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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42256

FusionGeneSummary for XYLB_ITGA9

check button Fusion gene summary
Fusion gene informationFusion gene name: XYLB_ITGA9
Fusion gene ID: 42256
HgeneTgene
Gene symbol

XYLB

ITGA9

Gene ID

9942

3680

Gene namexylulokinaseintegrin subunit alpha 9
Synonyms-ALPHA-RLC|ITGA4L|RLC
Cytomap

3p22.2

3p22.2

Type of geneprotein-codingprotein-coding
Descriptionxylulose kinaseD-xylulokinasexylulokinase homolog (H. influenzae)integrin alpha-9integrin alpha-RLC
Modification date2018052320180519
UniProtAcc

O75191

Q13797

Ensembl transtripts involved in fusion geneENST00000207870, ENST00000542835, 
ENST00000427323, ENST00000472721, 
ENST00000264741, ENST00000422441, 
Fusion gene scores* DoF score3 X 2 X 2=126 X 6 X 4=144
# samples 36
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: XYLB [Title/Abstract] AND ITGA9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneXYLB

GO:0005997

xylulose metabolic process

23179721


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AN-A0AR-01AXYLBchr3

38390123

+ITGA9chr3

37695205

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000207870ENST00000264741XYLBchr3

38390123

+ITGA9chr3

37695205

+
5CDS-intronENST00000207870ENST00000422441XYLBchr3

38390123

+ITGA9chr3

37695205

+
5UTR-3CDSENST00000542835ENST00000264741XYLBchr3

38390123

+ITGA9chr3

37695205

+
5UTR-intronENST00000542835ENST00000422441XYLBchr3

38390123

+ITGA9chr3

37695205

+
Frame-shitENST00000427323ENST00000264741XYLBchr3

38390123

+ITGA9chr3

37695205

+
5CDS-intronENST00000427323ENST00000422441XYLBchr3

38390123

+ITGA9chr3

37695205

+
intron-3CDSENST00000472721ENST00000264741XYLBchr3

38390123

+ITGA9chr3

37695205

+
intron-intronENST00000472721ENST00000422441XYLBchr3

38390123

+ITGA9chr3

37695205

+

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FusionProtFeatures for XYLB_ITGA9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
XYLB

O75191

ITGA9

Q13797

Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in theregulation of glucose metabolism and lipogenesis.{ECO:0000269|PubMed:23179721}. Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor forVCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for XYLB_ITGA9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for XYLB_ITGA9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
XYLBTHOP1, RPE, SCRN2, TALDO1, SERPINB6ITGA9ITGB1, ALDH1A3, LCN2, SERPINB4, SPRR1B, PCYOX1L, SMOC1, IGLL5, KLK10, IVL, HSPA5, CALML5, EVPL, IGKC, TUBA4A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for XYLB_ITGA9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for XYLB_ITGA9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneITGA9C0005586Bipolar Disorder1PSYGENET
TgeneITGA9C1839839MAJOR AFFECTIVE DISORDER 21PSYGENET