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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 42182

FusionGeneSummary for XPO5_KIF6

check button Fusion gene summary
Fusion gene informationFusion gene name: XPO5_KIF6
Fusion gene ID: 42182
HgeneTgene
Gene symbol

XPO5

KIF6

Gene ID

57510

221458

Gene nameexportin 5kinesin family member 6
Synonymsexp5C6orf102|dJ1043E3.1|dJ137F1.4|dJ188D3.1
Cytomap

6p21.1

6p21.2

Type of geneprotein-codingprotein-coding
Descriptionexportin-5ran-binding protein 21kinesin-like protein KIF6
Modification date2018052720180523
UniProtAcc

Q9HAV4

Q6ZMV9

Ensembl transtripts involved in fusion geneENST00000265351, ENST00000424378, 
ENST00000287152, ENST00000394362, 
ENST00000373213, ENST00000373216, 
ENST00000229913, ENST00000373215, 
ENST00000538893, ENST00000541946, 
ENST00000465719, 
Fusion gene scores* DoF score6 X 7 X 5=21010 X 7 X 8=560
# samples 610
** MAII scorelog2(6/210*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/560*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: XPO5 [Title/Abstract] AND KIF6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneXPO5

GO:0006611

protein export from nucleus

11777942|24209753

HgeneXPO5

GO:0035281

pre-miRNA export from nucleus

15613540

HgeneXPO5

GO:1900370

positive regulation of RNA interference

15613540


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-V1-A9O9-01AXPO5chr6

43540243

-KIF6chr6

39314302

-
TCGALDPRADTCGA-V1-A9O9-01AXPO5chr6

43541217

-KIF6chr6

39314302

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000265351ENST00000287152XPO5chr6

