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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 42113

FusionGeneSummary for WWOX_NUDT7

check button Fusion gene summary
Fusion gene informationFusion gene name: WWOX_NUDT7
Fusion gene ID: 42113
HgeneTgene
Gene symbol

WWOX

NUDT7

Gene ID

51741

283927

Gene nameWW domain containing oxidoreductasenudix hydrolase 7
SynonymsD16S432E|EIEE28|FOR|FRA16D|HHCMA56|PRO0128|SCAR12|SDR41C1|WOX1-
Cytomap

16q23.1-q23.2

16q23.1

Type of geneprotein-codingprotein-coding
DescriptionWW domain-containing oxidoreductaseWW domain-containing protein WWOXfragile site FRA16D oxidoreductaseshort chain dehydrogenase/reductase family 41C member 1peroxisomal coenzyme A diphosphatase NUDT7nudix (nucleoside diphosphate linked moiety X)-type motif 7
Modification date2018052320180522
UniProtAcc

Q9NZC7

P0C024

Ensembl transtripts involved in fusion geneENST00000566780, ENST00000406884, 
ENST00000539474, ENST00000402655, 
ENST00000408984, ENST00000355860, 
ENST00000565791, ENST00000569818, 
ENST00000564085, ENST00000268533, 
ENST00000568787, ENST00000437314, 
ENST00000563839, ENST00000564031, 
Fusion gene scores* DoF score9 X 10 X 7=6301 X 1 X 2=2
# samples 142
** MAII scorelog2(14/630*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/2*10)=3.32192809488736
Context

PubMed: WWOX [Title/Abstract] AND NUDT7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWWOX

GO:0030178

negative regulation of Wnt signaling pathway

19465938

HgeneWWOX

GO:0071560

cellular response to transforming growth factor beta stimulus

19366691


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-H4-A2HQ-01AWWOXchr16

78458952

+NUDT7chr16

77775479

+
TCGALDOVTCGA-24-1842-01AWWOXchr16

78149051

+NUDT7chr16

77775479

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000566780ENST00000564085WWOXchr16

78458952

+NUDT7chr16

77775479

+
In-frameENST00000566780ENST00000268533WWOXchr16

78458952

+NUDT7chr16

77775479

+
5CDS-intronENST00000566780ENST00000568787WWOXchr16

78458952

+NUDT7chr16

77775479

+
5CDS-intronENST00000566780ENST00000437314WWOXchr16

78458952

+NUDT7chr16

77775479

+
5CDS-intronENST00000566780ENST00000563839WWOXchr16

78458952

+NUDT7chr16

77775479

+
5CDS-3UTRENST00000566780ENST00000564031WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3CDSENST00000406884ENST00000564085WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3CDSENST00000406884ENST00000268533WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000406884ENST00000568787WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000406884ENST00000437314WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000406884ENST00000563839WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3UTRENST00000406884ENST00000564031WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3CDSENST00000539474ENST00000564085WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3CDSENST00000539474ENST00000268533WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000539474ENST00000568787WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000539474ENST00000437314WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000539474ENST00000563839WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3UTRENST00000539474ENST00000564031WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3CDSENST00000402655ENST00000564085WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3CDSENST00000402655ENST00000268533WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000402655ENST00000568787WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000402655ENST00000437314WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000402655ENST00000563839WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3UTRENST00000402655ENST00000564031WWOXchr16

78458952

+NUDT7chr16

77775479

+
Frame-shiftENST00000408984ENST00000564085WWOXchr16

78458952

+NUDT7chr16

77775479

+
In-frameENST00000408984ENST00000268533WWOXchr16

78458952

+NUDT7chr16

77775479

+
5CDS-intronENST00000408984ENST00000568787WWOXchr16

78458952

+NUDT7chr16

77775479

+
5CDS-intronENST00000408984ENST00000437314WWOXchr16

78458952

+NUDT7chr16

77775479

+
5CDS-intronENST00000408984ENST00000563839WWOXchr16

78458952

+NUDT7chr16

77775479

+
5CDS-3UTRENST00000408984ENST00000564031WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3CDSENST00000355860ENST00000564085WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3CDSENST00000355860ENST00000268533WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000355860ENST00000568787WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000355860ENST00000437314WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000355860ENST00000563839WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3UTRENST00000355860ENST00000564031WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3CDSENST00000565791ENST00000564085WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3CDSENST00000565791ENST00000268533WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000565791ENST00000568787WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000565791ENST00000437314WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000565791ENST00000563839WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3UTRENST00000565791ENST00000564031WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3CDSENST00000569818ENST00000564085WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3CDSENST00000569818ENST00000268533WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000569818ENST00000568787WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000569818ENST00000437314WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000569818ENST00000563839WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3UTRENST00000569818ENST00000564031WWOXchr16

78458952

+NUDT7chr16

77775479

+
In-frameENST00000566780ENST00000564085WWOXchr16

78149051

+NUDT7chr16

77775479

+
Frame-shiftENST00000566780ENST00000268533WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000566780ENST00000568787WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000566780ENST00000437314WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000566780ENST00000563839WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-3UTRENST00000566780ENST00000564031WWOXchr16

