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Fusion gene ID: 42180 |
FusionGeneSummary for XPO5_EYS |
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Fusion gene information | Fusion gene name: XPO5_EYS | Fusion gene ID: 42180 | Hgene | Tgene | Gene symbol | XPO5 | EYS | Gene ID | 57510 | 346007 |
Gene name | exportin 5 | eyes shut homolog (Drosophila) | |
Synonyms | exp5 | C6orf178|C6orf179|C6orf180|EGFL10|EGFL11|RP25|SPAM|bA166P24.2|bA307F22.3|bA74E24.1|dJ1018A4.2|dJ22I17.2|dJ303F19.1 | |
Cytomap | 6p21.1 | 6q12 | |
Type of gene | protein-coding | protein-coding | |
Description | exportin-5ran-binding protein 21 | protein eyes shut homologEGF-like-domain, multiple 10EGF-like-domain, multiple 11epidermal growth factor-like protein 10epidermal growth factor-like protein 11protein spacemaker homolog | |
Modification date | 20180527 | 20180519 | |
UniProtAcc | Q9HAV4 | Q5T1H1 | |
Ensembl transtripts involved in fusion gene | ENST00000265351, ENST00000424378, | ENST00000503581, ENST00000370621, ENST00000370616, ENST00000393380, ENST00000342421, ENST00000370618, ENST00000486069, | |
Fusion gene scores | * DoF score | 6 X 7 X 5=210 | 26 X 15 X 12=4680 |
# samples | 6 | 27 | |
** MAII score | log2(6/210*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(27/4680*10)=-4.11547721741994 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: XPO5 [Title/Abstract] AND EYS [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | XPO5 | GO:0006611 | protein export from nucleus | 11777942|24209753 |
Hgene | XPO5 | GO:0035281 | pre-miRNA export from nucleus | 15613540 |
Hgene | XPO5 | GO:1900370 | positive regulation of RNA interference | 15613540 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LIHC | TCGA-BC-A10T-01A | XPO5 | chr6 | 43514308 | - | EYS | chr6 | 64436573 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000265351 | ENST00000503581 | XPO5 | chr6 | 43514308 | - | EYS | chr6 | 64436573 | - |
Frame-shift | ENST00000265351 | ENST00000370621 | XPO5 | chr6 | 43514308 | - | EYS | chr6 | 64436573 | - |
Frame-shift | ENST00000265351 | ENST00000370616 | XPO5 | chr6 | 43514308 | - | EYS | chr6 | 64436573 | - |
5CDS-intron | ENST00000265351 | ENST00000393380 | XPO5 | chr6 | 43514308 | - | EYS | chr6 | 64436573 | - |
5CDS-intron | ENST00000265351 | ENST00000342421 | XPO5 | chr6 | 43514308 | - | EYS | chr6 | 64436573 | - |
5CDS-intron | ENST00000265351 | ENST00000370618 | XPO5 | chr6 | 43514308 | - | EYS | chr6 | 64436573 | - |
5CDS-intron | ENST00000265351 | ENST00000486069 | XPO5 | chr6 | 43514308 | - | EYS | chr6 | 64436573 | - |
intron-3CDS | ENST00000424378 | ENST00000503581 | XPO5 | chr6 | 43514308 | - | EYS | chr6 | 64436573 | - |
intron-3CDS | ENST00000424378 | ENST00000370621 | XPO5 | chr6 | 43514308 | - | EYS | chr6 | 64436573 | - |
intron-3CDS | ENST00000424378 | ENST00000370616 | XPO5 | chr6 | 43514308 | - | EYS | chr6 | 64436573 | - |
intron-intron | ENST00000424378 | ENST00000393380 | XPO5 | chr6 | 43514308 | - | EYS | chr6 | 64436573 | - |
intron-intron | ENST00000424378 | ENST00000342421 | XPO5 | chr6 | 43514308 | - | EYS | chr6 | 64436573 | - |
intron-intron | ENST00000424378 | ENST00000370618 | XPO5 | chr6 | 43514308 | - | EYS | chr6 | 64436573 | - |
intron-intron | ENST00000424378 | ENST00000486069 | XPO5 | chr6 | 43514308 | - | EYS | chr6 | 64436573 | - |
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FusionProtFeatures for XPO5_EYS |
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Hgene | Tgene |
XPO5 | EYS |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for XPO5_EYS |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for XPO5_EYS |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
XPO5 | PTP4A3, GSTK1, SERINC3, NEK6, PHLDA3, MAGEA6, EEF1A1, RAN, ILF3, NUP214, NUP153, UBC, MYC, ZNF346, SIRT7, MRTO4, UCHL5, NOTCH1, CA9, FN1, VCAM1, SMAD4, ITGA4, MMS19, CLN3, SOX2, EGFR, AARSD1, EFTUD2, ELAC2, HARS, P3H1, MAT2B, NRD1, NSUN2, PDIA6, PFDN5, PPP1R12A, SARS, SERPINE2, SHMT1, SNX5, TTC1, UGDH, ARIH1, BAG1, DUS3L, GTF2E1, PPP3CA, WDR4, CHORDC1, ITGB1BP2, MOV10, NXF1, CLEC12A, VSIG2, NUP98, PPME1, NTRK1, LCA5, HSPA5, RAB11A, KRBOX4, CDC5L, ZNF131, NCR3LG1, RALB, PVR, PTPRA, PTPRN, STOM, FOXA1 | EYS | EGFR |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for XPO5_EYS |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for XPO5_EYS |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | XPO5 | C0920269 | Microsatellite Instability | 1 | CTD_human |
Hgene | XPO5 | C1868672 | NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE | 1 | CTD_human |
Tgene | EYS | C1864446 | Retinitis Pigmentosa 25 | 2 | CTD_human;UNIPROT |
Tgene | EYS | C0035334 | Retinitis Pigmentosa | 1 | CTD_human;ORPHANET |