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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42197

FusionGeneSummary for XPO7_XPO7

check button Fusion gene summary
Fusion gene informationFusion gene name: XPO7_XPO7
Fusion gene ID: 42197
HgeneTgene
Gene symbol

XPO7

XPO7

Gene ID

23039

23039

Gene nameexportin 7exportin 7
SynonymsEXP7|RANBP16EXP7|RANBP16
Cytomap

8p21.3

8p21.3

Type of geneprotein-codingprotein-coding
Descriptionexportin-7RAN binding protein 16exportin-7RAN binding protein 16
Modification date2018052320180523
UniProtAcc

Q9UIA9

Q9UIA9

Ensembl transtripts involved in fusion geneENST00000434536, ENST00000252512, 
ENST00000518017, ENST00000433566, 
ENST00000434536, ENST00000252512, 
ENST00000518017, ENST00000433566, 
Fusion gene scores* DoF score5 X 6 X 4=1205 X 6 X 3=90
# samples 77
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/90*10)=-0.362570079384708
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: XPO7 [Title/Abstract] AND XPO7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneXPO7

GO:0006611

protein export from nucleus

11024021

TgeneXPO7

GO:0006611

protein export from nucleus

11024021


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI444618XPO7chr8

21863041

+XPO7chrMT

374

-
ChiTaRS3.1AA514694XPO7chr8

21821790

-XPO7chr8

21821561

+
ChiTaRS3.1BQ359489XPO7chr8

21832285

+XPO7chr8

21835313

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000434536ENST00000434536XPO7chr8

