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Fusion gene ID: 42096 |
FusionGeneSummary for WTAP_CBR4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: WTAP_CBR4 | Fusion gene ID: 42096 | Hgene | Tgene | Gene symbol | WTAP | CBR4 | Gene ID | 9589 | 84869 |
| Gene name | WT1 associated protein | carbonyl reductase 4 | |
| Synonyms | Mum2 | SDR45C1 | |
| Cytomap | 6q25.3 | 4q32.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pre-mRNA-splicing regulator WTAPPNAS-132Wilms tumor 1 associated proteinWilms' tumour 1-associating proteinfemale-lethal(2)D homologhFL(2)Dputative pre-mRNA splicing regulator female-lethal(2D)wilms tumor 1-associating protein | carbonyl reductase family member 43-ketoacyl-[acyl-carrier-protein] reductase beta subunit3-oxoacyl-[acyl-carrier-protein] reductaseKAR beta subunitcarbonic reductase 4quinone reductase CBR4short chain dehydrogenase/reductase family 45C member 1 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q15007 | Q8N4T8 | |
| Ensembl transtripts involved in fusion gene | ENST00000358372, ENST00000337387, ENST00000494513, | ENST00000509108, ENST00000306193, ENST00000504480, | |
| Fusion gene scores | * DoF score | 3 X 3 X 4=36 | 2 X 2 X 2=8 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/36*10)=0.473931188332412 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/8*10)=1.90689059560852 | |
| Context | PubMed: WTAP [Title/Abstract] AND CBR4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CBR4 | GO:0051290 | protein heterotetramerization | 25203508 |
| Tgene | CBR4 | GO:0055114 | oxidation-reduction process | 25203508 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF930782 | WTAP | chr6 | 160169280 | + | CBR4 | chr4 | 169917007 | - | ||
| ChiTaRS3.1 | BF930048 | WTAP | chr6 | 160169280 | + | CBR4 | chr4 | 169917007 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000358372 | ENST00000509108 | WTAP | chr6 | 160169280 | + | CBR4 | chr4 | 169917007 | - |
| 5CDS-intron | ENST00000358372 | ENST00000306193 | WTAP | chr6 | 160169280 | + | CBR4 | chr4 | 169917007 | - |
| 5CDS-intron | ENST00000358372 | ENST00000504480 | WTAP | chr6 | 160169280 | + | CBR4 | chr4 | 169917007 | - |
| 5CDS-intron | ENST00000337387 | ENST00000509108 | WTAP | chr6 | 160169280 | + | CBR4 | chr4 | 169917007 | - |
| 5CDS-intron | ENST00000337387 | ENST00000306193 | WTAP | chr6 | 160169280 | + | CBR4 | chr4 | 169917007 | - |
| 5CDS-intron | ENST00000337387 | ENST00000504480 | WTAP | chr6 | 160169280 | + | CBR4 | chr4 | 169917007 | - |
| intron-intron | ENST00000494513 | ENST00000509108 | WTAP | chr6 | 160169280 | + | CBR4 | chr4 | 169917007 | - |
| intron-intron | ENST00000494513 | ENST00000306193 | WTAP | chr6 | 160169280 | + | CBR4 | chr4 | 169917007 | - |
| intron-intron | ENST00000494513 | ENST00000504480 | WTAP | chr6 | 160169280 | + | CBR4 | chr4 | 169917007 | - |
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FusionProtFeatures for WTAP_CBR4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| WTAP | CBR4 |
| Associated component of the WMM complex, a complex thatmediates N6-methyladenosine (m6A) methylation of RNAs, amodification that plays a role in the efficiency of mRNA splicingand RNA processing (PubMed:29507755). Required for accumulation ofMETTL3 and METTL14 to nuclear speckle (PubMed:24316715,PubMed:24407421, PubMed:24981863). Acts as a mRNA splicingregulator (PubMed:12444081). Regulates G2/M cell-cycle transitionby binding to the 3' UTR of CCNA2, which enhances its stability(PubMed:17088532). Impairs WT1 DNA-binding ability and inhibitsexpression of WT1 target genes (PubMed:17095724).{ECO:0000269|PubMed:12444081, ECO:0000269|PubMed:17088532,ECO:0000269|PubMed:17095724, ECO:0000269|PubMed:24316715,ECO:0000269|PubMed:24407421, ECO:0000269|PubMed:24981863,ECO:0000269|PubMed:29507755}. | The heterotetramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and therebyplays a role in mitochondrial fatty acid biosynthesis(PubMed:19571038, PubMed:25203508). Within the heterotetramer,HSD17B8 binds NADH; CBR4 binds NADPD (PubMed:25203508). Thehomotetramer has NADPH-dependent quinone reductase activity(PubMed:19000905). Both homotetramer and the heterotetramer havebroad substrate specificity and can reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinonesand p-quinones (in vitro) (PubMed:19000905, PubMed:19571038,PubMed:25203508). {ECO:0000269|PubMed:19000905,ECO:0000269|PubMed:19571038, ECO:0000269|PubMed:25203508}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for WTAP_CBR4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for WTAP_CBR4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for WTAP_CBR4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WTAP_CBR4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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