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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 42208

FusionGeneSummary for XPR1_KHDRBS1

check button Fusion gene summary
Fusion gene informationFusion gene name: XPR1_KHDRBS1
Fusion gene ID: 42208
HgeneTgene
Gene symbol

XPR1

KHDRBS1

Gene ID

9213

10657

Gene namexenotropic and polytropic retrovirus receptor 1KH RNA binding domain containing, signal transduction associated 1
SynonymsIBGC6|SLC53A1|SYG1|X3Sam68|p62|p68
Cytomap

1q25.3

1p35.2

Type of geneprotein-codingprotein-coding
Descriptionxenotropic and polytropic retrovirus receptor 1X-receptorprotein SYG1 homologsolute carrier family 53 (phosphate exporter), member 1xenotropic and polytropic murine leukemia virus receptor X3KH domain-containing, RNA-binding, signal transduction-associated protein 1GAP-associated tyrosine phosphoprotein p62 (Sam68)KH domain containing, RNA binding, signal transduction associated 1p21 Ras GTPase-activating protein-associated p62src-associa
Modification date2018052320180522
UniProtAcc

Q9UBH6

Q07666

Ensembl transtripts involved in fusion geneENST00000367590, ENST00000367589, 
ENST00000467345, 		ENST00000327300, 
ENST00000307714, ENST00000492989, 
Fusion gene scores* DoF score14 X 4 X 10=5607 X 5 X 6=210
# samples 147
** MAII scorelog2(14/560*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: XPR1 [Title/Abstract] AND KHDRBS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKHDRBS1

GO:0007166

cell surface receptor signaling pathway

9045636

TgeneKHDRBS1

GO:0031647

regulation of protein stability

21613532

TgeneKHDRBS1

GO:0045948

positive regulation of translational initiation

21613532

TgeneKHDRBS1

GO:0046833

positive regulation of RNA export from nucleus

21613532

TgeneKHDRBS1

GO:0051259

protein complex oligomerization

10332027|10749975


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-BR-8060-01AXPR1chr1

180651547

+KHDRBS1chr1

32495899

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000367590ENST00000327300XPR1chr1

180651547

+KHDRBS1chr1

32495899

+
5CDS-3UTRENST00000367590ENST00000307714XPR1chr1

180651547

+KHDRBS1chr1

32495899

+
5CDS-3UTRENST00000367590ENST00000492989XPR1chr1

180651547

+KHDRBS1chr1

32495899

+
In-frameENST00000367589ENST00000327300XPR1chr1

180651547

+KHDRBS1chr1

32495899

+
5CDS-3UTRENST00000367589ENST00000307714XPR1chr1

180651547

+KHDRBS1chr1

32495899

+
5CDS-3UTRENST00000367589ENST00000492989XPR1chr1

180651547

+KHDRBS1chr1

32495899

+
intron-3CDSENST00000467345ENST00000327300XPR1chr1

180651547

+KHDRBS1chr1

32495899

+
intron-3UTRENST00000467345ENST00000307714XPR1chr1

180651547

+KHDRBS1chr1

32495899

+
intron-3UTRENST00000467345ENST00000492989XPR1chr1

180651547

+KHDRBS1chr1

32495899

+

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FusionProtFeatures for XPR1_KHDRBS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
XPR1

Q9UBH6

KHDRBS1

Q07666

Plays a role in phosphate homeostasis. Mediatesphosphate export from the cell (PubMed:23791524, PubMed:25938945).Binds inositol hexakisphosphate (Ins6P) and similar inositolpolyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules(PubMed:27080106). {ECO:0000250|UniProtKB:Q9Z0U0,ECO:0000269|PubMed:23791524, ECO:0000269|PubMed:25938945,ECO:0000269|PubMed:27080106}. Recruited and tyrosine phosphorylated by severalreceptor systems, for example the T-cell, leptin and insulinreceptors. Once phosphorylated, functions as an adapter protein insignal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle.Represses CBP-dependent transcriptional activation apparently bycompeting with other nuclear factors for binding to CBP. Also actsas a putative regulator of mRNA stability and/or translation ratesand mediates mRNA nuclear export. Positively regulates theassociation of constitutive transport element (CTE)-containingmRNA with large polyribosomes and translation initiation.According to some authors, is not involved in thenucleocytoplasmic export of unspliced (CTE)-containing RNA speciesaccording to (PubMed:22253824). RNA-binding protein that plays arole in the regulation of alternative splicing and influences mRNAsplice site selection and exon inclusion. Binds to RNA containing5'-[AU]UAA-3' as a bipartite motif spaced by more than 15nucleotides. Binds poly(A). Can regulate CD44 alternative splicingin a Ras pathway-dependent manner (By similarity). In cooperationwith HNRNPA1 modulates alternative splicing of BCL2L1 by promotingsplicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836,PubMed:20186123). Can regulate alternative splicing of NRXN1 andNRXN3 in the laminin G-like domain 6 containing the evolutionaryconserved neurexin alternative spliced segment 4 (AS4) involved inneurexin selective targeting to postsynaptic partners. In aneuronal activity-dependent manner cooperates synergistically withKHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. Thecooperation with KHDRBS2/SLIM-1 is antagonistic for regulation ofNXRN3 alternative splicing at AS4 (By similarity).{ECO:0000250|UniProtKB:Q60749, ECO:0000269|PubMed:15021911,ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20186123,ECO:0000269|PubMed:20610388, ECO:0000269|PubMed:22253824,ECO:0000269|PubMed:26758068}. Isoform 3, which is expressed in growth-arrested cellsonly, inhibits S phase. {ECO:0000269|PubMed:9013542}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKHDRBS1chr1:180651547chr1:32495899ENST00000327300+09282_292127444Compositional biasDMA/Gly-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST00000327300+09295_301127444Compositional biasPro-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST00000327300+09302_332127444Compositional biasArg/Gly-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST00000327300+09334_363127444Compositional biasPro-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST00000492989+08282_292127405Compositional biasDMA/Gly-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST00000492989+08295_301127405Compositional biasPro-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST00000492989+08302_332127405Compositional biasArg/Gly-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST00000492989+08334_363127405Compositional biasPro-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST00000327300+09171_197127444DomainKH
TgeneKHDRBS1chr1:180651547chr1:32495899ENST00000492989+08171_197127405DomainKH

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+2141_17740632DomainSPX
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214439_64340632DomainEXS
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+2151_17740697DomainSPX
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215439_64340697DomainEXS
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214158_16540632RegionImportant for inositol polyphosphate binding
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215158_16540697RegionImportant for inositol polyphosphate binding
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+2141_23640632Topological domainCytoplasmic
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214258_26440632Topological domainExtracellular
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214286_31840632Topological domainCytoplasmic
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214340_34540632Topological domainExtracellular
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214369_37640632Topological domainCytoplasmic
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214398_40240632Topological domainExtracellular
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214424_47340632Topological domainCytoplasmic
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214497_50740632Topological domainExtracellular
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214529_69640632Topological domainCytoplasmic
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+2151_23640697Topological domainCytoplasmic
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215258_26440697Topological domainExtracellular
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215286_31840697Topological domainCytoplasmic
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215340_34540697Topological domainExtracellular
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215369_37640697Topological domainCytoplasmic
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215398_40240697Topological domainExtracellular
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215424_47340697Topological domainCytoplasmic
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215497_50740697Topological domainExtracellular
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215529_69640697Topological domainCytoplasmic
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214237_25740632TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214265_28540632TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214319_33940632TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214346_36840632TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214377_39740632TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214403_42340632TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214474_49640632TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367589+214508_52840632TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215237_25740697TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215265_28540697TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215319_33940697TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215346_36840697TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215377_39740697TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215403_42340697TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215474_49640697TransmembraneHelical
HgeneXPR1chr1:180651547chr1:32495899ENST00000367590+215508_52840697TransmembraneHelical
TgeneKHDRBS1chr1:180651547chr1:32495899ENST00000327300+0934_41127444Compositional biasPro-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST00000327300+0944_55127444Compositional biasDMA/Gly-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST00000327300+0959_89127444Compositional biasPro-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST00000492989+0834_41127405Compositional biasPro-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST00000492989+0844_55127405Compositional biasDMA/Gly-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST00000492989+0859_89127405Compositional biasPro-rich
TgeneKHDRBS1chr1:180651547chr1:32495899ENST00000327300+09100_260127444RegionInvolved in homodimerization
TgeneKHDRBS1chr1:180651547chr1:32495899ENST00000492989+08100_260127405RegionInvolved in homodimerization


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FusionGeneSequence for XPR1_KHDRBS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_XPR1_ENST00000367590_chr1_180651547_+_KHDRBS1_ENST00000327300_chr1_32495899_+_357aa
MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEEIEKIQKGDSKKDDEENYLDLFSHKNMKLKERVLIPVKQYPKFNFVGKIL
GPQGNTIKRLQEETGAKISVLGKGSMRDKAKEEELRKGGDPKYAHLNMDLHVFIEVFGPPCEAYALMAHAMEEVKKFLVPDMMDDICQEQ
FLELSYLNGVPEPSRGRGVPVRGRGAAPPPPPVPRGRGVGPPRGALVRGTPVRGAITRGATVTRGVPPPPTVRGAPAPRARTAGIQRIPL

>In-frame_XPR1_ENST00000367589_chr1_180651547_+_KHDRBS1_ENST00000327300_chr1_32495899_+_357aa
MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEEIEKIQKGDSKKDDEENYLDLFSHKNMKLKERVLIPVKQYPKFNFVGKIL
GPQGNTIKRLQEETGAKISVLGKGSMRDKAKEEELRKGGDPKYAHLNMDLHVFIEVFGPPCEAYALMAHAMEEVKKFLVPDMMDDICQEQ
FLELSYLNGVPEPSRGRGVPVRGRGAAPPPPPVPRGRGVGPPRGALVRGTPVRGAITRGATVTRGVPPPPTVRGAPAPRARTAGIQRIPL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_XPR1_ENST00000367590_chr1_180651547_+_KHDRBS1_ENST00000327300_chr1_32495899_+_1071nt
ATGAAGTTCGCCGAGCACCTCTCCGCGCACATCACTCCCGAGTGGAGGAAGCAATACATCCAGTATGAGGCTTTCAAGGATATGCTGTAT
TCAGCTCAGGACCAGGCACCTTCTGTGGAAGAAATTGAGAAGATTCAGAAAGGAGACTCAAAAAAGGATGATGAGGAGAATTACTTGGAT
TTATTTTCTCATAAGAACATGAAACTGAAAGAGCGAGTGCTGATACCTGTCAAGCAGTATCCCAAGTTCAATTTTGTGGGGAAGATTCTT
GGACCACAAGGGAATACAATCAAAAGACTGCAGGAAGAGACTGGTGCAAAGATCTCTGTATTGGGAAAGGGCTCAATGAGAGACAAAGCC
AAGGAGGAAGAGCTGCGCAAAGGTGGAGACCCCAAATATGCCCACTTGAATATGGATCTGCATGTCTTCATTGAAGTCTTTGGACCCCCA
TGTGAGGCTTATGCTCTTATGGCCCATGCCATGGAGGAAGTCAAGAAATTTCTAGTACCGGATATGATGGATGATATCTGTCAGGAGCAA
TTTCTAGAGCTGTCCTACTTGAATGGAGTACCTGAACCCTCTCGTGGACGTGGGGTGCCAGTGAGAGGCCGGGGAGCTGCACCTCCTCCA
CCACCTGTTCCCAGGGGCCGTGGTGTTGGACCACCTCGGGGGGCTTTGGTACGTGGTACACCAGTAAGGGGAGCCATCACCAGAGGTGCC
ACTGTGACTCGAGGCGTGCCACCCCCACCTACTGTGAGGGGTGCTCCAGCACCAAGAGCACGGACAGCGGGCATCCAGAGGATACCTTTG
CCTCCACCTCCTGCACCAGAAACATATGAAGAATATGGATATGATGATACATACGCAGAACAAAGTTACGAAGGCTACGAAGGCTATTAC
AGCCAGAGTCAAGGGGACTCAGAATATTATGACTATGGACATGGGGAGGTTCAAGATTCTTATGAAGCTTATGGCCAGGACGACTGGAAT

