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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42236

FusionGeneSummary for XRN1_SMYD3

check button Fusion gene summary
Fusion gene informationFusion gene name: XRN1_SMYD3
Fusion gene ID: 42236
HgeneTgene
Gene symbol

XRN1

SMYD3

Gene ID

54464

64754

Gene name5'-3' exoribonuclease 1SET and MYND domain containing 3
SynonymsSEP1KMT3E|ZMYND1|ZNFN3A1|bA74P14.1
Cytomap

3q23

1q44

Type of geneprotein-codingprotein-coding
Description5'-3' exoribonuclease 1strand-exchange protein 1 homologhistone-lysine N-methyltransferase SMYD3SET and MYND domain-containing protein 3bA74P14.1 (novel protein)zinc finger MYND domain-containing protein 1zinc finger protein, subfamily 3A (MYND domain containing), 1zinc finger, MYND domain containing 1
Modification date2018051920180519
UniProtAcc

Q8IZH2

Q9H7B4

Ensembl transtripts involved in fusion geneENST00000264951, ENST00000392981, 
ENST00000463916, ENST00000544157, 
ENST00000465074, 
ENST00000541742, 
ENST00000490107, ENST00000388985, 
ENST00000366517, ENST00000403792, 
Fusion gene scores* DoF score6 X 5 X 6=18017 X 9 X 13=1989
# samples 731
** MAII scorelog2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(31/1989*10)=-2.68170315555951
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: XRN1 [Title/Abstract] AND SMYD3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVGBMTCGA-14-1402-02AXRN1chr3

142166712

-SMYD3chr1

246093239

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000264951ENST00000541742XRN1chr3

142166712

-SMYD3chr1

246093239

-
In-frameENST00000264951ENST00000490107XRN1chr3

142166712

-SMYD3chr1

246093239

-
In-frameENST00000264951ENST00000388985XRN1chr3

142166712

-SMYD3chr1

246093239

-
5CDS-5UTRENST00000264951ENST00000366517XRN1chr3

142166712

-SMYD3chr1

246093239

-
5CDS-intronENST00000264951ENST00000403792XRN1chr3

142166712

-SMYD3chr1

246093239

-
In-frameENST00000392981ENST00000541742XRN1chr3

142166712

-SMYD3chr1

246093239

-
In-frameENST00000392981ENST00000490107XRN1chr3

142166712

-SMYD3chr1

246093239

-
In-frameENST00000392981ENST00000388985XRN1chr3

142166712

-SMYD3chr1

246093239

-
5CDS-5UTRENST00000392981ENST00000366517XRN1chr3

142166712

-SMYD3chr1

246093239

-
5CDS-intronENST00000392981ENST00000403792XRN1chr3

142166712

-SMYD3chr1

246093239

-
In-frameENST00000463916ENST00000541742XRN1chr3

142166712

-SMYD3chr1

246093239

-
In-frameENST00000463916ENST00000490107XRN1chr3

142166712

-SMYD3chr1

246093239

-
In-frameENST00000463916ENST00000388985XRN1chr3

142166712

-SMYD3chr1

246093239

-
5CDS-5UTRENST00000463916ENST00000366517XRN1chr3

142166712

-SMYD3chr1

246093239

-
5CDS-intronENST00000463916ENST00000403792XRN1chr3

142166712

-SMYD3chr1

246093239

-
5UTR-3CDSENST00000544157ENST00000541742XRN1chr3

142166712

-SMYD3chr1

246093239

-
5UTR-3CDSENST00000544157ENST00000490107XRN1chr3

142166712

-SMYD3chr1

246093239

-
5UTR-3CDSENST00000544157ENST00000388985XRN1chr3

142166712

-SMYD3chr1

246093239

-
5UTR-5UTRENST00000544157ENST00000366517XRN1chr3

142166712

-SMYD3chr1

246093239

-
5UTR-intronENST00000544157ENST00000403792XRN1chr3

142166712

-SMYD3chr1

246093239

-
5UTR-3CDSENST00000465074ENST00000541742XRN1chr3

142166712

-SMYD3chr1

246093239

-
5UTR-3CDSENST00000465074ENST00000490107XRN1chr3

142166712

-SMYD3chr1

246093239

-
5UTR-3CDSENST00000465074ENST00000388985XRN1chr3

142166712

-SMYD3chr1

246093239

-
5UTR-5UTRENST00000465074ENST00000366517XRN1chr3

142166712

-SMYD3chr1

246093239

-
5UTR-intronENST00000465074ENST00000403792XRN1chr3

142166712

-SMYD3chr1

246093239

-

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FusionProtFeatures for XRN1_SMYD3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
XRN1