43540243

-KIF6chr6

39314302

-
5CDS-intronENST00000265351ENST00000394362XPO5chr6

43540243

-KIF6chr6

39314302

-
5CDS-intronENST00000265351ENST00000373213XPO5chr6

43540243

-KIF6chr6

39314302

-
5CDS-intronENST00000265351ENST00000373216XPO5chr6

43540243

-KIF6chr6

39314302

-
5CDS-intronENST00000265351ENST00000229913XPO5chr6

43540243

-KIF6chr6

39314302

-
5CDS-intronENST00000265351ENST00000373215XPO5chr6

43540243

-KIF6chr6

39314302

-
5CDS-intronENST00000265351ENST00000538893XPO5chr6

43540243

-KIF6chr6

39314302

-
5CDS-intronENST00000265351ENST00000541946XPO5chr6

43540243

-KIF6chr6

39314302

-
5CDS-intronENST00000265351ENST00000465719XPO5chr6

43540243

-KIF6chr6

39314302

-
intron-3CDSENST00000424378ENST00000287152XPO5chr6

43540243

-KIF6chr6

39314302

-
intron-intronENST00000424378ENST00000394362XPO5chr6

43540243

-KIF6chr6

39314302

-
intron-intronENST00000424378ENST00000373213XPO5chr6

43540243

-KIF6chr6

39314302

-
intron-intronENST00000424378ENST00000373216XPO5chr6

43540243

-KIF6chr6

39314302

-
intron-intronENST00000424378ENST00000229913XPO5chr6

43540243

-KIF6chr6

39314302

-
intron-intronENST00000424378ENST00000373215XPO5chr6

43540243

-KIF6chr6

39314302

-
intron-intronENST00000424378ENST00000538893XPO5chr6

43540243

-KIF6chr6

39314302

-
intron-intronENST00000424378ENST00000541946XPO5chr6

43540243

-KIF6chr6

39314302

-
intron-intronENST00000424378ENST00000465719XPO5chr6

43540243

-KIF6chr6

39314302

-
In-frameENST00000265351ENST00000287152XPO5chr6

43541217

-KIF6chr6

39314302

-
5CDS-intronENST00000265351ENST00000394362XPO5chr6

43541217

-KIF6chr6

39314302

-
5CDS-intronENST00000265351ENST00000373213XPO5chr6

43541217

-KIF6chr6

39314302

-
5CDS-intronENST00000265351ENST00000373216XPO5chr6

43541217

-KIF6chr6

39314302

-
5CDS-intronENST00000265351ENST00000229913XPO5chr6

43541217

-KIF6chr6

39314302

-
5CDS-intronENST00000265351ENST00000373215XPO5chr6

43541217

-KIF6chr6

39314302

-
5CDS-intronENST00000265351ENST00000538893XPO5chr6

43541217

-KIF6chr6

39314302

-
5CDS-intronENST00000265351ENST00000541946XPO5chr6

43541217

-KIF6chr6

39314302

-
5CDS-intronENST00000265351ENST00000465719XPO5chr6

43541217

-KIF6chr6

39314302

-
intron-3CDSENST00000424378ENST00000287152XPO5chr6

43541217

-KIF6chr6

39314302

-
intron-intronENST00000424378ENST00000394362XPO5chr6

43541217

-KIF6chr6

39314302

-
intron-intronENST00000424378ENST00000373213XPO5chr6

43541217

-KIF6chr6

39314302

-
intron-intronENST00000424378ENST00000373216XPO5chr6

43541217

-KIF6chr6

39314302

-
intron-intronENST00000424378ENST00000229913XPO5chr6

43541217

-KIF6chr6

39314302

-
intron-intronENST00000424378ENST00000373215XPO5chr6

43541217

-KIF6chr6

39314302

-
intron-intronENST00000424378ENST00000538893XPO5chr6

43541217

-KIF6chr6

39314302

-
intron-intronENST00000424378ENST00000541946XPO5chr6

43541217

-KIF6chr6

39314302

-
intron-intronENST00000424378ENST00000465719XPO5chr6

43541217

-KIF6chr6

39314302

-

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FusionProtFeatures for XPO5_KIF6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
XPO5

Q9HAV4

KIF6

Q6ZMV9


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKIF6chr6:43541217chr6:39314302ENST00000229913-510356_385177266Coiled coilOntology_term=ECO:0000255
TgeneKIF6chr6:43541217chr6:39314302ENST00000229913-510456_494177266Coiled coilOntology_term=ECO:0000255
TgeneKIF6chr6:43541217chr6:39314302ENST00000229913-510588_683177266Coiled coilOntology_term=ECO:0000255
TgeneKIF6chr6:43541217chr6:39314302ENST00000373216-022356_385-32798Coiled coilOntology_term=ECO:0000255
TgeneKIF6chr6:43541217chr6:39314302ENST00000373216-022456_494-32798Coiled coilOntology_term=ECO:0000255
TgeneKIF6chr6:43541217chr6:39314302ENST00000373216-022588_683-32798Coiled coilOntology_term=ECO:0000255
TgeneKIF6chr6:43541217chr6:39314302ENST00000373216-0225_345-32798DomainKinesin motor
TgeneKIF6chr6:43541217chr6:39314302ENST00000373216-02297_104-32798Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneXPO5chr6:43541217chr6:39314302ENST00000265351-232641_642751205RegionPre-miRNA binding
TgeneKIF6chr6:43541217chr6:39314302ENST00000287152-1823356_385726815Coiled coilOntology_term=ECO:0000255
TgeneKIF6chr6:43541217chr6:39314302ENST00000287152-1823456_494726815Coiled coilOntology_term=ECO:0000255
TgeneKIF6chr6:43541217chr6:39314302ENST00000287152-1823588_683726815Coiled coilOntology_term=ECO:0000255
TgeneKIF6chr6:43541217chr6:39314302ENST00000229913-5105_345177266DomainKinesin motor
TgeneKIF6chr6:43541217chr6:39314302ENST00000287152-18235_345726815DomainKinesin motor
TgeneKIF6chr6:43541217chr6:39314302ENST00000229913-51097_104177266Nucleotide bindingATP
TgeneKIF6chr6:43541217chr6:39314302ENST00000287152-182397_104726815Nucleotide bindingATP


