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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 42258

FusionGeneSummary for XYLT1_ABR

check button Fusion gene summary
Fusion gene informationFusion gene name: XYLT1_ABR
Fusion gene ID: 42258
HgeneTgene
Gene symbol

XYLT1

ABR

Gene ID

64131

29

Gene namexylosyltransferase 1ABR, RhoGEF and GTPase activating protein
SynonymsDBQD2|PXYLT1|XT-I|XT1|XTI|XYLTI|xylT-IMDB
Cytomap

16p12.3

17p13.3

Type of geneprotein-codingprotein-coding
Descriptionxylosyltransferase 1beta-D-xylosyltransferase 1peptide O-xylosyltransferase 1xylosyltransferase Ixylosyltransferase iotaactive breakpoint cluster region-related proteinactive BCR-related
Modification date2018051920180523
UniProtAcc

Q86Y38

Q12979

Ensembl transtripts involved in fusion geneENST00000261381, ENST00000568226, 
ENST00000302538, ENST00000544583, 
ENST00000572441, ENST00000574437, 
ENST00000291107, ENST00000543210, 
ENST00000536794, ENST00000573895, 
Fusion gene scores* DoF score7 X 4 X 4=11214 X 13 X 8=1456
# samples 618
** MAII scorelog2(6/112*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1456*10)=-3.01594154386902
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: XYLT1 [Title/Abstract] AND ABR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-IE-A4EJ-01AXYLT1chr16

17352845

-ABRchr17

1028702

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000261381ENST00000302538XYLT1chr16

17352845

-ABRchr17

1028702

-
5CDS-5UTRENST00000261381ENST00000544583XYLT1chr16

17352845

-ABRchr17

1028702

-
5CDS-intronENST00000261381ENST00000572441XYLT1chr16

17352845

-ABRchr17

1028702

-
5CDS-5UTRENST00000261381ENST00000574437XYLT1chr16

17352845

-ABRchr17

1028702

-
5CDS-intronENST00000261381ENST00000291107XYLT1chr16

17352845

-ABRchr17

1028702

-
5CDS-intronENST00000261381ENST00000543210XYLT1chr16

17352845

-ABRchr17

1028702

-
5CDS-intronENST00000261381ENST00000536794XYLT1chr16

17352845

-ABRchr17

1028702

-
5CDS-intronENST00000261381ENST00000573895XYLT1chr16

17352845

-ABRchr17

1028702

-
intron-3CDSENST00000568226ENST00000302538XYLT1chr16

17352845

-ABRchr17

1028702

-
intron-5UTRENST00000568226ENST00000544583XYLT1chr16

17352845

-ABRchr17

1028702

-
intron-intronENST00000568226ENST00000572441XYLT1chr16

17352845

-ABRchr17

1028702

-
intron-5UTRENST00000568226ENST00000574437XYLT1chr16

17352845

-ABRchr17

1028702

-
intron-intronENST00000568226ENST00000291107XYLT1chr16

17352845

-ABRchr17

1028702

-
intron-intronENST00000568226ENST00000543210XYLT1chr16

17352845

-ABRchr17

1028702

-
intron-intronENST00000568226ENST00000536794XYLT1chr16

17352845

-ABRchr17

1028702

-
intron-intronENST00000568226ENST00000573895XYLT1chr16

17352845

-ABRchr17

1028702

-

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FusionProtFeatures for XYLT1_ABR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
XYLT1

