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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42194

FusionGeneSummary for XPO7_ETV4

check button Fusion gene summary
Fusion gene informationFusion gene name: XPO7_ETV4
Fusion gene ID: 42194
HgeneTgene
Gene symbol

XPO7

ETV4

Gene ID

23039

2118

Gene nameexportin 7ETS variant 4
SynonymsEXP7|RANBP16E1A-F|E1AF|PEA3|PEAS3
Cytomap

8p21.3

17q21.31

Type of geneprotein-codingprotein-coding
Descriptionexportin-7RAN binding protein 16ETS translocation variant 4EWS protein/E1A enhancer binding protein chimeraadenovirus E1A enhancer-binding proteinets variant gene 4 (E1A enhancer-binding protein, E1AF)polyomavirus enhancer activator 3 homolog
Modification date2018052320180523
UniProtAcc

Q9UIA9

P43268

Ensembl transtripts involved in fusion geneENST00000434536, ENST00000252512, 
ENST00000518017, ENST00000433566, 
ENST00000319349, ENST00000393664, 
ENST00000538265, ENST00000545954, 
ENST00000545089, ENST00000591713, 
ENST00000586826, 
Fusion gene scores* DoF score5 X 6 X 4=1209 X 8 X 3=216
# samples 718
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/216*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: XPO7 [Title/Abstract] AND ETV4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneXPO7

GO:0006611

protein export from nucleus

11024021

TgeneETV4

GO:0045944

positive regulation of transcription by RNA polymerase II

24983502


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-73-4659-01AXPO7chr8

21837714

+ETV4chr17

41613847

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000434536ENST00000319349XPO7chr8

21837714

+ETV4chr17

41613847

-
Frame-shiftENST00000434536ENST00000393664XPO7chr8

21837714

+ETV4chr17

41613847

-
Frame-shiftENST00000434536ENST00000538265XPO7chr8

21837714

+ETV4chr17

41613847

-
Frame-shiftENST00000434536ENST00000545954XPO7chr8

21837714

+ETV4chr17

41613847

-
Frame-shiftENST00000434536ENST00000545089XPO7chr8

21837714

+ETV4chr17

41613847

-
Frame-shiftENST00000434536ENST00000591713XPO7chr8

21837714

+ETV4chr17

41613847

-
5CDS-intronENST00000434536ENST00000586826XPO7chr8

21837714

+ETV4chr17

41613847

-
Frame-shiftENST00000252512ENST00000319349XPO7chr8

21837714

+ETV4chr17

41613847

-
Frame-shiftENST00000252512ENST00000393664XPO7chr8

21837714

+ETV4chr17

41613847

-
Frame-shiftENST00000252512ENST00000538265XPO7chr8

21837714

+ETV4chr17

41613847

-
Frame-shiftENST00000252512ENST00000545954XPO7chr8

21837714

+ETV4chr17

41613847

-
Frame-shiftENST00000252512ENST00000545089XPO7chr8

21837714

+ETV4chr17

41613847

-
Frame-shiftENST00000252512ENST00000591713XPO7chr8

21837714

+ETV4chr17

41613847

-
5CDS-intronENST00000252512ENST00000586826XPO7chr8

21837714

+ETV4chr17

41613847

-
intron-3CDSENST00000518017ENST00000319349XPO7chr8

21837714

+ETV4chr17

41613847

-
intron-3CDSENST00000518017ENST00000393664XPO7chr8

21837714

+ETV4chr17

41613847

-
intron-3CDSENST00000518017ENST00000538265XPO7chr8

21837714

+ETV4chr17

41613847

-
intron-3CDSENST00000518017ENST00000545954XPO7chr8

21837714

+ETV4chr17

41613847

-
intron-3CDSENST00000518017ENST00000545089XPO7chr8

21837714

+ETV4chr17

41613847

-
intron-3CDSENST00000518017ENST00000591713XPO7chr8

21837714

+ETV4chr17

41613847

-
intron-intronENST00000518017ENST00000586826XPO7chr8

21837714

+ETV4chr17

41613847

-
Frame-shiftENST00000433566ENST00000319349XPO7chr8

21837714

+ETV4chr17

41613847

-
Frame-shiftENST00000433566ENST00000393664XPO7chr8

21837714

+ETV4chr17

41613847

-
Frame-shiftENST00000433566ENST00000538265XPO7chr8

21837714

+ETV4chr17

41613847

-
Frame-shiftENST00000433566ENST00000545954XPO7chr8

21837714

+ETV4chr17

41613847

-
Frame-shiftENST00000433566ENST00000545089XPO7chr8

21837714

+ETV4chr17

41613847

-
Frame-shiftENST00000433566ENST00000591713XPO7chr8

21837714

+ETV4chr17

41613847

-
5CDS-intronENST00000433566ENST00000586826XPO7chr8

21837714

+ETV4chr17

41613847

-

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FusionProtFeatures for XPO7_ETV4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
XPO7

Q9UIA9

ETV4

P43268

Mediates the nuclear export of proteins (cargos) withbroad substrate specificity. In the nucleus binds cooperatively toits cargo and to the GTPase Ran in its active GTP-bound form.Docking of this trimeric complex to the nuclear pore complex (NPC)is mediated through binding to nucleoporins. Upon transit of anuclear export complex into the cytoplasm, disassembling of thecomplex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1and RANGAP1, respectively) cause release of the cargo from theexport receptor. XPO7 then return to the nuclear compartment andmediate another round of transport. The directionality of nuclearexport is thought to be conferred by an asymmetric distribution ofthe GTP- and GDP-bound forms of Ran between the cytoplasm andnucleus. {ECO:0000269|PubMed:11024021,ECO:0000269|PubMed:15282546}. Transcriptional activator that binds to the enhancer ofthe adenovirus E1A gene; the core-binding sequence is5'[AC]GGA[AT]GT-3'. {ECO:0000269|PubMed:19307308}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for XPO7_ETV4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for XPO7_ETV4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
XPO7PTP4A3, C20orf24, BRF2, DDX19B, MAPK9, PDPK1, TAB1, RAN, NUP153, SIRT7, XPO1, SEPHS1, VPS37B, USP14, TLK2, UBE2I, TLK1, XRN2, EGFR, CARS, DPYSL2, JMJD6, RANBP3, SEC24C, SF1, AP2B1, CARM1, CTNNA1, DNAJB1, EIF4B, FAF1, GARS, GART, GFPT1, HIRIP3, HIST1H4A, HSPH1, NARS, OSBP, PLOD2, PPM1G, PRMT3, SAMHD1, SEC23A, THUMPD3, TROVE2, TTC1, USP11, POLK, USO1, ENO1, MOV10, NXF1, CCDC8, BSG, CD274, VSIG2, NT5E, LYPD3, RP2, SCN2B, SCARA3, DSCR3, CCDC22, COMMD9, SH3GLB1, NTRK1, NPHP1, DAXX, FOXB1, FOXI2, CD70, VIPR2, FZD10, VASN, HTR2C, TMEM206, CDHR5, DLK2, CHRM4, OPRM1, APLNR, MAS1, EDNRB, VSIG1, SLC39A9, PDCD1, TMEM108, TRIM25ETV4HOXD4, RFWD2, SAE1, UBA2, SMAD2, APP, HTT, ATXN1, STK11, TP63, JUN, CARM1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for XPO7_ETV4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for XPO7_ETV4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneETV4C0027627Neoplasm Metastasis1CTD_human
TgeneETV4C0033578Prostatic Neoplasms1CTD_human
TgeneETV4C1458155Mammary Neoplasms1CTD_human