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FusionGeneSequence for XPO5_KIF6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_XPO5_ENST00000265351_chr6_43541217_-_KIF6_ENST00000287152_chr6_39314302_-_164aa
MAMDQVNALCEQLVKAVTVMMDPNSTQRYRLEALKFCEEFKEKCPICVPCGLRLAEKTQVAIVRHFGLQILEHVVNSGGWEVQDQGTGRF


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_XPO5_ENST00000265351_chr6_43541217_-_KIF6_ENST00000287152_chr6_39314302_-_492nt
ATGGCGATGGATCAAGTAAACGCGCTGTGCGAGCAGCTGGTGAAAGCGGTGACGGTCATGATGGACCCCAACTCCACCCAGCGCTACCGG
CTGGAAGCCCTCAAGTTTTGTGAGGAGTTTAAAGAAAAGTGTCCTATCTGTGTCCCCTGTGGCTTGAGGTTGGCTGAGAAAACACAAGTT
GCCATCGTCAGACATTTTGGCCTTCAGATCCTGGAACACGTTGTCAATTCTGGAGGCTGGGAAGTCCAAGATCAAGGCACTGGCAGATTC
GATGTCTGTGATGTGAATGCCAGGAAAATCCTGCCCTCGCCTTGCCCCAGTCCACACAGCCAGAAACAGAGCAGCACCAGCACCCCACTG
GAAGACAGCATCCCCAAGAGGCCAGTGTCGTCCATCCCTCTCACCGGAGACAGCCAGACGGACTCGGACATCATCGCCTTCATCAAGGCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_XPO5_ENST00000265351_chr6_43541217_-_KIF6_ENST00000287152_chr6_39314302_-_7245nt
ACTTCCGCGGGCGCGTGCGCAGTGGCGGGCCGGGCGCGTGCGCAGCGCCGGCTTCTTCCCAGCGCGAGTTGCTGCTAACGCTCCTCCTCC
AGCTTCCCACCCCCGCCGCCCGCCGCGGCCCGGTACCAACGGGTGGTCTCGCCGAGGGAGCTGTCGTGCCTCGTGGTCCCGGGACTGCAG
TGGTGTGCGCTCTCGGCGCGTGGCGCTAGGCATGGCGATGGATCAAGTAAACGCGCTGTGCGAGCAGCTGGTGAAAGCGGTGACGGTCAT
GATGGACCCCAACTCCACCCAGCGCTACCGGCTGGAAGCCCTCAAGTTTTGTGAGGAGTTTAAAGAAAAGTGTCCTATCTGTGTCCCCTG
TGGCTTGAGGTTGGCTGAGAAAACACAAGTTGCCATCGTCAGACATTTTGGCCTTCAGATCCTGGAACACGTTGTCAATTCTGGAGGCTG
GGAAGTCCAAGATCAAGGCACTGGCAGATTCGATGTCTGTGATGTGAATGCCAGGAAAATCCTGCCCTCGCCTTGCCCCAGTCCACACAG
CCAGAAACAGAGCAGCACCAGCACCCCACTGGAAGACAGCATCCCCAAGAGGCCAGTGTCGTCCATCCCTCTCACCGGAGACAGCCAGAC
GGACTCGGACATCATCGCCTTCATCAAGGCCAGACAGAGCATTCTGCAGAAGCAATGTTTGGGAAGCAATTGAATTTCCAGGAAATATCC
ATCCATGAATTATGCCAGCAAGAATGAAGCACAGATGAAGGCAGCGCCCCTCACTTGCTCTGGCTTCAGAAGTGAACTATGGGCTGCTGG
GAGCAACTAGTGACTTTGATTCCCATGGAGGGGACTGTGTTTCTTTAAGGATGCTGACCTGGAGGCCACCGAGAGGCTGGGGCTGGGGCT
GACCACAACATCCTTCCTGTGGTTGCTGGAGCTGCTGGCAGGGCCAGGCAAGGCCAGAGTGCTAGGGGCAGGGTGAAGGCTTCAGCTCAC
