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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42224

FusionGeneSummary for XRCC6_ACO2

check button Fusion gene summary
Fusion gene informationFusion gene name: XRCC6_ACO2
Fusion gene ID: 42224
HgeneTgene
Gene symbol

XRCC6

ACO2

Gene ID

2547

50

Gene nameX-ray repair cross complementing 6aconitase 2
SynonymsCTC75|CTCBF|G22P1|KU70|ML8|TLAAACONM|HEL-S-284|ICRD|OCA8|OPA9
Cytomap

22q13.2

22q13.2

Type of geneprotein-codingprotein-coding
DescriptionX-ray repair cross-complementing protein 65'-dRP lyase Ku705'-deoxyribose-5-phosphate lyase Ku7070 kDa subunit of Ku antigenATP-dependent DNA helicase 2 subunit 1ATP-dependent DNA helicase II, 70 kDa subunitCTC box binding factor 75 kDa subunitDNA aconitate hydratase, mitochondrialaconitase 2, mitochondrialcitrate hydro-lyaseepididymis secretory sperm binding protein Li 284mitochondrial aconitase
Modification date2018052320180523
UniProtAcc

P12956

Q99798

Ensembl transtripts involved in fusion geneENST00000360079, ENST00000402580, 
ENST00000428575, ENST00000359308, 
ENST00000405878, ENST00000405506, 
ENST00000216254, ENST00000396512, 
ENST00000466237, 
Fusion gene scores* DoF score7 X 5 X 7=24511 X 9 X 6=594
# samples 712
** MAII scorelog2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/594*10)=-2.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: XRCC6 [Title/Abstract] AND ACO2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneXRCC6

GO:0002218

activation of innate immune response

28712728

HgeneXRCC6

GO:0045860

positive regulation of protein kinase activity

22504299

HgeneXRCC6

GO:0045893

positive regulation of transcription, DNA-templated

12145306

HgeneXRCC6

GO:0051290

protein heterotetramerization

24095731

HgeneXRCC6

GO:0071480

cellular response to gamma radiation

26359349

HgeneXRCC6

GO:0097680

double-strand break repair via classical nonhomologous end joining

24095731

TgeneACO2

GO:0006099

tricarboxylic acid cycle

9630632

TgeneACO2

GO:0006101

citrate metabolic process

9630632


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-DD-A11C-01AXRCC6chr22

42024234

+ACO2chr22

41916175

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000360079ENST00000216254XRCC6chr22

42024234

+ACO2chr22

41916175

+
In-frameENST00000360079ENST00000396512XRCC6chr22

42024234

+ACO2chr22

41916175

+
5CDS-3UTRENST00000360079ENST00000466237XRCC6chr22

42024234

+ACO2chr22

41916175

+
In-frameENST00000402580ENST00000216254XRCC6chr22

42024234

+ACO2chr22

41916175

+
In-frameENST00000402580ENST00000396512XRCC6chr22

42024234

+ACO2chr22

41916175

+
5CDS-3UTRENST00000402580ENST00000466237XRCC6chr22

42024234

+ACO2chr22

41916175

+
intron-3CDSENST00000428575ENST00000216254XRCC6chr22

42024234

+ACO2chr22

41916175

+
intron-3CDSENST00000428575ENST00000396512XRCC6chr22

42024234

+ACO2chr22

41916175

+
intron-3UTRENST00000428575ENST00000466237XRCC6chr22

42024234

+ACO2chr22

41916175

+
In-frameENST00000359308ENST00000216254XRCC6chr22

42024234

+ACO2chr22

41916175

+
In-frameENST00000359308ENST00000396512XRCC6chr22

42024234

+ACO2chr22

41916175

+
5CDS-3UTRENST00000359308ENST00000466237XRCC6chr22

42024234

+ACO2chr22

41916175

+
In-frameENST00000405878ENST00000216254XRCC6chr22

42024234

+ACO2chr22

41916175

+
In-frameENST00000405878ENST00000396512XRCC6chr22

42024234

+ACO2chr22

41916175

+
5CDS-3UTRENST00000405878ENST00000466237XRCC6chr22

42024234

+ACO2chr22

41916175

+
intron-3CDSENST00000405506ENST00000216254XRCC6chr22

42024234

+ACO2chr22

41916175

+
intron-3CDSENST00000405506ENST00000396512XRCC6chr22

42024234

+ACO2chr22

41916175

+
intron-3UTRENST00000405506ENST00000466237XRCC6chr22

42024234

+ACO2chr22

41916175

+

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FusionProtFeatures for XRCC6_ACO2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
XRCC6

P12956

ACO2

Q99798

Single-stranded DNA-dependent ATP-dependent helicase.Has a role in chromosome translocation. The DNA helicase IIcomplex binds preferentially to fork-like ends of double-strandedDNA in a cell cycle-dependent manner. It works in the 3'-5'direction. Binding to DNA may be mediated by XRCC6. Involved inDNA non-homologous end joining (NHEJ) required for double-strandbreak repair and V(D)J recombination. The XRCC5/6 dimer acts asregulatory subunit of the DNA-dependent protein kinase complexDNA-PK by increasing the affinity of the catalytic subunit PRKDCto DNA by 100-fold. The XRCC5/6 dimer is probably involved instabilizing broken DNA ends and bringing them together. Theassembly of the DNA-PK complex to DNA ends is required for theNHEJ ligation step. Required for osteocalcin gene expression.Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRPlyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRPlyase activity allows to 'clean' the termini of abasic sites, aclass of nucleotide damage commonly associated with strand breaks,before such broken ends can be joined. The XRCC5/6 dimer togetherwith APEX1 acts as a negative regulator of transcription. Plays arole in the regulation of DNA virus-mediated innate immuneresponse by assembling into the HDP-RNP complex, a complex thatserves as a platform for IRF3 phosphorylation and subsequentinnate immune response activation through the cGAS-STING pathway.{ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123,ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:2466842,ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:7957065,ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:9742108}. Catalyzes the isomerization of citrate to isocitrate viacis-aconitate. {ECO:0000250|UniProtKB:P16276}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneXRCC6chr22:42024234chr22:41916175ENST00000359308+21211_2965610Compositional biasNote=Asp/Glu-rich (acidic)
HgeneXRCC6chr22:42024234chr22:41916175ENST00000359308+2122_6165610Compositional biasNote=Ser-rich (potentially targets for phosphorylation)
HgeneXRCC6chr22:42024234chr22:41916175ENST00000360079+31311_2965610Compositional biasNote=Asp/Glu-rich (acidic)
HgeneXRCC6chr22:42024234chr22:41916175ENST00000360079+3132_6165610Compositional biasNote=Ser-rich (potentially targets for phosphorylation)
HgeneXRCC6chr22:42024234chr22:41916175ENST00000405878+31311_2965610Compositional biasNote=Asp/Glu-rich (acidic)
HgeneXRCC6chr22:42024234chr22:41916175ENST00000405878+3132_6165610Compositional biasNote=Ser-rich (potentially targets for phosphorylation)
TgeneACO2chr22:42024234chr22:41916175ENST00000216254+718670_671344781RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneXRCC6chr22:42024234chr22:41916175ENST00000359308+212330_34265610Compositional biasNote=Asp/Glu-rich (acidic)
HgeneXRCC6chr22:42024234chr22:41916175ENST00000360079+313330_34265610Compositional biasNote=Asp/Glu-rich (acidic)
HgeneXRCC6chr22:42024234chr22:41916175ENST00000405878+313330_34265610Compositional biasNote=Asp/Glu-rich (acidic)
HgeneXRCC6chr22:42024234chr22:41916175ENST00000359308+212261_46865610DomainNote=Ku
HgeneXRCC6chr22:42024234chr22:41916175ENST00000359308+212573_60765610DomainSAP
HgeneXRCC6chr22:42024234chr22:41916175ENST00000360079+313261_46865610DomainNote=Ku
HgeneXRCC6chr22:42024234chr22:41916175ENST00000360079+313573_60765610DomainSAP
HgeneXRCC6chr22:42024234chr22:41916175ENST00000405878+313261_46865610DomainNote=Ku
HgeneXRCC6chr22:42024234chr22:41916175ENST00000405878+313573_60765610DomainSAP
TgeneACO2chr22:42024234chr22:41916175ENST00000216254+718192_194344781RegionSubstrate binding


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FusionGeneSequence for XRCC6_ACO2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_XRCC6_ENST00000360079_chr22_42024234_+_ACO2_ENST00000216254_chr22_41916175_+_502aa
MSGWESTYKTEGDEEAEEEQEENLEASGDTKTSGRDSLIFLVDASKAMFESQSEDELTPFDMSIQLKPHINGPFTPDLAHPVAEVGKVAE
KEGWPLDIRVGLIGSCTNSSTEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGTAQILRDLGGIVLANACGPCIGQWDRKD
IKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELPKGEFDPGQDTYQHPPK
DSSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQE
FGPVPDTARYYKKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLTIQGL

>In-frame_XRCC6_ENST00000360079_chr22_42024234_+_ACO2_ENST00000396512_chr22_41916175_+_502aa
MSGWESTYKTEGDEEAEEEQEENLEASGDTKTSGRDSLIFLVDASKAMFESQSEDELTPFDMSIQLKPHINGPFTPDLAHPVAEVGKVAE
KEGWPLDIRVGLIGSCTNSSTEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGTAQILRDLGGIVLANACGPCIGQWDRKD
IKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELPKGEFDPGQDTYQHPPK
DSSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQE
FGPVPDTARYYKKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLTIQGL

>In-frame_XRCC6_ENST00000402580_chr22_42024234_+_ACO2_ENST00000216254_chr22_41916175_+_502aa
MSGWESTYKTEGDEEAEEEQEENLEASGDTKTSGRDSLIFLVDASKAMFESQSEDELTPFDMSIQLKPHINGPFTPDLAHPVAEVGKVAE
KEGWPLDIRVGLIGSCTNSSTEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGTAQILRDLGGIVLANACGPCIGQWDRKD
IKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELPKGEFDPGQDTYQHPPK
DSSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQE
FGPVPDTARYYKKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLTIQGL

>In-frame_XRCC6_ENST00000402580_chr22_42024234_+_ACO2_ENST00000396512_chr22_41916175_+_502aa
MSGWESTYKTEGDEEAEEEQEENLEASGDTKTSGRDSLIFLVDASKAMFESQSEDELTPFDMSIQLKPHINGPFTPDLAHPVAEVGKVAE
KEGWPLDIRVGLIGSCTNSSTEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGTAQILRDLGGIVLANACGPCIGQWDRKD
IKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELPKGEFDPGQDTYQHPPK
DSSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQE
FGPVPDTARYYKKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLTIQGL

>In-frame_XRCC6_ENST00000359308_chr22_42024234_+_ACO2_ENST00000216254_chr22_41916175_+_502aa
MSGWESTYKTEGDEEAEEEQEENLEASGDTKTSGRDSLIFLVDASKAMFESQSEDELTPFDMSIQLKPHINGPFTPDLAHPVAEVGKVAE
KEGWPLDIRVGLIGSCTNSSTEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGTAQILRDLGGIVLANACGPCIGQWDRKD
IKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELPKGEFDPGQDTYQHPPK
DSSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQE
FGPVPDTARYYKKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLTIQGL

>In-frame_XRCC6_ENST00000359308_chr22_42024234_+_ACO2_ENST00000396512_chr22_41916175_+_502aa
MSGWESTYKTEGDEEAEEEQEENLEASGDTKTSGRDSLIFLVDASKAMFESQSEDELTPFDMSIQLKPHINGPFTPDLAHPVAEVGKVAE
KEGWPLDIRVGLIGSCTNSSTEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGTAQILRDLGGIVLANACGPCIGQWDRKD
IKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELPKGEFDPGQDTYQHPPK
DSSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQE
FGPVPDTARYYKKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLTIQGL

>In-frame_XRCC6_ENST00000405878_chr22_42024234_+_ACO2_ENST00000216254_chr22_41916175_+_502aa
MSGWESTYKTEGDEEAEEEQEENLEASGDTKTSGRDSLIFLVDASKAMFESQSEDELTPFDMSIQLKPHINGPFTPDLAHPVAEVGKVAE
KEGWPLDIRVGLIGSCTNSSTEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGTAQILRDLGGIVLANACGPCIGQWDRKD
IKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELPKGEFDPGQDTYQHPPK
DSSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQE
FGPVPDTARYYKKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLTIQGL

>In-frame_XRCC6_ENST00000405878_chr22_42024234_+_ACO2_ENST00000396512_chr22_41916175_+_502aa
MSGWESTYKTEGDEEAEEEQEENLEASGDTKTSGRDSLIFLVDASKAMFESQSEDELTPFDMSIQLKPHINGPFTPDLAHPVAEVGKVAE
KEGWPLDIRVGLIGSCTNSSTEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGTAQILRDLGGIVLANACGPCIGQWDRKD
IKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELPKGEFDPGQDTYQHPPK
DSSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQE
FGPVPDTARYYKKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLTIQGL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_XRCC6_ENST00000360079_chr22_42024234_+_ACO2_ENST00000216254_chr22_41916175_+_1506nt
ATGTCAGGGTGGGAGTCATATTACAAAACCGAGGGCGATGAAGAAGCAGAGGAAGAACAAGAAGAGAACCTTGAAGCAAGTGGAGACTAT
AAATATTCAGGAAGAGATAGTTTGATTTTTTTGGTTGATGCCTCCAAGGCTATGTTTGAATCTCAGAGTGAAGATGAGTTGACACCTTTT
GACATGAGCATCCAGCTGAAGCCACACATCAATGGGCCCTTCACCCCTGACCTGGCTCACCCTGTGGCAGAAGTGGGCAAGGTGGCAGAG
AAGGAAGGATGGCCTCTGGACATCCGAGTGGGTCTAATTGGTAGCTGCACCAATTCAAGCTATGAAGATATGGGGCGCTCAGCAGCTGTG
GCCAAGCAGGCACTGGCCCATGGCCTCAAGTGCAAGTCCCAGTTCACCATCACTCCAGGTTCCGAGCAGATCCGCGCCACCATTGAGCGG
GACGGCTATGCACAGATCTTGAGGGATCTGGGTGGCATTGTCCTGGCCAATGCTTGTGGCCCCTGCATTGGCCAGTGGGACAGGAAGGAC
ATCAAGAAGGGGGAGAAGAACACAATCGTCACCTCCTACAACAGGAACTTCACGGGCCGCAACGACGCAAACCCCGAGACCCATGCCTTT
GTCACGTCCCCAGAGATTGTCACAGCCCTGGCCATTGCGGGAACCCTCAAGTTCAACCCAGAGACCGACTACCTGACGGGCACGGATGGC
AAGAAGTTCAGGCTGGAGGCTCCGGATGCAGATGAGCTTCCCAAAGGGGAGTTTGACCCAGGGCAGGACACCTACCAGCACCCACCCAAG
GACAGCAGCGGGCAGCATGTGGACGTGAGCCCCACCAGCCAGCGCCTGCAGCTCCTGGAGCCTTTTGACAAGTGGGATGGCAAGGACCTG
GAGGACCTGCAGATCCTCATCAAGGTCAAAGGGAAGTGTACCACTGACCACATCTCAGCTGCTGGCCCCTGGCTCAAGTTCCGTGGGCAC
TTGGATAACATCTCCAACAACCTGCTCATTGGTGCCATCAACATTGAAAACGGCAAGGCCAACTCCGTGCGCAATGCCGTCACTCAGGAG
TTTGGCCCCGTCCCTGACACTGCCCGCTACTACAAGAAACATGGCATCAGGTGGGTGGTGATCGGAGACGAGAACTACGGCGAGGGCTCG
AGCCGGGAGCATGCAGCTCTGGAGCCTCGCCACCTTGGGGGCCGGGCCATCATCACCAAGAGCTTTGCCAGGATCCACGAGACCAACCTG
AAGAAACAGGGCCTGCTGCCTCTGACCTTCGCTGACCCGGCTGACTACAACAAGATTCACCCTGTGGACAAGCTGACCATTCAGGGCCTG
AAGGACTTCACCCCTGGCAAGCCCCTGAAGTGCATCATCAAGCACCCCAACGGGACCCAGGAGACCATCCTCCTGAACCACACCTTCAAC

>In-frame_XRCC6_ENST00000360079_chr22_42024234_+_ACO2_ENST00000396512_chr22_41916175_+_1506nt
ATGTCAGGGTGGGAGTCATATTACAAAACCGAGGGCGATGAAGAAGCAGAGGAAGAACAAGAAGAGAACCTTGAAGCAAGTGGAGACTAT
AAATATTCAGGAAGAGATAGTTTGATTTTTTTGGTTGATGCCTCCAAGGCTATGTTTGAATCTCAGAGTGAAGATGAGTTGACACCTTTT
GACATGAGCATCCAGCTGAAGCCACACATCAATGGGCCCTTCACCCCTGACCTGGCTCACCCTGTGGCAGAAGTGGGCAAGGTGGCAGAG
AAGGAAGGATGGCCTCTGGACATCCGAGTGGGTCTAATTGGTAGCTGCACCAATTCAAGCTATGAAGATATGGGGCGCTCAGCAGCTGTG
GCCAAGCAGGCACTGGCCCATGGCCTCAAGTGCAAGTCCCAGTTCACCATCACTCCAGGTTCCGAGCAGATCCGCGCCACCATTGAGCGG
GACGGCTATGCACAGATCTTGAGGGATCTGGGTGGCATTGTCCTGGCCAATGCTTGTGGCCCCTGCATTGGCCAGTGGGACAGGAAGGAC
ATCAAGAAGGGGGAGAAGAACACAATCGTCACCTCCTACAACAGGAACTTCACGGGCCGCAACGACGCAAACCCCGAGACCCATGCCTTT
GTCACGTCCCCAGAGATTGTCACAGCCCTGGCCATTGCGGGAACCCTCAAGTTCAACCCAGAGACCGACTACCTGACGGGCACGGATGGC
AAGAAGTTCAGGCTGGAGGCTCCGGATGCAGATGAGCTTCCCAAAGGGGAGTTTGACCCAGGGCAGGACACCTACCAGCACCCACCCAAG
GACAGCAGCGGGCAGCATGTGGACGTGAGCCCCACCAGCCAGCGCCTGCAGCTCCTGGAGCCTTTTGACAAGTGGGATGGCAAGGACCTG
GAGGACCTGCAGATCCTCATCAAGGTCAAAGGGAAGTGTACCACTGACCACATCTCAGCTGCTGGCCCCTGGCTCAAGTTCCGTGGGCAC
TTGGATAACATCTCCAACAACCTGCTCATTGGTGCCATCAACATTGAAAACGGCAAGGCCAACTCCGTGCGCAATGCCGTCACTCAGGAG
TTTGGCCCCGTCCCTGACACTGCCCGCTACTACAAGAAACATGGCATCAGGTGGGTGGTGATCGGAGACGAGAACTACGGCGAGGGCTCG
AGCCGGGAGCATGCAGCTCTGGAGCCTCGCCACCTTGGGGGCCGGGCCATCATCACCAAGAGCTTTGCCAGGATCCACGAGACCAACCTG
AAGAAACAGGGCCTGCTGCCTCTGACCTTCGCTGACCCGGCTGACTACAACAAGATTCACCCTGTGGACAAGCTGACCATTCAGGGCCTG
AAGGACTTCACCCCTGGCAAGCCCCTGAAGTGCATCATCAAGCACCCCAACGGGACCCAGGAGACCATCCTCCTGAACCACACCTTCAAC