Q86Y38

ABR

Q12979

Catalyzes the first step in the biosynthesis ofchondroitin sulfate and dermatan sulfate proteoglycans, such asDCN. Transfers D-xylose from UDP-D-xylose to specific serineresidues of the core protein (PubMed:15461586, PubMed:17189265,PubMed:24581741, PubMed:23982343). Required for normal embryonicand postnatal skeleton development, especially of the long bones(PubMed:24581741, PubMed:23982343). Required for normal maturationof chondrocytes during bone development, and normal onset ofossification (By similarity). {ECO:0000250|UniProtKB:Q811B1,ECO:0000269|PubMed:15461586, ECO:0000269|PubMed:17189265,ECO:0000269|PubMed:23982343, ECO:0000269|PubMed:24581741}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneXYLT1chr16:17352845chr17:1028702ENST00000261381-3121_17304960Topological domainCytoplasmic
HgeneXYLT1chr16:17352845chr17:1028702ENST00000261381-31218_38304960TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneABRchr16:17352845chr17:1028702ENST00000291107-022417_420-11823Compositional biasNote=Poly-Leu
TgeneABRchr16:17352845chr17:1028702ENST00000302538-023417_42020860Compositional biasNote=Poly-Leu
TgeneABRchr16:17352845chr17:1028702ENST00000543210-08417_420-33311Compositional biasNote=Poly-Leu
TgeneABRchr16:17352845chr17:1028702ENST00000544583-023417_420-26814Compositional biasNote=Poly-Leu
TgeneABRchr16:17352845chr17:1028702ENST00000574437-022417_420-155814Compositional biasNote=Poly-Leu
TgeneABRchr16:17352845chr17:1028702ENST00000291107-022301_459-11823DomainPH
TgeneABRchr16:17352845chr17:1028702ENST00000291107-022463_595-11823DomainC2
TgeneABRchr16:17352845chr17:1028702ENST00000291107-022647_845-11823DomainRho-GAP
TgeneABRchr16:17352845chr17:1028702ENST00000291107-02291_284-11823DomainDH
TgeneABRchr16:17352845chr17:1028702ENST00000302538-023301_45920860DomainPH
TgeneABRchr16:17352845chr17:1028702ENST00000302538-023463_59520860DomainC2
TgeneABRchr16:17352845chr17:1028702ENST00000302538-023647_84520860DomainRho-GAP
TgeneABRchr16:17352845chr17:1028702ENST00000302538-02391_28420860DomainDH
TgeneABRchr16:17352845chr17:1028702ENST00000543210-08301_459-33311DomainPH
TgeneABRchr16:17352845chr17:1028702ENST00000543210-08463_595-33311DomainC2
TgeneABRchr16:17352845chr17:1028702ENST00000543210-08647_845-33311DomainRho-GAP
TgeneABRchr16:17352845chr17:1028702ENST00000543210-0891_284-33311DomainDH
TgeneABRchr16:17352845chr17:1028702ENST00000544583-023301_459-26814DomainPH
TgeneABRchr16:17352845chr17:1028702ENST00000544583-023463_595-26814DomainC2
TgeneABRchr16:17352845chr17:1028702ENST00000544583-023647_845-26814DomainRho-GAP
TgeneABRchr16:17352845chr17:1028702ENST00000544583-02391_284-26814DomainDH
TgeneABRchr16:17352845chr17:1028702ENST00000574437-022301_459-155814DomainPH
TgeneABRchr16:17352845chr17:1028702ENST00000574437-022463_595-155814DomainC2
TgeneABRchr16:17352845chr17:1028702ENST00000574437-022647_845-155814DomainRho-GAP
TgeneABRchr16:17352845chr17:1028702ENST00000574437-02291_284-155814DomainDH

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneXYLT1chr16:17352845chr17:1028702ENST00000261381-312390_392304960RegionUDP-xylose binding
HgeneXYLT1chr16:17352845chr17:1028702ENST00000261381-312494_495304960RegionUDP-xylose binding
HgeneXYLT1chr16:17352845chr17:1028702ENST00000261381-312598_599304960RegionUDP-xylose binding
HgeneXYLT1chr16:17352845chr17:1028702ENST00000261381-31239_959304960Topological domainLumenal


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FusionGeneSequence for XYLT1_ABR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_XYLT1_ENST00000261381_chr16_17352845_-_ABR_ENST00000302538_chr17_1028702_-_1144aa
MVAAPCARRLARRSHSALLAALTVLLLQTLVVWNFSSLDSGAGERRGGAAVGGGEQPPPAPAPRRERRDLPAEPAAARGGGGGGGGGGGG
RGPQARARGGGPGEPRGQQPASRGALPARALDPHPSPLITLETQDGYFSHRPKEKVRTDSNNENSVPKDFENVDNSNFAPRTQKQKHQPE
LAKKPPSRQKELLKRKLEQQEKGKGHTFPGKGPGEVLPPGDRAAANSSHGKDVSRPPHARKTGGSSPETKYDQPPKCDISGKEAISALSR
AKSKHCRQEIGETYCRHKLGLLMPEKVTRFCPLEDFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPP
EGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDS
QVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKH
TPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDC
KWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKS
YLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTL
EVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMN
GIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDIL
LMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_XYLT1_ENST00000261381_chr16_17352845_-_ABR_ENST00000302538_chr17_1028702_-_3432nt
ATGGTGGCGGCGCCGTGCGCCCGGAGGCTGGCCCGGCGCTCGCACTCGGCGCTGCTCGCGGCGCTCACGGTGCTGCTGCTGCAGACGCTG
GTCGTGTGGAATTTCAGCAGCCTCGACTCCGGGGCCGGGGAGCGCCGCGGGGGCGCAGCGGTCGGCGGCGGGGAGCAGCCGCCCCCGGCC
CCGGCCCCGCGCCGGGAGCGCCGGGACCTGCCCGCCGAGCCGGCTGCAGCCCGAGGAGGAGGAGGAGGCGGCGGCGGAGGAGGAGGAGGA
CGGGGGCCCCAGGCGCGGGCGCGGGGAGGCGGCCCCGGAGAACCGCGGGGACAGCAGCCGGCCAGCCGGGGGGCACTGCCCGCCCGGGCT
CTGGATCCACACCCAAGTCCGCTCATCACCCTGGAGACTCAGGATGGCTACTTTTCTCATCGGCCGAAAGAGAAAGTGCGAACAGACAGC
AACAACGAGAACTCTGTCCCCAAAGACTTTGAGAATGTCGACAACAGCAACTTCGCACCCAGGACTCAAAAGCAGAAGCACCAGCCTGAG
TTGGCGAAGAAGCCACCGAGTAGACAGAAGGAGCTTTTGAAAAGGAAGCTGGAACAGCAGGAGAAAGGAAAAGGACATACATTCCCTGGG
AAAGGCCCCGGTGAGGTGCTGCCTCCCGGGGACAGAGCCGCAGCCAACAGCAGCCACGGGAAGGATGTGTCCAGACCGCCTCATGCCAGG
AAAACTGGGGGCAGCTCCCCCGAGACCAAGTATGACCAGCCCCCTAAGTGTGACATCTCAGGCAAGGAGGCCATCTCTGCCCTGTCCCGT
GCTAAGTCCAAGCACTGCCGCCAGGAGATTGGGGAGACTTACTGCCGCCACAAGTTAGGGCTGCTGATGCCTGAGAAGGTGACTCGGTTC
TGCCCCCTCGAGGACTTCAGCTACGGGACGGACGAGTACGACGGAGAGGGGAATGAGGAGCAGAAGGGGCCCCCGGAGGGCTCAGAGACC
ATGCCGTACATCGATGAGTCGCCCACCATGTCCCCGCAGCTCAGCGCCCGCAGCCAGGGCGGGGGGGATGGCGTCTCCCCGACTCCACCT
GAGGGACTGGCTCCTGGGGTGGAAGCAGGGAAAGGCCTGGAGATGAGGAAGCTGGTTCTCTCGGGGTTCTTGGCCAGCGAAGAGATCTAC
ATTAACCAGCTGGAAGCCCTGTTGCTGCCCATGAAACCCCTGAAGGCCACCGCCACCACCTCCCAGCCCGTGCTCACCATCCAGCAGATC
GAGACCATCTTCTACAAGATCCAGGACATCTATGAGATCCACAAGGAGTTCTATGACAACCTGTGCCCCAAGGTGCAACAGTGGGACAGC
CAGGTCACCATGGGCCACCTCTTCCAGAAGCTGGCCAGCCAGCTCGGTGTGTACAAAGCGTTTGTCGATAACTATAAAGTCGCTCTGGAG
ACAGCTGAGAAGTGCAGCCAGTCCAACAACCAGTTCCAGAAGATCTCAGAGGAACTCAAAGTGAAAGGTCCCAAGGACTCCAAGGACAGC
CACACGTCTGTCACCATGGAAGCTCTGCTCTACAAGCCCATTGACCGGGTCACTCGGAGCACCCTAGTCCTACACGACCTGCTGAAGCAC
ACACCTGTGGACCACCCCGACTACCCGCTGCTGCAGGATGCCCTCCGCATCTCCCAGAACTTCCTGTCCAGCATCAACGAGGACATCGAC
CCCCGCCGGACTGCAGTGACAACGCCCAAGGGGGAGACGCGACAGCTGGTGAAGGACGGCTTCCTGGTGGAAGTGTCAGAGAGCTCCCGG
AAGCTGCGGCACGTCTTCCTCTTTACAGATGTCCTACTGTGTGCCAAGCTGAAGAAGACCTCTGCAGGGAAGCACCAGCAGTATGACTGT
AAGTGGTACATCCCCCTGGCCGACCTGGTGTTTCCATCCCCCGAGGAGTCTGAGGCCAGCCCCCAGGTGCACCCCTTCCCAGACCATGAG
CTGGAGGACATGAAGATGAAGATCTCTGCCCTCAAGAGTGAAATCCAGAAGGAGAAAGCCAACAAAGGCCAGAGCCGGGCCATCGAGCGC
CTGAAGAAGAAGATGTTTGAGAATGAGTTCCTGCTGCTGCTCAACTCCCCCACAATCCCGTTCAGGATCCACAATCGGAATGGAAAGAGT
TACCTGTTCCTACTGTCCTCGGACTACGAGAGGTCAGAGTGGAGAGAAGCAATTCAGAAACTACAGAAGAAGGATCTCCAGGCCTTTGTC
CTGAGCTCAGTGGAGCTCCAGGTGCTCACAGGATCCTGTTTCAAGCTTAGGACTGTACACAACATTCCTGTCACCAGCAATAAAGACGAC
GATGAGTCTCCAGGACTCTATGGCTTCCTTCATGTCATCGTCCACTCTGCCAAGGGATTTAAGCAATCAGCCAACCTGTACTGTACCCTG
GAGGTGGATTCCTTCGGCTATTTTGTCAGCAAAGCCAAAACCAGGGTGTTCCGGGACACAGCGGAGCCCAAGTGGGATGAGGAGTTTGAG
ATCGAGCTGGAGGGCTCCCAGTCCCTGAGGATCCTGTGCTATGAGAAGTGCTATGACAAGACCAAGGTCAACAAGGACAACAATGAGATC
GTGGACAAGATCATGGGCAAAGGACAGATCCAGCTGGACCCACAAACCGTGGAGACCAAGAACTGGCACACGGACGTGATTGAGATGAAC
GGGATCAAAGTGGAATTTTCCATGAAATTCACCAGCCGAGATATGAGCCTGAAGAGGACCCCGTCCAAAAAGCAGACCGGCGTCTTCGGT
GTGAAGATCAGCGTGGTGACGAAGCGGGAGCGCTCCAAGGTGCCCTACATCGTCCGGCAGTGTGTGGAGGAGGTGGAGAAGAGGGGTATC
GAGGAGGTTGGCATCTACAGGATATCGGGCGTGGCCACGGACATCCAGGCGCTCAAGGCCGTCTTCGATGCCAATAACAAGGACATCCTG
CTGATGCTGAGTGACATGGACATCAACGCCATCGCCGGGACGCTCAAGCTGTACTTCCGGGAACTGCCCGAGCCGCTCCTCACGGACCGA
CTCTACCCAGCCTTCATGGAGGGCATCGCCCTGTCAGACCCTGCTGCCAAGGAAAACTGCATGATGCACCTGCTCCGCTCCCTGCCCGAC
CCCAACCTCATCACCTTCCTCTTCCTGCTGGAACACTTGAAAAGGGTTGCCGAGAAGGAGCCCATCAACAAAATGTCACTTCACAACCTG
GCTACCGTGTTTGGACCCACGTTACTGAGACCCTCAGAAGTGGAGAGCAAAGCACACCTCACCTCGGCTGCGGACATCTGGTCCCATGAC
GTCATGGCGCAGGTCCAGGTCCTCCTCTACTACCTGCAGCACCCCCCCATTTCCTTCGCAGAACTCAAGCGGAACACACTGTACTTCTCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_XYLT1_ENST00000261381_chr16_17352845_-_ABR_ENST00000302538_chr17_1028702_-_6079nt
GCGGCCGCGGGAGCTGCGGGGAGCGCGGGGGCGGCCCGGAGCGTGCCGGGGTCCCCGCGCCTCGCTCGCCGGCCGCGCTCCGAAGATGGT
GGCGGCGCCGTGCGCCCGGAGGCTGGCCCGGCGCTCGCACTCGGCGCTGCTCGCGGCGCTCACGGTGCTGCTGCTGCAGACGCTGGTCGT
GTGGAATTTCAGCAGCCTCGACTCCGGGGCCGGGGAGCGCCGCGGGGGCGCAGCGGTCGGCGGCGGGGAGCAGCCGCCCCCGGCCCCGGC
CCCGCGCCGGGAGCGCCGGGACCTGCCCGCCGAGCCGGCTGCAGCCCGAGGAGGAGGAGGAGGCGGCGGCGGAGGAGGAGGAGGACGGGG
GCCCCAGGCGCGGGCGCGGGGAGGCGGCCCCGGAGAACCGCGGGGACAGCAGCCGGCCAGCCGGGGGGCACTGCCCGCCCGGGCTCTGGA
TCCACACCCAAGTCCGCTCATCACCCTGGAGACTCAGGATGGCTACTTTTCTCATCGGCCGAAAGAGAAAGTGCGAACAGACAGCAACAA
CGAGAACTCTGTCCCCAAAGACTTTGAGAATGTCGACAACAGCAACTTCGCACCCAGGACTCAAAAGCAGAAGCACCAGCCTGAGTTGGC
GAAGAAGCCACCGAGTAGACAGAAGGAGCTTTTGAAAAGGAAGCTGGAACAGCAGGAGAAAGGAAAAGGACATACATTCCCTGGGAAAGG
CCCCGGTGAGGTGCTGCCTCCCGGGGACAGAGCCGCAGCCAACAGCAGCCACGGGAAGGATGTGTCCAGACCGCCTCATGCCAGGAAAAC
TGGGGGCAGCTCCCCCGAGACCAAGTATGACCAGCCCCCTAAGTGTGACATCTCAGGCAAGGAGGCCATCTCTGCCCTGTCCCGTGCTAA
GTCCAAGCACTGCCGCCAGGAGATTGGGGAGACTTACTGCCGCCACAAGTTAGGGCTGCTGATGCCTGAGAAGGTGACTCGGTTCTGCCC
