCACAAGACTGTGAAGCATCCTGTGTGTGTGAAGCA CCCGCCGTCCGTCAAATATGCCCGGTGCTTTCTCTCAGAACTCATCAAAAAGCACGAGGCTGTCCACACAGAGCCTTTGGACGAGCTGTA TGAAGCGCTGGCGGAGACCCTGATGGCCAAGGAGTCCACCCAGGGCCACCGGAGCTATTTGCTGCCCTCGGGAGGCTCGGTCACACTCTC CGAGAGCACGGCCATCATCTCCTACGGTACCACAGGCCTGGTCACATGGGACGCCGCCCTCTACCTTGCAGAATGGGCCATCGAGAACCC GGCAGTCTTCACTAACAGGACTGTCCTAGAGCTTGGCAGTGGTGCTGGCCTCACAGGCCTGGCCATCTGCAAGATGTGCCGCCCCCGGGC ATACATCTTCAGCGACTGTCACAGCCGGGTCCTTGAGCAGCTCCGAGGGAATGTCCTTCTCAATGGCCTCTCATTAGAGGCAGACATCAC TGCCAAGTTAGACAGCCCCAGGGTGACAGTGGCCCAGCTGGACTGGGACGTCGCGACGGTCCATCAGCTCTCTGCCTTCCAGCCAGATGT TGTCATTGCAGCAGATGTGCTGTATTGCCCAGAAGCCATCATGTCGCTGGTCGGGGTCCTGCGGAGGCTGGCTGCCTGCCGGGAGCACCA GCGGGCTCCTGAGGTCTACGTGGCCTTTACCGTCCGCAACCCAGAGACGTGCCAGCTGTTCACCACCGAGCTAGGCCGGGCCGGGATCAG ATGGGAAGTGGAACCTCGTCATGAGCAGAAACTGTTTCCCTACGAAGAGCACTTGGAGATGGCAATGCTGAATCTCACCCTGTAGGACTC ACACACGACTCCAACGGGATTGTGAGAATCAAGTCACTCTCATGGGAAGAATTTTTATATGGGAAAGCGGATAAAACTTTCATTGGACTG GAATGTTTGGAGAATGTTAATTTCCAAATCAGGAACCACAAACTGCCCTCTAATAAGACATCGGCTATCTAAGCGTGTGGGTGCCCCCTT TCTGCCAGCAGTTCTGGTTCTTAAGAAAATCACCATAAATCAGACATGAAAATTCTGGCTCCAAAAATAGCATTTTCTTTGTGCAAATAA AAACGTGTGTATCAAGTATGATGTTCCCCCAACGTGGACACACTCAGTTCCTCACAAAGCCAAGCCCACTGCAGCTGCCACATCCCTGGG CTTACGGTGCAGCAGGTGCTTTTTTCAAGACAGGAATCAAAATGTTAGGAACACGGCAGAAAGGGGACACCTGGAGACCAAACGCAGGAT GAGGAGTTCTGCAGAGGTCACAGGGAAGTCACAGAACAGTAATACGCTAGCAGGGGCATGGGGCGTGAAGAACAGAAGAAGAGAGGAAGC GTTTCCAAGCCTCCAGAGAAGAAATCAAGGCCAACCAAAGCTTCCCGGGTCACAGAACCAATTCTTTTACCAGGCAGTACCACTGCTGTC ATTTCAGCTTCTGGCCACTGGGAGGTGCTGCTCGAAAGGGTTTGCCCTGAGACTCCAAGAAGAAGCTGCGGGAAGGACAGCAGGGGTCCT GGGGTTTTAGCCTCTGGCCCAGGAGTTATGTGTCCATAACCAAAGGGAGCACAGTCTGCACCCAGCTCTCATCCCATCGGAGCTGCTGCG ACTCCCGCAGGTTCTTCCGGAACTGGTTTAGCTTGCCCGCAGGATCAGGAAAGTTTGAGAAAAGCATCTGCAAAAAAATAAAGAGCAGAG CTTACCTCATTGCCTGTCCCCACCCCATCCCAGGTCACCACCTGGCTGACCCCAGGTCCCCGACCCAACAACAACCCCTCCCAAGTCCCT AACTCCCTCACTTGGACTCGAGACCCTTCACACCCCAGCAGCACTCCGCCTCCAACTTGACATCACAGTTTCTGGAAACTTCCCCGCATG TCCCACTTTCCCACACTTGGTGCCCTGGAGCACCTCCCGGCCTCTACGTGCTGCCCATTCCCCTGTGAGCACCCTCCTCTCGGCCTCTGG