>In-frame_XRCC6_ENST00000402580_chr22_42024234_+_ACO2_ENST00000216254_chr22_41916175_+_1506nt
ATGTCAGGGTGGGAGTCATATTACAAAACCGAGGGCGATGAAGAAGCAGAGGAAGAACAAGAAGAGAACCTTGAAGCAAGTGGAGACTAT
AAATATTCAGGAAGAGATAGTTTGATTTTTTTGGTTGATGCCTCCAAGGCTATGTTTGAATCTCAGAGTGAAGATGAGTTGACACCTTTT
GACATGAGCATCCAGCTGAAGCCACACATCAATGGGCCCTTCACCCCTGACCTGGCTCACCCTGTGGCAGAAGTGGGCAAGGTGGCAGAG
AAGGAAGGATGGCCTCTGGACATCCGAGTGGGTCTAATTGGTAGCTGCACCAATTCAAGCTATGAAGATATGGGGCGCTCAGCAGCTGTG
GCCAAGCAGGCACTGGCCCATGGCCTCAAGTGCAAGTCCCAGTTCACCATCACTCCAGGTTCCGAGCAGATCCGCGCCACCATTGAGCGG
GACGGCTATGCACAGATCTTGAGGGATCTGGGTGGCATTGTCCTGGCCAATGCTTGTGGCCCCTGCATTGGCCAGTGGGACAGGAAGGAC
ATCAAGAAGGGGGAGAAGAACACAATCGTCACCTCCTACAACAGGAACTTCACGGGCCGCAACGACGCAAACCCCGAGACCCATGCCTTT
GTCACGTCCCCAGAGATTGTCACAGCCCTGGCCATTGCGGGAACCCTCAAGTTCAACCCAGAGACCGACTACCTGACGGGCACGGATGGC
AAGAAGTTCAGGCTGGAGGCTCCGGATGCAGATGAGCTTCCCAAAGGGGAGTTTGACCCAGGGCAGGACACCTACCAGCACCCACCCAAG
GACAGCAGCGGGCAGCATGTGGACGTGAGCCCCACCAGCCAGCGCCTGCAGCTCCTGGAGCCTTTTGACAAGTGGGATGGCAAGGACCTG
GAGGACCTGCAGATCCTCATCAAGGTCAAAGGGAAGTGTACCACTGACCACATCTCAGCTGCTGGCCCCTGGCTCAAGTTCCGTGGGCAC
TTGGATAACATCTCCAACAACCTGCTCATTGGTGCCATCAACATTGAAAACGGCAAGGCCAACTCCGTGCGCAATGCCGTCACTCAGGAG
TTTGGCCCCGTCCCTGACACTGCCCGCTACTACAAGAAACATGGCATCAGGTGGGTGGTGATCGGAGACGAGAACTACGGCGAGGGCTCG
AGCCGGGAGCATGCAGCTCTGGAGCCTCGCCACCTTGGGGGCCGGGCCATCATCACCAAGAGCTTTGCCAGGATCCACGAGACCAACCTG
AAGAAACAGGGCCTGCTGCCTCTGACCTTCGCTGACCCGGCTGACTACAACAAGATTCACCCTGTGGACAAGCTGACCATTCAGGGCCTG
AAGGACTTCACCCCTGGCAAGCCCCTGAAGTGCATCATCAAGCACCCCAACGGGACCCAGGAGACCATCCTCCTGAACCACACCTTCAAC

>In-frame_XRCC6_ENST00000402580_chr22_42024234_+_ACO2_ENST00000396512_chr22_41916175_+_1506nt
ATGTCAGGGTGGGAGTCATATTACAAAACCGAGGGCGATGAAGAAGCAGAGGAAGAACAAGAAGAGAACCTTGAAGCAAGTGGAGACTAT
AAATATTCAGGAAGAGATAGTTTGATTTTTTTGGTTGATGCCTCCAAGGCTATGTTTGAATCTCAGAGTGAAGATGAGTTGACACCTTTT
GACATGAGCATCCAGCTGAAGCCACACATCAATGGGCCCTTCACCCCTGACCTGGCTCACCCTGTGGCAGAAGTGGGCAAGGTGGCAGAG
AAGGAAGGATGGCCTCTGGACATCCGAGTGGGTCTAATTGGTAGCTGCACCAATTCAAGCTATGAAGATATGGGGCGCTCAGCAGCTGTG
GCCAAGCAGGCACTGGCCCATGGCCTCAAGTGCAAGTCCCAGTTCACCATCACTCCAGGTTCCGAGCAGATCCGCGCCACCATTGAGCGG
GACGGCTATGCACAGATCTTGAGGGATCTGGGTGGCATTGTCCTGGCCAATGCTTGTGGCCCCTGCATTGGCCAGTGGGACAGGAAGGAC
ATCAAGAAGGGGGAGAAGAACACAATCGTCACCTCCTACAACAGGAACTTCACGGGCCGCAACGACGCAAACCCCGAGACCCATGCCTTT
GTCACGTCCCCAGAGATTGTCACAGCCCTGGCCATTGCGGGAACCCTCAAGTTCAACCCAGAGACCGACTACCTGACGGGCACGGATGGC
AAGAAGTTCAGGCTGGAGGCTCCGGATGCAGATGAGCTTCCCAAAGGGGAGTTTGACCCAGGGCAGGACACCTACCAGCACCCACCCAAG
GACAGCAGCGGGCAGCATGTGGACGTGAGCCCCACCAGCCAGCGCCTGCAGCTCCTGGAGCCTTTTGACAAGTGGGATGGCAAGGACCTG
GAGGACCTGCAGATCCTCATCAAGGTCAAAGGGAAGTGTACCACTGACCACATCTCAGCTGCTGGCCCCTGGCTCAAGTTCCGTGGGCAC
TTGGATAACATCTCCAACAACCTGCTCATTGGTGCCATCAACATTGAAAACGGCAAGGCCAACTCCGTGCGCAATGCCGTCACTCAGGAG
TTTGGCCCCGTCCCTGACACTGCCCGCTACTACAAGAAACATGGCATCAGGTGGGTGGTGATCGGAGACGAGAACTACGGCGAGGGCTCG
AGCCGGGAGCATGCAGCTCTGGAGCCTCGCCACCTTGGGGGCCGGGCCATCATCACCAAGAGCTTTGCCAGGATCCACGAGACCAACCTG
AAGAAACAGGGCCTGCTGCCTCTGACCTTCGCTGACCCGGCTGACTACAACAAGATTCACCCTGTGGACAAGCTGACCATTCAGGGCCTG
AAGGACTTCACCCCTGGCAAGCCCCTGAAGTGCATCATCAAGCACCCCAACGGGACCCAGGAGACCATCCTCCTGAACCACACCTTCAAC

>In-frame_XRCC6_ENST00000359308_chr22_42024234_+_ACO2_ENST00000216254_chr22_41916175_+_1506nt
ATGTCAGGGTGGGAGTCATATTACAAAACCGAGGGCGATGAAGAAGCAGAGGAAGAACAAGAAGAGAACCTTGAAGCAAGTGGAGACTAT
AAATATTCAGGAAGAGATAGTTTGATTTTTTTGGTTGATGCCTCCAAGGCTATGTTTGAATCTCAGAGTGAAGATGAGTTGACACCTTTT
GACATGAGCATCCAGCTGAAGCCACACATCAATGGGCCCTTCACCCCTGACCTGGCTCACCCTGTGGCAGAAGTGGGCAAGGTGGCAGAG
AAGGAAGGATGGCCTCTGGACATCCGAGTGGGTCTAATTGGTAGCTGCACCAATTCAAGCTATGAAGATATGGGGCGCTCAGCAGCTGTG
GCCAAGCAGGCACTGGCCCATGGCCTCAAGTGCAAGTCCCAGTTCACCATCACTCCAGGTTCCGAGCAGATCCGCGCCACCATTGAGCGG
GACGGCTATGCACAGATCTTGAGGGATCTGGGTGGCATTGTCCTGGCCAATGCTTGTGGCCCCTGCATTGGCCAGTGGGACAGGAAGGAC
ATCAAGAAGGGGGAGAAGAACACAATCGTCACCTCCTACAACAGGAACTTCACGGGCCGCAACGACGCAAACCCCGAGACCCATGCCTTT
GTCACGTCCCCAGAGATTGTCACAGCCCTGGCCATTGCGGGAACCCTCAAGTTCAACCCAGAGACCGACTACCTGACGGGCACGGATGGC
AAGAAGTTCAGGCTGGAGGCTCCGGATGCAGATGAGCTTCCCAAAGGGGAGTTTGACCCAGGGCAGGACACCTACCAGCACCCACCCAAG
GACAGCAGCGGGCAGCATGTGGACGTGAGCCCCACCAGCCAGCGCCTGCAGCTCCTGGAGCCTTTTGACAAGTGGGATGGCAAGGACCTG
GAGGACCTGCAGATCCTCATCAAGGTCAAAGGGAAGTGTACCACTGACCACATCTCAGCTGCTGGCCCCTGGCTCAAGTTCCGTGGGCAC
TTGGATAACATCTCCAACAACCTGCTCATTGGTGCCATCAACATTGAAAACGGCAAGGCCAACTCCGTGCGCAATGCCGTCACTCAGGAG
TTTGGCCCCGTCCCTGACACTGCCCGCTACTACAAGAAACATGGCATCAGGTGGGTGGTGATCGGAGACGAGAACTACGGCGAGGGCTCG
AGCCGGGAGCATGCAGCTCTGGAGCCTCGCCACCTTGGGGGCCGGGCCATCATCACCAAGAGCTTTGCCAGGATCCACGAGACCAACCTG
AAGAAACAGGGCCTGCTGCCTCTGACCTTCGCTGACCCGGCTGACTACAACAAGATTCACCCTGTGGACAAGCTGACCATTCAGGGCCTG
AAGGACTTCACCCCTGGCAAGCCCCTGAAGTGCATCATCAAGCACCCCAACGGGACCCAGGAGACCATCCTCCTGAACCACACCTTCAAC

>In-frame_XRCC6_ENST00000359308_chr22_42024234_+_ACO2_ENST00000396512_chr22_41916175_+_1506nt
ATGTCAGGGTGGGAGTCATATTACAAAACCGAGGGCGATGAAGAAGCAGAGGAAGAACAAGAAGAGAACCTTGAAGCAAGTGGAGACTAT
AAATATTCAGGAAGAGATAGTTTGATTTTTTTGGTTGATGCCTCCAAGGCTATGTTTGAATCTCAGAGTGAAGATGAGTTGACACCTTTT
GACATGAGCATCCAGCTGAAGCCACACATCAATGGGCCCTTCACCCCTGACCTGGCTCACCCTGTGGCAGAAGTGGGCAAGGTGGCAGAG
AAGGAAGGATGGCCTCTGGACATCCGAGTGGGTCTAATTGGTAGCTGCACCAATTCAAGCTATGAAGATATGGGGCGCTCAGCAGCTGTG
GCCAAGCAGGCACTGGCCCATGGCCTCAAGTGCAAGTCCCAGTTCACCATCACTCCAGGTTCCGAGCAGATCCGCGCCACCATTGAGCGG
GACGGCTATGCACAGATCTTGAGGGATCTGGGTGGCATTGTCCTGGCCAATGCTTGTGGCCCCTGCATTGGCCAGTGGGACAGGAAGGAC
ATCAAGAAGGGGGAGAAGAACACAATCGTCACCTCCTACAACAGGAACTTCACGGGCCGCAACGACGCAAACCCCGAGACCCATGCCTTT
GTCACGTCCCCAGAGATTGTCACAGCCCTGGCCATTGCGGGAACCCTCAAGTTCAACCCAGAGACCGACTACCTGACGGGCACGGATGGC
AAGAAGTTCAGGCTGGAGGCTCCGGATGCAGATGAGCTTCCCAAAGGGGAGTTTGACCCAGGGCAGGACACCTACCAGCACCCACCCAAG
GACAGCAGCGGGCAGCATGTGGACGTGAGCCCCACCAGCCAGCGCCTGCAGCTCCTGGAGCCTTTTGACAAGTGGGATGGCAAGGACCTG
GAGGACCTGCAGATCCTCATCAAGGTCAAAGGGAAGTGTACCACTGACCACATCTCAGCTGCTGGCCCCTGGCTCAAGTTCCGTGGGCAC
TTGGATAACATCTCCAACAACCTGCTCATTGGTGCCATCAACATTGAAAACGGCAAGGCCAACTCCGTGCGCAATGCCGTCACTCAGGAG
TTTGGCCCCGTCCCTGACACTGCCCGCTACTACAAGAAACATGGCATCAGGTGGGTGGTGATCGGAGACGAGAACTACGGCGAGGGCTCG
AGCCGGGAGCATGCAGCTCTGGAGCCTCGCCACCTTGGGGGCCGGGCCATCATCACCAAGAGCTTTGCCAGGATCCACGAGACCAACCTG
AAGAAACAGGGCCTGCTGCCTCTGACCTTCGCTGACCCGGCTGACTACAACAAGATTCACCCTGTGGACAAGCTGACCATTCAGGGCCTG
AAGGACTTCACCCCTGGCAAGCCCCTGAAGTGCATCATCAAGCACCCCAACGGGACCCAGGAGACCATCCTCCTGAACCACACCTTCAAC

