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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42176

FusionGeneSummary for XPO1_XPO1

check button Fusion gene summary
Fusion gene informationFusion gene name: XPO1_XPO1
Fusion gene ID: 42176
HgeneTgene
Gene symbol

XPO1

XPO1

Gene ID

7514

7514

Gene nameexportin 1exportin 1
SynonymsCRM1|emb|exp1CRM1|emb|exp1
Cytomap

2p15

2p15

Type of geneprotein-codingprotein-coding
Descriptionexportin-1chromosome region maintenance 1 homologchromosome region maintenance 1 protein homologexportin 1 (CRM1 homolog, yeast)exportin-1 (required for chromosome region maintenance)exportin-1chromosome region maintenance 1 homologchromosome region maintenance 1 protein homologexportin 1 (CRM1 homolog, yeast)exportin-1 (required for chromosome region maintenance)
Modification date2018052320180523
UniProtAcc

O14980

O14980

Ensembl transtripts involved in fusion geneENST00000401558, ENST00000404992, 
ENST00000406957, ENST00000481214, 
ENST00000401558, ENST00000404992, 
ENST00000406957, ENST00000481214, 
Fusion gene scores* DoF score4 X 7 X 3=842 X 5 X 1=10
# samples 75
** MAII scorelog2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/10*10)=2.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: XPO1 [Title/Abstract] AND XPO1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneXPO1

GO:0006611

protein export from nucleus

22250199

TgeneXPO1

GO:0006611

protein export from nucleus

22250199


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA559883XPO1chr2

61724028

-XPO1chr2

61722680

+
ChiTaRS3.1BG259252XPO1chr2

61715746

+XPO1chr2

61715358

-
ChiTaRS3.1BM462202XPO1chr2

61705298

+XPO1chr2

61705189

-
ChiTaRS3.1DB198554XPO1chr2

61713792

-XPO1chr2

61716065

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000401558ENST00000401558XPO1chr2