21863041

+XPO7chrMT

374

-
3UTR-intronENST00000434536ENST00000252512XPO7chr8

21863041

+XPO7chrMT

374

-
3UTR-intronENST00000434536ENST00000518017XPO7chr8

21863041

+XPO7chrMT

374

-
3UTR-intronENST00000434536ENST00000433566XPO7chr8

21863041

+XPO7chrMT

374

-
3UTR-intronENST00000252512ENST00000434536XPO7chr8

21863041

+XPO7chrMT

374

-
3UTR-intronENST00000252512ENST00000252512XPO7chr8

21863041

+XPO7chrMT

374

-
3UTR-intronENST00000252512ENST00000518017XPO7chr8

21863041

+XPO7chrMT

374

-
3UTR-intronENST00000252512ENST00000433566XPO7chr8

21863041

+XPO7chrMT

374

-
intron-intronENST00000518017ENST00000434536XPO7chr8

21863041

+XPO7chrMT

374

-
intron-intronENST00000518017ENST00000252512XPO7chr8

21863041

+XPO7chrMT

374

-
intron-intronENST00000518017ENST00000518017XPO7chr8

21863041

+XPO7chrMT

374

-
intron-intronENST00000518017ENST00000433566XPO7chr8

21863041

+XPO7chrMT

374

-
3UTR-intronENST00000433566ENST00000434536XPO7chr8

21863041

+XPO7chrMT

374

-
3UTR-intronENST00000433566ENST00000252512XPO7chr8

21863041

+XPO7chrMT

374

-
3UTR-intronENST00000433566ENST00000518017XPO7chr8

21863041

+XPO7chrMT

374

-
3UTR-intronENST00000433566ENST00000433566XPO7chr8

21863041

+XPO7chrMT

374

-
intron-intronENST00000434536ENST00000434536XPO7chr8

21821790

-XPO7chr8

21821561

+
intron-intronENST00000434536ENST00000252512XPO7chr8

21821790

-XPO7chr8

21821561

+
intron-intronENST00000434536ENST00000518017XPO7chr8

21821790

-XPO7chr8

21821561

+
intron-intronENST00000434536ENST00000433566XPO7chr8

21821790

-XPO7chr8

21821561

+
intron-intronENST00000252512ENST00000434536XPO7chr8

21821790

-XPO7chr8

21821561

+
intron-intronENST00000252512ENST00000252512XPO7chr8

21821790

-XPO7chr8

21821561

+
intron-intronENST00000252512ENST00000518017XPO7chr8

21821790

-XPO7chr8

21821561

+
intron-intronENST00000252512ENST00000433566XPO7chr8

21821790

-XPO7chr8

21821561

+
intron-intronENST00000518017ENST00000434536XPO7chr8

21821790

-XPO7chr8

21821561

+
intron-intronENST00000518017ENST00000252512XPO7chr8

21821790

-XPO7chr8

21821561

+
intron-intronENST00000518017ENST00000518017XPO7chr8

21821790

-XPO7chr8

21821561

+
intron-intronENST00000518017ENST00000433566XPO7chr8

21821790

-XPO7chr8

21821561

+
intron-intronENST00000433566ENST00000434536XPO7chr8

21821790

-XPO7chr8

21821561

+
intron-intronENST00000433566ENST00000252512XPO7chr8

21821790

-XPO7chr8

21821561

+
intron-intronENST00000433566ENST00000518017XPO7chr8

21821790

-XPO7chr8

21821561

+
intron-intronENST00000433566ENST00000433566XPO7chr8

21821790

-XPO7chr8

21821561

+
Frame-shiftENST00000434536ENST00000434536XPO7chr8

21832285

+XPO7chr8

21835313

-
Frame-shiftENST00000434536ENST00000252512XPO7chr8

21832285

+XPO7chr8

21835313

-
5CDS-intronENST00000434536ENST00000518017XPO7chr8

21832285

+XPO7chr8

21835313

-
5CDS-intronENST00000434536ENST00000433566XPO7chr8

21832285

+XPO7chr8

21835313

-
Frame-shiftENST00000252512ENST00000434536XPO7chr8

21832285

+XPO7chr8

21835313

-
Frame-shiftENST00000252512ENST00000252512XPO7chr8

21832285

+XPO7chr8

21835313

-
5CDS-intronENST00000252512ENST00000518017XPO7chr8

21832285

+XPO7chr8

21835313

-
5CDS-intronENST00000252512ENST00000433566XPO7chr8

21832285

+XPO7chr8

21835313

-
3UTR-3CDSENST00000518017ENST00000434536XPO7chr8

21832285

+XPO7chr8

21835313

-
3UTR-3CDSENST00000518017ENST00000252512XPO7chr8

21832285

+XPO7chr8

21835313

-
3UTR-intronENST00000518017ENST00000518017XPO7chr8

21832285

+XPO7chr8

21835313

-
3UTR-intronENST00000518017ENST00000433566XPO7chr8

21832285

+XPO7chr8

21835313

-
Frame-shiftENST00000433566ENST00000434536XPO7chr8

21832285

+XPO7chr8

21835313

-
Frame-shiftENST00000433566ENST00000252512XPO7chr8

21832285

+XPO7chr8

21835313

-
5CDS-intronENST00000433566ENST00000518017XPO7chr8

21832285

+XPO7chr8

21835313

-
5CDS-intronENST00000433566ENST00000433566XPO7chr8

21832285

+XPO7chr8

21835313

-

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FusionProtFeatures for XPO7_XPO7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
XPO7

Q9UIA9

XPO7

Q9UIA9

Mediates the nuclear export of proteins (cargos) withbroad substrate specificity. In the nucleus binds cooperatively toits cargo and to the GTPase Ran in its active GTP-bound form.Docking of this trimeric complex to the nuclear pore complex (NPC)is mediated through binding to nucleoporins. Upon transit of anuclear export complex into the cytoplasm, disassembling of thecomplex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1and RANGAP1, respectively) cause release of the cargo from theexport receptor. XPO7 then return to the nuclear compartment andmediate another round of transport. The directionality of nuclearexport is thought to be conferred by an asymmetric distribution ofthe GTP- and GDP-bound forms of Ran between the cytoplasm andnucleus. {ECO:0000269|PubMed:11024021,ECO:0000269|PubMed:15282546}. Mediates the nuclear export of proteins (cargos) withbroad substrate specificity. In the nucleus binds cooperatively toits cargo and to the GTPase Ran in its active GTP-bound form.Docking of this trimeric complex to the nuclear pore complex (NPC)is mediated through binding to nucleoporins. Upon transit of anuclear export complex into the cytoplasm, disassembling of thecomplex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1and RANGAP1, respectively) cause release of the cargo from theexport receptor. XPO7 then return to the nuclear compartment andmediate another round of transport. The directionality of nuclearexport is thought to be conferred by an asymmetric distribution ofthe GTP- and GDP-bound forms of Ran between the cytoplasm andnucleus. {ECO:0000269|PubMed:11024021,ECO:0000269|PubMed:15282546}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for XPO7_XPO7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for XPO7_XPO7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for XPO7_XPO7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for XPO7_XPO7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource