FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 42188

FusionGeneSummary for XPO6_HIRIP3

check button Fusion gene summary
Fusion gene informationFusion gene name: XPO6_HIRIP3
Fusion gene ID: 42188
HgeneTgene
Gene symbol

XPO6

HIRIP3

Gene ID

23214

8479

Gene nameexportin 6HIRA interacting protein 3
SynonymsEXP6|RANBP20-
Cytomap

16p12.1

16p11.2

Type of geneprotein-codingprotein-coding
Descriptionexportin-6ran-binding protein 20HIRA-interacting protein 3
Modification date2018051920180519
UniProtAcc

Q96QU8

Q9BW71

Ensembl transtripts involved in fusion geneENST00000565698, ENST00000304658, 
ENST00000561488, 
ENST00000279392, 
ENST00000564026, ENST00000566471, 
Fusion gene scores* DoF score7 X 8 X 3=1681 X 1 X 1=1
# samples 101
** MAII scorelog2(10/168*10)=-0.748461233004036
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: XPO6 [Title/Abstract] AND HIRIP3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneXPO6

GO:0006611

protein export from nucleus

14592989


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-77-8130-01AXPO6chr16

28222687

-HIRIP3chr16

30007131

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000565698ENST00000279392XPO6chr16

28222687

-HIRIP3chr16

30007131

-
5UTR-intronENST00000565698ENST00000564026XPO6chr16

28222687

-HIRIP3chr16

30007131

-
5UTR-5UTRENST00000565698ENST00000566471XPO6chr16

28222687

-HIRIP3chr16

30007131

-
5CDS-5UTRENST00000304658ENST00000279392XPO6chr16

28222687

-HIRIP3chr16

30007131

-
5CDS-intronENST00000304658ENST00000564026XPO6chr16

28222687

-HIRIP3chr16

30007131

-
5CDS-5UTRENST00000304658ENST00000566471XPO6chr16

28222687

-HIRIP3chr16

30007131

-
intron-5UTRENST00000561488ENST00000279392XPO6chr16

28222687

-HIRIP3chr16

30007131

-
intron-intronENST00000561488ENST00000564026XPO6chr16

28222687

-HIRIP3chr16

30007131

-
intron-5UTRENST00000561488ENST00000566471XPO6chr16

28222687

-HIRIP3chr16

30007131

-

Top

FusionProtFeatures for XPO6_HIRIP3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
XPO6

Q96QU8

HIRIP3

Q9BW71

May play a role in chromatin function and histonemetabolism via its interaction with HIRA and histones.{ECO:0000269|PubMed:9710638}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for XPO6_HIRIP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for XPO6_HIRIP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
XPO6NUP62, GSK3B, BRF2, VASP, RAN, ACTA1, PFN1, DIAPH1, ENAH, RANBP17, VPS39, UBXN6, EGFR, SMAD3, CD274, VSIG2, CA14, LYPD3, SCN2B, STK4, RASSF1, CSTF1, DCUN1D1, DNAAF5, MAPK1, PFKM, PPP2R5D, SNW1, FCGRT, OPRM1, NCR3LG1, CD83, CHRM4, PVR, VIPR1, SIGLECL1, ILVBL, FPR2, NPY2R, PTPRA, PTPRN, MTOR, THADA, MLST8, TRIM25HIRIP3HIRA, CSNK2B, CSNK2A1, APP, IQCB1, SRPK2, SRPK1, CARS, FAF1, GARS, GART, HIST1H4A, HSPH1, PPM1G, PRMT3, PUF60, RPL24, SEC23A, SET, SNX2, STAT1, TROVE2, TSNAX, UGP2, RANBP3, SF1, XPO7, CSNK2A2, GTF2F1, RPL8, HIST1H2BG, XPO1, TMPO


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for XPO6_HIRIP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for XPO6_HIRIP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneXPO6C0236969Substance-Related Disorders1CTD_human