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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42213

FusionGeneSummary for XPR1_NME7

check button Fusion gene summary
Fusion gene informationFusion gene name: XPR1_NME7
Fusion gene ID: 42213
HgeneTgene
Gene symbol

XPR1

NME7

Gene ID

9213

29922

Gene namexenotropic and polytropic retrovirus receptor 1NME/NM23 family member 7
SynonymsIBGC6|SLC53A1|SYG1|X3CFAP67|MN23H7|NDK 7|NDK7|nm23-H7
Cytomap

1q25.3

1q24.2

Type of geneprotein-codingprotein-coding
Descriptionxenotropic and polytropic retrovirus receptor 1X-receptorprotein SYG1 homologsolute carrier family 53 (phosphate exporter), member 1xenotropic and polytropic murine leukemia virus receptor X3nucleoside diphosphate kinase 7NDP kinase 7cilia and flagella associated protein 67non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase)
Modification date2018052320180522
UniProtAcc

Q9UBH6

Q9Y5B8

Ensembl transtripts involved in fusion geneENST00000367590, ENST00000367589, 
ENST00000467345, 		ENST00000472647, 
ENST00000367811, ENST00000469474, 
Fusion gene scores* DoF score14 X 4 X 10=5609 X 7 X 7=441
# samples 149
** MAII scorelog2(14/560*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/441*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: XPR1 [Title/Abstract] AND NME7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-G3-A25U-01AXPR1chr1

180601406

+NME7chr1

169138792

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000367590ENST00000472647XPR1chr1

180601406

+NME7chr1

169138792

-
In-frameENST00000367590ENST00000367811XPR1chr1

180601406

+NME7chr1

169138792

-
5CDS-intronENST00000367590ENST00000469474XPR1chr1

180601406

+NME7chr1

169138792

-
In-frameENST00000367589ENST00000472647XPR1chr1

180601406

+NME7chr1

169138792

-
In-frameENST00000367589ENST00000367811XPR1chr1

180601406

+NME7chr1

169138792

-
5CDS-intronENST00000367589ENST00000469474XPR1chr1

180601406

+NME7chr1

169138792

-
intron-3CDSENST00000467345ENST00000472647XPR1chr1

180601406

+NME7chr1

169138792

-
intron-3CDSENST00000467345ENST00000367811XPR1chr1

180601406

+NME7chr1

169138792

-
intron-intronENST00000467345ENST00000469474XPR1chr1

180601406

+NME7chr1

169138792

-

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FusionProtFeatures for XPR1_NME7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
XPR1