78149051

+NUDT7chr16

77775479

+
In-frameENST00000406884ENST00000564085WWOXchr16

78149051

+NUDT7chr16

77775479

+
Frame-shiftENST00000406884ENST00000268533WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000406884ENST00000568787WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000406884ENST00000437314WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000406884ENST00000563839WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-3UTRENST00000406884ENST00000564031WWOXchr16

78149051

+NUDT7chr16

77775479

+
In-frameENST00000539474ENST00000564085WWOXchr16

78149051

+NUDT7chr16

77775479

+
Frame-shiftENST00000539474ENST00000268533WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000539474ENST00000568787WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000539474ENST00000437314WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000539474ENST00000563839WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-3UTRENST00000539474ENST00000564031WWOXchr16

78149051

+NUDT7chr16

77775479

+
In-frameENST00000402655ENST00000564085WWOXchr16

78149051

+NUDT7chr16

77775479

+
Frame-shiftENST00000402655ENST00000268533WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000402655ENST00000568787WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000402655ENST00000437314WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000402655ENST00000563839WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-3UTRENST00000402655ENST00000564031WWOXchr16

78149051

+NUDT7chr16

77775479

+
In-frameENST00000408984ENST00000564085WWOXchr16

78149051

+NUDT7chr16

77775479

+
Frame-shiftENST00000408984ENST00000268533WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000408984ENST00000568787WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000408984ENST00000437314WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000408984ENST00000563839WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-3UTRENST00000408984ENST00000564031WWOXchr16

78149051

+NUDT7chr16

77775479

+
In-frameENST00000355860ENST00000564085WWOXchr16

78149051

+NUDT7chr16

77775479

+
Frame-shiftENST00000355860ENST00000268533WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000355860ENST00000568787WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000355860ENST00000437314WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000355860ENST00000563839WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-3UTRENST00000355860ENST00000564031WWOXchr16

78149051

+NUDT7chr16

77775479

+
intron-3CDSENST00000565791ENST00000564085WWOXchr16

78149051

+NUDT7chr16

77775479

+
intron-3CDSENST00000565791ENST00000268533WWOXchr16

78149051

+NUDT7chr16

77775479

+
intron-intronENST00000565791ENST00000568787WWOXchr16

78149051

+NUDT7chr16

77775479

+
intron-intronENST00000565791ENST00000437314WWOXchr16

78149051

+NUDT7chr16

77775479

+
intron-intronENST00000565791ENST00000563839WWOXchr16

78149051

+NUDT7chr16

77775479

+
intron-3UTRENST00000565791ENST00000564031WWOXchr16

78149051

+NUDT7chr16

77775479

+
intron-3CDSENST00000569818ENST00000564085WWOXchr16

78149051

+NUDT7chr16

77775479

+
intron-3CDSENST00000569818ENST00000268533WWOXchr16

78149051

+NUDT7chr16

77775479

+
intron-intronENST00000569818ENST00000568787WWOXchr16

78149051

+NUDT7chr16

77775479

+
intron-intronENST00000569818ENST00000437314WWOXchr16

78149051

+NUDT7chr16

77775479

+
intron-intronENST00000569818ENST00000563839WWOXchr16

78149051

+NUDT7chr16

77775479

+
intron-3UTRENST00000569818ENST00000564031WWOXchr16

78149051

+NUDT7chr16

77775479

+

Top

FusionProtFeatures for WWOX_NUDT7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WWOX

Q9NZC7

NUDT7

P0C024

Coenzyme A diphosphatase which mediates the cleavage ofCoA, CoA esters and oxidized CoA with similar efficiencies,yielding 3',5'-ADP and the corresponding 4'-phosphopantetheinederivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di ormonophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPHor thymidine-5'-monophospho-p-nitrophenyl ester. May be requiredto eliminate oxidized CoA from peroxisomes, or regulate CoA andacyl-CoA levels in this organelle in response to metabolic demand.Does not play a role in U8 snoRNA decapping activity. Binds U8snoRNA (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWWOXchr16:78149051chr16:77775479ENST00000355860+4616_49136190DomainWW 1
HgeneWWOXchr16:78149051chr16:77775479ENST00000355860+4657_90136190DomainWW 2
HgeneWWOXchr16:78149051chr16:77775479ENST00000402655+4516_49136312DomainWW 1
HgeneWWOXchr16:78149051chr16:77775479ENST00000402655+4557_90136312DomainWW 2
HgeneWWOXchr16:78149051chr16:77775479ENST00000406884+4616_49136235DomainWW 1
HgeneWWOXchr16:78149051chr16:77775479ENST00000406884+4657_90136235DomainWW 2
HgeneWWOXchr16:78149051chr16:77775479ENST00000408984+41016_49136311DomainWW 1
HgeneWWOXchr16:78149051chr16:77775479ENST00000408984+41057_90136311DomainWW 2
HgeneWWOXchr16:78149051chr16:77775479ENST00000566780+4916_49136415DomainWW 1
HgeneWWOXchr16:78149051chr16:77775479ENST00000566780+4957_90136415DomainWW 2
HgeneWWOXchr16:78149051chr16:77775479ENST00000355860+4650_55136190MotifNuclear localization signal
HgeneWWOXchr16:78149051chr16:77775479ENST00000402655+4550_55136312MotifNuclear localization signal
HgeneWWOXchr16:78149051chr16:77775479ENST00000406884+4650_55136235MotifNuclear localization signal
HgeneWWOXchr16:78149051chr16:77775479ENST00000408984+41050_55136311MotifNuclear localization signal
HgeneWWOXchr16:78149051chr16:77775479ENST00000566780+4950_55136415MotifNuclear localization signal
HgeneWWOXchr16:78149051chr16:77775479ENST00000355860+46131_137136190Nucleotide bindingNADP
HgeneWWOXchr16:78149051chr16:77775479ENST00000402655+45131_137136312Nucleotide bindingNADP
HgeneWWOXchr16:78149051chr16:77775479ENST00000406884+46131_137136235Nucleotide bindingNADP
HgeneWWOXchr16:78149051chr16:77775479ENST00000408984+410131_137136311Nucleotide bindingNADP
HgeneWWOXchr16:78149051chr16:77775479ENST00000566780+49131_137136415Nucleotide bindingNADP
TgeneNUDT7chr16:78149051chr16:77775479ENST00000268533+24236_238116239MotifMicrobody targeting signal
TgeneNUDT7chr16:78149051chr16:77775479ENST00000437314+13236_23863186MotifMicrobody targeting signal
TgeneNUDT7chr16:78149051chr16:77775479ENST00000437314+1377_9863186MotifNote=Nudix box

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWWOXchr16:78149051chr16:77775479ENST00000569818+1116_49-3537DomainWW 1
HgeneWWOXchr16:78149051chr16:77775479ENST00000569818+1157_90-3537DomainWW 2
HgeneWWOXchr16:78149051chr16:77775479ENST00000569818+1150_55-3537MotifNuclear localization signal
HgeneWWOXchr16:78149051chr16:77775479ENST00000569818+11131_137-3537Nucleotide bindingNADP
HgeneWWOXchr16:78149051chr16:77775479ENST00000355860+46209_273136190RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78149051chr16:77775479ENST00000402655+45209_273136312RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78149051chr16:77775479ENST00000406884+46209_273136235RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78149051chr16:77775479ENST00000408984+410209_273136311RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78149051chr16:77775479ENST00000566780+49209_273136415RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78149051chr16:77775479ENST00000569818+11209_273-3537RegionMediates targeting to the mitochondria
TgeneNUDT7chr16:78149051chr16:77775479ENST00000268533+2437_172116239DomainNudix hydrolase
TgeneNUDT7chr16:78149051chr16:77775479ENST00000437314+1337_17263186DomainNudix hydrolase
TgeneNUDT7chr16:78149051chr16:77775479ENST00000268533+2477_98116239MotifNote=Nudix box


Top

FusionGeneSequence for WWOX_NUDT7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_WWOX_ENST00000566780_chr16_78458952_+_NUDT7_ENST00000268533_chr16_77775479_+_386aa
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL
AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVEAM
TLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRQIHXXL
HLWVXXTTTSRPSRILLKLRMYSWCLWPISCIHRSMTSITSHVLVTVLLIISLSTQTLKTVSLTRSREXRQTLQCWWPLSFWKKNPPLRF

>In-frame_WWOX_ENST00000408984_chr16_78458952_+_NUDT7_ENST00000268533_chr16_77775479_+_386aa
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL
AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVEAM
TLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRQIHXXL
HLWVXXTTTSRPSRILLKLRMYSWCLWPISCIHRSMTSITSHVLVTVLLIISLSTQTLKTVSLTRSREXRQTLQCWWPLSFWKKNPPLRF

>In-frame_WWOX_ENST00000566780_chr16_78149051_+_NUDT7_ENST00000564085_chr16_77775479_+_160aa
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL

>In-frame_WWOX_ENST00000406884_chr16_78149051_+_NUDT7_ENST00000564085_chr16_77775479_+_160aa
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL

>In-frame_WWOX_ENST00000539474_chr16_78149051_+_NUDT7_ENST00000564085_chr16_77775479_+_160aa
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL

>In-frame_WWOX_ENST00000402655_chr16_78149051_+_NUDT7_ENST00000564085_chr16_77775479_+_160aa
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL

>In-frame_WWOX_ENST00000408984_chr16_78149051_+_NUDT7_ENST00000564085_chr16_77775479_+_160aa
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL

>In-frame_WWOX_ENST00000355860_chr16_78149051_+_NUDT7_ENST00000564085_chr16_77775479_+_160aa
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_WWOX_ENST00000566780_chr16_78458952_+_NUDT7_ENST00000268533_chr16_77775479_+_1160nt
ATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGC
TGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCA
TACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGACCCAAGACTG
GCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCCAGGGCCGG
GATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGGGTTCGAAACCGCCAAGTCTTTTGCCCTCCATGGTGCACAT
GTGATCTTGGCCTGCAGGAACATGGCAAGGGCGAGTGAAGCAGTGTCACGCATTTTAGAAGAATGGCATAAAGCCAAGGTAGAAGCAATG
ACCCTGGACCTCGCTCTGCTCCGTAGCGTGCAGCATTTTGCTGAAGCATTCAAGGCCAAGAATGTGCCTCTTCATGTGCTTGTGTGCAAC
GCAGCAACTTTTGCTCTACCCTGGAGTCTCACCAAAGATGGCCTGGAGACCACCTTTCAAGTGAATCATCTGGGGCACTTCTACCTTGTC
CAGCTCCTCCAGGATGTTTTGTGCCGCTCAGCTCCTGCCCGTGTCATTGTGGTCTCCTCAGAGTCCCATCGACAGATACATTGATAACTC
CATTTGTGGGTTTAATAGACCACAACTTCCAGGCCCAGCCGAATCCTGCTGAAGTTAAGGATGTATTCCTGGTGCCTCTGGCCTATTTCC
TGCATCCACAGGTCCATGACCAGCATTACGTCACACGTCTTGGTCACCGTTTTATTAATCATATCTTTGAGTACACAAACCCTGAAGACG
GTGTCACTTACCAGATCAAGGGAATGACGGCAAACCTTGCAGTGTTGGTGGCCTTTATCATTTTGGAAAAAAAACCCACCTTTGAGGTTC

>In-frame_WWOX_ENST00000408984_chr16_78458952_+_NUDT7_ENST00000268533_chr16_77775479_+_1160nt
ATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGC
TGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCA
TACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGACCCAAGACTG
GCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCCAGGGCCGG
GATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGGGTTCGAAACCGCCAAGTCTTTTGCCCTCCATGGTGCACAT
GTGATCTTGGCCTGCAGGAACATGGCAAGGGCGAGTGAAGCAGTGTCACGCATTTTAGAAGAATGGCATAAAGCCAAGGTAGAAGCAATG
ACCCTGGACCTCGCTCTGCTCCGTAGCGTGCAGCATTTTGCTGAAGCATTCAAGGCCAAGAATGTGCCTCTTCATGTGCTTGTGTGCAAC
GCAGCAACTTTTGCTCTACCCTGGAGTCTCACCAAAGATGGCCTGGAGACCACCTTTCAAGTGAATCATCTGGGGCACTTCTACCTTGTC
CAGCTCCTCCAGGATGTTTTGTGCCGCTCAGCTCCTGCCCGTGTCATTGTGGTCTCCTCAGAGTCCCATCGACAGATACATTGATAACTC
CATTTGTGGGTTTAATAGACCACAACTTCCAGGCCCAGCCGAATCCTGCTGAAGTTAAGGATGTATTCCTGGTGCCTCTGGCCTATTTCC
TGCATCCACAGGTCCATGACCAGCATTACGTCACACGTCTTGGTCACCGTTTTATTAATCATATCTTTGAGTACACAAACCCTGAAGACG
GTGTCACTTACCAGATCAAGGGAATGACGGCAAACCTTGCAGTGTTGGTGGCCTTTATCATTTTGGAAAAAAAACCCACCTTTGAGGTTC

>In-frame_WWOX_ENST00000566780_chr16_78149051_+_NUDT7_ENST00000564085_chr16_77775479_+_480nt
ATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGC
TGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCA
TACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGACCCAAGACTG
GCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCCAGGGCCGG
GATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGACAGATACATTGATAACTCCATTTGTGGGTTTAATAGACCA

>In-frame_WWOX_ENST00000406884_chr16_78149051_+_NUDT7_ENST00000564085_chr16_77775479_+_480nt
ATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGC
TGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCA
TACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGACCCAAGACTG
GCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCCAGGGCCGG
GATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGACAGATACATTGATAACTCCATTTGTGGGTTTAATAGACCA

>In-frame_WWOX_ENST00000539474_chr16_78149051_+_NUDT7_ENST00000564085_chr16_77775479_+_480nt
ATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGC
TGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCA
TACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGACCCAAGACTG
GCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCCAGGGCCGG
GATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGACAGATACATTGATAACTCCATTTGTGGGTTTAATAGACCA

>In-frame_WWOX_ENST00000402655_chr16_78149051_+_NUDT7_ENST00000564085_chr16_77775479_+_480nt
ATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGC
TGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCA
TACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGACCCAAGACTG
GCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCCAGGGCCGG
GATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGACAGATACATTGATAACTCCATTTGTGGGTTTAATAGACCA

>In-frame_WWOX_ENST00000408984_chr16_78149051_+_NUDT7_ENST00000564085_chr16_77775479_+_480nt
ATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGC
TGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCA
TACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGACCCAAGACTG
GCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCCAGGGCCGG
GATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGACAGATACATTGATAACTCCATTTGTGGGTTTAATAGACCA

>In-frame_WWOX_ENST00000355860_chr16_78149051_+_NUDT7_ENST00000564085_chr16_77775479_+_480nt
ATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGC
TGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCA
TACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGACCCAAGACTG
GCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCCAGGGCCGG
GATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGACAGATACATTGATAACTCCATTTGTGGGTTTAATAGACCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_WWOX_ENST00000566780_chr16_78458952_+_NUDT7_ENST00000268533_chr16_77775479_+_1836nt
GTCCTGGCCCGAAACTGGATGCGCACGCCCCTTCCCTGCGGCGGGGAGGCTGACAAGGCTCCGCTCTATCTCTAGCGCCTCGGAGCGCTC
TCCGGCTTTGCTGTCTAGCCCGGCGGCAGCGCGATCTCTTAGGCACTTTCACCGCCTTCCTCTCCAGGCCCTGCCCCTTTGACGCCGGCC
GTCGCGATATTGCGGAGACTGGATTTCAGCTTCGTGGTCGGCGGAGCGGCCCCTGGAGGGCGCAGTGCGCAGGCGTGAGCGGTCGGGCCC
CGACGCGCGCGGGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCGGGCGATAGGGGGGCCAGGTGCCTCCACAG
TCAGCCATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCACCAAG
GACGGCTGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAGAT
TTGCCATACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGACCCA
AGACTGGCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCCAG
GGCCGGGATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGGGTTCGAAACCGCCAAGTCTTTTGCCCTCCATGGT
GCACATGTGATCTTGGCCTGCAGGAACATGGCAAGGGCGAGTGAAGCAGTGTCACGCATTTTAGAAGAATGGCATAAAGCCAAGGTAGAA
GCAATGACCCTGGACCTCGCTCTGCTCCGTAGCGTGCAGCATTTTGCTGAAGCATTCAAGGCCAAGAATGTGCCTCTTCATGTGCTTGTG
TGCAACGCAGCAACTTTTGCTCTACCCTGGAGTCTCACCAAAGATGGCCTGGAGACCACCTTTCAAGTGAATCATCTGGGGCACTTCTAC
CTTGTCCAGCTCCTCCAGGATGTTTTGTGCCGCTCAGCTCCTGCCCGTGTCATTGTGGTCTCCTCAGAGTCCCATCGACAGATACATTGA
TAACTCCATTTGTGGGTTTAATAGACCACAACTTCCAGGCCCAGCCGAATCCTGCTGAAGTTAAGGATGTATTCCTGGTGCCTCTGGCCT
ATTTCCTGCATCCACAGGTCCATGACCAGCATTACGTCACACGTCTTGGTCACCGTTTTATTAATCATATCTTTGAGTACACAAACCCTG
AAGACGGTGTCACTTACCAGATCAAGGGAATGACGGCAAACCTTGCAGTGTTGGTGGCCTTTATCATTTTGGAAAAAAAACCCACCTTTG
AGGTTCAATTTAATCTTAATGATGTATTAGCATCCTCTGAAGAGTTATTCCTGAAGGTTCATAAAAAAGCTACAAGCAGGTTATGATTTA
CTAGAGCAAGAGACAAAGAACTATTCACGAGGATTCTGTGTGTGCTTATTCGTAGAACAACAACAATGCCAGCTGTTGGAATTTGACAGG
TGTGAATATTTTTTCTGCAGTATGTAGTTAGAATCCTTGCCTCTTTTCCAGTTGCCTTCTATTGTCTGAAAAAGTAAAAGCCATTCAAAA
ATGAAAACTATGTTCATAGTGTTGCATATTTTCACCCACAATATGTTAATAATATTTTTCTTACACATATAATAAAGAATATCTGGCACA

>In-frame_WWOX_ENST00000408984_chr16_78458952_+_NUDT7_ENST00000268533_chr16_77775479_+_1555nt
GGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCGGGCGATAGGGGGGCCAGGTGCCTCCACAGTCAGCCATGGC
AGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGCTGGGT
TTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCATACGG
ATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGACCCAAGACTGGCGTT
TACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCCAGGGCCGGGATTT
CACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGGGTTCGAAACCGCCAAGTCTTTTGCCCTCCATGGTGCACATGTGAT
CTTGGCCTGCAGGAACATGGCAAGGGCGAGTGAAGCAGTGTCACGCATTTTAGAAGAATGGCATAAAGCCAAGGTAGAAGCAATGACCCT
GGACCTCGCTCTGCTCCGTAGCGTGCAGCATTTTGCTGAAGCATTCAAGGCCAAGAATGTGCCTCTTCATGTGCTTGTGTGCAACGCAGC
AACTTTTGCTCTACCCTGGAGTCTCACCAAAGATGGCCTGGAGACCACCTTTCAAGTGAATCATCTGGGGCACTTCTACCTTGTCCAGCT
CCTCCAGGATGTTTTGTGCCGCTCAGCTCCTGCCCGTGTCATTGTGGTCTCCTCAGAGTCCCATCGACAGATACATTGATAACTCCATTT
GTGGGTTTAATAGACCACAACTTCCAGGCCCAGCCGAATCCTGCTGAAGTTAAGGATGTATTCCTGGTGCCTCTGGCCTATTTCCTGCAT
CCACAGGTCCATGACCAGCATTACGTCACACGTCTTGGTCACCGTTTTATTAATCATATCTTTGAGTACACAAACCCTGAAGACGGTGTC
ACTTACCAGATCAAGGGAATGACGGCAAACCTTGCAGTGTTGGTGGCCTTTATCATTTTGGAAAAAAAACCCACCTTTGAGGTTCAATTT
AATCTTAATGATGTATTAGCATCCTCTGAAGAGTTATTCCTGAAGGTTCATAAAAAAGCTACAAGCAGGTTATGATTTACTAGAGCAAGA
GACAAAGAACTATTCACGAGGATTCTGTGTGTGCTTATTCGTAGAACAACAACAATGCCAGCTGTTGGAATTTGACAGGTGTGAATATTT
TTTCTGCAGTATGTAGTTAGAATCCTTGCCTCTTTTCCAGTTGCCTTCTATTGTCTGAAAAAGTAAAAGCCATTCAAAAATGAAAACTAT
GTTCATAGTGTTGCATATTTTCACCCACAATATGTTAATAATATTTTTCTTACACATATAATAAAGAATATCTGGCACATACTAGGCCCT

>In-frame_WWOX_ENST00000566780_chr16_78149051_+_NUDT7_ENST00000564085_chr16_77775479_+_1163nt
GTCCTGGCCCGAAACTGGATGCGCACGCCCCTTCCCTGCGGCGGGGAGGCTGACAAGGCTCCGCTCTATCTCTAGCGCCTCGGAGCGCTC
TCCGGCTTTGCTGTCTAGCCCGGCGGCAGCGCGATCTCTTAGGCACTTTCACCGCCTTCCTCTCCAGGCCCTGCCCCTTTGACGCCGGCC
GTCGCGATATTGCGGAGACTGGATTTCAGCTTCGTGGTCGGCGGAGCGGCCCCTGGAGGGCGCAGTGCGCAGGCGTGAGCGGTCGGGCCC
CGACGCGCGCGGGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCGGGCGATAGGGGGGCCAGGTGCCTCCACAG
TCAGCCATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCACCAAG
GACGGCTGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAGAT
TTGCCATACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGACCCA
AGACTGGCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCCAG
GGCCGGGATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGACAGATACATTGATAACTCCATTTGTGGGTTTAAT
AGACCACAACTTCCAGGCCCAGCCGAATCCTGCTGAAGTTAAGGATGTATTCCTGGTGCCTCTGGCCTATTTCCTGCATCCACAGGTCCA
TGACCAGCATTACGTCACACGTCTTGGTCACCGTTTTATTAATCATATCTTTGAGTACACAAACCCTGAAGACGGTGTCACTTACCAGAT
CAAGGGAATGACGGCAAACCTTGCAGTGTTGGTGGCCTTTATCATTTTGGAAAAAAAACCCACCTTTGAGGTTCAATTTAATCTTAATGA

>In-frame_WWOX_ENST00000406884_chr16_78149051_+_NUDT7_ENST00000564085_chr16_77775479_+_922nt
GCAGTGCGCAGGCGTGAGCGGTCGGGCCCCGACGCGCGCGGGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCG
GGCGATAGGGGGGCCAGGTGCCTCCACAGTCAGCCATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGC
CTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGCTGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAA
CTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCATACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATA
TAAATAAAAGAACCACCTACTTGGACCCAAGACTGGCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACG
GCAGCACCACTGCCATGGAAATTCTCCAGGGCCGGGATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGACAGAT
ACATTGATAACTCCATTTGTGGGTTTAATAGACCACAACTTCCAGGCCCAGCCGAATCCTGCTGAAGTTAAGGATGTATTCCTGGTGCCT
CTGGCCTATTTCCTGCATCCACAGGTCCATGACCAGCATTACGTCACACGTCTTGGTCACCGTTTTATTAATCATATCTTTGAGTACACA
AACCCTGAAGACGGTGTCACTTACCAGATCAAGGGAATGACGGCAAACCTTGCAGTGTTGGTGGCCTTTATCATTTTGGAAAAAAAACCC
ACCTTTGAGGTTCAATTTAATCTTAATGATGTATTAGCATCCTCTGAAGAGTTATTCCTGAAGGTTCATAAAAAAGCTACAAGCAGGTTA

>In-frame_WWOX_ENST00000539474_chr16_78149051_+_NUDT7_ENST00000564085_chr16_77775479_+_922nt
GCAGTGCGCAGGCGTGAGCGGTCGGGCCCCGACGCGCGCGGGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCG
GGCGATAGGGGGGCCAGGTGCCTCCACAGTCAGCCATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGC
CTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGCTGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAA
CTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCATACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATA
TAAATAAAAGAACCACCTACTTGGACCCAAGACTGGCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACG
GCAGCACCACTGCCATGGAAATTCTCCAGGGCCGGGATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGACAGAT
ACATTGATAACTCCATTTGTGGGTTTAATAGACCACAACTTCCAGGCCCAGCCGAATCCTGCTGAAGTTAAGGATGTATTCCTGGTGCCT
CTGGCCTATTTCCTGCATCCACAGGTCCATGACCAGCATTACGTCACACGTCTTGGTCACCGTTTTATTAATCATATCTTTGAGTACACA
AACCCTGAAGACGGTGTCACTTACCAGATCAAGGGAATGACGGCAAACCTTGCAGTGTTGGTGGCCTTTATCATTTTGGAAAAAAAACCC
ACCTTTGAGGTTCAATTTAATCTTAATGATGTATTAGCATCCTCTGAAGAGTTATTCCTGAAGGTTCATAAAAAAGCTACAAGCAGGTTA

>In-frame_WWOX_ENST00000402655_chr16_78149051_+_NUDT7_ENST00000564085_chr16_77775479_+_922nt
GCAGTGCGCAGGCGTGAGCGGTCGGGCCCCGACGCGCGCGGGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCG
GGCGATAGGGGGGCCAGGTGCCTCCACAGTCAGCCATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGC
CTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGCTGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAA
CTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCATACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATA
TAAATAAAAGAACCACCTACTTGGACCCAAGACTGGCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACG
GCAGCACCACTGCCATGGAAATTCTCCAGGGCCGGGATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGACAGAT
ACATTGATAACTCCATTTGTGGGTTTAATAGACCACAACTTCCAGGCCCAGCCGAATCCTGCTGAAGTTAAGGATGTATTCCTGGTGCCT
CTGGCCTATTTCCTGCATCCACAGGTCCATGACCAGCATTACGTCACACGTCTTGGTCACCGTTTTATTAATCATATCTTTGAGTACACA
AACCCTGAAGACGGTGTCACTTACCAGATCAAGGGAATGACGGCAAACCTTGCAGTGTTGGTGGCCTTTATCATTTTGGAAAAAAAACCC
ACCTTTGAGGTTCAATTTAATCTTAATGATGTATTAGCATCCTCTGAAGAGTTATTCCTGAAGGTTCATAAAAAAGCTACAAGCAGGTTA

>In-frame_WWOX_ENST00000408984_chr16_78149051_+_NUDT7_ENST00000564085_chr16_77775479_+_882nt
GGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCGGGCGATAGGGGGGCCAGGTGCCTCCACAGTCAGCCATGGC
AGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGCTGGGT
TTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCATACGG
ATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGACCCAAGACTGGCGTT
TACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCCAGGGCCGGGATTT
CACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGACAGATACATTGATAACTCCATTTGTGGGTTTAATAGACCACAACT
TCCAGGCCCAGCCGAATCCTGCTGAAGTTAAGGATGTATTCCTGGTGCCTCTGGCCTATTTCCTGCATCCACAGGTCCATGACCAGCATT
ACGTCACACGTCTTGGTCACCGTTTTATTAATCATATCTTTGAGTACACAAACCCTGAAGACGGTGTCACTTACCAGATCAAGGGAATGA
CGGCAAACCTTGCAGTGTTGGTGGCCTTTATCATTTTGGAAAAAAAACCCACCTTTGAGGTTCAATTTAATCTTAATGATGTATTAGCAT

>In-frame_WWOX_ENST00000355860_chr16_78149051_+_NUDT7_ENST00000564085_chr16_77775479_+_897nt
GCCCCGACGCGCGCGGGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCGGGCGATAGGGGGGCCAGGTGCCTCC
ACAGTCAGCCATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCAC
CAAGGACGGCTGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGG
AGATTTGCCATACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGA
CCCAAGACTGGCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCT
CCAGGGCCGGGATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGACAGATACATTGATAACTCCATTTGTGGGTT
TAATAGACCACAACTTCCAGGCCCAGCCGAATCCTGCTGAAGTTAAGGATGTATTCCTGGTGCCTCTGGCCTATTTCCTGCATCCACAGG
TCCATGACCAGCATTACGTCACACGTCTTGGTCACCGTTTTATTAATCATATCTTTGAGTACACAAACCCTGAAGACGGTGTCACTTACC
AGATCAAGGGAATGACGGCAAACCTTGCAGTGTTGGTGGCCTTTATCATTTTGGAAAAAAAACCCACCTTTGAGGTTCAATTTAATCTTA


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FusionGenePPI for WWOX_NUDT7


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check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WWOXTP53, CPSF6, TNK2, ERBB4, MDM2, TP63, MAPK8, LMNA, POLR2A, POLR2B, SMARCC1, TCERG1, CPSF1, CPSF2, CPSF3, NUDT21, FIP1L1, CPSF7, HNRNPK, RPRD2, PABPC1, SF3A1, SF3B1, SF3B3, SFPQ, SYMPK, WIPF2, WDR33, WBP2, SF3B2, KHSRP, CSTF3, HSPA4, DHX15, KRT4, MIA3, OTUD7B, PRPF8, ACIN1, PATL1, P4HA1, DSP, ANXA1, HSPA1A, PRRC2A, SERPINB3, COIL, PGD, DIAPH3, CSNK2A1, SNRNP200, DAZAP1, RPRD1B, HSPA8, ENAH, PABPC4, IGF2BP1, HSD17B10, HDLBP, DVL2, SF3A3, CCT2, SNRPD2, SMARCA4, CDC5L, YWHAZ, UBAP2, CANX, SNRPD1, JUP, RARA, PRMT5, U2SURP, TGM3, TDRD3, PKLR, NOLC1, YLPM1, WASL, CSTF2, MATR3, TOE1, BCL9, CRNN, HIST2H2AA3, DVL3, P3H1, PRPF3, CSNK2A2, SCAF4, DSG3, RBMX, CYFIP1, USP6NL, DDX6, XRN2, IVL, XAB2, AMOTL1, MPDZ, DDX3Y, HNRNPUL1, DHX9, POLR2E, FBRS, WDR77, SEC23A, ZMAT5, DGCR14, LZTS2, NOSIP, DCAF7, GEMIN5, PRPF40A, EIF4A3, INPPL1, LSM4, DDX17, IGF2BP3, RC3H1, MPP5, POLR2C, FARSA, HNRNPH3, DHX30, RPRD1A, ZG16B, NONO, PREB, PABPC3, LONP2, ATN1, GABARAPL2, HNRNPR, HNRNPCL1, CYFIP2, ELAVL1, ITCH, DRG1, SNRPD3, RPAP3, DROSHA, HNRNPU, SMN2, CAD, CCT7, PTPN14, PPP1CA, HNRNPA3, DDX39B, SCGB2A1, KRT75, DDX21, SPG20, CSDE1, HNRNPF, SRSF10, SEC23IP, ATP2A1, DIAPH1, LCN1, DOCK7, CXorf57, SF3A2, HSPB1, TARDBP, SF3B6, A2ML1, AMOT, THOC6, KIF2A, LUC7L3, MYH7, MYH1, MYH4, MYH16, DDX1, ENO1, TP73, CCT6A, SMARCE1, ANXA2, ACLY, SCAF8, ALDH3A1, PPIB, EDC4, RPL6, USP39, EIF3A, H2AFZ, RPL30, KDM3B, FUS, SERPINB5, DVL1, RAPGEF2, DHX36, HN1L, POLR2G, BAIAP2, WDR91, DCTPP1, IQSEC1, PRDX5, LZTS3, RPS15AP21, SRSF3, ZNF598, LACRT, IGF2BP2, PAICS, KIAA1522, SLC4A1AP, ATXN2, THRAP3, RBM39, CAPZA1, SEC24C, NOP56, SRPK1, DKC1, IK, HADHA, OGT, PRPF31, DIDO1, ATAD3A, PDCD7, HUWE1, ATM, TRIM28, HIF1A, LATS1, FAM189B, TMEM171, FAM189A2, WBP1, TMEM92, LDLRAD4, CLNK, BTRC, NUP133, CDH1, FKBP15, SERPINA5, ARRDC3, NME2, GORASP1, ZBTB33, LYZ, TRIM25, BRCA1NUDT7CUL1, PEX5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneWWOXchr16:78149051chr16:77775479ENST00000355860+46125_414136190MAPT
HgeneWWOXchr16:78149051chr16:77775479ENST00000402655+45125_414136312MAPT
HgeneWWOXchr16:78149051chr16:77775479ENST00000406884+46125_414136235MAPT
HgeneWWOXchr16:78149051chr16:77775479ENST00000408984+410125_414136311MAPT
HgeneWWOXchr16:78149051chr16:77775479ENST00000566780+49125_414136415MAPT
HgeneWWOXchr16:78149051chr16:77775479ENST00000569818+11125_414-3537MAPT


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WWOX_NUDT7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WWOX_NUDT7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneWWOXC0007137Squamous cell carcinoma1CTD_human
HgeneWWOXC0038356Stomach Neoplasms1CTD_human
HgeneWWOXC0042076Urologic Neoplasms1CTD_human
HgeneWWOXC0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneWWOXC1458155Mammary Neoplasms1CTD_human
HgeneWWOXC3280452SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 121ORPHANET;UNIPROT
HgeneWWOXC3495559Juvenile arthritis1CTD_human
HgeneWWOXC4015519EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 281UNIPROT
TgeneNUDT7C0023903Liver neoplasms1CTD_human