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Fusion gene ID: 42200 |
FusionGeneSummary for XPOT_EPYC |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: XPOT_EPYC | Fusion gene ID: 42200 | Hgene | Tgene | Gene symbol | XPOT | EPYC | Gene ID | 11260 | 1833 |
| Gene name | exportin for tRNA | epiphycan | |
| Synonyms | XPO3 | DSPG3|PGLB|Pg-Lb|SLRR3B | |
| Cytomap | 12q14.2 | 12q21.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | exportin-Texportin(tRNA)exportin, tRNA (nuclear export receptor for tRNAs)tRNA exportin | epiphycandermatan sulfate proteoglycan 3epiphycan proteoglycanproteoglycan-lbsmall chondroitin/dermatan sulfate proteoglycan | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O43592 | Q99645 | |
| Ensembl transtripts involved in fusion gene | ENST00000332707, | ENST00000261172, | |
| Fusion gene scores | * DoF score | 6 X 5 X 4=120 | 8 X 4 X 4=128 |
| # samples | 5 | 7 | |
| ** MAII score | log2(5/120*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/128*10)=-0.870716983055034 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: XPOT [Title/Abstract] AND EPYC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | XPOT | GO:0006409 | tRNA export from nucleus | 9660920 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-DK-A6B2-01A | XPOT | chr12 | 64833095 | + | EPYC | chr12 | 91396355 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000332707 | ENST00000261172 | XPOT | chr12 | 64833095 | + | EPYC | chr12 | 91396355 | - |
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FusionProtFeatures for XPOT_EPYC |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| XPOT | EPYC |
| Mediates the nuclear export of aminoacylated tRNAs. Inthe nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear porecomplex (NPC) is mediated through binding to nucleoporins. Upontransit of a nuclear export complex into the cytoplasm,disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP(induced by RANBP1 and RANGAP1, respectively) cause release of thetRNA from the export receptor. XPOT then return to the nuclearcompartment and mediate another round of transport. Thedirectionality of nuclear export is thought to be conferred by anasymmetric distribution of the GTP- and GDP-bound forms of Ranbetween the cytoplasm and nucleus. {ECO:0000269|PubMed:12138183,ECO:0000269|PubMed:9512417, ECO:0000269|PubMed:9660920}. | May have a role in bone formation and also inestablishing the ordered structure of cartilage through matrixorganization. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for XPOT_EPYC |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for XPOT_EPYC |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| XPOT | HDLBP, RAN, AIRE, CAMKK2, CLN3, MYC, HDAC5, SIRT7, FBXO25, CUL5, USP7, TXNL1, ECT2, CA9, IQCB1, EGFR, FBXO6, APEX1, PAPSS1, MCMBP, NFRKB, RNF2, HTR6, GCSH, NAA40, PSMA3, PSMA4, WDR11, PSMB2, NTRK1, XRCC1, HDAC6, FBXO7, FAM46A, ARMC6, RNF126, DPF3, PTPRE, CDC14B, EPHA1, PTPRA, PTPRN, AAR2, TRIM25 | EPYC | CRK, PLCG2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for XPOT_EPYC |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for XPOT_EPYC |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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