Q9UBH6

NME7

Q9Y5B8

Plays a role in phosphate homeostasis. Mediatesphosphate export from the cell (PubMed:23791524, PubMed:25938945).Binds inositol hexakisphosphate (Ins6P) and similar inositolpolyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules(PubMed:27080106). {ECO:0000250|UniProtKB:Q9Z0U0,ECO:0000269|PubMed:23791524, ECO:0000269|PubMed:25938945,ECO:0000269|PubMed:27080106}. Major role in the synthesis of nucleoside triphosphatesother than ATP. The ATP gamma phosphate is transferred to the NDPbeta phosphate via a ping-pong mechanism, using a phosphorylatedactive-site intermediate.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneXPR1chr1:180601406chr1:169138792ENST00000367589+1141_17723632DomainSPX
HgeneXPR1chr1:180601406chr1:169138792ENST00000367589+114439_64323632DomainEXS
HgeneXPR1chr1:180601406chr1:169138792ENST00000367590+1151_17723697DomainSPX
HgeneXPR1chr1:180601406chr1:169138792ENST00000367590+115439_64323697DomainEXS
HgeneXPR1chr1:180601406chr1:169138792ENST00000367589+114158_16523632RegionImportant for inositol polyphosphate binding
HgeneXPR1chr1:180601406chr1:169138792ENST00000367590+115158_16523697RegionImportant for inositol polyphosphate binding
HgeneXPR1chr1:180601406chr1:169138792ENST00000367589+1141_23623632Topological domainCytoplasmic
HgeneXPR1chr1:180601406chr1:169138792ENST00000367589+114258_26423632Topological domainExtracellular
HgeneXPR1chr1:180601406chr1:169138792ENST00000367589+114286_31823632Topological domainCytoplasmic
HgeneXPR1chr1:180601406chr1:169138792ENST00000367589+114340_34523632Topological domainExtracellular
HgeneXPR1chr1:180601406chr1:169138792ENST00000367589+114369_37623632Topological domainCytoplasmic
HgeneXPR1chr1:180601406chr1:169138792ENST00000367589+114398_40223632Topological domainExtracellular
HgeneXPR1chr1:180601406chr1:169138792ENST00000367589+114424_47323632Topological domainCytoplasmic
HgeneXPR1chr1:180601406chr1:169138792ENST00000367589+114497_50723632Topological domainExtracellular
HgeneXPR1chr1:180601406chr1:169138792ENST00000367589+114529_69623632Topological domainCytoplasmic
HgeneXPR1chr1:180601406chr1:169138792ENST00000367590+1151_23623697Topological domainCytoplasmic
HgeneXPR1chr1:180601406chr1:169138792ENST00000367590+115258_26423697Topological domainExtracellular
HgeneXPR1chr1:180601406chr1:169138792ENST00000367590+115286_31823697Topological domainCytoplasmic
HgeneXPR1chr1:180601406chr1:169138792ENST00000367590+115340_34523697Topological domainExtracellular
HgeneXPR1chr1:180601406chr1:169138792ENST00000367590+115369_37623697Topological domainCytoplasmic
HgeneXPR1chr1:180601406chr1:169138792ENST00000367590+115398_40223697Topological domainExtracellular
HgeneXPR1chr1:180601406chr1:169138792ENST00000367590+115424_47323697Topological domainCytoplasmic
HgeneXPR1chr1:180601406chr1:169138792ENST00000367590+115497_50723697Topological domainExtracellular
HgeneXPR1chr1:180601406chr1:169138792ENST00000367590+115529_69623697Topological domainCytoplasmic
HgeneXPR1chr1:180601406chr1:169138792ENST00000367589+114237_25723632TransmembraneHelical
HgeneXPR1chr1:180601406chr1:169138792ENST00000367589+114265_28523632TransmembraneHelical
HgeneXPR1chr1:180601406chr1:169138792ENST00000367589+114319_33923632TransmembraneHelical
HgeneXPR1chr1:180601406chr1:169138792ENST00000367589+114346_36823632TransmembraneHelical
HgeneXPR1chr1:180601406chr1:169138792ENST00000367589+114377_39723632TransmembraneHelical
HgeneXPR1chr1:180601406chr1:169138792ENST00000367589+114403_42323632TransmembraneHelical
HgeneXPR1chr1:180601406chr1:169138792ENST00000367589+114474_49623632TransmembraneHelical
HgeneXPR1chr1:180601406chr1:169138792ENST00000367589+114508_52823632TransmembraneHelical
HgeneXPR1chr1:180601406chr1:169138792ENST00000367590+115237_25723697TransmembraneHelical
HgeneXPR1chr1:180601406chr1:169138792ENST00000367590+115265_28523697TransmembraneHelical
HgeneXPR1chr1:180601406chr1:169138792ENST00000367590+115319_33923697TransmembraneHelical
HgeneXPR1chr1:180601406chr1:169138792ENST00000367590+115346_36823697TransmembraneHelical
HgeneXPR1chr1:180601406chr1:169138792ENST00000367590+115377_39723697TransmembraneHelical
HgeneXPR1chr1:180601406chr1:169138792ENST00000367590+115403_42323697TransmembraneHelical
HgeneXPR1chr1:180601406chr1:169138792ENST00000367590+115474_49623697TransmembraneHelical
HgeneXPR1chr1:180601406chr1:169138792ENST00000367590+115508_52823697TransmembraneHelical
TgeneNME7chr1:180601406chr1:169138792ENST00000367811-9123_91330377DomainDM10
TgeneNME7chr1:180601406chr1:169138792ENST00000472647-9123_91294341DomainDM10


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FusionGeneSequence for XPR1_NME7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_XPR1_ENST00000367590_chr1_180601406_+_NME7_ENST00000472647_chr1_169138792_-_70aa

>In-frame_XPR1_ENST00000367590_chr1_180601406_+_NME7_ENST00000367811_chr1_169138792_-_70aa

>In-frame_XPR1_ENST00000367589_chr1_180601406_+_NME7_ENST00000472647_chr1_169138792_-_70aa

>In-frame_XPR1_ENST00000367589_chr1_180601406_+_NME7_ENST00000367811_chr1_169138792_-_70aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_XPR1_ENST00000367590_chr1_180601406_+_NME7_ENST00000472647_chr1_169138792_-_210nt
ATGAAGTTCGCCGAGCACCTCTCCGCGCACATCACTCCCGAGTGGAGGAAGCAATACATCCAGTATGAGGAAATTGCCCGGCATTTACGC
CCTGGAACTCTCAGAGCAATCTTTGGTAAAACTAAGATCCAGAATGCTGTTCACTGTACTGATCTGCCAGAGGATGGCCTATTAGAGGTT

>In-frame_XPR1_ENST00000367590_chr1_180601406_+_NME7_ENST00000367811_chr1_169138792_-_210nt
ATGAAGTTCGCCGAGCACCTCTCCGCGCACATCACTCCCGAGTGGAGGAAGCAATACATCCAGTATGAGGAAATTGCCCGGCATTTACGC
CCTGGAACTCTCAGAGCAATCTTTGGTAAAACTAAGATCCAGAATGCTGTTCACTGTACTGATCTGCCAGAGGATGGCCTATTAGAGGTT