CCAACGCAGTCTCACCCATCTGTGGGTAACAAGGGGGTGTCGGTGTTCTTTGCAGCCTTGCTAAACTGTCTGAATCAAGGATCACAAACT >In-frame_XYLT1_ENST00000261381_chr16_17564291_-_FAM86A_ENST00000587133_chr16_5145515_-_1222nt GCGGCCGCGGGAGCTGCGGGGAGCGCGGGGGCGGCCCGGAGCGTGCCGGGGTCCCCGCGCCTCGCTCGCCGGCCGCGCTCCGAAGATGGT GGCGGCGCCGTGCGCCCGGAGGCTGGCCCGGCGCTCGCACTCGGCGCTGCTCGCGGCGCTCACGGTGCTGCTGCTGCAGACGCTGGTCGT GTGGAATTTCAGCAGCCTCGACTCCGGGGCCGGGGAGCGCCGCGGGGGCGCAGCGGTCGGCGGCGGGGAGCAGCCGCCCCCGGCCCCGGC CCCGCGCCGGGAGCGCCGGGACCTGCCCGCCGAGCCGGCTGCAGCCCGAGGAGGAGGAGGAGGCGGCGGCGGAGGAGGAGGAGGACGGGG GCCCCAGGCGCGGGCGCGGGGAGGCGGCCCCGGAGAACCGCGGGGACAGCAGCCGGCCAGCCGGGGGGCACTGCCCGCCCGGGCTCTGAG CTTAGAAGCAAAGTTAAGAGACTCATCAGATTCTGAGCTGCTGCGGGATATTTTGCACAAGCCCTCGGGAGGCTCGGTCACACTCTCCGA GAGCACGGCCATCATCTCCTACGGTACCACAGGCCTGGTCACATGGGACGCCGCCCTCTACCTTGCAGAATGGGCCATCGAGAACCCGGC AGTCTTCACTAACAGGACTGTCCTAGAGCTTGGCAGTGGTGCTGGCCTCACAGGCCTGGCCATCTGCAAGATGTGCCGCCCCCGGGCATA CATCTTCAGCGACTGTCACAGCCGGGTCCTTGAGCAGCTCCGAGGGAATGTCCTTCTCAATGGCCTCTCATTAGAGGCAGACATCACTGC CAAGTTAGACAGCCCCAGGGTGACAGTGGCCCAGCTGGACTGGGACGTCGCGACGGTCCATCAGCTCTCTGCCTTCCAGCCAGATGTTGT CATTGCAGCAGATGTGCTGTATTGCCCAGAAGCCATCATGTCGCTGGTCGGGGTCCTGCGGAGGCTGGCTGCCTGCCGGGAGCACCAGCG GGCTCCTGAGGTCTACGTGGCCTTTACCGTCCGCAACCCAGAGACGTGCCAGCTGTTCACCACCGAGCTAGGCCGGGCCGGGATCAGATG GGAAGTGGAACCTCGTCATGAGCAGAAACTGTTTCCCTACGAAGAGCACTTGGAGATGGCAATGCTGAATCTCACCCTGTAGGACTCACA |
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FusionGenePPI for XYLT1_FAM86A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| XYLT1 | MYC, ADH1C, MEF2A | FAM86A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for XYLT1_FAM86A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for XYLT1_FAM86A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | XYLT1 | C4014294 | DESBUQUOIS DYSPLASIA 2 | 2 | UNIPROT |
| Hgene | XYLT1 | C0033847 | Pseudoxanthoma Elasticum | 1 | CTD_human;UNIPROT |
| Hgene | XYLT1 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
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