TGTTGTAGTGACGTTTTGTGTAGATCTTTATAAGCTTTTGAGAATGTGAAATAGCACCATCAAAATATAATGTCAGAGGATGCTCACACC
AGTGGAATGTGGGGGGAATATTTTTATTTTTAACGATTTGCCAGCTCTCTCCCTTGGCCCGTGCTCTGGTTTGGAAGCCCAGAAATGGCC
ATGACAGGTCCAGGCAGGATGTCCCAGCCACAGGCAAGGCAGTGGAATGCAGGGCATCCTGAAGGCCAATCCTGATCTCCCAGACCACAT
CTTTCACCATCAGCCTCTTGGCCAGGATGACCTGGAGGCAGTGCCTGAACAGCTGTGTCTCCAGGGAGCCATCTGCCCTGCAGGGTCTAA
GGACATCATAGCACCCAGAGAACAGTGGGCAGCTCCCAGGGGCTCTGCTGAGAGCTTGAGAGAGGGCAGTGTGGGTACCTTGGGCCTCAC
AACCTTCACCCAGCCACTTGGGAGGATTTGGGCTGACACTCCCCACTTCCACAGGGAAAAACATAGCTGCCTGGGGGTCTTGTCTCCATG
GGCCCTCTCCATGACAGATCCAAGGGAAGGTGGGCAGCCCTCAAGGAGGTTCTTGAAGAACTGCCCCCTGGGCCAGGGGGTTCCAACCCA
GCTGCAGCCAGGGAGGGGCAGCGGAGGGTGAGCAGGAGTGGCACCTGGAAATGAAGCTAACTGGATAAAAGTGCTGGTCCACTGCTCCTG
GTGTCTCTGTCCTATAAATACAGGACCTGATGACCCTGGAGGGGAGCAGAGTGGTAATATAGTATAATTGGCTTGATTTTCTTTTTCGTT
TTTTAGGACTGGGTAACAGGATCATGCAGGAGAAGATTAAACCATTACATTTCTAAGCTAGGCAGGCCCATCGAGCTCCTCTAATCCACA
CCCCTATTTTATATAATTAGAAGGCCAGAGTGAAGGGGAGATTCAGCTTGCTGTTCTATGCCACTGACAAATGTCCCCTCTTCAGGGGGC
TTCCCCTGACCACTCCATCTCGAGTCACCCCCTAGTTATCCCCTATCCCATTACCATTTTTTCTGCATCACTATCTGACATGTTATCCTT
CCGAACTTGCCTATTTTTGAAATACCTGCAACCCCCCATAATACTAAGAGCTCCAATGCAACAGGGACCTGTTTGTCTTGCTCATTGCTG
TGTCCCAAGCACAGAGTCGCTGTTCAGTAAACGGTCCTTCAGTTCATGAGTAGACGAGCCAGAACCCAGATGTGTTTCTCAGGCTGGTGT
CACTCTGACTTCCCCCAGGCTCTGACTGAATCCCATCGGGACAGGGGCCAGCATCTCTGGTCCACTCCTGGCCCTCACAGTTCAATGGAA
CATAGTAAGCCCTCTGTAAAGTCTGTAGAACCAGAGGAAGACCAAATTCTGATTCTAGAAGCCTCCCCAAGAGTCCATGGAACACACATG
TAACTGCACACACACACACACATACACACACACACTCTCAAGAGCCCTGAAGATGGCATGGCATTTGCCCCAGTCCCCTATGTAGCAGCA
GCAGTATTCTTGGCATGCCTTAGTGCCCTCAGCCCTCTAGAGCTGGGTAGAGTCTACTAACTTTTATTTTCTTTTATTTTTACTTTCTTT
TATTTATTTTTTGAGATGGGGGGGGTCTCTGTCAGCCAGGCTGGGGTGCAGTGGTGCGACCATACCTCACTAGTCAGCCTCCAACTCCTG
GGCTCAAGCCATACTCAGCCTCCAACTCCTGGGCTCAAGCGATCCTCTCACCTCAGCCTCCAAAGTAGCTGGAACTACAGGCATGCACCA
CCACACCTAGCTCGTTTTAAATTTTTTGTAGAGACAGGGTCTCACTGTGTGGCTCAGGATGGTCTCAAATTCCTGGCCTTAAGCGATGCT
CCCGCCTTGGCCTCCCAAAGTGCTGGGATTGCAGGCATGAGCCACATACCCTGCCAGAGTCTTTCAACATTAGATCTCCCACTGAGACAT
CATCTCCTGGATCCAAAGGCCTTACTGACAGAGATGTGTGGCATGGCCCCATGCGGGGTGTGAACCAGCCTCCTGGGGCAATCACTAAGA
CAGGAAAGGAAATGAAGACAGAAAAACACACAACATGGGATCTGGGGCCACTGGTGTCCAGAGCATATGCAAAGTGTGTGCAGCAACTGG
CCAAGGGGCCTTTTGCTCCGAACATCCCCTAATGGAAGCCCAGCCTTTGATATGGACACATGCTTGACAGCAGTGCACCTTCCCAGAGTT
CACTGGCCTCTGCAAATGGGAGAAATTGATGCAATGTTTTGAAAAGACTTTCCAGCAATCCACCTGGGATCAGTGGAGCCACGGATGACA
AGAAGTATCTGAGTTCACTCTAGGCCAAAATGTGGGATTTTCAAAAACATTTTCTGGAAAGCAGCCTAGCCAGTGACTCCAGCCCAGTCC
CTGCTAGAATTCAACTGGCTCTACCAATCCCTTGACAAGAAGTAGGGTGGACGGAGGTTGGAGGAGGGAAGTTAAAATGTAGCTTGCCCA
GATCTTGCTAAAAAGGAGTTTTAGAAAGCAGATAGAGAAATTGTGGTATACTGAATACATCATTTTAATTCTTCACCACCAGTATAGAAT
TACACATCCAAAGCTTTGTCATGGCCCACTTTGACTAATGTGGTGTTGGCAAACCTGATCCAGGCAGAGGCTTGAATTGTGCTCTCATGG
TTGAGCTTGCCTCTTGCTCCAGTGATCTCTCTTGGGATGAACATGCCATGGGTAGCTGCTGCCCCTTCAGCCTGGAACATCCAGAGAGCA
GACCTGAGCCCAGTCTACAGCCTGGAGCAGAGCCTCCCAGGCAAGCCCAGCCCAGATCAGCTGAACTATGGCTCACCCAAAGACCTATTG
GCATGAGAATATATGCTGCTTGTCATAAACCACTGAGGTTTAGAGTGGTTTGTTATATAGCATTAATTGTAGCAATAGCAGACTGGCACA
GAAATTGGAACCCAGAGACAGTATATGACTGGATCTAGGATTTCTCAGTGCAGAGTTCATTGTCTCTCCATGCAGCCTGTGGAAAGGCAC
TGAGAGCATCCTGTATATGGAAAAGCAGGACCACCACCTACAGCCATGATGAAGCAACAAGGACCTGATTTACCCTCCTGCTTTAAATGA
CTAAAAATGAGACAAAATCCTCTATACAAACCAATGGTTTTCAGCCATTGGATAACAAGCAATATAGGGTATGATTGATCCGCAAGAGAA
GGGAAACAAGTGAGGGGAGCCCTATGATTGCTCCAACTTACTGCCTGCAGTGAGTTTTCAGGCTGCAGCCCAGGAAGGGGGAACCAGGTA
GAGCCCAGTGGTTTCCCTGAGTTGAGGAAATGGAGCTGGGAATCCAGGGAGGACAAAGTGGCTTAAATTTGCAAGGCAGAGTCCCAGGGA
TGAGAGAGAGAGAAGGAGAGAGAGAGGAGAAAAAAGAGAGAGAAAGAGAGAGAGCATGCTCTGGAGATCTTCAGAGGGTTACCCTTGAGT
CTTCAGCTAACTACCGATCAACATCTGCATGTGAAGAAATTACCCAAGGCAGGGGAAAGAACCACCAGGAGGAAGCAGGTGGAATAATTT
CCTGAGATAACACTGTGTTGGGAAGAGTTCATGTTTCCAACAGCCAGAGTGGAGAAACCTCCCAAAACAGTCATTGTATAGAGACACATA
AGGTACTGCCTCAGAAGTGGGGCCAAATTAGTCCTAGATGATAGATTGCTCTGGTCCCACCTAACAAAGCTTAAAAAGCCAGCCCCAAAG
GAGTCAAATTGTTTCCAGTAAGTTTCCAAGTAACTTCAATGAGTCCCAAAACAAAGCTTCAAAATATCTAAAGGAATATGAAAAACAAAC
CAAAAAGAAACCAGCATCCAACAATATAGAATCCACAATGTCTGGTGTCCATTAAAAAATAATCAGGCATGCAAAGAAGCAGGAAAATAT
GGGCCATGAGAGGAGAAAAAACCATCAATAGAAATAGAGGCCGGGTGTGGTGGCTCACTCCTATAATCCCAGCACTTTGGGAGGCCGAGG
CAGGAGGATCACCTGAGGTCAGGAGTTCAAGAACAGCCTGTTCAACATGGGGAAACCCCGTCTCTACTAAAAATACAAAAAATAGCCGGG