>In-frame_XRCC6_ENST00000405878_chr22_42024234_+_ACO2_ENST00000216254_chr22_41916175_+_1506nt
ATGTCAGGGTGGGAGTCATATTACAAAACCGAGGGCGATGAAGAAGCAGAGGAAGAACAAGAAGAGAACCTTGAAGCAAGTGGAGACTAT
AAATATTCAGGAAGAGATAGTTTGATTTTTTTGGTTGATGCCTCCAAGGCTATGTTTGAATCTCAGAGTGAAGATGAGTTGACACCTTTT
GACATGAGCATCCAGCTGAAGCCACACATCAATGGGCCCTTCACCCCTGACCTGGCTCACCCTGTGGCAGAAGTGGGCAAGGTGGCAGAG
AAGGAAGGATGGCCTCTGGACATCCGAGTGGGTCTAATTGGTAGCTGCACCAATTCAAGCTATGAAGATATGGGGCGCTCAGCAGCTGTG
GCCAAGCAGGCACTGGCCCATGGCCTCAAGTGCAAGTCCCAGTTCACCATCACTCCAGGTTCCGAGCAGATCCGCGCCACCATTGAGCGG
GACGGCTATGCACAGATCTTGAGGGATCTGGGTGGCATTGTCCTGGCCAATGCTTGTGGCCCCTGCATTGGCCAGTGGGACAGGAAGGAC
ATCAAGAAGGGGGAGAAGAACACAATCGTCACCTCCTACAACAGGAACTTCACGGGCCGCAACGACGCAAACCCCGAGACCCATGCCTTT
GTCACGTCCCCAGAGATTGTCACAGCCCTGGCCATTGCGGGAACCCTCAAGTTCAACCCAGAGACCGACTACCTGACGGGCACGGATGGC
AAGAAGTTCAGGCTGGAGGCTCCGGATGCAGATGAGCTTCCCAAAGGGGAGTTTGACCCAGGGCAGGACACCTACCAGCACCCACCCAAG
GACAGCAGCGGGCAGCATGTGGACGTGAGCCCCACCAGCCAGCGCCTGCAGCTCCTGGAGCCTTTTGACAAGTGGGATGGCAAGGACCTG
GAGGACCTGCAGATCCTCATCAAGGTCAAAGGGAAGTGTACCACTGACCACATCTCAGCTGCTGGCCCCTGGCTCAAGTTCCGTGGGCAC
TTGGATAACATCTCCAACAACCTGCTCATTGGTGCCATCAACATTGAAAACGGCAAGGCCAACTCCGTGCGCAATGCCGTCACTCAGGAG
TTTGGCCCCGTCCCTGACACTGCCCGCTACTACAAGAAACATGGCATCAGGTGGGTGGTGATCGGAGACGAGAACTACGGCGAGGGCTCG
AGCCGGGAGCATGCAGCTCTGGAGCCTCGCCACCTTGGGGGCCGGGCCATCATCACCAAGAGCTTTGCCAGGATCCACGAGACCAACCTG
AAGAAACAGGGCCTGCTGCCTCTGACCTTCGCTGACCCGGCTGACTACAACAAGATTCACCCTGTGGACAAGCTGACCATTCAGGGCCTG
AAGGACTTCACCCCTGGCAAGCCCCTGAAGTGCATCATCAAGCACCCCAACGGGACCCAGGAGACCATCCTCCTGAACCACACCTTCAAC

>In-frame_XRCC6_ENST00000405878_chr22_42024234_+_ACO2_ENST00000396512_chr22_41916175_+_1506nt
ATGTCAGGGTGGGAGTCATATTACAAAACCGAGGGCGATGAAGAAGCAGAGGAAGAACAAGAAGAGAACCTTGAAGCAAGTGGAGACTAT
AAATATTCAGGAAGAGATAGTTTGATTTTTTTGGTTGATGCCTCCAAGGCTATGTTTGAATCTCAGAGTGAAGATGAGTTGACACCTTTT
GACATGAGCATCCAGCTGAAGCCACACATCAATGGGCCCTTCACCCCTGACCTGGCTCACCCTGTGGCAGAAGTGGGCAAGGTGGCAGAG
AAGGAAGGATGGCCTCTGGACATCCGAGTGGGTCTAATTGGTAGCTGCACCAATTCAAGCTATGAAGATATGGGGCGCTCAGCAGCTGTG
GCCAAGCAGGCACTGGCCCATGGCCTCAAGTGCAAGTCCCAGTTCACCATCACTCCAGGTTCCGAGCAGATCCGCGCCACCATTGAGCGG
GACGGCTATGCACAGATCTTGAGGGATCTGGGTGGCATTGTCCTGGCCAATGCTTGTGGCCCCTGCATTGGCCAGTGGGACAGGAAGGAC
ATCAAGAAGGGGGAGAAGAACACAATCGTCACCTCCTACAACAGGAACTTCACGGGCCGCAACGACGCAAACCCCGAGACCCATGCCTTT
GTCACGTCCCCAGAGATTGTCACAGCCCTGGCCATTGCGGGAACCCTCAAGTTCAACCCAGAGACCGACTACCTGACGGGCACGGATGGC
AAGAAGTTCAGGCTGGAGGCTCCGGATGCAGATGAGCTTCCCAAAGGGGAGTTTGACCCAGGGCAGGACACCTACCAGCACCCACCCAAG
GACAGCAGCGGGCAGCATGTGGACGTGAGCCCCACCAGCCAGCGCCTGCAGCTCCTGGAGCCTTTTGACAAGTGGGATGGCAAGGACCTG
GAGGACCTGCAGATCCTCATCAAGGTCAAAGGGAAGTGTACCACTGACCACATCTCAGCTGCTGGCCCCTGGCTCAAGTTCCGTGGGCAC
TTGGATAACATCTCCAACAACCTGCTCATTGGTGCCATCAACATTGAAAACGGCAAGGCCAACTCCGTGCGCAATGCCGTCACTCAGGAG
TTTGGCCCCGTCCCTGACACTGCCCGCTACTACAAGAAACATGGCATCAGGTGGGTGGTGATCGGAGACGAGAACTACGGCGAGGGCTCG
AGCCGGGAGCATGCAGCTCTGGAGCCTCGCCACCTTGGGGGCCGGGCCATCATCACCAAGAGCTTTGCCAGGATCCACGAGACCAACCTG
AAGAAACAGGGCCTGCTGCCTCTGACCTTCGCTGACCCGGCTGACTACAACAAGATTCACCCTGTGGACAAGCTGACCATTCAGGGCCTG
AAGGACTTCACCCCTGGCAAGCCCCTGAAGTGCATCATCAAGCACCCCAACGGGACCCAGGAGACCATCCTCCTGAACCACACCTTCAAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_XRCC6_ENST00000360079_chr22_42024234_+_ACO2_ENST00000216254_chr22_41916175_+_2124nt
GTAGGAAGGGGCGGGGCTTTGCCGAAGGGGGCGGGGCTCTCGCTGATGGGTTGGCTTTCGTCAGGGACATAGGTAGAAGCTGGTTGGGGA
GTGTGCGTGCCAGCCTGACGCGATATAGTGCGCACATGCGTGATGACGTAGAGGGCGTTGATTGGGACCGAGTACAGGGCCCGCGCATGC
GTGGATTGTCGTCTTCTGTCCAAGTTGGTCGCTTCCCTGCGCCAAAGTGAGCAGTAGCCAACATGTCAGGGTGGGAGTCATATTACAAAA
CCGAGGGCGATGAAGAAGCAGAGGAAGAACAAGAAGAGAACCTTGAAGCAAGTGGAGACTATAAATATTCAGGAAGAGATAGTTTGATTT
TTTTGGTTGATGCCTCCAAGGCTATGTTTGAATCTCAGAGTGAAGATGAGTTGACACCTTTTGACATGAGCATCCAGCTGAAGCCACACA
TCAATGGGCCCTTCACCCCTGACCTGGCTCACCCTGTGGCAGAAGTGGGCAAGGTGGCAGAGAAGGAAGGATGGCCTCTGGACATCCGAG
TGGGTCTAATTGGTAGCTGCACCAATTCAAGCTATGAAGATATGGGGCGCTCAGCAGCTGTGGCCAAGCAGGCACTGGCCCATGGCCTCA
AGTGCAAGTCCCAGTTCACCATCACTCCAGGTTCCGAGCAGATCCGCGCCACCATTGAGCGGGACGGCTATGCACAGATCTTGAGGGATC
TGGGTGGCATTGTCCTGGCCAATGCTTGTGGCCCCTGCATTGGCCAGTGGGACAGGAAGGACATCAAGAAGGGGGAGAAGAACACAATCG
TCACCTCCTACAACAGGAACTTCACGGGCCGCAACGACGCAAACCCCGAGACCCATGCCTTTGTCACGTCCCCAGAGATTGTCACAGCCC
TGGCCATTGCGGGAACCCTCAAGTTCAACCCAGAGACCGACTACCTGACGGGCACGGATGGCAAGAAGTTCAGGCTGGAGGCTCCGGATG
CAGATGAGCTTCCCAAAGGGGAGTTTGACCCAGGGCAGGACACCTACCAGCACCCACCCAAGGACAGCAGCGGGCAGCATGTGGACGTGA
GCCCCACCAGCCAGCGCCTGCAGCTCCTGGAGCCTTTTGACAAGTGGGATGGCAAGGACCTGGAGGACCTGCAGATCCTCATCAAGGTCA
AAGGGAAGTGTACCACTGACCACATCTCAGCTGCTGGCCCCTGGCTCAAGTTCCGTGGGCACTTGGATAACATCTCCAACAACCTGCTCA
TTGGTGCCATCAACATTGAAAACGGCAAGGCCAACTCCGTGCGCAATGCCGTCACTCAGGAGTTTGGCCCCGTCCCTGACACTGCCCGCT
ACTACAAGAAACATGGCATCAGGTGGGTGGTGATCGGAGACGAGAACTACGGCGAGGGCTCGAGCCGGGAGCATGCAGCTCTGGAGCCTC
GCCACCTTGGGGGCCGGGCCATCATCACCAAGAGCTTTGCCAGGATCCACGAGACCAACCTGAAGAAACAGGGCCTGCTGCCTCTGACCT
TCGCTGACCCGGCTGACTACAACAAGATTCACCCTGTGGACAAGCTGACCATTCAGGGCCTGAAGGACTTCACCCCTGGCAAGCCCCTGA
AGTGCATCATCAAGCACCCCAACGGGACCCAGGAGACCATCCTCCTGAACCACACCTTCAACGAGACGCAGATTGAGTGGTTCCGCGCTG
GCAGTGCCCTCAACAGAATGAAGGAACTGCAACAGTGAGGGCAGTGCCTCCCCGCCCCGCCGCTGGCGTCAAGTTCAGCTCCACGTGTGC
CATCAGTGGATCCGATCCGTCCAGCCATGGCTTCCTATTCCAAGATGGTGTGACCAGACATGCTTCCTGCTCCCCGCTTAGCCCACGGAG
TGACTGTGGTTGTGGTGGGGGGGTTCTTAAAATAACTTTTTAGCCCCCGTCTTCCTATTTTGAGTTTGGTTCAGATCTTAAGCAGCTCCA
TGCAACTGTATTTATTTTTGATGACAAGACTCCCATCTAAAGTTTTTCTCCTGCCTGATCATTTCATTGGTGGCTGAAGGATTCTAGAGA