>In-frame_XPR1_ENST00000367589_chr1_180601406_+_NME7_ENST00000472647_chr1_169138792_-_210nt
ATGAAGTTCGCCGAGCACCTCTCCGCGCACATCACTCCCGAGTGGAGGAAGCAATACATCCAGTATGAGGAAATTGCCCGGCATTTACGC
CCTGGAACTCTCAGAGCAATCTTTGGTAAAACTAAGATCCAGAATGCTGTTCACTGTACTGATCTGCCAGAGGATGGCCTATTAGAGGTT

>In-frame_XPR1_ENST00000367589_chr1_180601406_+_NME7_ENST00000367811_chr1_169138792_-_210nt
ATGAAGTTCGCCGAGCACCTCTCCGCGCACATCACTCCCGAGTGGAGGAAGCAATACATCCAGTATGAGGAAATTGCCCGGCATTTACGC
CCTGGAACTCTCAGAGCAATCTTTGGTAAAACTAAGATCCAGAATGCTGTTCACTGTACTGATCTGCCAGAGGATGGCCTATTAGAGGTT


* Fusion transcript sequences (Full-length transcript).
>In-frame_XPR1_ENST00000367590_chr1_180601406_+_NME7_ENST00000472647_chr1_169138792_-_662nt
GCGGGGAGGGGCGGGGCTATGGAGAGGAGGAGGAAGATGGCGGGCGGGCTGCTCTGAAGAGACCTCGGCGGCGGCGGAGGAGGAGAGAAG
CGCAGCGCCGCGCCGCGCCGGGGCCCATGTGGGGAGGAGTCGGAGTCGCTGTTGCCGCCGCCGCCTGTAGCTGCTGGACCCGAGTGGGAG
TGAGGGGGAAACGGCAGGATGAAGTTCGCCGAGCACCTCTCCGCGCACATCACTCCCGAGTGGAGGAAGCAATACATCCAGTATGAGGAA
ATTGCCCGGCATTTACGCCCTGGAACTCTCAGAGCAATCTTTGGTAAAACTAAGATCCAGAATGCTGTTCACTGTACTGATCTGCCAGAG
GATGGCCTATTAGAGGTTCAATACTTCTTCAAGATCTTGGATAATTAGTGGTGTGGAAAGTAAAGAAGTCACAGGTTGGGACATTTAGAC
AAGAGTGAATCACACACGAGGAATGTGTTCATTCTTTTATTGTCCGTTGTTTTAACCTGACTGAATACAAGATCAACAAGAGCACTGTAC
TCCTGGCAATTATTACATATGTTAGAACATGGATTTTGCACTGTAGACAACATTTAACACCAGTCTATGGGGTACTGCATTGCTTTTTAT

>In-frame_XPR1_ENST00000367590_chr1_180601406_+_NME7_ENST00000367811_chr1_169138792_-_662nt
GCGGGGAGGGGCGGGGCTATGGAGAGGAGGAGGAAGATGGCGGGCGGGCTGCTCTGAAGAGACCTCGGCGGCGGCGGAGGAGGAGAGAAG
CGCAGCGCCGCGCCGCGCCGGGGCCCATGTGGGGAGGAGTCGGAGTCGCTGTTGCCGCCGCCGCCTGTAGCTGCTGGACCCGAGTGGGAG
TGAGGGGGAAACGGCAGGATGAAGTTCGCCGAGCACCTCTCCGCGCACATCACTCCCGAGTGGAGGAAGCAATACATCCAGTATGAGGAA
ATTGCCCGGCATTTACGCCCTGGAACTCTCAGAGCAATCTTTGGTAAAACTAAGATCCAGAATGCTGTTCACTGTACTGATCTGCCAGAG
GATGGCCTATTAGAGGTTCAATACTTCTTCAAGATCTTGGATAATTAGTGGTGTGGAAAGTAAAGAAGTCACAGGTTGGGACATTTAGAC
AAGAGTGAATCACACACGAGGAATGTGTTCATTCTTTTATTGTCCGTTGTTTTAACCTGACTGAATACAAGATCAACAAGAGCACTGTAC
TCCTGGCAATTATTACATATGTTAGAACATGGATTTTGCACTGTAGACAACATTTAACACCAGTCTATGGGGTACTGCATTGCTTTTTAT

