FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 42180

FusionGeneSummary for XPO5_EYS

check button Fusion gene summary
Fusion gene informationFusion gene name: XPO5_EYS
Fusion gene ID: 42180
HgeneTgene
Gene symbol

XPO5

EYS

Gene ID

57510

346007

Gene nameexportin 5eyes shut homolog (Drosophila)
Synonymsexp5C6orf178|C6orf179|C6orf180|EGFL10|EGFL11|RP25|SPAM|bA166P24.2|bA307F22.3|bA74E24.1|dJ1018A4.2|dJ22I17.2|dJ303F19.1
Cytomap

6p21.1

6q12

Type of geneprotein-codingprotein-coding
Descriptionexportin-5ran-binding protein 21protein eyes shut homologEGF-like-domain, multiple 10EGF-like-domain, multiple 11epidermal growth factor-like protein 10epidermal growth factor-like protein 11protein spacemaker homolog
Modification date2018052720180519
UniProtAcc

Q9HAV4

Q5T1H1

Ensembl transtripts involved in fusion geneENST00000265351, ENST00000424378, 
ENST00000503581, ENST00000370621, 
ENST00000370616, ENST00000393380, 
ENST00000342421, ENST00000370618, 
ENST00000486069, 
Fusion gene scores* DoF score6 X 7 X 5=21026 X 15 X 12=4680
# samples 627
** MAII scorelog2(6/210*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(27/4680*10)=-4.11547721741994
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: XPO5 [Title/Abstract] AND EYS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneXPO5

GO:0006611

protein export from nucleus

11777942|24209753

HgeneXPO5

GO:0035281

pre-miRNA export from nucleus

15613540

HgeneXPO5

GO:1900370

positive regulation of RNA interference

15613540


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-BC-A10T-01AXPO5chr6

43514308

-EYSchr6

64436573

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000265351ENST00000503581XPO5chr6

43514308

-EYSchr6

64436573

-
Frame-shiftENST00000265351ENST00000370621XPO5chr6

43514308

-EYSchr6

64436573

-
Frame-shiftENST00000265351ENST00000370616XPO5chr6

43514308

-EYSchr6

64436573

-
5CDS-intronENST00000265351ENST00000393380XPO5chr6

43514308

-EYSchr6

64436573

-
5CDS-intronENST00000265351ENST00000342421XPO5chr6

43514308

-EYSchr6

64436573

-
5CDS-intronENST00000265351ENST00000370618XPO5chr6

43514308

-EYSchr6

64436573

-
5CDS-intronENST00000265351ENST00000486069XPO5chr6

43514308

-EYSchr6

64436573

-
intron-3CDSENST00000424378ENST00000503581XPO5chr6

43514308

-EYSchr6

64436573

-
intron-3CDSENST00000424378ENST00000370621XPO5chr6

43514308

-EYSchr6

64436573

-
intron-3CDSENST00000424378ENST00000370616XPO5chr6

43514308

-EYSchr6

64436573

-
intron-intronENST00000424378ENST00000393380XPO5chr6

43514308

-EYSchr6

64436573

-
intron-intronENST00000424378ENST00000342421XPO5chr6

43514308

-EYSchr6

64436573

-
intron-intronENST00000424378ENST00000370618XPO5chr6

43514308

-EYSchr6

64436573

-
intron-intronENST00000424378ENST00000486069XPO5chr6

43514308

-EYSchr6

64436573

-

Top

FusionProtFeatures for XPO5_EYS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
XPO5

Q9HAV4

EYS

Q5T1H1


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for XPO5_EYS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for XPO5_EYS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
XPO5PTP4A3, GSTK1, SERINC3, NEK6, PHLDA3, MAGEA6, EEF1A1, RAN, ILF3, NUP214, NUP153, UBC, MYC, ZNF346, SIRT7, MRTO4, UCHL5, NOTCH1, CA9, FN1, VCAM1, SMAD4, ITGA4, MMS19, CLN3, SOX2, EGFR, AARSD1, EFTUD2, ELAC2, HARS, P3H1, MAT2B, NRD1, NSUN2, PDIA6, PFDN5, PPP1R12A, SARS, SERPINE2, SHMT1, SNX5, TTC1, UGDH, ARIH1, BAG1, DUS3L, GTF2E1, PPP3CA, WDR4, CHORDC1, ITGB1BP2, MOV10, NXF1, CLEC12A, VSIG2, NUP98, PPME1, NTRK1, LCA5, HSPA5, RAB11A, KRBOX4, CDC5L, ZNF131, NCR3LG1, RALB, PVR, PTPRA, PTPRN, STOM, FOXA1EYSEGFR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for XPO5_EYS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for XPO5_EYS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneXPO5C0920269Microsatellite Instability1CTD_human
HgeneXPO5C1868672NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE1CTD_human
TgeneEYSC1864446Retinitis Pigmentosa 252CTD_human;UNIPROT
TgeneEYSC0035334Retinitis Pigmentosa1CTD_human;ORPHANET