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Fusion gene ID: 42188 |
FusionGeneSummary for XPO6_HIRIP3 |
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Fusion gene information | Fusion gene name: XPO6_HIRIP3 | Fusion gene ID: 42188 | Hgene | Tgene | Gene symbol | XPO6 | HIRIP3 | Gene ID | 23214 | 8479 |
Gene name | exportin 6 | HIRA interacting protein 3 | |
Synonyms | EXP6|RANBP20 | - | |
Cytomap | 16p12.1 | 16p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | exportin-6ran-binding protein 20 | HIRA-interacting protein 3 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q96QU8 | Q9BW71 | |
Ensembl transtripts involved in fusion gene | ENST00000565698, ENST00000304658, ENST00000561488, | ENST00000279392, ENST00000564026, ENST00000566471, | |
Fusion gene scores | * DoF score | 7 X 8 X 3=168 | 1 X 1 X 1=1 |
# samples | 10 | 1 | |
** MAII score | log2(10/168*10)=-0.748461233004036 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: XPO6 [Title/Abstract] AND HIRIP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | XPO6 | GO:0006611 | protein export from nucleus | 14592989 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-77-8130-01A | XPO6 | chr16 | 28222687 | - | HIRIP3 | chr16 | 30007131 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-5UTR | ENST00000565698 | ENST00000279392 | XPO6 | chr16 | 28222687 | - | HIRIP3 | chr16 | 30007131 | - |
5UTR-intron | ENST00000565698 | ENST00000564026 | XPO6 | chr16 | 28222687 | - | HIRIP3 | chr16 | 30007131 | - |
5UTR-5UTR | ENST00000565698 | ENST00000566471 | XPO6 | chr16 | 28222687 | - | HIRIP3 | chr16 | 30007131 | - |
5CDS-5UTR | ENST00000304658 | ENST00000279392 | XPO6 | chr16 | 28222687 | - | HIRIP3 | chr16 | 30007131 | - |
5CDS-intron | ENST00000304658 | ENST00000564026 | XPO6 | chr16 | 28222687 | - | HIRIP3 | chr16 | 30007131 | - |
5CDS-5UTR | ENST00000304658 | ENST00000566471 | XPO6 | chr16 | 28222687 | - | HIRIP3 | chr16 | 30007131 | - |
intron-5UTR | ENST00000561488 | ENST00000279392 | XPO6 | chr16 | 28222687 | - | HIRIP3 | chr16 | 30007131 | - |
intron-intron | ENST00000561488 | ENST00000564026 | XPO6 | chr16 | 28222687 | - | HIRIP3 | chr16 | 30007131 | - |
intron-5UTR | ENST00000561488 | ENST00000566471 | XPO6 | chr16 | 28222687 | - | HIRIP3 | chr16 | 30007131 | - |
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FusionProtFeatures for XPO6_HIRIP3 |
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Hgene | Tgene |
XPO6 | HIRIP3 |
May play a role in chromatin function and histonemetabolism via its interaction with HIRA and histones.{ECO:0000269|PubMed:9710638}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for XPO6_HIRIP3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for XPO6_HIRIP3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
XPO6 | NUP62, GSK3B, BRF2, VASP, RAN, ACTA1, PFN1, DIAPH1, ENAH, RANBP17, VPS39, UBXN6, EGFR, SMAD3, CD274, VSIG2, CA14, LYPD3, SCN2B, STK4, RASSF1, CSTF1, DCUN1D1, DNAAF5, MAPK1, PFKM, PPP2R5D, SNW1, FCGRT, OPRM1, NCR3LG1, CD83, CHRM4, PVR, VIPR1, SIGLECL1, ILVBL, FPR2, NPY2R, PTPRA, PTPRN, MTOR, THADA, MLST8, TRIM25 | HIRIP3 | HIRA, CSNK2B, CSNK2A1, APP, IQCB1, SRPK2, SRPK1, CARS, FAF1, GARS, GART, HIST1H4A, HSPH1, PPM1G, PRMT3, PUF60, RPL24, SEC23A, SET, SNX2, STAT1, TROVE2, TSNAX, UGP2, RANBP3, SF1, XPO7, CSNK2A2, GTF2F1, RPL8, HIST1H2BG, XPO1, TMPO |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for XPO6_HIRIP3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for XPO6_HIRIP3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | XPO6 | C0236969 | Substance-Related Disorders | 1 | CTD_human |