CATGGTGTTGCGTACCTGTAATCCCAGCTACTCAGAGGCTGAGGCAGGAGAATTGCTTGAGCCCAGGAGGCAGAGGTTACAGTGAGCCGA
AATTGTGCCATTGCACTCCAGCTTGGGCAACAAGAGTGAAACTCTGTCTCAAAAAAAAAAAAAAGAAAAAACAAATAGAAACAGCCCCAG
GCATGGCACAGTTGATAGAGTAAATAGACAGAAACATTTTTTAAAATGCAATGGGTGTGTGTTTCAAATCTAGGCAGAAAAAATGCTCCT
TGTAATTCCTTAAACATAAGCATGTCTCATTCATCTGGTCATTGTTTTGACAAGGATGTGCCATCCATTGTGCTAAGTTCTGAGGAGTCA
GAGGTGACAGAGACAGAGAAAGTGCCAGCATTCTTGGAACCTTCTAACGAAGGAGAGGGACAAGCCAGGCATGGTGGCTCACGCCTGTAA
TCCCAACACTTTGGGAGACTGAGGCTGGCGGATCACGAGGTCAGGAGTTTGAGACCAACCTGGCCAACATGGCGAAACCCCATCGCTACT
AAAAATACAAAAATTAGCTGGGTGTGGTGGTGCGCACCTGTAATCCCAGCTACTCTGGAGGCTGAGGCAGGACAATCACTTGAACCCTGG
AGGCAGAGTTTGCAGTGAGCTGAGATCGTGCCACTGCACTCCAACCTGGGCAACAAGAGCGAGACTCCTTCTCTGAAAAAAAAAAAAAGA
GAGGGACAATAAACAAGTAAGCAAGACAATCTGATTAAGAAGGAGTTGGGGTTAGCTGGGCATGGTAGCAAGCGCCTGTAGTCTCAGCTA
CTCGGGAGGCTGAGGTGGGAGGATCCTTGAACCCAGGAGGTTAAGGCTGCAGTGAGCTGTGATCACACCACTGCACTCCAGCCTGGATGA
CAGAGCAAGACCCTGTCTCAGAAAAAGAAGAAGGAGTTGGGGGTGGGGTAGGATGGGCTTGGACTCACTATCAAGGTGGGTGGGAGTGTG
AGAACCCGGCAAGGTGCAAAGAGAGAAGCAGGGAAGGGAAGCTTAGGACAATGATGGCAGGTTGGGTATTGGGTGATGGGAAGAGGCAAA
GGACGTGGAGCTTGGCAAAAAGGGGACTTGTGGGGATTTGGGCCATGTGAGCATGTGGGGGAGACAGTGTTCCTTCCATAACACGTGTCC
AGGGACTGCCAGGGCTCCGAGGCAGAGCAGGTGTAGAGAGGTTGGCTGTGAATGTTGGATGTTGAAAACATATGTGTCAAATGTGGGAGG
AAAAAGCAGTGTTTCCTTGAATACAAGCTCCTCCTCACCTTGCGAAAAGTGGCCTCTGAGTGTAGCCCTGAATGCATCTCCCAAGGAATA
GGAGGAAGCAGCAACCTTTTCAGAGTTAACTGCTTTATTTGGGTTTTCCATGGCCTCGTGCCAGCCAGCAGGGCTGAGCCAGTTTCACCC
ACACTGAGAGGGAACTCAGCAAAGAGCAAGCAGCATGCCAGCTGGTACTCTTCCCTCTCCATTCACTCAGCTCCTGATCTCAGGAGGGCA
GCCCCTCCCCAGGCCAGCACCCCTCCCCTTCTGGCCCCAGGTGTGGGATGTTGTTGTTTTCTTTTCTCCGAAACATCTCCTGGGTTTGTC
TTTTCCATCACTGTCTTTAGACTGAGGCAAGCAGTCCCCATGCCTTCAGCCCCATGTTTTGGGGGTAACCTGTGCTTTGACATGCTTTGC
TAAAAACTTTCTAAGTCTCCCTCTGGTGCTGGGACCAGCCATGACCAACAACGTCATCCATGCAGGCCACCCCTAACATAGTCCAGGCCT
CATGTGGGTCTCAGTTCCCTTTTCTTCTTTCAGGAAGTTCTCCAGTGCATGCATAGGGTTGACCAGATGTCCCAAGGTGCTCTAGGACTT
ATGCCTATGAAGCTGTTTTAGGGCTTCCTAGTCAGTCCCTGGTTCCAGGAAAGCAGCCTGATGAGGAGATCATTCCCGCTGGCTGGTGTG
GCATTTCTTTTATGGCACTACCTGGGATTGGGCCACCAGACCTGCGCTAACATGCTGATTTGATGGACTCTTAACATCATAGGACAAAGA


