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Fusion gene ID: 42198 |
FusionGeneSummary for XPOT_ARL14EPL |
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Fusion gene information | Fusion gene name: XPOT_ARL14EPL | Fusion gene ID: 42198 | Hgene | Tgene | Gene symbol | XPOT | ARL14EPL | Gene ID | 11260 | 644100 |
Gene name | exportin for tRNA | ADP ribosylation factor like GTPase 14 effector protein like | |
Synonyms | XPO3 | - | |
Cytomap | 12q14.2 | 5q23.1 | |
Type of gene | protein-coding | protein-coding | |
Description | exportin-Texportin(tRNA)exportin, tRNA (nuclear export receptor for tRNAs)tRNA exportin | ARL14 effector protein-likeADP-ribosylation factor-like 14 effector protein-like | |
Modification date | 20180523 | 20180409 | |
UniProtAcc | O43592 | P0DKL9 | |
Ensembl transtripts involved in fusion gene | ENST00000332707, | ENST00000601302, | |
Fusion gene scores | * DoF score | 6 X 5 X 4=120 | 2 X 2 X 2=8 |
# samples | 5 | 2 | |
** MAII score | log2(5/120*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: XPOT [Title/Abstract] AND ARL14EPL [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | XPOT | GO:0006409 | tRNA export from nucleus | 9660920 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CN409157 | XPOT | chr12 | 64811874 | + | ARL14EPL | chr5 | 115387639 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000332707 | ENST00000601302 | XPOT | chr12 | 64811874 | + | ARL14EPL | chr5 | 115387639 | - |
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FusionProtFeatures for XPOT_ARL14EPL |
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Hgene | Tgene |
XPOT | ARL14EPL |
Mediates the nuclear export of aminoacylated tRNAs. Inthe nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear porecomplex (NPC) is mediated through binding to nucleoporins. Upontransit of a nuclear export complex into the cytoplasm,disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP(induced by RANBP1 and RANGAP1, respectively) cause release of thetRNA from the export receptor. XPOT then return to the nuclearcompartment and mediate another round of transport. Thedirectionality of nuclear export is thought to be conferred by anasymmetric distribution of the GTP- and GDP-bound forms of Ranbetween the cytoplasm and nucleus. {ECO:0000269|PubMed:12138183,ECO:0000269|PubMed:9512417, ECO:0000269|PubMed:9660920}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for XPOT_ARL14EPL |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for XPOT_ARL14EPL |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for XPOT_ARL14EPL |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for XPOT_ARL14EPL |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |