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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42138

FusionGeneSummary for WWTR1_ESRRG

check button Fusion gene summary
Fusion gene informationFusion gene name: WWTR1_ESRRG
Fusion gene ID: 42138
HgeneTgene
Gene symbol

WWTR1

ESRRG

Gene ID

25937

2104

Gene nameWW domain containing transcription regulator 1estrogen related receptor gamma
SynonymsTAZERR-gamma|ERR3|ERRg|ERRgamma|NR3B3
Cytomap

3q25.1

1q41

Type of geneprotein-codingprotein-coding
DescriptionWW domain-containing transcription regulator protein 1transcriptional co-activator with PDZ-binding motifestrogen-related receptor gammaERR gamma-2estrogen receptor-related protein 3nuclear receptor subfamily 3 group B member 3
Modification date2018052220180519
UniProtAcc

Q9GZV5

P62508

Ensembl transtripts involved in fusion geneENST00000465804, ENST00000360632, 
ENST00000467467, ENST00000474080, 
ENST00000361525, ENST00000366940, 
ENST00000361395, ENST00000366938, 
ENST00000359162, ENST00000493603, 
ENST00000463665, ENST00000487276, 
ENST00000493748, ENST00000471371, 
ENST00000391890, ENST00000366937, 
ENST00000408911, ENST00000360012, 
Fusion gene scores* DoF score5 X 3 X 5=755 X 4 X 4=80
# samples 55
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WWTR1 [Title/Abstract] AND ESRRG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWWTR1

GO:0008284

positive regulation of cell proliferation

18227151

HgeneWWTR1

GO:0010718

positive regulation of epithelial to mesenchymal transition

18227151

HgeneWWTR1

GO:0017145

stem cell division

18568018

HgeneWWTR1

GO:0035329

hippo signaling

18227151|20412773

HgeneWWTR1

GO:0060390

regulation of SMAD protein signal transduction

18568018

TgeneESRRG

GO:0006355

regulation of transcription, DNA-templated

23836911


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-WE-AAA4-06AWWTR1chr3

149290651

-ESRRGchr1

216741440

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000465804ENST00000361525WWTR1chr3