>In-frame_XRCC6_ENST00000360079_chr22_42024234_+_ACO2_ENST00000396512_chr22_41916175_+_2124nt
GTAGGAAGGGGCGGGGCTTTGCCGAAGGGGGCGGGGCTCTCGCTGATGGGTTGGCTTTCGTCAGGGACATAGGTAGAAGCTGGTTGGGGA
GTGTGCGTGCCAGCCTGACGCGATATAGTGCGCACATGCGTGATGACGTAGAGGGCGTTGATTGGGACCGAGTACAGGGCCCGCGCATGC
GTGGATTGTCGTCTTCTGTCCAAGTTGGTCGCTTCCCTGCGCCAAAGTGAGCAGTAGCCAACATGTCAGGGTGGGAGTCATATTACAAAA
CCGAGGGCGATGAAGAAGCAGAGGAAGAACAAGAAGAGAACCTTGAAGCAAGTGGAGACTATAAATATTCAGGAAGAGATAGTTTGATTT
TTTTGGTTGATGCCTCCAAGGCTATGTTTGAATCTCAGAGTGAAGATGAGTTGACACCTTTTGACATGAGCATCCAGCTGAAGCCACACA
TCAATGGGCCCTTCACCCCTGACCTGGCTCACCCTGTGGCAGAAGTGGGCAAGGTGGCAGAGAAGGAAGGATGGCCTCTGGACATCCGAG
TGGGTCTAATTGGTAGCTGCACCAATTCAAGCTATGAAGATATGGGGCGCTCAGCAGCTGTGGCCAAGCAGGCACTGGCCCATGGCCTCA
AGTGCAAGTCCCAGTTCACCATCACTCCAGGTTCCGAGCAGATCCGCGCCACCATTGAGCGGGACGGCTATGCACAGATCTTGAGGGATC
TGGGTGGCATTGTCCTGGCCAATGCTTGTGGCCCCTGCATTGGCCAGTGGGACAGGAAGGACATCAAGAAGGGGGAGAAGAACACAATCG
TCACCTCCTACAACAGGAACTTCACGGGCCGCAACGACGCAAACCCCGAGACCCATGCCTTTGTCACGTCCCCAGAGATTGTCACAGCCC
TGGCCATTGCGGGAACCCTCAAGTTCAACCCAGAGACCGACTACCTGACGGGCACGGATGGCAAGAAGTTCAGGCTGGAGGCTCCGGATG
CAGATGAGCTTCCCAAAGGGGAGTTTGACCCAGGGCAGGACACCTACCAGCACCCACCCAAGGACAGCAGCGGGCAGCATGTGGACGTGA
GCCCCACCAGCCAGCGCCTGCAGCTCCTGGAGCCTTTTGACAAGTGGGATGGCAAGGACCTGGAGGACCTGCAGATCCTCATCAAGGTCA
AAGGGAAGTGTACCACTGACCACATCTCAGCTGCTGGCCCCTGGCTCAAGTTCCGTGGGCACTTGGATAACATCTCCAACAACCTGCTCA
TTGGTGCCATCAACATTGAAAACGGCAAGGCCAACTCCGTGCGCAATGCCGTCACTCAGGAGTTTGGCCCCGTCCCTGACACTGCCCGCT
ACTACAAGAAACATGGCATCAGGTGGGTGGTGATCGGAGACGAGAACTACGGCGAGGGCTCGAGCCGGGAGCATGCAGCTCTGGAGCCTC
GCCACCTTGGGGGCCGGGCCATCATCACCAAGAGCTTTGCCAGGATCCACGAGACCAACCTGAAGAAACAGGGCCTGCTGCCTCTGACCT
TCGCTGACCCGGCTGACTACAACAAGATTCACCCTGTGGACAAGCTGACCATTCAGGGCCTGAAGGACTTCACCCCTGGCAAGCCCCTGA
AGTGCATCATCAAGCACCCCAACGGGACCCAGGAGACCATCCTCCTGAACCACACCTTCAACGAGACGCAGATTGAGTGGTTCCGCGCTG
GCAGTGCCCTCAACAGAATGAAGGAACTGCAACAGTGAGGGCAGTGCCTCCCCGCCCCGCCGCTGGCGTCAAGTTCAGCTCCACGTGTGC
CATCAGTGGATCCGATCCGTCCAGCCATGGCTTCCTATTCCAAGATGGTGTGACCAGACATGCTTCCTGCTCCCCGCTTAGCCCACGGAG
TGACTGTGGTTGTGGTGGGGGGGTTCTTAAAATAACTTTTTAGCCCCCGTCTTCCTATTTTGAGTTTGGTTCAGATCTTAAGCAGCTCCA
TGCAACTGTATTTATTTTTGATGACAAGACTCCCATCTAAAGTTTTTCTCCTGCCTGATCATTTCATTGGTGGCTGAAGGATTCTAGAGA

>In-frame_XRCC6_ENST00000402580_chr22_42024234_+_ACO2_ENST00000216254_chr22_41916175_+_1948nt
ATGCGTGGATTGTCGTCTTCTGTCCAAGTTGGTCGCTTCCCTGCGCCAAAGTGAGCAGTAGCCAACATGTCAGGGTGGGAGTCATATTAC
AAAACCGAGGGCGATGAAGAAGCAGAGGAAGAACAAGAAGAGAACCTTGAAGCAAGTGGAGACTATAAATATTCAGGAAGAGATAGTTTG
ATTTTTTTGGTTGATGCCTCCAAGGCTATGTTTGAATCTCAGAGTGAAGATGAGTTGACACCTTTTGACATGAGCATCCAGCTGAAGCCA
CACATCAATGGGCCCTTCACCCCTGACCTGGCTCACCCTGTGGCAGAAGTGGGCAAGGTGGCAGAGAAGGAAGGATGGCCTCTGGACATC
CGAGTGGGTCTAATTGGTAGCTGCACCAATTCAAGCTATGAAGATATGGGGCGCTCAGCAGCTGTGGCCAAGCAGGCACTGGCCCATGGC
CTCAAGTGCAAGTCCCAGTTCACCATCACTCCAGGTTCCGAGCAGATCCGCGCCACCATTGAGCGGGACGGCTATGCACAGATCTTGAGG
GATCTGGGTGGCATTGTCCTGGCCAATGCTTGTGGCCCCTGCATTGGCCAGTGGGACAGGAAGGACATCAAGAAGGGGGAGAAGAACACA
ATCGTCACCTCCTACAACAGGAACTTCACGGGCCGCAACGACGCAAACCCCGAGACCCATGCCTTTGTCACGTCCCCAGAGATTGTCACA
GCCCTGGCCATTGCGGGAACCCTCAAGTTCAACCCAGAGACCGACTACCTGACGGGCACGGATGGCAAGAAGTTCAGGCTGGAGGCTCCG
GATGCAGATGAGCTTCCCAAAGGGGAGTTTGACCCAGGGCAGGACACCTACCAGCACCCACCCAAGGACAGCAGCGGGCAGCATGTGGAC
GTGAGCCCCACCAGCCAGCGCCTGCAGCTCCTGGAGCCTTTTGACAAGTGGGATGGCAAGGACCTGGAGGACCTGCAGATCCTCATCAAG
GTCAAAGGGAAGTGTACCACTGACCACATCTCAGCTGCTGGCCCCTGGCTCAAGTTCCGTGGGCACTTGGATAACATCTCCAACAACCTG
CTCATTGGTGCCATCAACATTGAAAACGGCAAGGCCAACTCCGTGCGCAATGCCGTCACTCAGGAGTTTGGCCCCGTCCCTGACACTGCC
CGCTACTACAAGAAACATGGCATCAGGTGGGTGGTGATCGGAGACGAGAACTACGGCGAGGGCTCGAGCCGGGAGCATGCAGCTCTGGAG
CCTCGCCACCTTGGGGGCCGGGCCATCATCACCAAGAGCTTTGCCAGGATCCACGAGACCAACCTGAAGAAACAGGGCCTGCTGCCTCTG
ACCTTCGCTGACCCGGCTGACTACAACAAGATTCACCCTGTGGACAAGCTGACCATTCAGGGCCTGAAGGACTTCACCCCTGGCAAGCCC
CTGAAGTGCATCATCAAGCACCCCAACGGGACCCAGGAGACCATCCTCCTGAACCACACCTTCAACGAGACGCAGATTGAGTGGTTCCGC
GCTGGCAGTGCCCTCAACAGAATGAAGGAACTGCAACAGTGAGGGCAGTGCCTCCCCGCCCCGCCGCTGGCGTCAAGTTCAGCTCCACGT
GTGCCATCAGTGGATCCGATCCGTCCAGCCATGGCTTCCTATTCCAAGATGGTGTGACCAGACATGCTTCCTGCTCCCCGCTTAGCCCAC
GGAGTGACTGTGGTTGTGGTGGGGGGGTTCTTAAAATAACTTTTTAGCCCCCGTCTTCCTATTTTGAGTTTGGTTCAGATCTTAAGCAGC
TCCATGCAACTGTATTTATTTTTGATGACAAGACTCCCATCTAAAGTTTTTCTCCTGCCTGATCATTTCATTGGTGGCTGAAGGATTCTA

>In-frame_XRCC6_ENST00000402580_chr22_42024234_+_ACO2_ENST00000396512_chr22_41916175_+_1948nt
ATGCGTGGATTGTCGTCTTCTGTCCAAGTTGGTCGCTTCCCTGCGCCAAAGTGAGCAGTAGCCAACATGTCAGGGTGGGAGTCATATTAC
AAAACCGAGGGCGATGAAGAAGCAGAGGAAGAACAAGAAGAGAACCTTGAAGCAAGTGGAGACTATAAATATTCAGGAAGAGATAGTTTG
ATTTTTTTGGTTGATGCCTCCAAGGCTATGTTTGAATCTCAGAGTGAAGATGAGTTGACACCTTTTGACATGAGCATCCAGCTGAAGCCA
CACATCAATGGGCCCTTCACCCCTGACCTGGCTCACCCTGTGGCAGAAGTGGGCAAGGTGGCAGAGAAGGAAGGATGGCCTCTGGACATC
CGAGTGGGTCTAATTGGTAGCTGCACCAATTCAAGCTATGAAGATATGGGGCGCTCAGCAGCTGTGGCCAAGCAGGCACTGGCCCATGGC
CTCAAGTGCAAGTCCCAGTTCACCATCACTCCAGGTTCCGAGCAGATCCGCGCCACCATTGAGCGGGACGGCTATGCACAGATCTTGAGG
GATCTGGGTGGCATTGTCCTGGCCAATGCTTGTGGCCCCTGCATTGGCCAGTGGGACAGGAAGGACATCAAGAAGGGGGAGAAGAACACA
ATCGTCACCTCCTACAACAGGAACTTCACGGGCCGCAACGACGCAAACCCCGAGACCCATGCCTTTGTCACGTCCCCAGAGATTGTCACA
GCCCTGGCCATTGCGGGAACCCTCAAGTTCAACCCAGAGACCGACTACCTGACGGGCACGGATGGCAAGAAGTTCAGGCTGGAGGCTCCG
GATGCAGATGAGCTTCCCAAAGGGGAGTTTGACCCAGGGCAGGACACCTACCAGCACCCACCCAAGGACAGCAGCGGGCAGCATGTGGAC
GTGAGCCCCACCAGCCAGCGCCTGCAGCTCCTGGAGCCTTTTGACAAGTGGGATGGCAAGGACCTGGAGGACCTGCAGATCCTCATCAAG
GTCAAAGGGAAGTGTACCACTGACCACATCTCAGCTGCTGGCCCCTGGCTCAAGTTCCGTGGGCACTTGGATAACATCTCCAACAACCTG
CTCATTGGTGCCATCAACATTGAAAACGGCAAGGCCAACTCCGTGCGCAATGCCGTCACTCAGGAGTTTGGCCCCGTCCCTGACACTGCC
CGCTACTACAAGAAACATGGCATCAGGTGGGTGGTGATCGGAGACGAGAACTACGGCGAGGGCTCGAGCCGGGAGCATGCAGCTCTGGAG
CCTCGCCACCTTGGGGGCCGGGCCATCATCACCAAGAGCTTTGCCAGGATCCACGAGACCAACCTGAAGAAACAGGGCCTGCTGCCTCTG
ACCTTCGCTGACCCGGCTGACTACAACAAGATTCACCCTGTGGACAAGCTGACCATTCAGGGCCTGAAGGACTTCACCCCTGGCAAGCCC
CTGAAGTGCATCATCAAGCACCCCAACGGGACCCAGGAGACCATCCTCCTGAACCACACCTTCAACGAGACGCAGATTGAGTGGTTCCGC
GCTGGCAGTGCCCTCAACAGAATGAAGGAACTGCAACAGTGAGGGCAGTGCCTCCCCGCCCCGCCGCTGGCGTCAAGTTCAGCTCCACGT
GTGCCATCAGTGGATCCGATCCGTCCAGCCATGGCTTCCTATTCCAAGATGGTGTGACCAGACATGCTTCCTGCTCCCCGCTTAGCCCAC
GGAGTGACTGTGGTTGTGGTGGGGGGGTTCTTAAAATAACTTTTTAGCCCCCGTCTTCCTATTTTGAGTTTGGTTCAGATCTTAAGCAGC
TCCATGCAACTGTATTTATTTTTGATGACAAGACTCCCATCTAAAGTTTTTCTCCTGCCTGATCATTTCATTGGTGGCTGAAGGATTCTA

>In-frame_XRCC6_ENST00000359308_chr22_42024234_+_ACO2_ENST00000216254_chr22_41916175_+_2537nt
GCGGGCCGTTATCCATTTGTGTTGTTCGCCAGCTAGGCCTGGCCTCGTCCCGCTTCGCTCGGTCGGTCTCGCGCGCCCCCATAGCCTTGC
TAGAGGGTTAGCGTTAGCCTTAAGTGTGCGAATCCGAGGAGCAGCGACAGACTCGAGACCACGCTCCTTCCTCGGGAAGGAGGCGGCACC
TCGCGTTTGAGGCCCGCCTGCGTTTGAGGCCCGCCTGCGCTTGCGGCCCGCCTGCGCTTGAGGCCTGTCTGCGTTTGAGATCTCATTGGG
CGTGATTGAGGAATTTGGGGAGGTTTTTGGGCGGTATTGAGGACGAGGGGGTCCGTTAGTCAGCATAGAATCCTGGAGCGGGAATCCCTC
ACCGTCTAAATGGCGTCGGGGGCGGGACCTCCGGGATCTGGCTTCCGCGGGCCGCCGCCGGCCCTGAAACGTGAGGGATAGCTGAGATGA
GGCAGCTACTGGGATGGCCCCCATGCGCATTTACATGCAGTCCGACTGCCGAGCTTTCGAGGCAGCAGGATTTACCGTCCACATTCCTCA
CTACTAACCAAGCTTTTAGAACAGATCTCACAAGAACCTAGAGGTCGGTATTTTTTCGATTTAAATTTGCCTGTTACTGACGTTAACGTC
TTTCGCCTAGTGAGCAGTAGCCAACATGTCAGGGTGGGAGTCATATTACAAAACCGAGGGCGATGAAGAAGCAGAGGAAGAACAAGAAGA
GAACCTTGAAGCAAGTGGAGACTATAAATATTCAGGAAGAGATAGTTTGATTTTTTTGGTTGATGCCTCCAAGGCTATGTTTGAATCTCA
GAGTGAAGATGAGTTGACACCTTTTGACATGAGCATCCAGCTGAAGCCACACATCAATGGGCCCTTCACCCCTGACCTGGCTCACCCTGT
GGCAGAAGTGGGCAAGGTGGCAGAGAAGGAAGGATGGCCTCTGGACATCCGAGTGGGTCTAATTGGTAGCTGCACCAATTCAAGCTATGA
AGATATGGGGCGCTCAGCAGCTGTGGCCAAGCAGGCACTGGCCCATGGCCTCAAGTGCAAGTCCCAGTTCACCATCACTCCAGGTTCCGA
GCAGATCCGCGCCACCATTGAGCGGGACGGCTATGCACAGATCTTGAGGGATCTGGGTGGCATTGTCCTGGCCAATGCTTGTGGCCCCTG
CATTGGCCAGTGGGACAGGAAGGACATCAAGAAGGGGGAGAAGAACACAATCGTCACCTCCTACAACAGGAACTTCACGGGCCGCAACGA
CGCAAACCCCGAGACCCATGCCTTTGTCACGTCCCCAGAGATTGTCACAGCCCTGGCCATTGCGGGAACCCTCAAGTTCAACCCAGAGAC
CGACTACCTGACGGGCACGGATGGCAAGAAGTTCAGGCTGGAGGCTCCGGATGCAGATGAGCTTCCCAAAGGGGAGTTTGACCCAGGGCA
GGACACCTACCAGCACCCACCCAAGGACAGCAGCGGGCAGCATGTGGACGTGAGCCCCACCAGCCAGCGCCTGCAGCTCCTGGAGCCTTT
TGACAAGTGGGATGGCAAGGACCTGGAGGACCTGCAGATCCTCATCAAGGTCAAAGGGAAGTGTACCACTGACCACATCTCAGCTGCTGG
CCCCTGGCTCAAGTTCCGTGGGCACTTGGATAACATCTCCAACAACCTGCTCATTGGTGCCATCAACATTGAAAACGGCAAGGCCAACTC
CGTGCGCAATGCCGTCACTCAGGAGTTTGGCCCCGTCCCTGACACTGCCCGCTACTACAAGAAACATGGCATCAGGTGGGTGGTGATCGG
AGACGAGAACTACGGCGAGGGCTCGAGCCGGGAGCATGCAGCTCTGGAGCCTCGCCACCTTGGGGGCCGGGCCATCATCACCAAGAGCTT
TGCCAGGATCCACGAGACCAACCTGAAGAAACAGGGCCTGCTGCCTCTGACCTTCGCTGACCCGGCTGACTACAACAAGATTCACCCTGT
GGACAAGCTGACCATTCAGGGCCTGAAGGACTTCACCCCTGGCAAGCCCCTGAAGTGCATCATCAAGCACCCCAACGGGACCCAGGAGAC
CATCCTCCTGAACCACACCTTCAACGAGACGCAGATTGAGTGGTTCCGCGCTGGCAGTGCCCTCAACAGAATGAAGGAACTGCAACAGTG
AGGGCAGTGCCTCCCCGCCCCGCCGCTGGCGTCAAGTTCAGCTCCACGTGTGCCATCAGTGGATCCGATCCGTCCAGCCATGGCTTCCTA
TTCCAAGATGGTGTGACCAGACATGCTTCCTGCTCCCCGCTTAGCCCACGGAGTGACTGTGGTTGTGGTGGGGGGGTTCTTAAAATAACT
TTTTAGCCCCCGTCTTCCTATTTTGAGTTTGGTTCAGATCTTAAGCAGCTCCATGCAACTGTATTTATTTTTGATGACAAGACTCCCATC
TAAAGTTTTTCTCCTGCCTGATCATTTCATTGGTGGCTGAAGGATTCTAGAGAACCTTTTGTTCTTGCAAGGAAAACAAGAATCCAAAAC

