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Fusion gene ID: 42236 |
FusionGeneSummary for XRN1_SMYD3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: XRN1_SMYD3 | Fusion gene ID: 42236 | Hgene | Tgene | Gene symbol | XRN1 | SMYD3 | Gene ID | 54464 | 64754 |
| Gene name | 5'-3' exoribonuclease 1 | SET and MYND domain containing 3 | |
| Synonyms | SEP1 | KMT3E|ZMYND1|ZNFN3A1|bA74P14.1 | |
| Cytomap | 3q23 | 1q44 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 5'-3' exoribonuclease 1strand-exchange protein 1 homolog | histone-lysine N-methyltransferase SMYD3SET and MYND domain-containing protein 3bA74P14.1 (novel protein)zinc finger MYND domain-containing protein 1zinc finger protein, subfamily 3A (MYND domain containing), 1zinc finger, MYND domain containing 1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q8IZH2 | Q9H7B4 | |
| Ensembl transtripts involved in fusion gene | ENST00000264951, ENST00000392981, ENST00000463916, ENST00000544157, ENST00000465074, | ENST00000541742, ENST00000490107, ENST00000388985, ENST00000366517, ENST00000403792, | |
| Fusion gene scores | * DoF score | 6 X 5 X 6=180 | 17 X 9 X 13=1989 |
| # samples | 7 | 31 | |
| ** MAII score | log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(31/1989*10)=-2.68170315555951 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: XRN1 [Title/Abstract] AND SMYD3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | GBM | TCGA-14-1402-02A | XRN1 | chr3 | 142166712 | - | SMYD3 | chr1 | 246093239 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000264951 | ENST00000541742 | XRN1 | chr3 | 142166712 | - | SMYD3 | chr1 | 246093239 | - |
| In-frame | ENST00000264951 | ENST00000490107 | XRN1 | chr3 | 142166712 | - | SMYD3 | chr1 | 246093239 | - |
| In-frame | ENST00000264951 | ENST00000388985 | XRN1 | chr3 | 142166712 | - | SMYD3 | chr1 | 246093239 | - |
| 5CDS-5UTR | ENST00000264951 | ENST00000366517 | XRN1 | chr3 | 142166712 | - | SMYD3 | chr1 | 246093239 | - |
| 5CDS-intron | ENST00000264951 | ENST00000403792 | XRN1 | chr3 | 142166712 | - | SMYD3 | chr1 | 246093239 | - |
| In-frame | ENST00000392981 | ENST00000541742 | XRN1 | chr3 | 142166712 | - | SMYD3 | chr1 | 246093239 | - |
| In-frame | ENST00000392981 | ENST00000490107 | XRN1 | chr3 | 142166712 | - | SMYD3 | chr1 | 246093239 | - |
| In-frame | ENST00000392981 | ENST00000388985 | XRN1 | chr3 | 142166712 | - | SMYD3 | chr1 | 246093239 | - |
| 5CDS-5UTR | ENST00000392981 | ENST00000366517 | XRN1 | chr3 | 142166712 | - | SMYD3 | chr1 | 246093239 | - |
| 5CDS-intron | ENST00000392981 | ENST00000403792 | XRN1 | chr3 | 142166712 | - | SMYD3 | chr1 | 246093239 | - |
| In-frame | ENST00000463916 | ENST00000541742 | XRN1 | chr3 | 142166712 | - | SMYD3 | chr1 | 246093239 | - |
| In-frame | ENST00000463916 | ENST00000490107 | XRN1 | chr3 | 142166712 | - | SMYD3 | chr1 | 246093239 | - |
| In-frame | ENST00000463916 | ENST00000388985 | XRN1 | chr3 | 142166712 | - | SMYD3 | chr1 | 246093239 | - |
| 5CDS-5UTR | ENST00000463916 | ENST00000366517 | XRN1 | chr3 | 142166712 | - | SMYD3 | chr1 | 246093239 | - |
| 5CDS-intron | ENST00000463916 | ENST00000403792 | XRN1 | chr3 | 142166712 | - | SMYD3 | chr1 | 246093239 | - |
| 5UTR-3CDS | ENST00000544157 | ENST00000541742 | XRN1 | chr3 | 142166712 | - | SMYD3 | chr1 | 246093239 | - |
| 5UTR-3CDS | ENST00000544157 | ENST00000490107 | XRN1 | chr3 | 142166712 | - | SMYD3 | chr1 | 246093239 | - |
| 5UTR-3CDS | ENST00000544157 | ENST00000388985 | XRN1 | chr3 | 142166712 | - | SMYD3 | chr1 | 246093239 | - |
| 5UTR-5UTR | ENST00000544157 | ENST00000366517 | XRN1 | chr3 | 142166712 | - | SMYD3 | chr1 | 246093239 | - |
| 5UTR-intron | ENST00000544157 | ENST00000403792 | XRN1 | chr3 | 142166712 | - | SMYD3 | chr1 | 246093239 | - |
| 5UTR-3CDS | ENST00000465074 | ENST00000541742 | XRN1 | chr3 | 142166712 | - | SMYD3 | chr1 | 246093239 | - |
| 5UTR-3CDS | ENST00000465074 | ENST00000490107 | XRN1 | chr3 | 142166712 | - | SMYD3 | chr1 | 246093239 | - |
| 5UTR-3CDS | ENST00000465074 | ENST00000388985 | XRN1 | chr3 | 142166712 | - | SMYD3 | chr1 | 246093239 | - |
| 5UTR-5UTR | ENST00000465074 | ENST00000366517 | XRN1 | chr3 | 142166712 | - | SMYD3 | chr1 | 246093239 | - |
| 5UTR-intron | ENST00000465074 | ENST00000403792 | XRN1 | chr3 | 142166712 | - | SMYD3 | chr1 | 246093239 | - |
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FusionProtFeatures for XRN1_SMYD3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| XRN1 | SMYD3 |
| Major 5'-3' exoribonuclease involved in mRNA decay.Required for the 5'-3'-processing of the G4 tetraplex-containingDNA and RNA substrates. The kinetic of hydrolysis is faster for G4RNA tetraplex than for G4 DNA tetraplex and monomeric RNAtetraplex. Binds to RNA and DNA (By similarity). Plays a role inreplication-dependent histone mRNA degradation. May act as a tumorsuppressor protein in osteogenic sarcoma (OGS).{ECO:0000250|UniProtKB:P97789, ECO:0000269|PubMed:18172165}. | Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but notmonomethylation (PubMed:15235609, PubMed:22419068). Alsomethylates 'Lys-5' of histone H4 (PubMed:22419068). Plays animportant role in transcriptional activation as a member of an RNApolymerase complex (PubMed:15235609). Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609).{ECO:0000269|PubMed:15235609, ECO:0000269|PubMed:22419068}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >SMYD3 | chr3:142166712 | chr1:246093239 | ENST00000388985 | - | 4 | 12 | 205_206 | 177 | 429 | Region | S-adenosyl-L-methionine binding |
| Tgene | >SMYD3 | chr3:142166712 | chr1:246093239 | ENST00000490107 | - | 4 | 12 | 205_206 | 118 | 370 | Region | S-adenosyl-L-methionine binding |
| Tgene | >SMYD3 | chr3:142166712 | chr1:246093239 | ENST00000541742 | - | 4 | 12 | 205_206 | 118 | 370 | Region | S-adenosyl-L-methionine binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | SMYD3 | chr3:142166712 | chr1:246093239 | ENST00000388985 | - | 4 | 12 | 4_240 | 177 | 429 | Domain | SET |
| Tgene | SMYD3 | chr3:142166712 | chr1:246093239 | ENST00000490107 | - | 4 | 12 | 4_240 | 118 | 370 | Domain | SET |
| Tgene | SMYD3 | chr3:142166712 | chr1:246093239 | ENST00000541742 | - | 4 | 12 | 4_240 | 118 | 370 | Domain | SET |
| Tgene | SMYD3 | chr3:142166712 | chr1:246093239 | ENST00000388985 | - | 4 | 12 | 14_16 | 177 | 429 | Region | S-adenosyl-L-methionine binding |
| Tgene | SMYD3 | chr3:142166712 | chr1:246093239 | ENST00000490107 | - | 4 | 12 | 14_16 | 118 | 370 | Region | S-adenosyl-L-methionine binding |
| Tgene | SMYD3 | chr3:142166712 | chr1:246093239 | ENST00000541742 | - | 4 | 12 | 14_16 | 118 | 370 | Region | S-adenosyl-L-methionine binding |
| Tgene | SMYD3 | chr3:142166712 | chr1:246093239 | ENST00000388985 | - | 4 | 12 | 49_87 | 177 | 429 | Zinc finger | MYND-type |
| Tgene | SMYD3 | chr3:142166712 | chr1:246093239 | ENST00000490107 | - | 4 | 12 | 49_87 | 118 | 370 | Zinc finger | MYND-type |
| Tgene | SMYD3 | chr3:142166712 | chr1:246093239 | ENST00000541742 | - | 4 | 12 | 49_87 | 118 | 370 | Zinc finger | MYND-type |
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FusionGeneSequence for XRN1_SMYD3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_XRN1_ENST00000264951_chr3_142166712_-_SMYD3_ENST00000541742_chr1_246093239_-_277aa MGVPKFYRWISERYPCLSEVVKEHQVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDM LMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLD CAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECD >In-frame_XRN1_ENST00000264951_chr3_142166712_-_SMYD3_ENST00000490107_chr1_246093239_-_277aa MGVPKFYRWISERYPCLSEVVKEHQVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDM LMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLD CAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECD >In-frame_XRN1_ENST00000264951_chr3_142166712_-_SMYD3_ENST00000388985_chr1_246093239_-_277aa MGVPKFYRWISERYPCLSEVVKEHQVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDM LMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLD CAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECD >In-frame_XRN1_ENST00000392981_chr3_142166712_-_SMYD3_ENST00000541742_chr1_246093239_-_277aa MGVPKFYRWISERYPCLSEVVKEHQVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDM LMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLD CAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECD >In-frame_XRN1_ENST00000392981_chr3_142166712_-_SMYD3_ENST00000490107_chr1_246093239_-_277aa MGVPKFYRWISERYPCLSEVVKEHQVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDM LMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLD CAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECD >In-frame_XRN1_ENST00000392981_chr3_142166712_-_SMYD3_ENST00000388985_chr1_246093239_-_277aa MGVPKFYRWISERYPCLSEVVKEHQVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDM LMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLD CAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECD >In-frame_XRN1_ENST00000463916_chr3_142166712_-_SMYD3_ENST00000541742_chr1_246093239_-_277aa MGVPKFYRWISERYPCLSEVVKEHQVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDM LMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLD CAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECD >In-frame_XRN1_ENST00000463916_chr3_142166712_-_SMYD3_ENST00000490107_chr1_246093239_-_277aa MGVPKFYRWISERYPCLSEVVKEHQVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDM LMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLD CAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECD >In-frame_XRN1_ENST00000463916_chr3_142166712_-_SMYD3_ENST00000388985_chr1_246093239_-_277aa MGVPKFYRWISERYPCLSEVVKEHQVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDM LMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLD CAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_XRN1_ENST00000264951_chr3_142166712_-_SMYD3_ENST00000541742_chr1_246093239_-_831nt ATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCT TTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGT TCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATG CTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGAT GCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGG GAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGAC TGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTC CCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAAT CTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGAC >In-frame_XRN1_ENST00000264951_chr3_142166712_-_SMYD3_ENST00000490107_chr1_246093239_-_831nt ATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCT TTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGT TCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATG CTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGAT GCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGG GAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGAC TGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTC CCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAAT CTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGAC >In-frame_XRN1_ENST00000264951_chr3_142166712_-_SMYD3_ENST00000388985_chr1_246093239_-_831nt ATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCT TTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGT TCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATG CTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGAT GCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGG GAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGAC TGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTC CCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAAT CTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGAC >In-frame_XRN1_ENST00000392981_chr3_142166712_-_SMYD3_ENST00000541742_chr1_246093239_-_831nt ATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCT TTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGT TCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATG CTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGAT GCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGG GAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGAC TGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTC CCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAAT CTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGAC >In-frame_XRN1_ENST00000392981_chr3_142166712_-_SMYD3_ENST00000490107_chr1_246093239_-_831nt ATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCT TTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGT TCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATG CTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGAT GCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGG GAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGAC TGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTC CCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAAT CTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGAC >In-frame_XRN1_ENST00000392981_chr3_142166712_-_SMYD3_ENST00000388985_chr1_246093239_-_831nt ATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCT TTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGT TCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATG CTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGAT GCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGG GAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGAC TGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTC CCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAAT CTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGAC >In-frame_XRN1_ENST00000463916_chr3_142166712_-_SMYD3_ENST00000541742_chr1_246093239_-_831nt ATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCT TTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGT TCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATG CTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGAT GCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGG GAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGAC TGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTC CCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAAT CTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGAC >In-frame_XRN1_ENST00000463916_chr3_142166712_-_SMYD3_ENST00000490107_chr1_246093239_-_831nt ATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCT TTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGT TCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATG CTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGAT GCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGG GAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGAC TGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTC CCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAAT CTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGAC >In-frame_XRN1_ENST00000463916_chr3_142166712_-_SMYD3_ENST00000388985_chr1_246093239_-_831nt ATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCT TTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGT TCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATG CTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGAT GCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGG GAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGAC TGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTC CCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAAT CTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_XRN1_ENST00000264951_chr3_142166712_-_SMYD3_ENST00000541742_chr1_246093239_-_1172nt ATGGTCGGCCGGGCGGTGTGTTGTCATCCGCGGAGCGACGACCGGAGGCTGCGGCGGAGCCCCGGCGGGGCGTTTGGTTTCGGTTTGGCC CTGACTGGGATTAGTGTTGACGATCGAAATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGT GAAAGAGCATCAGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTT GCTCAATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGA GGAGCTCACCATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTG TTTCCGTTGCCAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAAT TGAAGAACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATAT CAACATCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCG GACCATGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCA AGGCATGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGA TTTGATTCTACTTTTAGAAGAATGCGACGCCAACATCAGAGCATCCTAAGGGAACGCAGTCAGAGGGAAATACGGCGTGTGTCTTTGTTG AATGCCTTATTGAGGTCACACACTCTATGCTTTGTTAGCTGTGTGAACCTCTCCTATTGGAAATTCTGTTCCGTGTTTGTGTAGGTAAAT AAAGGCAGACATGGTTTGCAAACCACAAGAATCATTAGTTGTAGAGAAGCACGATTATAATAAATTCAAAACATTTGGTTGAGGATGCCA >In-frame_XRN1_ENST00000264951_chr3_142166712_-_SMYD3_ENST00000490107_chr1_246093239_-_1170nt