>In-frame_XPR1_ENST00000367589_chr1_180601406_+_NME7_ENST00000472647_chr1_169138792_-_634nt
GGAGGAAGATGGCGGGCGGGCTGCTCTGAAGAGACCTCGGCGGCGGCGGAGGAGGAGAGAAGCGCAGCGCCGCGCCGCGCCGGGGCCCAT
GTGGGGAGGAGTCGGAGTCGCTGTTGCCGCCGCCGCCTGTAGCTGCTGGACCCGAGTGGGAGTGAGGGGGAAACGGCAGGATGAAGTTCG
CCGAGCACCTCTCCGCGCACATCACTCCCGAGTGGAGGAAGCAATACATCCAGTATGAGGAAATTGCCCGGCATTTACGCCCTGGAACTC
TCAGAGCAATCTTTGGTAAAACTAAGATCCAGAATGCTGTTCACTGTACTGATCTGCCAGAGGATGGCCTATTAGAGGTTCAATACTTCT
TCAAGATCTTGGATAATTAGTGGTGTGGAAAGTAAAGAAGTCACAGGTTGGGACATTTAGACAAGAGTGAATCACACACGAGGAATGTGT
TCATTCTTTTATTGTCCGTTGTTTTAACCTGACTGAATACAAGATCAACAAGAGCACTGTACTCCTGGCAATTATTACATATGTTAGAAC
ATGGATTTTGCACTGTAGACAACATTTAACACCAGTCTATGGGGTACTGCATTGCTTTTTATAAAGTTCAAAATAAAGATTTATTTTCAA

>In-frame_XPR1_ENST00000367589_chr1_180601406_+_NME7_ENST00000367811_chr1_169138792_-_634nt
GGAGGAAGATGGCGGGCGGGCTGCTCTGAAGAGACCTCGGCGGCGGCGGAGGAGGAGAGAAGCGCAGCGCCGCGCCGCGCCGGGGCCCAT
GTGGGGAGGAGTCGGAGTCGCTGTTGCCGCCGCCGCCTGTAGCTGCTGGACCCGAGTGGGAGTGAGGGGGAAACGGCAGGATGAAGTTCG
CCGAGCACCTCTCCGCGCACATCACTCCCGAGTGGAGGAAGCAATACATCCAGTATGAGGAAATTGCCCGGCATTTACGCCCTGGAACTC
TCAGAGCAATCTTTGGTAAAACTAAGATCCAGAATGCTGTTCACTGTACTGATCTGCCAGAGGATGGCCTATTAGAGGTTCAATACTTCT
TCAAGATCTTGGATAATTAGTGGTGTGGAAAGTAAAGAAGTCACAGGTTGGGACATTTAGACAAGAGTGAATCACACACGAGGAATGTGT
TCATTCTTTTATTGTCCGTTGTTTTAACCTGACTGAATACAAGATCAACAAGAGCACTGTACTCCTGGCAATTATTACATATGTTAGAAC
ATGGATTTTGCACTGTAGACAACATTTAACACCAGTCTATGGGGTACTGCATTGCTTTTTATAAAGTTCAAAATAAAGATTTATTTTCAA


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FusionGenePPI for XPR1_NME7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
XPR1ELAVL1, AMOT, CEACAM21, VSIG4, TGOLN2, FAF2, NTRK1, CLTC, DBN1, GAK, KIF5B, RAB5C, RAB7A, VAPA, TACC3, GOLT1B, KIDINS220, FGFR2, VSIG1, B4GAT1, RHOT2, DKKL1, TNFRSF1A, PTGIR, APLNR, SLC15A1, CD79B, PDCD1, SLC4A2, UPK1A, RNF19B, TRIM25NME7FKBP6, NT5C2, TCHP, KRT18, ZNF263, CDK5RAP2, TUFT1, DDX1, OFD1, MAP4K4, TNIP1, YWHAQ, LATS2, TUBG1, TUBGCP2, TUBGCP3, GOLGA2, ZBTB48, NAB2, NEFL, REL, TRIM27, TCF4, FOSL1, MYOT, CDC42EP2, CCHCR1, CEP72, KIAA1598, LNX1, SYCE1, C1orf189, CSPP1, MZT2B, WNT2, GLUL, LPPR2, PCED1B, BTRC, SSX2IP, PCM1, CEP170, KIAA0753, CEP104, CEP162, CEP290, CNTROB, CEP128, CEP135, CEP63, CEP89, CNTRL, NINL, NIN, ODF2, RPGRIP1L, STIL, LGALS3BP, SCAF11, TUBGCP4, TUBGCP5, NEDD1, MZT1, TXNDC12, TUBG2, PRICKLE3, KIAA1683, AMPD2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for XPR1_NME7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for XPR1_NME7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneXPR1C0004782Basal Ganglia Diseases1CTD_human
HgeneXPR1C0006663Calcinosis1CTD_human
HgeneXPR1C4225335BASAL GANGLIA CALCIFICATION, IDIOPATHIC, 61UNIPROT
TgeneNME7C0236969Substance-Related Disorders1CTD_human