>In-frame_XRCC6_ENST00000359308_chr22_42024234_+_ACO2_ENST00000396512_chr22_41916175_+_2537nt
GCGGGCCGTTATCCATTTGTGTTGTTCGCCAGCTAGGCCTGGCCTCGTCCCGCTTCGCTCGGTCGGTCTCGCGCGCCCCCATAGCCTTGC
TAGAGGGTTAGCGTTAGCCTTAAGTGTGCGAATCCGAGGAGCAGCGACAGACTCGAGACCACGCTCCTTCCTCGGGAAGGAGGCGGCACC
TCGCGTTTGAGGCCCGCCTGCGTTTGAGGCCCGCCTGCGCTTGCGGCCCGCCTGCGCTTGAGGCCTGTCTGCGTTTGAGATCTCATTGGG
CGTGATTGAGGAATTTGGGGAGGTTTTTGGGCGGTATTGAGGACGAGGGGGTCCGTTAGTCAGCATAGAATCCTGGAGCGGGAATCCCTC
ACCGTCTAAATGGCGTCGGGGGCGGGACCTCCGGGATCTGGCTTCCGCGGGCCGCCGCCGGCCCTGAAACGTGAGGGATAGCTGAGATGA
GGCAGCTACTGGGATGGCCCCCATGCGCATTTACATGCAGTCCGACTGCCGAGCTTTCGAGGCAGCAGGATTTACCGTCCACATTCCTCA
CTACTAACCAAGCTTTTAGAACAGATCTCACAAGAACCTAGAGGTCGGTATTTTTTCGATTTAAATTTGCCTGTTACTGACGTTAACGTC
TTTCGCCTAGTGAGCAGTAGCCAACATGTCAGGGTGGGAGTCATATTACAAAACCGAGGGCGATGAAGAAGCAGAGGAAGAACAAGAAGA
GAACCTTGAAGCAAGTGGAGACTATAAATATTCAGGAAGAGATAGTTTGATTTTTTTGGTTGATGCCTCCAAGGCTATGTTTGAATCTCA
GAGTGAAGATGAGTTGACACCTTTTGACATGAGCATCCAGCTGAAGCCACACATCAATGGGCCCTTCACCCCTGACCTGGCTCACCCTGT
GGCAGAAGTGGGCAAGGTGGCAGAGAAGGAAGGATGGCCTCTGGACATCCGAGTGGGTCTAATTGGTAGCTGCACCAATTCAAGCTATGA
AGATATGGGGCGCTCAGCAGCTGTGGCCAAGCAGGCACTGGCCCATGGCCTCAAGTGCAAGTCCCAGTTCACCATCACTCCAGGTTCCGA
GCAGATCCGCGCCACCATTGAGCGGGACGGCTATGCACAGATCTTGAGGGATCTGGGTGGCATTGTCCTGGCCAATGCTTGTGGCCCCTG
CATTGGCCAGTGGGACAGGAAGGACATCAAGAAGGGGGAGAAGAACACAATCGTCACCTCCTACAACAGGAACTTCACGGGCCGCAACGA
CGCAAACCCCGAGACCCATGCCTTTGTCACGTCCCCAGAGATTGTCACAGCCCTGGCCATTGCGGGAACCCTCAAGTTCAACCCAGAGAC
CGACTACCTGACGGGCACGGATGGCAAGAAGTTCAGGCTGGAGGCTCCGGATGCAGATGAGCTTCCCAAAGGGGAGTTTGACCCAGGGCA
GGACACCTACCAGCACCCACCCAAGGACAGCAGCGGGCAGCATGTGGACGTGAGCCCCACCAGCCAGCGCCTGCAGCTCCTGGAGCCTTT
TGACAAGTGGGATGGCAAGGACCTGGAGGACCTGCAGATCCTCATCAAGGTCAAAGGGAAGTGTACCACTGACCACATCTCAGCTGCTGG
CCCCTGGCTCAAGTTCCGTGGGCACTTGGATAACATCTCCAACAACCTGCTCATTGGTGCCATCAACATTGAAAACGGCAAGGCCAACTC
CGTGCGCAATGCCGTCACTCAGGAGTTTGGCCCCGTCCCTGACACTGCCCGCTACTACAAGAAACATGGCATCAGGTGGGTGGTGATCGG
AGACGAGAACTACGGCGAGGGCTCGAGCCGGGAGCATGCAGCTCTGGAGCCTCGCCACCTTGGGGGCCGGGCCATCATCACCAAGAGCTT
TGCCAGGATCCACGAGACCAACCTGAAGAAACAGGGCCTGCTGCCTCTGACCTTCGCTGACCCGGCTGACTACAACAAGATTCACCCTGT
GGACAAGCTGACCATTCAGGGCCTGAAGGACTTCACCCCTGGCAAGCCCCTGAAGTGCATCATCAAGCACCCCAACGGGACCCAGGAGAC
CATCCTCCTGAACCACACCTTCAACGAGACGCAGATTGAGTGGTTCCGCGCTGGCAGTGCCCTCAACAGAATGAAGGAACTGCAACAGTG
AGGGCAGTGCCTCCCCGCCCCGCCGCTGGCGTCAAGTTCAGCTCCACGTGTGCCATCAGTGGATCCGATCCGTCCAGCCATGGCTTCCTA
TTCCAAGATGGTGTGACCAGACATGCTTCCTGCTCCCCGCTTAGCCCACGGAGTGACTGTGGTTGTGGTGGGGGGGTTCTTAAAATAACT
TTTTAGCCCCCGTCTTCCTATTTTGAGTTTGGTTCAGATCTTAAGCAGCTCCATGCAACTGTATTTATTTTTGATGACAAGACTCCCATC
TAAAGTTTTTCTCCTGCCTGATCATTTCATTGGTGGCTGAAGGATTCTAGAGAACCTTTTGTTCTTGCAAGGAAAACAAGAATCCAAAAC

>In-frame_XRCC6_ENST00000405878_chr22_42024234_+_ACO2_ENST00000216254_chr22_41916175_+_2028nt
AAGTGTGCGAATCCGAGGAGCAGCGACAGACTCGAGACCACGCTCCTTCCTCGGGAAGGAGGCGGCACCTCGCGTTTGAGGCCCGCCTGC
GTTTGAGGCCCGCCTGCGCTTGCGGCCCGCCTGCGCTTGAGTGAGCAGTAGCCAACATGTCAGGGTGGGAGTCATATTACAAAACCGAGG
GCGATGAAGAAGCAGAGGAAGAACAAGAAGAGAACCTTGAAGCAAGTGGAGACTATAAATATTCAGGAAGAGATAGTTTGATTTTTTTGG
TTGATGCCTCCAAGGCTATGTTTGAATCTCAGAGTGAAGATGAGTTGACACCTTTTGACATGAGCATCCAGCTGAAGCCACACATCAATG
GGCCCTTCACCCCTGACCTGGCTCACCCTGTGGCAGAAGTGGGCAAGGTGGCAGAGAAGGAAGGATGGCCTCTGGACATCCGAGTGGGTC
TAATTGGTAGCTGCACCAATTCAAGCTATGAAGATATGGGGCGCTCAGCAGCTGTGGCCAAGCAGGCACTGGCCCATGGCCTCAAGTGCA
AGTCCCAGTTCACCATCACTCCAGGTTCCGAGCAGATCCGCGCCACCATTGAGCGGGACGGCTATGCACAGATCTTGAGGGATCTGGGTG
GCATTGTCCTGGCCAATGCTTGTGGCCCCTGCATTGGCCAGTGGGACAGGAAGGACATCAAGAAGGGGGAGAAGAACACAATCGTCACCT
CCTACAACAGGAACTTCACGGGCCGCAACGACGCAAACCCCGAGACCCATGCCTTTGTCACGTCCCCAGAGATTGTCACAGCCCTGGCCA
TTGCGGGAACCCTCAAGTTCAACCCAGAGACCGACTACCTGACGGGCACGGATGGCAAGAAGTTCAGGCTGGAGGCTCCGGATGCAGATG
AGCTTCCCAAAGGGGAGTTTGACCCAGGGCAGGACACCTACCAGCACCCACCCAAGGACAGCAGCGGGCAGCATGTGGACGTGAGCCCCA
CCAGCCAGCGCCTGCAGCTCCTGGAGCCTTTTGACAAGTGGGATGGCAAGGACCTGGAGGACCTGCAGATCCTCATCAAGGTCAAAGGGA
AGTGTACCACTGACCACATCTCAGCTGCTGGCCCCTGGCTCAAGTTCCGTGGGCACTTGGATAACATCTCCAACAACCTGCTCATTGGTG
CCATCAACATTGAAAACGGCAAGGCCAACTCCGTGCGCAATGCCGTCACTCAGGAGTTTGGCCCCGTCCCTGACACTGCCCGCTACTACA
AGAAACATGGCATCAGGTGGGTGGTGATCGGAGACGAGAACTACGGCGAGGGCTCGAGCCGGGAGCATGCAGCTCTGGAGCCTCGCCACC
TTGGGGGCCGGGCCATCATCACCAAGAGCTTTGCCAGGATCCACGAGACCAACCTGAAGAAACAGGGCCTGCTGCCTCTGACCTTCGCTG
ACCCGGCTGACTACAACAAGATTCACCCTGTGGACAAGCTGACCATTCAGGGCCTGAAGGACTTCACCCCTGGCAAGCCCCTGAAGTGCA
TCATCAAGCACCCCAACGGGACCCAGGAGACCATCCTCCTGAACCACACCTTCAACGAGACGCAGATTGAGTGGTTCCGCGCTGGCAGTG
CCCTCAACAGAATGAAGGAACTGCAACAGTGAGGGCAGTGCCTCCCCGCCCCGCCGCTGGCGTCAAGTTCAGCTCCACGTGTGCCATCAG
TGGATCCGATCCGTCCAGCCATGGCTTCCTATTCCAAGATGGTGTGACCAGACATGCTTCCTGCTCCCCGCTTAGCCCACGGAGTGACTG
TGGTTGTGGTGGGGGGGTTCTTAAAATAACTTTTTAGCCCCCGTCTTCCTATTTTGAGTTTGGTTCAGATCTTAAGCAGCTCCATGCAAC
TGTATTTATTTTTGATGACAAGACTCCCATCTAAAGTTTTTCTCCTGCCTGATCATTTCATTGGTGGCTGAAGGATTCTAGAGAACCTTT