61724028

-XPO1chr2

61722680

+
intron-3CDSENST00000401558ENST00000404992XPO1chr2

61724028

-XPO1chr2

61722680

+
intron-3CDSENST00000401558ENST00000406957XPO1chr2

61724028

-XPO1chr2

61722680

+
intron-intronENST00000401558ENST00000481214XPO1chr2

61724028

-XPO1chr2

61722680

+
intron-3CDSENST00000404992ENST00000401558XPO1chr2

61724028

-XPO1chr2

61722680

+
intron-3CDSENST00000404992ENST00000404992XPO1chr2

61724028

-XPO1chr2

61722680

+
intron-3CDSENST00000404992ENST00000406957XPO1chr2

61724028

-XPO1chr2

61722680

+
intron-intronENST00000404992ENST00000481214XPO1chr2

61724028

-XPO1chr2

61722680

+
intron-3CDSENST00000406957ENST00000401558XPO1chr2

61724028

-XPO1chr2

61722680

+
intron-3CDSENST00000406957ENST00000404992XPO1chr2

61724028

-XPO1chr2

61722680

+
intron-3CDSENST00000406957ENST00000406957XPO1chr2

61724028

-XPO1chr2

61722680

+
intron-intronENST00000406957ENST00000481214XPO1chr2

61724028

-XPO1chr2

61722680

+
intron-3CDSENST00000481214ENST00000401558XPO1chr2

61724028

-XPO1chr2

61722680

+
intron-3CDSENST00000481214ENST00000404992XPO1chr2

61724028

-XPO1chr2

61722680

+
intron-3CDSENST00000481214ENST00000406957XPO1chr2

61724028

-XPO1chr2

61722680

+
intron-intronENST00000481214ENST00000481214XPO1chr2

61724028

-XPO1chr2

61722680

+
intron-3CDSENST00000401558ENST00000401558XPO1chr2

61715746

+XPO1chr2

61715358

-
intron-3CDSENST00000401558ENST00000404992XPO1chr2

61715746

+XPO1chr2

61715358

-
intron-3CDSENST00000401558ENST00000406957XPO1chr2

61715746

+XPO1chr2

61715358

-
intron-intronENST00000401558ENST00000481214XPO1chr2

61715746

+XPO1chr2

61715358

-
intron-3CDSENST00000404992ENST00000401558XPO1chr2

61715746

+XPO1chr2

61715358

-
intron-3CDSENST00000404992ENST00000404992XPO1chr2

61715746

+XPO1chr2

61715358

-
intron-3CDSENST00000404992ENST00000406957XPO1chr2

61715746

+XPO1chr2

61715358

-
intron-intronENST00000404992ENST00000481214XPO1chr2

61715746

+XPO1chr2

61715358

-
intron-3CDSENST00000406957ENST00000401558XPO1chr2

61715746

+XPO1chr2

61715358

-
intron-3CDSENST00000406957ENST00000404992XPO1chr2

61715746

+XPO1chr2

61715358

-
intron-3CDSENST00000406957ENST00000406957XPO1chr2

61715746

+XPO1chr2

61715358

-
intron-intronENST00000406957ENST00000481214XPO1chr2

61715746

+XPO1chr2

61715358

-
intron-3CDSENST00000481214ENST00000401558XPO1chr2

61715746

+XPO1chr2

61715358

-
intron-3CDSENST00000481214ENST00000404992XPO1chr2

61715746

+XPO1chr2

61715358

-
intron-3CDSENST00000481214ENST00000406957XPO1chr2

61715746

+XPO1chr2

61715358

-
intron-intronENST00000481214ENST00000481214XPO1chr2

61715746

+XPO1chr2

61715358

-
intron-3UTRENST00000401558ENST00000401558XPO1chr2

61705298

+XPO1chr2

61705189

-
intron-intronENST00000401558ENST00000404992XPO1chr2

61705298

+XPO1chr2

61705189

-
intron-intronENST00000401558ENST00000406957XPO1chr2

61705298

+XPO1chr2

61705189

-
intron-intronENST00000401558ENST00000481214XPO1chr2

61705298

+XPO1chr2

61705189

-
intron-3UTRENST00000404992ENST00000401558XPO1chr2

61705298

+XPO1chr2

61705189

-
intron-intronENST00000404992ENST00000404992XPO1chr2

61705298

+XPO1chr2

61705189

-
intron-intronENST00000404992ENST00000406957XPO1chr2

61705298

+XPO1chr2

61705189

-
intron-intronENST00000404992ENST00000481214XPO1chr2

61705298

+XPO1chr2

61705189

-
intron-3UTRENST00000406957ENST00000401558XPO1chr2

61705298

+XPO1chr2

61705189

-
intron-intronENST00000406957ENST00000404992XPO1chr2

61705298

+XPO1chr2

61705189

-
intron-intronENST00000406957ENST00000406957XPO1chr2

61705298

+XPO1chr2

61705189

-
intron-intronENST00000406957ENST00000481214XPO1chr2

61705298

+XPO1chr2

61705189

-
intron-3UTRENST00000481214ENST00000401558XPO1chr2

61705298

+XPO1chr2

61705189

-
intron-intronENST00000481214ENST00000404992XPO1chr2

61705298

+XPO1chr2

61705189

-
intron-intronENST00000481214ENST00000406957XPO1chr2

61705298

+XPO1chr2

61705189

-
intron-intronENST00000481214ENST00000481214XPO1chr2

61705298

+XPO1chr2

61705189

-
intron-intronENST00000401558ENST00000401558XPO1chr2

61713792

-XPO1chr2

61716065

-
intron-intronENST00000401558ENST00000404992XPO1chr2

61713792

-XPO1chr2

61716065

-
intron-intronENST00000401558ENST00000406957XPO1chr2

61713792

-XPO1chr2

61716065

-