149290651

-ESRRGchr1

216741440

-
Frame-shiftENST00000465804ENST00000366940WWTR1chr3

149290651

-ESRRGchr1

216741440

-
Frame-shiftENST00000465804ENST00000361395WWTR1chr3

149290651

-ESRRGchr1

216741440

-
Frame-shiftENST00000465804ENST00000366938WWTR1chr3

149290651

-ESRRGchr1

216741440

-
Frame-shiftENST00000465804ENST00000359162WWTR1chr3

149290651

-ESRRGchr1

216741440

-
Frame-shiftENST00000465804ENST00000493603WWTR1chr3

149290651

-ESRRGchr1

216741440

-
Frame-shiftENST00000465804ENST00000463665WWTR1chr3

149290651

-ESRRGchr1

216741440

-
Frame-shiftENST00000465804ENST00000487276WWTR1chr3

149290651

-ESRRGchr1

216741440

-
Frame-shiftENST00000465804ENST00000493748WWTR1chr3

149290651

-ESRRGchr1

216741440

-
5CDS-intronENST00000465804ENST00000471371WWTR1chr3

149290651

-ESRRGchr1

216741440

-
5CDS-intronENST00000465804ENST00000391890WWTR1chr3

149290651

-ESRRGchr1

216741440

-
5CDS-intronENST00000465804ENST00000366937WWTR1chr3

149290651

-ESRRGchr1

216741440

-
5CDS-intronENST00000465804ENST00000408911WWTR1chr3

149290651

-ESRRGchr1

216741440

-
5CDS-intronENST00000465804ENST00000360012WWTR1chr3

149290651

-ESRRGchr1

216741440

-
Frame-shiftENST00000360632ENST00000361525WWTR1chr3

149290651

-ESRRGchr1

216741440

-
Frame-shiftENST00000360632ENST00000366940WWTR1chr3

149290651

-ESRRGchr1

216741440

-
Frame-shiftENST00000360632ENST00000361395WWTR1chr3

149290651

-ESRRGchr1

216741440

-
Frame-shiftENST00000360632ENST00000366938WWTR1chr3

149290651

-ESRRGchr1

216741440

-
Frame-shiftENST00000360632ENST00000359162WWTR1chr3

149290651

-ESRRGchr1

216741440

-
Frame-shiftENST00000360632ENST00000493603WWTR1chr3

149290651

-ESRRGchr1

216741440

-
Frame-shiftENST00000360632ENST00000463665WWTR1chr3

149290651

-ESRRGchr1

216741440

-
Frame-shiftENST00000360632ENST00000487276WWTR1chr3

149290651

-ESRRGchr1

216741440

-
Frame-shiftENST00000360632ENST00000493748WWTR1chr3

149290651

-ESRRGchr1

216741440

-
5CDS-intronENST00000360632ENST00000471371WWTR1chr3

149290651

-ESRRGchr1

216741440

-
5CDS-intronENST00000360632ENST00000391890WWTR1chr3

149290651

-ESRRGchr1

216741440

-
5CDS-intronENST00000360632ENST00000366937WWTR1chr3

149290651

-ESRRGchr1

216741440

-
5CDS-intronENST00000360632ENST00000408911WWTR1chr3

149290651

-ESRRGchr1

216741440

-
5CDS-intronENST00000360632ENST00000360012WWTR1chr3

149290651

-ESRRGchr1

216741440

-
Frame-shiftENST00000467467ENST00000361525WWTR1chr3

149290651

-ESRRGchr1

216741440

-
Frame-shiftENST00000467467ENST00000366940WWTR1chr3

149290651

-ESRRGchr1

216741440

-
Frame-shiftENST00000467467ENST00000361395WWTR1chr3

149290651

-ESRRGchr1

216741440

-
Frame-shiftENST00000467467ENST00000366938WWTR1chr3

149290651

-ESRRGchr1

216741440

-
Frame-shiftENST00000467467ENST00000359162WWTR1chr3

149290651

-ESRRGchr1

216741440

-
Frame-shiftENST00000467467ENST00000493603WWTR1chr3

149290651

-ESRRGchr1

216741440

-
Frame-shiftENST00000467467ENST00000463665WWTR1chr3

149290651

-ESRRGchr1

216741440

-
Frame-shiftENST00000467467ENST00000487276WWTR1chr3

149290651

-ESRRGchr1

216741440

-
Frame-shiftENST00000467467ENST00000493748WWTR1chr3

149290651

-ESRRGchr1

216741440

-
5CDS-intronENST00000467467ENST00000471371WWTR1chr3

149290651

-ESRRGchr1

216741440

-
5CDS-intronENST00000467467ENST00000391890WWTR1chr3

149290651

-ESRRGchr1

216741440

-
5CDS-intronENST00000467467ENST00000366937WWTR1chr3

149290651

-ESRRGchr1

216741440

-
5CDS-intronENST00000467467ENST00000408911WWTR1chr3

149290651

-ESRRGchr1

216741440

-
5CDS-intronENST00000467467ENST00000360012WWTR1chr3

149290651

-ESRRGchr1

216741440

-
intron-3CDSENST00000474080ENST00000361525WWTR1chr3

149290651

-ESRRGchr1

216741440

-
intron-3CDSENST00000474080ENST00000366940WWTR1chr3

149290651

-ESRRGchr1

216741440

-
intron-3CDSENST00000474080ENST00000361395WWTR1chr3

149290651

-ESRRGchr1

216741440

-
intron-3CDSENST00000474080ENST00000366938WWTR1chr3

149290651

-ESRRGchr1

216741440

-
intron-3CDSENST00000474080ENST00000359162WWTR1chr3

149290651

-ESRRGchr1

216741440

-
intron-3CDSENST00000474080ENST00000493603WWTR1chr3

149290651

-ESRRGchr1

216741440

-
intron-3CDSENST00000474080ENST00000463665WWTR1chr3

149290651

-ESRRGchr1

216741440

-
intron-3CDSENST00000474080ENST00000487276WWTR1chr3

149290651

-ESRRGchr1

216741440

-
intron-3CDSENST00000474080ENST00000493748WWTR1chr3

149290651

-ESRRGchr1

216741440

-
intron-intronENST00000474080ENST00000471371WWTR1chr3

149290651

-ESRRGchr1

216741440

-
intron-intronENST00000474080ENST00000391890WWTR1chr3

149290651

-ESRRGchr1

216741440

-
intron-intronENST00000474080ENST00000366937WWTR1chr3

149290651

-ESRRGchr1

216741440

-
intron-intronENST00000474080ENST00000408911WWTR1chr3

149290651

-ESRRGchr1

216741440

-
intron-intronENST00000474080ENST00000360012WWTR1chr3

149290651

-ESRRGchr1

216741440

-

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FusionProtFeatures for WWTR1_ESRRG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WWTR1

Q9GZV5

ESRRG

P62508

Transcriptional coactivator which acts as a downstreamregulatory target in the Hippo signaling pathway that plays apivotal role in organ size control and tumor suppression byrestricting proliferation and promoting apoptosis. The core ofthis pathway is composed of a kinase cascade wherein STK3/MST2 andSTK4/MST1, in complex with its regulatory protein SAV1,phosphorylates and activates LATS1/2 in complex with itsregulatory protein MOB1, which in turn phosphorylates andinactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8and NKX2-1/TTF1-dependent gene activation. Regulates the nuclearaccumulation of SMADS and has a key role in coupling them to thetranscriptional machinery such as the mediator complex. Regulatesembryonic stem-cell self-renewal, promotes cell proliferation andepithelial-mesenchymal transition. {ECO:0000269|PubMed:11118213,ECO:0000269|PubMed:18227151, ECO:0000269|PubMed:18568018,ECO:0000269|PubMed:19010321}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WWTR1_ESRRG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WWTR1_ESRRG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WWTR1TEAD4, TEAD3, SLC9A3R2, YWHAE, YWHAZ, YWHAG, KLF5, PPP1CA, TP53BP2, BTRC, YWHAQ, LATS1, NOTCH1, MED28, DVL1, DVL2, DVL3, HIF1A, AMOTL1, AMOT, TEAD1, FBXW11, TEAD2, LATS2, WBP2, TRIM25ESRRGESRRG, NCOA1, HGS, ESRRA, NRIP1, SP1, PPARGC1A, NR0B2, PARK2, NR0B1, DUT, PROX1, EBP, PNRC1, PNRC2, ARHGEF15, TLE1, APP, SRA1, SRPK1, KIFC3, MEOX2, NUP160, KIAA1598, CCDC67, SUMO1P1, PSMC5, DNMT3L


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WWTR1_ESRRG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneESRRGP62508DB00675TamoxifenEstrogen-related receptor gammasmall moleculeapproved
TgeneESRRGP62508DB02659Cholic AcidEstrogen-related receptor gammasmall moleculeapproved
TgeneESRRGP62508DB00255DiethylstilbestrolEstrogen-related receptor gammasmall moleculeapproved|investigational
TgeneESRRGP62508DB00783EstradiolEstrogen-related receptor gammasmall moleculeapproved|investigational|vet_approved

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RelatedDiseases for WWTR1_ESRRG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneWWTR1C0026846Muscular Atrophy1CTD_human