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FusionGenePPI for XPO5_KIF6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
XPO5PTP4A3, GSTK1, SERINC3, NEK6, PHLDA3, MAGEA6, EEF1A1, RAN, ILF3, NUP214, NUP153, UBC, MYC, ZNF346, SIRT7, MRTO4, UCHL5, NOTCH1, CA9, FN1, VCAM1, SMAD4, ITGA4, MMS19, CLN3, SOX2, EGFR, AARSD1, EFTUD2, ELAC2, HARS, P3H1, MAT2B, NRD1, NSUN2, PDIA6, PFDN5, PPP1R12A, SARS, SERPINE2, SHMT1, SNX5, TTC1, UGDH, ARIH1, BAG1, DUS3L, GTF2E1, PPP3CA, WDR4, CHORDC1, ITGB1BP2, MOV10, NXF1, CLEC12A, VSIG2, NUP98, PPME1, NTRK1, LCA5, HSPA5, RAB11A, KRBOX4, CDC5L, ZNF131, NCR3LG1, RALB, PVR, PTPRA, PTPRN, STOM, FOXA1KIF6APPBP2, HEATR5A, SNX16, FEZ2, MLLT10, ACADS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for XPO5_KIF6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for XPO5_KIF6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneXPO5C0920269Microsatellite Instability1CTD_human
HgeneXPO5C1868672NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE1CTD_human
TgeneKIF6C0027051Myocardial Infarction1CTD_human