intron-intronENST00000401558ENST00000481214XPO1chr2

61713792

-XPO1chr2

61716065

-
intron-intronENST00000404992ENST00000401558XPO1chr2

61713792

-XPO1chr2

61716065

-
intron-intronENST00000404992ENST00000404992XPO1chr2

61713792

-XPO1chr2

61716065

-
intron-intronENST00000404992ENST00000406957XPO1chr2

61713792

-XPO1chr2

61716065

-
intron-intronENST00000404992ENST00000481214XPO1chr2

61713792

-XPO1chr2

61716065

-
intron-intronENST00000406957ENST00000401558XPO1chr2

61713792

-XPO1chr2

61716065

-
intron-intronENST00000406957ENST00000404992XPO1chr2

61713792

-XPO1chr2

61716065

-
intron-intronENST00000406957ENST00000406957XPO1chr2

61713792

-XPO1chr2

61716065

-
intron-intronENST00000406957ENST00000481214XPO1chr2

61713792

-XPO1chr2

61716065

-
intron-intronENST00000481214ENST00000401558XPO1chr2

61713792

-XPO1chr2

61716065

-
intron-intronENST00000481214ENST00000404992XPO1chr2

61713792

-XPO1chr2

61716065

-
intron-intronENST00000481214ENST00000406957XPO1chr2

61713792

-XPO1chr2

61716065

-
intron-intronENST00000481214ENST00000481214XPO1chr2

61713792

-XPO1chr2

61716065

-

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FusionProtFeatures for XPO1_XPO1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
XPO1

O14980

XPO1

O14980

Mediates the nuclear export of cellular proteins(cargos) bearing a leucine-rich nuclear export signal (NES) and ofRNAs. In the nucleus, in association with RANBP3, bindscooperatively to the NES on its target protein and to the GTPaseRAN in its active GTP-bound form (Ran-GTP). Docking of thiscomplex to the nuclear pore complex (NPC) is mediated throughbinding to nucleoporins. Upon transit of a nuclear export complexinto the cytoplasm, disassembling of the complex and hydrolysis ofRan-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively)cause release of the cargo from the export receptor. Thedirectionality of nuclear export is thought to be conferred by anasymmetric distribution of the GTP- and GDP-bound forms of Ranbetween the cytoplasm and nucleus. Involved in U3 snoRNA transportfrom Cajal bodies to nucleoli. Binds to late precursor U3 snoRNAbearing a TMG cap. {ECO:0000269|PubMed:15574332,ECO:0000269|PubMed:20921223, ECO:0000269|PubMed:9311922,ECO:0000269|PubMed:9323133}. (Microbial infection) Mediates the export of unsplicedor incompletely spliced RNAs out of the nucleus from differentviruses including HIV-1, HTLV-1 and influenza A. Interacts with,and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rexproteins. Involved in HTLV-1 Rex multimerization.{ECO:0000269|PubMed:14612415, ECO:0000269|PubMed:9837918}. Mediates the nuclear export of cellular proteins(cargos) bearing a leucine-rich nuclear export signal (NES) and ofRNAs. In the nucleus, in association with RANBP3, bindscooperatively to the NES on its target protein and to the GTPaseRAN in its active GTP-bound form (Ran-GTP). Docking of thiscomplex to the nuclear pore complex (NPC) is mediated throughbinding to nucleoporins. Upon transit of a nuclear export complexinto the cytoplasm, disassembling of the complex and hydrolysis ofRan-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively)cause release of the cargo from the export receptor. Thedirectionality of nuclear export is thought to be conferred by anasymmetric distribution of the GTP- and GDP-bound forms of Ranbetween the cytoplasm and nucleus. Involved in U3 snoRNA transportfrom Cajal bodies to nucleoli. Binds to late precursor U3 snoRNAbearing a TMG cap. {ECO:0000269|PubMed:15574332,ECO:0000269|PubMed:20921223, ECO:0000269|PubMed:9311922,ECO:0000269|PubMed:9323133}. (Microbial infection) Mediates the export of unsplicedor incompletely spliced RNAs out of the nucleus from differentviruses including HIV-1, HTLV-1 and influenza A. Interacts with,and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rexproteins. Involved in HTLV-1 Rex multimerization.{ECO:0000269|PubMed:14612415, ECO:0000269|PubMed:9837918}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for XPO1_XPO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for XPO1_XPO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for XPO1_XPO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for XPO1_XPO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource