	FusionGeneSummary
	FusionProtFeature
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	FusionGenePPI
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Fusion gene ID: 42176

FusionGeneSummary for XPO1_XPO1

Fusion gene summary

Fusion gene information	Fusion gene name: XPO1_XPO1
	Fusion gene ID: 42176
		Hgene	Tgene
	Gene symbol	XPO1	XPO1
	Gene ID	7514	7514
	Gene name	exportin 1	exportin 1
	Synonyms	CRM1\|emb\|exp1	CRM1\|emb\|exp1
	Cytomap	2p15	2p15
	Type of gene	protein-coding	protein-coding
	Description	exportin-1chromosome region maintenance 1 homologchromosome region maintenance 1 protein homologexportin 1 (CRM1 homolog, yeast)exportin-1 (required for chromosome region maintenance)	exportin-1chromosome region maintenance 1 homologchromosome region maintenance 1 protein homologexportin 1 (CRM1 homolog, yeast)exportin-1 (required for chromosome region maintenance)
	Modification date	20180523	20180523
	UniProtAcc	O14980	O14980
	Ensembl transtripts involved in fusion gene	ENST00000401558, ENST00000404992, ENST00000406957, ENST00000481214,	ENST00000401558, ENST00000404992, ENST00000406957, ENST00000481214,
Fusion gene scores	* DoF score	4 X 7 X 3=84	2 X 5 X 1=10
	# samples	7	5
	** MAII score	log2(7/84*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/10*10)=2.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: XPO1 [Title/Abstract] AND XPO1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	XPO1	GO:0006611	protein export from nucleus	22250199
Tgene	XPO1	GO:0006611	protein export from nucleus	22250199

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AA559883	XPO1	chr2	61724028	-	XPO1	chr2	61722680	+
ChiTaRS3.1			BG259252	XPO1	chr2	61715746	+	XPO1	chr2	61715358	-
ChiTaRS3.1			BM462202	XPO1	chr2	61705298	+	XPO1	chr2	61705189	-
ChiTaRS3.1			DB198554	XPO1	chr2	61713792	-	XPO1	chr2	61716065	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000401558	ENST00000401558	XPO1	chr2	61724028	-	XPO1	chr2	61722680	+
intron-3CDS	ENST00000401558	ENST00000404992	XPO1	chr2	61724028	-	XPO1	chr2	61722680	+
intron-3CDS	ENST00000401558	ENST00000406957	XPO1	chr2	61724028	-	XPO1	chr2	61722680	+
intron-intron	ENST00000401558	ENST00000481214	XPO1	chr2	61724028	-	XPO1	chr2	61722680	+
intron-3CDS	ENST00000404992	ENST00000401558	XPO1	chr2	61724028	-	XPO1	chr2	61722680	+
intron-3CDS	ENST00000404992	ENST00000404992	XPO1	chr2	61724028	-	XPO1	chr2	61722680	+
intron-3CDS	ENST00000404992	ENST00000406957	XPO1	chr2	61724028	-	XPO1	chr2	61722680	+
intron-intron	ENST00000404992	ENST00000481214	XPO1	chr2	61724028	-	XPO1	chr2	61722680	+
intron-3CDS	ENST00000406957	ENST00000401558	XPO1	chr2	61724028	-	XPO1	chr2	61722680	+
intron-3CDS	ENST00000406957	ENST00000404992	XPO1	chr2	61724028	-	XPO1	chr2	61722680	+
intron-3CDS	ENST00000406957	ENST00000406957	XPO1	chr2	61724028	-	XPO1	chr2	61722680	+
intron-intron	ENST00000406957	ENST00000481214	XPO1	chr2	61724028	-	XPO1	chr2	61722680	+
intron-3CDS	ENST00000481214	ENST00000401558	XPO1	chr2	61724028	-	XPO1	chr2	61722680	+
intron-3CDS	ENST00000481214	ENST00000404992	XPO1	chr2	61724028	-	XPO1	chr2	61722680	+
intron-3CDS	ENST00000481214	ENST00000406957	XPO1	chr2	61724028	-	XPO1	chr2	61722680	+
intron-intron	ENST00000481214	ENST00000481214	XPO1	chr2	61724028	-	XPO1	chr2	61722680	+
intron-3CDS	ENST00000401558	ENST00000401558	XPO1	chr2	61715746	+	XPO1	chr2	61715358	-
intron-3CDS	ENST00000401558	ENST00000404992	XPO1	chr2	61715746	+	XPO1	chr2	61715358	-
intron-3CDS	ENST00000401558	ENST00000406957	XPO1	chr2	61715746	+	XPO1	chr2	61715358	-
intron-intron	ENST00000401558	ENST00000481214	XPO1	chr2	61715746	+	XPO1	chr2	61715358	-
intron-3CDS	ENST00000404992	ENST00000401558	XPO1	chr2	61715746	+	XPO1	chr2	61715358	-
intron-3CDS	ENST00000404992	ENST00000404992	XPO1	chr2	61715746	+	XPO1	chr2	61715358	-
intron-3CDS	ENST00000404992	ENST00000406957	XPO1	chr2	61715746	+	XPO1	chr2	61715358	-
intron-intron	ENST00000404992	ENST00000481214	XPO1	chr2	61715746	+	XPO1	chr2	61715358	-
intron-3CDS	ENST00000406957	ENST00000401558	XPO1	chr2	61715746	+	XPO1	chr2	61715358	-
intron-3CDS	ENST00000406957	ENST00000404992	XPO1	chr2	61715746	+	XPO1	chr2	61715358	-
intron-3CDS	ENST00000406957	ENST00000406957	XPO1	chr2	61715746	+	XPO1	chr2	61715358	-
intron-intron	ENST00000406957	ENST00000481214	XPO1	chr2	61715746	+	XPO1	chr2	61715358	-
intron-3CDS	ENST00000481214	ENST00000401558	XPO1	chr2	61715746	+	XPO1	chr2	61715358	-
intron-3CDS	ENST00000481214	ENST00000404992	XPO1	chr2	61715746	+	XPO1	chr2	61715358	-
intron-3CDS	ENST00000481214	ENST00000406957	XPO1	chr2	61715746	+	XPO1	chr2	61715358	-
intron-intron	ENST00000481214	ENST00000481214	XPO1	chr2	61715746	+	XPO1	chr2	61715358	-
intron-3UTR	ENST00000401558	ENST00000401558	XPO1	chr2	61705298	+	XPO1	chr2	61705189	-
intron-intron	ENST00000401558	ENST00000404992	XPO1	chr2	61705298	+	XPO1	chr2	61705189	-
intron-intron	ENST00000401558	ENST00000406957	XPO1	chr2	61705298	+	XPO1	chr2	61705189	-
intron-intron	ENST00000401558	ENST00000481214	XPO1	chr2	61705298	+	XPO1	chr2	61705189	-
intron-3UTR	ENST00000404992	ENST00000401558	XPO1	chr2	61705298	+	XPO1	chr2	61705189	-
intron-intron	ENST00000404992	ENST00000404992	XPO1	chr2	61705298	+	XPO1	chr2	61705189	-
intron-intron	ENST00000404992	ENST00000406957	XPO1	chr2	61705298	+	XPO1	chr2	61705189	-
intron-intron	ENST00000404992	ENST00000481214	XPO1	chr2	61705298	+	XPO1	chr2	61705189	-
intron-3UTR	ENST00000406957	ENST00000401558	XPO1	chr2	61705298	+	XPO1	chr2	61705189	-
intron-intron	ENST00000406957	ENST00000404992	XPO1	chr2	61705298	+	XPO1	chr2	61705189	-
intron-intron	ENST00000406957	ENST00000406957	XPO1	chr2	61705298	+	XPO1	chr2	61705189	-
intron-intron	ENST00000406957	ENST00000481214	XPO1	chr2	61705298	+	XPO1	chr2	61705189	-
intron-3UTR	ENST00000481214	ENST00000401558	XPO1	chr2	61705298	+	XPO1	chr2	61705189	-
intron-intron	ENST00000481214	ENST00000404992	XPO1	chr2	61705298	+	XPO1	chr2	61705189	-
intron-intron	ENST00000481214	ENST00000406957	XPO1	chr2	61705298	+	XPO1	chr2	61705189	-
intron-intron	ENST00000481214	ENST00000481214	XPO1	chr2	61705298	+	XPO1	chr2	61705189	-
intron-intron	ENST00000401558	ENST00000401558	XPO1	chr2	61713792	-	XPO1	chr2	61716065	-
intron-intron	ENST00000401558	ENST00000404992	XPO1	chr2	61713792	-	XPO1	chr2	61716065	-
intron-intron	ENST00000401558	ENST00000406957	XPO1	chr2	61713792	-	XPO1	chr2	61716065	-
intron-intron	ENST00000401558	ENST00000481214	XPO1	chr2	61713792	-	XPO1	chr2	61716065	-
intron-intron	ENST00000404992	ENST00000401558	XPO1	chr2	61713792	-	XPO1	chr2	61716065	-
intron-intron	ENST00000404992	ENST00000404992	XPO1	chr2	61713792	-	XPO1	chr2	61716065	-
intron-intron	ENST00000404992	ENST00000406957	XPO1	chr2	61713792	-	XPO1	chr2	61716065	-
intron-intron	ENST00000404992	ENST00000481214	XPO1	chr2	61713792	-	XPO1	chr2	61716065	-
intron-intron	ENST00000406957	ENST00000401558	XPO1	chr2	61713792	-	XPO1	chr2	61716065	-
intron-intron	ENST00000406957	ENST00000404992	XPO1	chr2	61713792	-	XPO1	chr2	61716065	-
intron-intron	ENST00000406957	ENST00000406957	XPO1	chr2	61713792	-	XPO1	chr2	61716065	-
intron-intron	ENST00000406957	ENST00000481214	XPO1	chr2	61713792	-	XPO1	chr2	61716065	-
intron-intron	ENST00000481214	ENST00000401558	XPO1	chr2	61713792	-	XPO1	chr2	61716065	-
intron-intron	ENST00000481214	ENST00000404992	XPO1	chr2	61713792	-	XPO1	chr2	61716065	-
intron-intron	ENST00000481214	ENST00000406957	XPO1	chr2	61713792	-	XPO1	chr2	61716065	-
intron-intron	ENST00000481214	ENST00000481214	XPO1	chr2	61713792	-	XPO1	chr2	61716065	-