>In-frame_XPR1_ENST00000367589_chr1_180651547_+_KHDRBS1_ENST00000327300_chr1_32495899_+_1071nt
ATGAAGTTCGCCGAGCACCTCTCCGCGCACATCACTCCCGAGTGGAGGAAGCAATACATCCAGTATGAGGCTTTCAAGGATATGCTGTAT
TCAGCTCAGGACCAGGCACCTTCTGTGGAAGAAATTGAGAAGATTCAGAAAGGAGACTCAAAAAAGGATGATGAGGAGAATTACTTGGAT
TTATTTTCTCATAAGAACATGAAACTGAAAGAGCGAGTGCTGATACCTGTCAAGCAGTATCCCAAGTTCAATTTTGTGGGGAAGATTCTT
GGACCACAAGGGAATACAATCAAAAGACTGCAGGAAGAGACTGGTGCAAAGATCTCTGTATTGGGAAAGGGCTCAATGAGAGACAAAGCC
AAGGAGGAAGAGCTGCGCAAAGGTGGAGACCCCAAATATGCCCACTTGAATATGGATCTGCATGTCTTCATTGAAGTCTTTGGACCCCCA
TGTGAGGCTTATGCTCTTATGGCCCATGCCATGGAGGAAGTCAAGAAATTTCTAGTACCGGATATGATGGATGATATCTGTCAGGAGCAA
TTTCTAGAGCTGTCCTACTTGAATGGAGTACCTGAACCCTCTCGTGGACGTGGGGTGCCAGTGAGAGGCCGGGGAGCTGCACCTCCTCCA
CCACCTGTTCCCAGGGGCCGTGGTGTTGGACCACCTCGGGGGGCTTTGGTACGTGGTACACCAGTAAGGGGAGCCATCACCAGAGGTGCC
ACTGTGACTCGAGGCGTGCCACCCCCACCTACTGTGAGGGGTGCTCCAGCACCAAGAGCACGGACAGCGGGCATCCAGAGGATACCTTTG
CCTCCACCTCCTGCACCAGAAACATATGAAGAATATGGATATGATGATACATACGCAGAACAAAGTTACGAAGGCTACGAAGGCTATTAC
AGCCAGAGTCAAGGGGACTCAGAATATTATGACTATGGACATGGGGAGGTTCAAGATTCTTATGAAGCTTATGGCCAGGACGACTGGAAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_XPR1_ENST00000367590_chr1_180651547_+_KHDRBS1_ENST00000327300_chr1_32495899_+_2527nt
GCGGGGAGGGGCGGGGCTATGGAGAGGAGGAGGAAGATGGCGGGCGGGCTGCTCTGAAGAGACCTCGGCGGCGGCGGAGGAGGAGAGAAG
CGCAGCGCCGCGCCGCGCCGGGGCCCATGTGGGGAGGAGTCGGAGTCGCTGTTGCCGCCGCCGCCTGTAGCTGCTGGACCCGAGTGGGAG
TGAGGGGGAAACGGCAGGATGAAGTTCGCCGAGCACCTCTCCGCGCACATCACTCCCGAGTGGAGGAAGCAATACATCCAGTATGAGGCT
TTCAAGGATATGCTGTATTCAGCTCAGGACCAGGCACCTTCTGTGGAAGAAATTGAGAAGATTCAGAAAGGAGACTCAAAAAAGGATGAT
GAGGAGAATTACTTGGATTTATTTTCTCATAAGAACATGAAACTGAAAGAGCGAGTGCTGATACCTGTCAAGCAGTATCCCAAGTTCAAT
TTTGTGGGGAAGATTCTTGGACCACAAGGGAATACAATCAAAAGACTGCAGGAAGAGACTGGTGCAAAGATCTCTGTATTGGGAAAGGGC
TCAATGAGAGACAAAGCCAAGGAGGAAGAGCTGCGCAAAGGTGGAGACCCCAAATATGCCCACTTGAATATGGATCTGCATGTCTTCATT
GAAGTCTTTGGACCCCCATGTGAGGCTTATGCTCTTATGGCCCATGCCATGGAGGAAGTCAAGAAATTTCTAGTACCGGATATGATGGAT
GATATCTGTCAGGAGCAATTTCTAGAGCTGTCCTACTTGAATGGAGTACCTGAACCCTCTCGTGGACGTGGGGTGCCAGTGAGAGGCCGG
GGAGCTGCACCTCCTCCACCACCTGTTCCCAGGGGCCGTGGTGTTGGACCACCTCGGGGGGCTTTGGTACGTGGTACACCAGTAAGGGGA
GCCATCACCAGAGGTGCCACTGTGACTCGAGGCGTGCCACCCCCACCTACTGTGAGGGGTGCTCCAGCACCAAGAGCACGGACAGCGGGC
ATCCAGAGGATACCTTTGCCTCCACCTCCTGCACCAGAAACATATGAAGAATATGGATATGATGATACATACGCAGAACAAAGTTACGAA
GGCTACGAAGGCTATTACAGCCAGAGTCAAGGGGACTCAGAATATTATGACTATGGACATGGGGAGGTTCAAGATTCTTATGAAGCTTAT
GGCCAGGACGACTGGAATGGGACCAGGCCGTCGCTGAAGGCCCCTCCTGCTAGGCCAGTGAAGGGAGCATACAGAGAGCACCCATATGGA
CGTTATTAAAAACAAACATGAGGGGAAAATATCAGTTATGAGCAAAGTTGTTACTGATTTCTTGTATCTCCCAGGATTCCTGTTGCTTTA
CCCACAACAGACAAGTAATTGTCTAAGTGTTTTTCTTCGTGGTCCCCTTCTTCTCCCCACCTTATTCCATTCTTAACTCTGCATTCTGGC
TTCTGTATGTAGTATTTTAAAATGAGTTAAAATAGATTTAGGAATATTGAATTAATTTTTTAAGTGTGTAGATGCTTTTTTCTTTGTTGT
TTAAATATAAACAGAAGTGTACCTTTTATAATAAAAAAAAGAAGTTGAGTAAAAAAAAAAAACACACAAACCTGTTAGTTTCAAAAATGA
CATTGCTTGCTTAAAGGTTCTGAAGTAAAGGCTTGTTAAGTTTCTCTTAGTTTTGATTTGAGGCATCCCGTAAAGTTGTAGTTGCAGAAT
CCCAAACTAGGCTACATTTCAAAATTCAGGGCTGTTTAAGATTTAAAATCACAAACATTAACGGCAGTAGGCACCACCATGTAAAAGTGA
GCTCAGACGTCTCTAAAAAATGTTTCCTTTATAAAAGCACATGGCGGTTGAATCTTAAGGTTAAATTTTAATATGAAAGATCCTCATGAA
TTAAATAGTTGATGCAATTTTTAACGTTAATTGATATAAAAAAAAAAACAACAAAATTAGGCTTGTAAAACTGACTTTTTCATTACGTGG
GTTTTGAAATCTAGCCCCAGACATACTGTGTTGAGAGATACTTAGAGGGAGGGAGTAGGTTTTGAAGAGGTTGATGGTGGTGGGGAGGGA
AGGCCTCCTGAATTGAGTTTGATGCAGAGCTTTTTAGCCATGAAGAATCTTTCAGTCATAGTACTAATAATTAAATTTTCAGTATTTAAA
AAGACAAAGTATTTTGTCCATTTGAGATTCTGCACTCCATGAAAAGTTCACTTGGACGCTGGGGCCAAAAGCTGTTGATTTTCTTAAGTT
GACGGTTGTCAATATATCGAACTGTTCCCAAGTTAGTCAAGTATGTCTCAACACTAGCATGATATAAAAAGGGACACTGCAGCTGAATGA
AAAAGGAATCAAAATCCACTTTGTACATAAGTTAAAGTCCTAATTGGATTTGTACCGTCCTCCCATTTTGTTCTCGGAAGATTAAATGCT
ACATGTGTAAGTCTGCCTAAATAGGTAGCTTAAACTTATGTCAAAATGTCTGCAGCAGTTTGTCAATAAAGTTTAGTCCTTTTTTAATCA

>In-frame_XPR1_ENST00000367589_chr1_180651547_+_KHDRBS1_ENST00000327300_chr1_32495899_+_2499nt
GGAGGAAGATGGCGGGCGGGCTGCTCTGAAGAGACCTCGGCGGCGGCGGAGGAGGAGAGAAGCGCAGCGCCGCGCCGCGCCGGGGCCCAT
GTGGGGAGGAGTCGGAGTCGCTGTTGCCGCCGCCGCCTGTAGCTGCTGGACCCGAGTGGGAGTGAGGGGGAAACGGCAGGATGAAGTTCG
CCGAGCACCTCTCCGCGCACATCACTCCCGAGTGGAGGAAGCAATACATCCAGTATGAGGCTTTCAAGGATATGCTGTATTCAGCTCAGG
ACCAGGCACCTTCTGTGGAAGAAATTGAGAAGATTCAGAAAGGAGACTCAAAAAAGGATGATGAGGAGAATTACTTGGATTTATTTTCTC
ATAAGAACATGAAACTGAAAGAGCGAGTGCTGATACCTGTCAAGCAGTATCCCAAGTTCAATTTTGTGGGGAAGATTCTTGGACCACAAG
GGAATACAATCAAAAGACTGCAGGAAGAGACTGGTGCAAAGATCTCTGTATTGGGAAAGGGCTCAATGAGAGACAAAGCCAAGGAGGAAG
AGCTGCGCAAAGGTGGAGACCCCAAATATGCCCACTTGAATATGGATCTGCATGTCTTCATTGAAGTCTTTGGACCCCCATGTGAGGCTT
ATGCTCTTATGGCCCATGCCATGGAGGAAGTCAAGAAATTTCTAGTACCGGATATGATGGATGATATCTGTCAGGAGCAATTTCTAGAGC
TGTCCTACTTGAATGGAGTACCTGAACCCTCTCGTGGACGTGGGGTGCCAGTGAGAGGCCGGGGAGCTGCACCTCCTCCACCACCTGTTC
CCAGGGGCCGTGGTGTTGGACCACCTCGGGGGGCTTTGGTACGTGGTACACCAGTAAGGGGAGCCATCACCAGAGGTGCCACTGTGACTC
GAGGCGTGCCACCCCCACCTACTGTGAGGGGTGCTCCAGCACCAAGAGCACGGACAGCGGGCATCCAGAGGATACCTTTGCCTCCACCTC
CTGCACCAGAAACATATGAAGAATATGGATATGATGATACATACGCAGAACAAAGTTACGAAGGCTACGAAGGCTATTACAGCCAGAGTC
AAGGGGACTCAGAATATTATGACTATGGACATGGGGAGGTTCAAGATTCTTATGAAGCTTATGGCCAGGACGACTGGAATGGGACCAGGC
CGTCGCTGAAGGCCCCTCCTGCTAGGCCAGTGAAGGGAGCATACAGAGAGCACCCATATGGACGTTATTAAAAACAAACATGAGGGGAAA
ATATCAGTTATGAGCAAAGTTGTTACTGATTTCTTGTATCTCCCAGGATTCCTGTTGCTTTACCCACAACAGACAAGTAATTGTCTAAGT
GTTTTTCTTCGTGGTCCCCTTCTTCTCCCCACCTTATTCCATTCTTAACTCTGCATTCTGGCTTCTGTATGTAGTATTTTAAAATGAGTT
AAAATAGATTTAGGAATATTGAATTAATTTTTTAAGTGTGTAGATGCTTTTTTCTTTGTTGTTTAAATATAAACAGAAGTGTACCTTTTA
TAATAAAAAAAAGAAGTTGAGTAAAAAAAAAAAACACACAAACCTGTTAGTTTCAAAAATGACATTGCTTGCTTAAAGGTTCTGAAGTAA
AGGCTTGTTAAGTTTCTCTTAGTTTTGATTTGAGGCATCCCGTAAAGTTGTAGTTGCAGAATCCCAAACTAGGCTACATTTCAAAATTCA
GGGCTGTTTAAGATTTAAAATCACAAACATTAACGGCAGTAGGCACCACCATGTAAAAGTGAGCTCAGACGTCTCTAAAAAATGTTTCCT
TTATAAAAGCACATGGCGGTTGAATCTTAAGGTTAAATTTTAATATGAAAGATCCTCATGAATTAAATAGTTGATGCAATTTTTAACGTT
AATTGATATAAAAAAAAAAACAACAAAATTAGGCTTGTAAAACTGACTTTTTCATTACGTGGGTTTTGAAATCTAGCCCCAGACATACTG
TGTTGAGAGATACTTAGAGGGAGGGAGTAGGTTTTGAAGAGGTTGATGGTGGTGGGGAGGGAAGGCCTCCTGAATTGAGTTTGATGCAGA
GCTTTTTAGCCATGAAGAATCTTTCAGTCATAGTACTAATAATTAAATTTTCAGTATTTAAAAAGACAAAGTATTTTGTCCATTTGAGAT
TCTGCACTCCATGAAAAGTTCACTTGGACGCTGGGGCCAAAAGCTGTTGATTTTCTTAAGTTGACGGTTGTCAATATATCGAACTGTTCC
CAAGTTAGTCAAGTATGTCTCAACACTAGCATGATATAAAAAGGGACACTGCAGCTGAATGAAAAAGGAATCAAAATCCACTTTGTACAT
AAGTTAAAGTCCTAATTGGATTTGTACCGTCCTCCCATTTTGTTCTCGGAAGATTAAATGCTACATGTGTAAGTCTGCCTAAATAGGTAG


