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Fusion gene ID: 42259 |
FusionGeneSummary for XYLT1_CSNK1D |
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Fusion gene information | Fusion gene name: XYLT1_CSNK1D | Fusion gene ID: 42259 | Hgene | Tgene | Gene symbol | XYLT1 | CSNK1D | Gene ID | 64131 | 1453 |
Gene name | xylosyltransferase 1 | casein kinase 1 delta | |
Synonyms | DBQD2|PXYLT1|XT-I|XT1|XTI|XYLTI|xylT-I | ASPS|CKI-delta|CKId|CKIdelta|FASPS2|HCKID | |
Cytomap | 16p12.3 | 17q25.3 | |
Type of gene | protein-coding | protein-coding | |
Description | xylosyltransferase 1beta-D-xylosyltransferase 1peptide O-xylosyltransferase 1xylosyltransferase Ixylosyltransferase iota | casein kinase I isoform deltacasein kinase Itau-protein kinase CSNK1D | |
Modification date | 20180519 | 20180529 | |
UniProtAcc | Q86Y38 | P48730 | |
Ensembl transtripts involved in fusion gene | ENST00000261381, ENST00000568226, | ENST00000398519, ENST00000314028, ENST00000392334, ENST00000578904, | |
Fusion gene scores | * DoF score | 7 X 4 X 4=112 | 14 X 14 X 6=1176 |
# samples | 6 | 16 | |
** MAII score | log2(6/112*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/1176*10)=-2.877744249949 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: XYLT1 [Title/Abstract] AND CSNK1D [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CSNK1D | GO:0006468 | protein phosphorylation | 16618118 |
Tgene | CSNK1D | GO:0018105 | peptidyl-serine phosphorylation | 25500533 |
Tgene | CSNK1D | GO:0051225 | spindle assembly | 10826492 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BI021289 | XYLT1 | chr16 | 17268009 | + | CSNK1D | chr17 | 80228969 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000261381 | ENST00000398519 | XYLT1 | chr16 | 17268009 | + | CSNK1D | chr17 | 80228969 | - |
intron-intron | ENST00000261381 | ENST00000314028 | XYLT1 | chr16 | 17268009 | + | CSNK1D | chr17 | 80228969 | - |
intron-intron | ENST00000261381 | ENST00000392334 | XYLT1 | chr16 | 17268009 | + | CSNK1D | chr17 | 80228969 | - |
intron-intron | ENST00000261381 | ENST00000578904 | XYLT1 | chr16 | 17268009 | + | CSNK1D | chr17 | 80228969 | - |
intron-intron | ENST00000568226 | ENST00000398519 | XYLT1 | chr16 | 17268009 | + | CSNK1D | chr17 | 80228969 | - |
intron-intron | ENST00000568226 | ENST00000314028 | XYLT1 | chr16 | 17268009 | + | CSNK1D | chr17 | 80228969 | - |
intron-intron | ENST00000568226 | ENST00000392334 | XYLT1 | chr16 | 17268009 | + | CSNK1D | chr17 | 80228969 | - |
intron-intron | ENST00000568226 | ENST00000578904 | XYLT1 | chr16 | 17268009 | + | CSNK1D | chr17 | 80228969 | - |
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FusionProtFeatures for XYLT1_CSNK1D |
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Hgene | Tgene |
XYLT1 | CSNK1D |
Catalyzes the first step in the biosynthesis ofchondroitin sulfate and dermatan sulfate proteoglycans, such asDCN. Transfers D-xylose from UDP-D-xylose to specific serineresidues of the core protein (PubMed:15461586, PubMed:17189265,PubMed:24581741, PubMed:23982343). Required for normal embryonicand postnatal skeleton development, especially of the long bones(PubMed:24581741, PubMed:23982343). Required for normal maturationof chondrocytes during bone development, and normal onset ofossification (By similarity). {ECO:0000250|UniProtKB:Q811B1,ECO:0000269|PubMed:15461586, ECO:0000269|PubMed:17189265,ECO:0000269|PubMed:23982343, ECO:0000269|PubMed:24581741}. | Essential serine/threonine-protein kinase that regulatesdiverse cellular growth and survival processes including Wntsignaling, DNA repair and circadian rhythms. It can phosphorylatea large number of proteins. Casein kinases are operationallydefined by their preferential utilization of acidic proteins suchas caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A,SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3,ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Centralcomponent of the circadian clock. In balance with PP1, determinesthe circadian period length through the regulation of the speedand rhythmicity of PER1 and PER2 phosphorylation. Controls PER1and PER2 nuclear transport and degradation. YAP1 phosphorylationpromotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediatedubiquitination and subsequent degradation. DNMT1 phosphorylationreduces its DNA-binding activity. Phosphorylation of ESR1 andAIB1/NCOA3 stimulates their activity and coactivation.Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathwaythat controls neurite outgrowth. EIF6 phosphorylation promotes itsnuclear export. Triggers down-regulation of dopamine receptors inthe forebrain. Activates DCK in vitro by phosphorylation. TOP2Aphosphorylation favors DNA cleavable complex formation. Mayregulate the formation of the mitotic spindle apparatus inextravillous trophoblast. Modulates connexin-43/GJA1 gap junctionassembly by phosphorylation. Probably involved in lymphocytephysiology. Regulates fast synaptic transmission mediated byglutamate. {ECO:0000269|PubMed:10606744,ECO:0000269|PubMed:12270943, ECO:0000269|PubMed:14761950,ECO:0000269|PubMed:16027726, ECO:0000269|PubMed:17562708,ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:19043076,ECO:0000269|PubMed:19339517, ECO:0000269|PubMed:20041275,ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:20407760,ECO:0000269|PubMed:20637175, ECO:0000269|PubMed:20696890,ECO:0000269|PubMed:20699359, ECO:0000269|PubMed:21084295,ECO:0000269|PubMed:21422228, ECO:0000269|PubMed:23636092}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for XYLT1_CSNK1D |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for XYLT1_CSNK1D |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for XYLT1_CSNK1D |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for XYLT1_CSNK1D |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | XYLT1 | C4014294 | DESBUQUOIS DYSPLASIA 2 | 2 | UNIPROT |
Hgene | XYLT1 | C0033847 | Pseudoxanthoma Elasticum | 1 | CTD_human;UNIPROT |
Hgene | XYLT1 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
Tgene | CSNK1D | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | CSNK1D | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | CSNK1D | C0041696 | Unipolar Depression | 1 | PSYGENET |
Tgene | CSNK1D | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Tgene | CSNK1D | C3808874 | ADVANCED SLEEP PHASE SYNDROME, FAMILIAL, 2 | 1 | UNIPROT |