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FusionProtFeatures for XPO1_XPO1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
XPO1 O14980	XPO1 O14980
Mediates the nuclear export of cellular proteins(cargos) bearing a leucine-rich nuclear export signal (NES) and ofRNAs. In the nucleus, in association with RANBP3, bindscooperatively to the NES on its target protein and to the GTPaseRAN in its active GTP-bound form (Ran-GTP). Docking of thiscomplex to the nuclear pore complex (NPC) is mediated throughbinding to nucleoporins. Upon transit of a nuclear export complexinto the cytoplasm, disassembling of the complex and hydrolysis ofRan-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively)cause release of the cargo from the export receptor. Thedirectionality of nuclear export is thought to be conferred by anasymmetric distribution of the GTP- and GDP-bound forms of Ranbetween the cytoplasm and nucleus. Involved in U3 snoRNA transportfrom Cajal bodies to nucleoli. Binds to late precursor U3 snoRNAbearing a TMG cap. {ECO:0000269\|PubMed:15574332,ECO:0000269\|PubMed:20921223, ECO:0000269\|PubMed:9311922,ECO:0000269\|PubMed:9323133}. (Microbial infection) Mediates the export of unsplicedor incompletely spliced RNAs out of the nucleus from differentviruses including HIV-1, HTLV-1 and influenza A. Interacts with,and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rexproteins. Involved in HTLV-1 Rex multimerization.{ECO:0000269\|PubMed:14612415, ECO:0000269\|PubMed:9837918}.	Mediates the nuclear export of cellular proteins(cargos) bearing a leucine-rich nuclear export signal (NES) and ofRNAs. In the nucleus, in association with RANBP3, bindscooperatively to the NES on its target protein and to the GTPaseRAN in its active GTP-bound form (Ran-GTP). Docking of thiscomplex to the nuclear pore complex (NPC) is mediated throughbinding to nucleoporins. Upon transit of a nuclear export complexinto the cytoplasm, disassembling of the complex and hydrolysis ofRan-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively)cause release of the cargo from the export receptor. Thedirectionality of nuclear export is thought to be conferred by anasymmetric distribution of the GTP- and GDP-bound forms of Ranbetween the cytoplasm and nucleus. Involved in U3 snoRNA transportfrom Cajal bodies to nucleoli. Binds to late precursor U3 snoRNAbearing a TMG cap. {ECO:0000269\|PubMed:15574332,ECO:0000269\|PubMed:20921223, ECO:0000269\|PubMed:9311922,ECO:0000269\|PubMed:9323133}. (Microbial infection) Mediates the export of unsplicedor incompletely spliced RNAs out of the nucleus from differentviruses including HIV-1, HTLV-1 and influenza A. Interacts with,and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rexproteins. Involved in HTLV-1 Rex multimerization.{ECO:0000269\|PubMed:14612415, ECO:0000269\|PubMed:9837918}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for XPO1_XPO1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for XPO1_XPO1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for XPO1_XPO1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for XPO1_XPO1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 42176

FusionGeneSummary for XPO1_XPO1

FusionProtFeatures for XPO1_XPO1

FusionGeneSequence for XPO1_XPO1

FusionGenePPI for XPO1_XPO1

RelatedDrugs for XPO1_XPO1

RelatedDiseases for XPO1_XPO1