>In-frame_XRCC6_ENST00000405878_chr22_42024234_+_ACO2_ENST00000396512_chr22_41916175_+_2028nt
AAGTGTGCGAATCCGAGGAGCAGCGACAGACTCGAGACCACGCTCCTTCCTCGGGAAGGAGGCGGCACCTCGCGTTTGAGGCCCGCCTGC
GTTTGAGGCCCGCCTGCGCTTGCGGCCCGCCTGCGCTTGAGTGAGCAGTAGCCAACATGTCAGGGTGGGAGTCATATTACAAAACCGAGG
GCGATGAAGAAGCAGAGGAAGAACAAGAAGAGAACCTTGAAGCAAGTGGAGACTATAAATATTCAGGAAGAGATAGTTTGATTTTTTTGG
TTGATGCCTCCAAGGCTATGTTTGAATCTCAGAGTGAAGATGAGTTGACACCTTTTGACATGAGCATCCAGCTGAAGCCACACATCAATG
GGCCCTTCACCCCTGACCTGGCTCACCCTGTGGCAGAAGTGGGCAAGGTGGCAGAGAAGGAAGGATGGCCTCTGGACATCCGAGTGGGTC
TAATTGGTAGCTGCACCAATTCAAGCTATGAAGATATGGGGCGCTCAGCAGCTGTGGCCAAGCAGGCACTGGCCCATGGCCTCAAGTGCA
AGTCCCAGTTCACCATCACTCCAGGTTCCGAGCAGATCCGCGCCACCATTGAGCGGGACGGCTATGCACAGATCTTGAGGGATCTGGGTG
GCATTGTCCTGGCCAATGCTTGTGGCCCCTGCATTGGCCAGTGGGACAGGAAGGACATCAAGAAGGGGGAGAAGAACACAATCGTCACCT
CCTACAACAGGAACTTCACGGGCCGCAACGACGCAAACCCCGAGACCCATGCCTTTGTCACGTCCCCAGAGATTGTCACAGCCCTGGCCA
TTGCGGGAACCCTCAAGTTCAACCCAGAGACCGACTACCTGACGGGCACGGATGGCAAGAAGTTCAGGCTGGAGGCTCCGGATGCAGATG
AGCTTCCCAAAGGGGAGTTTGACCCAGGGCAGGACACCTACCAGCACCCACCCAAGGACAGCAGCGGGCAGCATGTGGACGTGAGCCCCA
CCAGCCAGCGCCTGCAGCTCCTGGAGCCTTTTGACAAGTGGGATGGCAAGGACCTGGAGGACCTGCAGATCCTCATCAAGGTCAAAGGGA
AGTGTACCACTGACCACATCTCAGCTGCTGGCCCCTGGCTCAAGTTCCGTGGGCACTTGGATAACATCTCCAACAACCTGCTCATTGGTG
CCATCAACATTGAAAACGGCAAGGCCAACTCCGTGCGCAATGCCGTCACTCAGGAGTTTGGCCCCGTCCCTGACACTGCCCGCTACTACA
AGAAACATGGCATCAGGTGGGTGGTGATCGGAGACGAGAACTACGGCGAGGGCTCGAGCCGGGAGCATGCAGCTCTGGAGCCTCGCCACC
TTGGGGGCCGGGCCATCATCACCAAGAGCTTTGCCAGGATCCACGAGACCAACCTGAAGAAACAGGGCCTGCTGCCTCTGACCTTCGCTG
ACCCGGCTGACTACAACAAGATTCACCCTGTGGACAAGCTGACCATTCAGGGCCTGAAGGACTTCACCCCTGGCAAGCCCCTGAAGTGCA
TCATCAAGCACCCCAACGGGACCCAGGAGACCATCCTCCTGAACCACACCTTCAACGAGACGCAGATTGAGTGGTTCCGCGCTGGCAGTG
CCCTCAACAGAATGAAGGAACTGCAACAGTGAGGGCAGTGCCTCCCCGCCCCGCCGCTGGCGTCAAGTTCAGCTCCACGTGTGCCATCAG
TGGATCCGATCCGTCCAGCCATGGCTTCCTATTCCAAGATGGTGTGACCAGACATGCTTCCTGCTCCCCGCTTAGCCCACGGAGTGACTG
TGGTTGTGGTGGGGGGGTTCTTAAAATAACTTTTTAGCCCCCGTCTTCCTATTTTGAGTTTGGTTCAGATCTTAAGCAGCTCCATGCAAC
TGTATTTATTTTTGATGACAAGACTCCCATCTAAAGTTTTTCTCCTGCCTGATCATTTCATTGGTGGCTGAAGGATTCTAGAGAACCTTT


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FusionGenePPI for XRCC6_ACO2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
XRCC6VAV1, NCF4, XRCC5, MRE11A, CBX5, AR, CCNA1, CDK2, TERF2IP, CHEK1, NCOA6, KAT2A, CREBBP, ACD, CDCA5, ARAP1, FMNL1, GAL3ST4, ILVBL, NOTCH1, PGAM1, RBBP4, TBCD, ABCD4, PLGRKT, GSE1, NHP2L1, NIT1, PECAM1, RRAS2, SNTA1, ATP6V1E1, PAEP, PAFAH1B3, RPLP1, SERPINB9, YWHAZ, XRCC6BP1, CLU, PRKDC, RPA2, TERT, DNTT, HOXC4, HOXD4, DLX2, POU2F2, POU2F1, TAL1, TERF2, WRN, BIN1, PTTG1, CD40, PCNA, HSF1, ABL1, DHX9, FCHSD1, SIRT6, NR1H4, CHD1L, TP53, BARD1, ESR1, PARP1, SIRT3, MGMT, PDX1, SRRM2, MSX2, RUNX2, NAA15, H2AFX, PHF1, XRCC4, LIG4, KAT2B, EP300, ATXN3, ILF2, THRA, THRB, BIRC5, CHAF1A, HIST1H3A, HIST1H3E, H3F3A, BAZ1A, MYC, USF1, HDAC5, UBE3A, RBM39, MDM2, BAX, DDB2, PSMA3, CMTM6, RPS10, RASA1, EFNA1, TAC1, PDK1, CENPU, KIAA0408, EID1, VBP1, SDHC, PDPK1, ANXA1, BTG1, PNRC2, QRSL1, RGS2, MAP4K2, HERPUD1, SEP15, SPARC, COIL, LIG3, HOXB7, YY1, RNF146, SMARCAD1, ORC3, ORC2, ORC6, ORC4, TCF7L2, NDRG1, HDGF, ILF3, MSH6, MSH2, CBX1, CBX3, CEBPA, ARRB2, SIRT7, HNRNPA1, CFLAR, HDAC6, ERG, ISG15, TONSL, CUL5, COPS5, CAND1, HTT, CLTC, TADA3, CCT3, KCND3, ARHGAP5, EEF2, SDHA, HSPA5, KIF23, PGR, XRCC6, BRCA1, ECT2, PAXIP1, TP53BP1, NCL, CSNK2A1, SMURF1, PNKP, FN1, VCAM1, GZMA, GZMB, SMAD7, SKIL, SMAD3, ZNF512B, ITGA4, PPID, IGSF8, ICAM1, HMGA1, HMGA2, LMNA, CTBP2, COPB1, ADCY7, EPS8, MAP2K5, CAPN11, SERPINA2, TARDBP, PARK2, PRPF40A, WBP4, PIN1, CTNNA1, CUL2, CSDE1, FARSB, GANAB, GART, IMPDH1, JUP, DPYSL3, PLOD2, RANBP3, SAMHD1, SET, ST13, SUPT5H, SWAP70, ATP6V1B2, HYOU1, RPSA, NARS, RPA1, RPA3, ATRX, EMD, ELF3, EHF, ENO1, SHMT2, MOV10, NXF1, PPARG, CUL7, OBSL1, CCDC8, EED, SUMO2, MAST3, WDR76, APLF, PHRF1, NTRK1, DYNC1LI1, GTF2I, HNRNPK, NAE1, PDIA3, RFC1, TKT, TMOD3, SCARNA22, CSNK1A1, DNM2, BAG2, ANKRD28, POT1, TINF2, TNRC18, CCDC57, C9orf142, BANP, CRY2, MACROD1, MCM2, NF2, SNW1, TFAP2A, UHRF2, U2AF2, RC3H1, FOXL2, NFATC1, NFATC2, AHSA1, RNF126, PARP2, XPC, SUPT16H, XRCC1, H2AFY, CDK5RAP1, SSRP1, SPTA1, COX15, DLD, DLST, DNM1L, HSD17B10, SOD1, VDAC1, TRIM25, UBE2S, YAP1ACO2SRRM2, PSMD4, ATXN1L, APP, AK3, ACAT1, SIN3A, ACAA2, VCAM1, ITGA4, ASB9, CKB, IDH3A, IDH3G, MYH7B, SOD2, ALDH5A1, ALDOA, ALDOC, ATP1B1, ATP5F1, ATP5J, ESD, GPD1, GPD1L, GPD2, PITPNB, VAPA, NTRK1, SOD1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneXRCC6chr22:42024234chr22:41916175ENST00000359308+212550_60965610DEAF1
HgeneXRCC6chr22:42024234chr22:41916175ENST00000360079+313550_60965610DEAF1
HgeneXRCC6chr22:42024234chr22:41916175ENST00000405878+313550_60965610DEAF1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for XRCC6_ACO2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for XRCC6_ACO2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneACO2C3281192INFANTILE CEREBELLAR-RETINAL DEGENERATION2ORPHANET;UNIPROT
TgeneACO2C0035222Respiratory Distress Syndrome, Adult1CTD_human
TgeneACO2C2239176Liver carcinoma1CTD_human
TgeneACO2C4225384OPTIC ATROPHY 91UNIPROT