CCTCGAGGACTTCAGCTACGGGACGGACGAGTACGACGGAGAGGGGAATGAGGAGCAGAAGGGGCCCCCGGAGGGCTCAGAGACCATGCC
GTACATCGATGAGTCGCCCACCATGTCCCCGCAGCTCAGCGCCCGCAGCCAGGGCGGGGGGGATGGCGTCTCCCCGACTCCACCTGAGGG
ACTGGCTCCTGGGGTGGAAGCAGGGAAAGGCCTGGAGATGAGGAAGCTGGTTCTCTCGGGGTTCTTGGCCAGCGAAGAGATCTACATTAA
CCAGCTGGAAGCCCTGTTGCTGCCCATGAAACCCCTGAAGGCCACCGCCACCACCTCCCAGCCCGTGCTCACCATCCAGCAGATCGAGAC
CATCTTCTACAAGATCCAGGACATCTATGAGATCCACAAGGAGTTCTATGACAACCTGTGCCCCAAGGTGCAACAGTGGGACAGCCAGGT
CACCATGGGCCACCTCTTCCAGAAGCTGGCCAGCCAGCTCGGTGTGTACAAAGCGTTTGTCGATAACTATAAAGTCGCTCTGGAGACAGC
TGAGAAGTGCAGCCAGTCCAACAACCAGTTCCAGAAGATCTCAGAGGAACTCAAAGTGAAAGGTCCCAAGGACTCCAAGGACAGCCACAC
GTCTGTCACCATGGAAGCTCTGCTCTACAAGCCCATTGACCGGGTCACTCGGAGCACCCTAGTCCTACACGACCTGCTGAAGCACACACC
TGTGGACCACCCCGACTACCCGCTGCTGCAGGATGCCCTCCGCATCTCCCAGAACTTCCTGTCCAGCATCAACGAGGACATCGACCCCCG
CCGGACTGCAGTGACAACGCCCAAGGGGGAGACGCGACAGCTGGTGAAGGACGGCTTCCTGGTGGAAGTGTCAGAGAGCTCCCGGAAGCT
GCGGCACGTCTTCCTCTTTACAGATGTCCTACTGTGTGCCAAGCTGAAGAAGACCTCTGCAGGGAAGCACCAGCAGTATGACTGTAAGTG
GTACATCCCCCTGGCCGACCTGGTGTTTCCATCCCCCGAGGAGTCTGAGGCCAGCCCCCAGGTGCACCCCTTCCCAGACCATGAGCTGGA
GGACATGAAGATGAAGATCTCTGCCCTCAAGAGTGAAATCCAGAAGGAGAAAGCCAACAAAGGCCAGAGCCGGGCCATCGAGCGCCTGAA
GAAGAAGATGTTTGAGAATGAGTTCCTGCTGCTGCTCAACTCCCCCACAATCCCGTTCAGGATCCACAATCGGAATGGAAAGAGTTACCT
GTTCCTACTGTCCTCGGACTACGAGAGGTCAGAGTGGAGAGAAGCAATTCAGAAACTACAGAAGAAGGATCTCCAGGCCTTTGTCCTGAG
CTCAGTGGAGCTCCAGGTGCTCACAGGATCCTGTTTCAAGCTTAGGACTGTACACAACATTCCTGTCACCAGCAATAAAGACGACGATGA
GTCTCCAGGACTCTATGGCTTCCTTCATGTCATCGTCCACTCTGCCAAGGGATTTAAGCAATCAGCCAACCTGTACTGTACCCTGGAGGT
GGATTCCTTCGGCTATTTTGTCAGCAAAGCCAAAACCAGGGTGTTCCGGGACACAGCGGAGCCCAAGTGGGATGAGGAGTTTGAGATCGA
GCTGGAGGGCTCCCAGTCCCTGAGGATCCTGTGCTATGAGAAGTGCTATGACAAGACCAAGGTCAACAAGGACAACAATGAGATCGTGGA
CAAGATCATGGGCAAAGGACAGATCCAGCTGGACCCACAAACCGTGGAGACCAAGAACTGGCACACGGACGTGATTGAGATGAACGGGAT
CAAAGTGGAATTTTCCATGAAATTCACCAGCCGAGATATGAGCCTGAAGAGGACCCCGTCCAAAAAGCAGACCGGCGTCTTCGGTGTGAA
GATCAGCGTGGTGACGAAGCGGGAGCGCTCCAAGGTGCCCTACATCGTCCGGCAGTGTGTGGAGGAGGTGGAGAAGAGGGGTATCGAGGA
GGTTGGCATCTACAGGATATCGGGCGTGGCCACGGACATCCAGGCGCTCAAGGCCGTCTTCGATGCCAATAACAAGGACATCCTGCTGAT
GCTGAGTGACATGGACATCAACGCCATCGCCGGGACGCTCAAGCTGTACTTCCGGGAACTGCCCGAGCCGCTCCTCACGGACCGACTCTA
CCCAGCCTTCATGGAGGGCATCGCCCTGTCAGACCCTGCTGCCAAGGAAAACTGCATGATGCACCTGCTCCGCTCCCTGCCCGACCCCAA
CCTCATCACCTTCCTCTTCCTGCTGGAACACTTGAAAAGGGTTGCCGAGAAGGAGCCCATCAACAAAATGTCACTTCACAACCTGGCTAC
CGTGTTTGGACCCACGTTACTGAGACCCTCAGAAGTGGAGAGCAAAGCACACCTCACCTCGGCTGCGGACATCTGGTCCCATGACGTCAT
GGCGCAGGTCCAGGTCCTCCTCTACTACCTGCAGCACCCCCCCATTTCCTTCGCAGAACTCAAGCGGAACACACTGTACTTCTCCACCGA
CGTGTAGCCCGAGGCAGGGTGGCTGCGGGCGGGTGGTGGAACCAGCCCCTCCAGCCTGGGGTCCAACTCAGACTTGAAAGACTGCAATAG
AAAACTCCCAAACCCAGCACTCCAGACTCGAGGGAAGCCAGCTTCCAAGAACTGGAATGCGTACGTCTTTTGTGCCACCTTGTACAAAGC
CGGCTGCCCAGCCCCAGCCTCACCACCGCATCCCACCTCCTGCCCTCCATACCTCTAGTTGTGTCTGATGCTCCGTGCTGTTCGGGAATT
GTTTTATGTACACTTGTCAGGCAGAAAAGGTAGTGACCGGCCCGGCGTGGGCACACAGACAGCCCGCTTTGTTCTTTCATTTCCTCCAGC
ACTTTCTTTCCGCCTGAGTCCAGCCCAAGGCCTTTTATTTTGCGCTGTGTAACTGCTGCCAGCTTCTCTCTTGGCCCTGCTCCCAGATGG
CGGTCTCCTGGCAGCCTCCCCTCAGTCTTCCTCCACCCGCTCTTCCTTCCCAGCCTGCCTGCATGCATGTGCACCCTTGGTCTTCGCTCC
ATCGCCTTGAAAGCTCTGAAGAGGCCCTGGGTTGCCGCGGCAGCAGTGGTCTGTTTGATGCTGCCGTTTGCCGCTGCCGGCCCCTCCTCA
GACTCCGCCTTTGGGAGCACACCTGCTTTGCCTTGCTGCCTGTGCAAATGTTGGACAAGCAGACACACTCACACTCGTCCCCAGCTTAGC
ACAGAGCTGGAGCGCCCATTTCTGGAATTTTCCGTTTGGGAATCTCCACTTCTGGGGTTTACCTGTTCGGCCTCCTGTCTATCAGTGAGG
CATCTCTGACTGTTTCTTCTACTGCTTTTCAGTTCCCTTCCCTGCTGTTCTATTTCCTTTGAGTGTAAAGACTCACAGGTGACCTGCTAT
CGAGATAGCCAGAGGGTCAGGAGAGAATGGGGGAGGAGGCGGTCAGGCTGCTGAGGAAACACCACAGGCTGAACGGGGGAGGAATGCACA
TGCCACGCTGGGTGTCCCGGGTCGCGGGGAGGCAGCTCAGCTCTTAGGAGCAAGTTGTGGGGGCTTTTCAAGAGGGGCCAGGCTTCCTGG
AGGGTGACTGATGTGGCCGAAGCAGGTGTCCAGGCAGGTAGGCTGCAGCCAGGAGCTCCCTGGCACCGCAGGACCTCGTGGTACTCTTGC
CTTAGATTTTACACACACTCCACAGCCAAGCACTGCCACGGTCCTCCAGGACCTGGGAAGCAAAGGCACAGGCCCACGGTGGCCAGCCAT