ATGGTCGGCCGGGCGGTGTGTTGTCATCCGCGGAGCGACGACCGGAGGCTGCGGCGGAGCCCCGGCGGGGCGTTTGGTTTCGGTTTGGCC CTGACTGGGATTAGTGTTGACGATCGAAATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGT GAAAGAGCATCAGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTT GCTCAATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGA GGAGCTCACCATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTG TTTCCGTTGCCAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAAT TGAAGAACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATAT CAACATCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCG GACCATGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCA AGGCATGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGA TTTGATTCTACTTTTAGAAGAATGCGACGCCAACATCAGAGCATCCTAAGGGAACGCAGTCAGAGGGAAATACGGCGTGTGTCTTTGTTG AATGCCTTATTGAGGTCACACACTCTATGCTTTGTTAGCTGTGTGAACCTCTCCTATTGGAAATTCTGTTCCGTGTTTGTGTAGGTAAAT AAAGGCAGACATGGTTTGCAAACCACAAGAATCATTAGTTGTAGAGAAGCACGATTATAATAAATTCAAAACATTTGGTTGAGGATGCCA >In-frame_XRN1_ENST00000264951_chr3_142166712_-_SMYD3_ENST00000388985_chr1_246093239_-_949nt ATGGTCGGCCGGGCGGTGTGTTGTCATCCGCGGAGCGACGACCGGAGGCTGCGGCGGAGCCCCGGCGGGGCGTTTGGTTTCGGTTTGGCC CTGACTGGGATTAGTGTTGACGATCGAAATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGT GAAAGAGCATCAGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTT GCTCAATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGA GGAGCTCACCATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTG TTTCCGTTGCCAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAAT TGAAGAACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATAT CAACATCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCG GACCATGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCA AGGCATGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGA >In-frame_XRN1_ENST00000392981_chr3_142166712_-_SMYD3_ENST00000541742_chr1_246093239_-_1102nt CGTTTGGTTTCGGTTTGGCCCTGACTGGGATTAGTGTTGACGATCGAAATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTAT CCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGC CTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTC CGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAG TACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTT CAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAAT TCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAA GCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTT GGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGA GAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGACGCCAACATCAGAGCATCCTAAGGGAACGCAGTCAGAGGGAAA TACGGCGTGTGTCTTTGTTGAATGCCTTATTGAGGTCACACACTCTATGCTTTGTTAGCTGTGTGAACCTCTCCTATTGGAAATTCTGTT CCGTGTTTGTGTAGGTAAATAAAGGCAGACATGGTTTGCAAACCACAAGAATCATTAGTTGTAGAGAAGCACGATTATAATAAATTCAAA >In-frame_XRN1_ENST00000392981_chr3_142166712_-_SMYD3_ENST00000490107_chr1_246093239_-_1100nt CGTTTGGTTTCGGTTTGGCCCTGACTGGGATTAGTGTTGACGATCGAAATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTAT CCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGC CTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTC CGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAG TACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTT CAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAAT TCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAA GCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTT GGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGA GAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGACGCCAACATCAGAGCATCCTAAGGGAACGCAGTCAGAGGGAAA TACGGCGTGTGTCTTTGTTGAATGCCTTATTGAGGTCACACACTCTATGCTTTGTTAGCTGTGTGAACCTCTCCTATTGGAAATTCTGTT CCGTGTTTGTGTAGGTAAATAAAGGCAGACATGGTTTGCAAACCACAAGAATCATTAGTTGTAGAGAAGCACGATTATAATAAATTCAAA >In-frame_XRN1_ENST00000392981_chr3_142166712_-_SMYD3_ENST00000388985_chr1_246093239_-_879nt CGTTTGGTTTCGGTTTGGCCCTGACTGGGATTAGTGTTGACGATCGAAATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTAT CCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGC CTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTC CGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAG TACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTT CAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAAT TCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAA GCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTT GGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGA >In-frame_XRN1_ENST00000463916_chr3_142166712_-_SMYD3_ENST00000541742_chr1_246093239_-_1120nt GGCGGAGCCCCGGCGGGGCGTTTGGTTTCGGTTTGGCCCTGACTGGGATTAGTGTTGACGATCGAAATGGGAGTCCCCAAGTTTTACAGA TGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATG CAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCAC CTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGG AAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAG CAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAG GCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAAC CTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGG GTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATG AGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGACGCCAACATCAGAGCATCCTAAGGG AACGCAGTCAGAGGGAAATACGGCGTGTGTCTTTGTTGAATGCCTTATTGAGGTCACACACTCTATGCTTTGTTAGCTGTGTGAACCTCT CCTATTGGAAATTCTGTTCCGTGTTTGTGTAGGTAAATAAAGGCAGACATGGTTTGCAAACCACAAGAATCATTAGTTGTAGAGAAGCAC >In-frame_XRN1_ENST00000463916_chr3_142166712_-_SMYD3_ENST00000490107_chr1_246093239_-_1118nt GGCGGAGCCCCGGCGGGGCGTTTGGTTTCGGTTTGGCCCTGACTGGGATTAGTGTTGACGATCGAAATGGGAGTCCCCAAGTTTTACAGA TGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATG CAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCAC CTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGG AAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAG CAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAG GCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAAC CTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGG GTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATG AGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGACGCCAACATCAGAGCATCCTAAGGG AACGCAGTCAGAGGGAAATACGGCGTGTGTCTTTGTTGAATGCCTTATTGAGGTCACACACTCTATGCTTTGTTAGCTGTGTGAACCTCT CCTATTGGAAATTCTGTTCCGTGTTTGTGTAGGTAAATAAAGGCAGACATGGTTTGCAAACCACAAGAATCATTAGTTGTAGAGAAGCAC >In-frame_XRN1_ENST00000463916_chr3_142166712_-_SMYD3_ENST00000388985_chr1_246093239_-_897nt GGCGGAGCCCCGGCGGGGCGTTTGGTTTCGGTTTGGCCCTGACTGGGATTAGTGTTGACGATCGAAATGGGAGTCCCCAAGTTTTACAGA TGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATG CAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCAC CTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGG AAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAG CAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAG GCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAAC CTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGG GTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATG |
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FusionGenePPI for XRN1_SMYD3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| XRN1 | ALDOA, BAG6, SMARCD2, CHD4, PABPC4, AP1G2, LSM4, CCT5, UPF1, UPF2, UPF3A, MLH1, MYC, SIRT7, SKIV2L, LDHA, VWA5B2, STAM2, NDUFA13, HEATR1, SPATA20, NDUFB10, NDUFB9, WAPAL, DPP7, HNRNPA1, PPP2CA, PSMB5, KATNB1, POLD2, MAN2C1, FADS1, TMEM50A, MTCH2, SRRM2, C1GALT1, ANGPTL6, PRADC1, MFSD5, CD97, B3GALT6, C1orf85, CBX5, LINC01541, PLEKHG2, RBMX, RNF187, SNHG1, LEPR, HERC2P4, CTSH, ATP5G2, DNASE2, SDHB, LGALS3BP, CTSB, DCP1A, EXOSC8, DXO, EXOSC6, DCP1B, EXOSC10, ZFP36, SKIV2L2, EXOSC1, TARDBP, HECW2, RPA1, RPA2, RPA3, BMI1, SCRN2, NTRK1, RPS4X, RPS7, SYNCRIP, ALYREF, DDX24, RPL5, IFI16, MED4, SSX2IP, PCM1, CC2D2A, CEP97, KIAA0753, CEP104, CEP120, CEP152, CEP128, CEP135, CEP44, CEP89, NINL, POC1A, STIL, CENPJ, XPO1, PSMC1, TUBG1, QSOX2, ZNF131, CDH1, FGF3, NAGK, RBM4, ADPRH, FGF8 | SMYD3 | MEST, HELZ, POLR2A, HSP90AA1, HIST3H3, ESR1, EZH2, EED, APP, CAMK2B, NDUFAB1, NFYB, CYP39A1, VANGL1, H3F3C, TRIT1, ZNF557, CDC37, HSP90AB1, HSP90AB4P, HSP90AB3P, HSP90AA5P, MAGED4B, KDM3B, RCAN3, PLCB3, TRMT2A, KMT2E |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for XRN1_SMYD3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for XRN1_SMYD3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SMYD3 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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