Q8IZH2

SMYD3

Q9H7B4

Major 5'-3' exoribonuclease involved in mRNA decay.Required for the 5'-3'-processing of the G4 tetraplex-containingDNA and RNA substrates. The kinetic of hydrolysis is faster for G4RNA tetraplex than for G4 DNA tetraplex and monomeric RNAtetraplex. Binds to RNA and DNA (By similarity). Plays a role inreplication-dependent histone mRNA degradation. May act as a tumorsuppressor protein in osteogenic sarcoma (OGS).{ECO:0000250|UniProtKB:P97789, ECO:0000269|PubMed:18172165}. Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but notmonomethylation (PubMed:15235609, PubMed:22419068). Alsomethylates 'Lys-5' of histone H4 (PubMed:22419068). Plays animportant role in transcriptional activation as a member of an RNApolymerase complex (PubMed:15235609). Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609).{ECO:0000269|PubMed:15235609, ECO:0000269|PubMed:22419068}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSMYD3chr3:142166712chr1:246093239ENST00000388985-412205_206177429RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr3:142166712chr1:246093239ENST00000490107-412205_206118370RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr3:142166712chr1:246093239ENST00000541742-412205_206118370RegionS-adenosyl-L-methionine binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSMYD3chr3:142166712chr1:246093239ENST00000388985-4124_240177429DomainSET
TgeneSMYD3chr3:142166712chr1:246093239ENST00000490107-4124_240118370DomainSET
TgeneSMYD3chr3:142166712chr1:246093239ENST00000541742-4124_240118370DomainSET
TgeneSMYD3chr3:142166712chr1:246093239ENST00000388985-41214_16177429RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr3:142166712chr1:246093239ENST00000490107-41214_16118370RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr3:142166712chr1:246093239ENST00000541742-41214_16118370RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr3:142166712chr1:246093239ENST00000388985-41249_87177429Zinc fingerMYND-type
TgeneSMYD3chr3:142166712chr1:246093239ENST00000490107-41249_87118370Zinc fingerMYND-type
TgeneSMYD3chr3:142166712chr1:246093239ENST00000541742-41249_87118370Zinc fingerMYND-type


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FusionGeneSequence for XRN1_SMYD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_XRN1_ENST00000264951_chr3_142166712_-_SMYD3_ENST00000541742_chr1_246093239_-_277aa
MGVPKFYRWISERYPCLSEVVKEHQVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDM
LMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLD
CAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECD

>In-frame_XRN1_ENST00000264951_chr3_142166712_-_SMYD3_ENST00000490107_chr1_246093239_-_277aa
MGVPKFYRWISERYPCLSEVVKEHQVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDM
LMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLD
CAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECD

>In-frame_XRN1_ENST00000264951_chr3_142166712_-_SMYD3_ENST00000388985_chr1_246093239_-_277aa
MGVPKFYRWISERYPCLSEVVKEHQVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDM
LMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLD
CAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECD

>In-frame_XRN1_ENST00000392981_chr3_142166712_-_SMYD3_ENST00000541742_chr1_246093239_-_277aa
MGVPKFYRWISERYPCLSEVVKEHQVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDM
LMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLD
CAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECD

>In-frame_XRN1_ENST00000392981_chr3_142166712_-_SMYD3_ENST00000490107_chr1_246093239_-_277aa
MGVPKFYRWISERYPCLSEVVKEHQVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDM
LMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLD
CAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECD

>In-frame_XRN1_ENST00000392981_chr3_142166712_-_SMYD3_ENST00000388985_chr1_246093239_-_277aa
MGVPKFYRWISERYPCLSEVVKEHQVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDM
LMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLD
CAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECD

>In-frame_XRN1_ENST00000463916_chr3_142166712_-_SMYD3_ENST00000541742_chr1_246093239_-_277aa
MGVPKFYRWISERYPCLSEVVKEHQVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDM
LMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLD
CAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECD

>In-frame_XRN1_ENST00000463916_chr3_142166712_-_SMYD3_ENST00000490107_chr1_246093239_-_277aa
MGVPKFYRWISERYPCLSEVVKEHQVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDM
LMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLD
CAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECD

>In-frame_XRN1_ENST00000463916_chr3_142166712_-_SMYD3_ENST00000388985_chr1_246093239_-_277aa
MGVPKFYRWISERYPCLSEVVKEHQVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDM
LMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLD
CAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECD


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_XRN1_ENST00000264951_chr3_142166712_-_SMYD3_ENST00000541742_chr1_246093239_-_831nt
ATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCT
TTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGT
TCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATG
CTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGAT
GCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGG
GAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGAC
TGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTC
CCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAAT
CTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGAC

>In-frame_XRN1_ENST00000264951_chr3_142166712_-_SMYD3_ENST00000490107_chr1_246093239_-_831nt
ATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCT
TTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGT
TCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATG
CTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGAT
GCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGG
GAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGAC
TGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTC
CCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAAT
CTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGAC

>In-frame_XRN1_ENST00000264951_chr3_142166712_-_SMYD3_ENST00000388985_chr1_246093239_-_831nt
ATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCT
TTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGT
TCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATG
CTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGAT
GCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGG
GAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGAC
TGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTC
CCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAAT
CTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGAC

>In-frame_XRN1_ENST00000392981_chr3_142166712_-_SMYD3_ENST00000541742_chr1_246093239_-_831nt
ATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCT
TTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGT
TCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATG
CTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGAT
GCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGG
GAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGAC
TGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTC
CCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAAT
CTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGAC

>In-frame_XRN1_ENST00000392981_chr3_142166712_-_SMYD3_ENST00000490107_chr1_246093239_-_831nt
ATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCT
TTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGT
TCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATG
CTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGAT
GCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGG
GAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGAC
TGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTC
CCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAAT
CTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGAC

>In-frame_XRN1_ENST00000392981_chr3_142166712_-_SMYD3_ENST00000388985_chr1_246093239_-_831nt
ATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCT
TTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGT
TCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATG
CTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGAT
GCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGG
GAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGAC
TGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTC
CCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAAT
CTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGAC

>In-frame_XRN1_ENST00000463916_chr3_142166712_-_SMYD3_ENST00000541742_chr1_246093239_-_831nt
ATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCT
TTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGT
TCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATG
CTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGAT
GCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGG
GAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGAC
TGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTC
CCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAAT
CTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGAC

>In-frame_XRN1_ENST00000463916_chr3_142166712_-_SMYD3_ENST00000490107_chr1_246093239_-_831nt
ATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCT
TTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGT
TCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATG
CTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGAT
GCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGG
GAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGAC
TGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTC
CCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAAT
CTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGAC

>In-frame_XRN1_ENST00000463916_chr3_142166712_-_SMYD3_ENST00000388985_chr1_246093239_-_831nt
ATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCT
TTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGT
TCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATG
CTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGAT
GCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGG
GAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGAC
TGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTC
CCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAAT
CTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_XRN1_ENST00000264951_chr3_142166712_-_SMYD3_ENST00000541742_chr1_246093239_-_1172nt
ATGGTCGGCCGGGCGGTGTGTTGTCATCCGCGGAGCGACGACCGGAGGCTGCGGCGGAGCCCCGGCGGGGCGTTTGGTTTCGGTTTGGCC
CTGACTGGGATTAGTGTTGACGATCGAAATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGT
GAAAGAGCATCAGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTT
GCTCAATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGA
GGAGCTCACCATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTG
TTTCCGTTGCCAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAAT
TGAAGAACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATAT
CAACATCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCG
GACCATGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCA
AGGCATGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGA
TTTGATTCTACTTTTAGAAGAATGCGACGCCAACATCAGAGCATCCTAAGGGAACGCAGTCAGAGGGAAATACGGCGTGTGTCTTTGTTG
AATGCCTTATTGAGGTCACACACTCTATGCTTTGTTAGCTGTGTGAACCTCTCCTATTGGAAATTCTGTTCCGTGTTTGTGTAGGTAAAT
AAAGGCAGACATGGTTTGCAAACCACAAGAATCATTAGTTGTAGAGAAGCACGATTATAATAAATTCAAAACATTTGGTTGAGGATGCCA

>In-frame_XRN1_ENST00000264951_chr3_142166712_-_SMYD3_ENST00000490107_chr1_246093239_-_1170nt
ATGGTCGGCCGGGCGGTGTGTTGTCATCCGCGGAGCGACGACCGGAGGCTGCGGCGGAGCCCCGGCGGGGCGTTTGGTTTCGGTTTGGCC
CTGACTGGGATTAGTGTTGACGATCGAAATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGT
GAAAGAGCATCAGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTT
GCTCAATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGA
GGAGCTCACCATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTG
TTTCCGTTGCCAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAAT
TGAAGAACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATAT
CAACATCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCG
GACCATGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCA
AGGCATGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGA
TTTGATTCTACTTTTAGAAGAATGCGACGCCAACATCAGAGCATCCTAAGGGAACGCAGTCAGAGGGAAATACGGCGTGTGTCTTTGTTG
AATGCCTTATTGAGGTCACACACTCTATGCTTTGTTAGCTGTGTGAACCTCTCCTATTGGAAATTCTGTTCCGTGTTTGTGTAGGTAAAT
AAAGGCAGACATGGTTTGCAAACCACAAGAATCATTAGTTGTAGAGAAGCACGATTATAATAAATTCAAAACATTTGGTTGAGGATGCCA

>In-frame_XRN1_ENST00000264951_chr3_142166712_-_SMYD3_ENST00000388985_chr1_246093239_-_949nt
ATGGTCGGCCGGGCGGTGTGTTGTCATCCGCGGAGCGACGACCGGAGGCTGCGGCGGAGCCCCGGCGGGGCGTTTGGTTTCGGTTTGGCC
CTGACTGGGATTAGTGTTGACGATCGAAATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGT
GAAAGAGCATCAGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTT
GCTCAATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGA
GGAGCTCACCATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTG
TTTCCGTTGCCAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAAT
TGAAGAACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATAT
CAACATCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCG
GACCATGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCA
AGGCATGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGA

>In-frame_XRN1_ENST00000392981_chr3_142166712_-_SMYD3_ENST00000541742_chr1_246093239_-_1102nt
CGTTTGGTTTCGGTTTGGCCCTGACTGGGATTAGTGTTGACGATCGAAATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTAT
CCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGC
CTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTC
CGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAG
TACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTT
CAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAAT
TCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAA
GCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTT
GGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGA
GAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGACGCCAACATCAGAGCATCCTAAGGGAACGCAGTCAGAGGGAAA
TACGGCGTGTGTCTTTGTTGAATGCCTTATTGAGGTCACACACTCTATGCTTTGTTAGCTGTGTGAACCTCTCCTATTGGAAATTCTGTT
CCGTGTTTGTGTAGGTAAATAAAGGCAGACATGGTTTGCAAACCACAAGAATCATTAGTTGTAGAGAAGCACGATTATAATAAATTCAAA

>In-frame_XRN1_ENST00000392981_chr3_142166712_-_SMYD3_ENST00000490107_chr1_246093239_-_1100nt
CGTTTGGTTTCGGTTTGGCCCTGACTGGGATTAGTGTTGACGATCGAAATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTAT
CCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGC
CTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTC
CGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAG
TACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTT
CAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAAT
TCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAA
GCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTT
GGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGA
GAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGACGCCAACATCAGAGCATCCTAAGGGAACGCAGTCAGAGGGAAA
TACGGCGTGTGTCTTTGTTGAATGCCTTATTGAGGTCACACACTCTATGCTTTGTTAGCTGTGTGAACCTCTCCTATTGGAAATTCTGTT
CCGTGTTTGTGTAGGTAAATAAAGGCAGACATGGTTTGCAAACCACAAGAATCATTAGTTGTAGAGAAGCACGATTATAATAAATTCAAA

>In-frame_XRN1_ENST00000392981_chr3_142166712_-_SMYD3_ENST00000388985_chr1_246093239_-_879nt
CGTTTGGTTTCGGTTTGGCCCTGACTGGGATTAGTGTTGACGATCGAAATGGGAGTCCCCAAGTTTTACAGATGGATCTCAGAGCGGTAT
CCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGC
CTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTC
CGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAG
TACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTT
CAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAAT
TCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAA
GCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTT
GGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGA

>In-frame_XRN1_ENST00000463916_chr3_142166712_-_SMYD3_ENST00000541742_chr1_246093239_-_1120nt
GGCGGAGCCCCGGCGGGGCGTTTGGTTTCGGTTTGGCCCTGACTGGGATTAGTGTTGACGATCGAAATGGGAGTCCCCAAGTTTTACAGA
TGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATG
CAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCAC
CTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGG
AAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAG
CAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAG
GCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAAC
CTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGG
GTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATG
AGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGACGCCAACATCAGAGCATCCTAAGGG
AACGCAGTCAGAGGGAAATACGGCGTGTGTCTTTGTTGAATGCCTTATTGAGGTCACACACTCTATGCTTTGTTAGCTGTGTGAACCTCT
CCTATTGGAAATTCTGTTCCGTGTTTGTGTAGGTAAATAAAGGCAGACATGGTTTGCAAACCACAAGAATCATTAGTTGTAGAGAAGCAC

>In-frame_XRN1_ENST00000463916_chr3_142166712_-_SMYD3_ENST00000490107_chr1_246093239_-_1118nt
GGCGGAGCCCCGGCGGGGCGTTTGGTTTCGGTTTGGCCCTGACTGGGATTAGTGTTGACGATCGAAATGGGAGTCCCCAAGTTTTACAGA
TGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATG
CAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCAC
CTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGG
AAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAG
CAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAG
GCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAAC
CTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGG
GTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATG
AGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCGACGCCAACATCAGAGCATCCTAAGGG
AACGCAGTCAGAGGGAAATACGGCGTGTGTCTTTGTTGAATGCCTTATTGAGGTCACACACTCTATGCTTTGTTAGCTGTGTGAACCTCT
CCTATTGGAAATTCTGTTCCGTGTTTGTGTAGGTAAATAAAGGCAGACATGGTTTGCAAACCACAAGAATCATTAGTTGTAGAGAAGCAC

>In-frame_XRN1_ENST00000463916_chr3_142166712_-_SMYD3_ENST00000388985_chr1_246093239_-_897nt
GGCGGAGCCCCGGCGGGGCGTTTGGTTTCGGTTTGGCCCTGACTGGGATTAGTGTTGACGATCGAAATGGGAGTCCCCAAGTTTTACAGA
TGGATCTCAGAGCGGTATCCCTGTCTCAGCGAAGTGGTGAAAGAGCATCAGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATG
CAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCAC
CTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGG
AAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAG
CAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAG
GCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAAC
CTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGG
GTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATG


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FusionGenePPI for XRN1_SMYD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
XRN1ALDOA, BAG6, SMARCD2, CHD4, PABPC4, AP1G2, LSM4, CCT5, UPF1, UPF2, UPF3A, MLH1, MYC, SIRT7, SKIV2L, LDHA, VWA5B2, STAM2, NDUFA13, HEATR1, SPATA20, NDUFB10, NDUFB9, WAPAL, DPP7, HNRNPA1, PPP2CA, PSMB5, KATNB1, POLD2, MAN2C1, FADS1, TMEM50A, MTCH2, SRRM2, C1GALT1, ANGPTL6, PRADC1, MFSD5, CD97, B3GALT6, C1orf85, CBX5, LINC01541, PLEKHG2, RBMX, RNF187, SNHG1, LEPR, HERC2P4, CTSH, ATP5G2, DNASE2, SDHB, LGALS3BP, CTSB, DCP1A, EXOSC8, DXO, EXOSC6, DCP1B, EXOSC10, ZFP36, SKIV2L2, EXOSC1, TARDBP, HECW2, RPA1, RPA2, RPA3, BMI1, SCRN2, NTRK1, RPS4X, RPS7, SYNCRIP, ALYREF, DDX24, RPL5, IFI16, MED4, SSX2IP, PCM1, CC2D2A, CEP97, KIAA0753, CEP104, CEP120, CEP152, CEP128, CEP135, CEP44, CEP89, NINL, POC1A, STIL, CENPJ, XPO1, PSMC1, TUBG1, QSOX2, ZNF131, CDH1, FGF3, NAGK, RBM4, ADPRH, FGF8SMYD3MEST, HELZ, POLR2A, HSP90AA1, HIST3H3, ESR1, EZH2, EED, APP, CAMK2B, NDUFAB1, NFYB, CYP39A1, VANGL1, H3F3C, TRIT1, ZNF557, CDC37, HSP90AB1, HSP90AB4P, HSP90AB3P, HSP90AA5P, MAGED4B, KDM3B, RCAN3, PLCB3, TRMT2A, KMT2E


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for XRN1_SMYD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for XRN1_SMYD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSMYD3C0236733Amphetamine-Related Disorders1CTD_human