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FusionGenePPI for XPR1_KHDRBS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
XPR1ELAVL1, AMOT, CEACAM21, VSIG4, TGOLN2, FAF2, NTRK1, CLTC, DBN1, GAK, KIF5B, RAB5C, RAB7A, VAPA, TACC3, GOLT1B, KIDINS220, FGFR2, VSIG1, B4GAT1, RHOT2, DKKL1, TNFRSF1A, PTGIR, APLNR, SLC15A1, CD79B, PDCD1, SLC4A2, UPK1A, RNF19B, TRIM25KHDRBS1RAPSN, CREBBP, PRMT1, EMG1, SRC, STUB1, TUBB3, GRB2, GRAP2, PLCG1, FYN, BTK, PIK3R1, IRS1, INSR, RASA1, CRK, NCK1, STAT3, YTHDC1, NCF1, KHDRBS1, PTK6, DHX9, ITK, WBP4, FNBP4, HNRNPK, LCK, KHDRBS2, PACSIN1, PACSIN2, PACSIN3, SMARCA2, SRRM1, SH3GL1, RIPK1, FADD, CASP8, SMARCAD1, LYN, YES1, ITSN2, HCK, NPHP1, SNX9, OSTF1, SH3KBP1, ABI2, AHI1, AMPH, ARHGEF9, ARHGEF4, PPP1R13B, BAIAP2L1, PSTPIP1, CD2AP, DLG1, DLG2, DLG3, DLG4, DOCK2, DOCK3, FGR, SH3PXD2A, FRK, BZRAP1, ITSN1, MIA2, MPP6, MYO1C, MYO7A, NCK2, SORBS1, RUSC2, SASH1, SH3YL1, SKAP2, SNX30, SPATA13, NCKIPSD, UBASH3B, DNMBP, VAV1, ZDHHC6, TJP1, CUL3, CAND1, HNRNPR, HNRNPC, ESR1, U2AF2, RALY, RBM7, DDX5, CIRBP, PTBP2, KHDRBS3, RBFOX2, SMAD2, CBX6, TNFRSF1A, CD81, CSK, AGO1, CREB3L3, PIK3R3, RBMX, CRKL, EFEMP1, SCG5, SSFA2, TBL1X, GPHN, POT1, AZIN1, ACTB, APBB1, GAS7, RPA1, RPA2, RPA3, LGR4, DROSHA, ZBTB7A, CUL7, OBSL1, CCDC8, EZH2, SUZ12, RNF2, BMI1, FBXW11, NTRK1, ATXN2, ATXN2L, COPA, DDX17, DHX15, GLRX3, SFPQ, SRSF3, NCSTN, RBM15, SYNCRIP, USO1, WBP11, BANP, HDAC6, EWSR1, SRPK2, CLK1, HIST1H3E, HNRNPA1, PPP1CB, MATR3, MPHOSPH8, CRY1, CRY2, SNW1, CDC5L, UBC, TRIM25, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneKHDRBS1chr1:180651547chr1:32495899ENST00000327300+09351_443127444HNRNPA1
TgeneKHDRBS1chr1:180651547chr1:32495899ENST00000492989+08351_443127405HNRNPA1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for XPR1_KHDRBS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for XPR1_KHDRBS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneXPR1C0004782Basal Ganglia Diseases1CTD_human
HgeneXPR1C0006663Calcinosis1CTD_human
HgeneXPR1C4225335BASAL GANGLIA CALCIFICATION, IDIOPATHIC, 61UNIPROT