TGTGGTGCCGCCCCAGCTTCTGGATACAGCCTTTTGGGTAAACACTGGGAACTCCAGAAGTTGTGGGGAGAGTGGGGAATCAGACAGCCG
CCTCTAGGGGCTGGGTTCTGCTGGGGCCTCCTTGTTGGTGCTGTAGGCACCCGCCAGGGAGCAGGGACCCGACTTGCAGACGCATTGCCC
GGTACTAGGAAGGAGTGAGGTGTGTTCCCACCGTACACTTCCCACACGAGCTGCGGCTGCCAGCCTCGGGCCATCAGCCTAGGAGAGCAG
ATGCAGCTCCAGGGGCTCGACTTATAGCCAGTTACAGCTCCCCGGCTCTTCTGTGTGGCAGAGCGTCGTTTCCGGGCCCTCAGGGCTGGG
GAGCTCAGTTCCCATTGCTTGTGCTCAGGGCTGAGTCTTAAAGAAGGGTTTGCCGGCCCTAACGCTGCAGCGCGTGCGCGGTGAGAGGCC
CTTTTTGAGCCTGTTTACTCCTGTGGCCTTGGGCAGAACAGTAAATACTCTGTGCACGGAGGAAAGACATGCCCAAGAGGAAGGAAGTAC
TGACCATCGGCTGCCTGTGAGCAGCTTAGCAAGGAGCCCTTGCTCCCTGGGAAAGGCGGTGAACTTGAGTCTAAAGATGCAGTGCCTGGC
CCTTCCTAAGGTCCCTGCCTGGCATCCGAGTGTCGGTGTGTGGCACAGAAGGCTCCTGCTTGCTTCCAAAGTGATGGACAGGAAGGGGCA
GAGTGAGTCACGGCCCAGACTGGGCACCTTCGCGTCTCAGCCTCAGGGAGCCCCACAGCCCCAAGCTCGCTGAGGCAACGTGAGAACAGG
CTATGGGAAGGCTGCAAAGGCTGAGAAATGCAAAGGCTCATATTTATAAATCCCACCCCCAGAGTGGGGAGGGTCAGGTGCCAGACCTGG
ACTAAACTGCACCAAGGAAACACCCAGCAGGGTCTCCTGTGAGCCGGGGACCATGCAGCCCGAAACCTCCAGTCACTGCGCCCGGCAGGA
GTCAGGAGCCAGGGACTGTGCAGCCTGGAACCTCCAGTCACTGTGCCCAGCAGGGTGGGCTGTGCCCAGCAGGAGTCAGGCTAAGAAACG
CCAGGTCTGCCTGTTCTTGCTGGGCAATGGCTGATGGCTGCCAGTTTCTGCTGATACACAGGTAGGATGGGACCCTTCATGAATATCTGA
CTTTAATAAGTTGGTAAGGATATATTTTTTTGTCTATGTTCTGTTTCAACTTATGTAGATTATTATAAATTGATGTAAACCACGTGAGAG


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FusionGenePPI for XYLT1_ABR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
XYLT1MYC, ADH1C, MEF2AABRLNX1, APP, ECT2, ERBB2IP, AURKB, CDKN1A, CEP250, CEP57, CEP76, TP53, MOV10, NXF1, HERC2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for XYLT1_ABR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for XYLT1_ABR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneXYLT1C4014294DESBUQUOIS DYSPLASIA 22UNIPROT
HgeneXYLT1C0033847Pseudoxanthoma Elasticum1CTD_human;UNIPROT
HgeneXYLT1C0236969Substance-Related Disorders1CTD_human
TgeneABRC0033578Prostatic Neoplasms1CTD_human