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Fusion gene ID: 42085 |
FusionGeneSummary for WSB1_RECK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: WSB1_RECK | Fusion gene ID: 42085 | Hgene | Tgene | Gene symbol | WSB1 | RECK | Gene ID | 26118 | 8434 |
| Gene name | WD repeat and SOCS box containing 1 | reversion inducing cysteine rich protein with kazal motifs | |
| Synonyms | SWIP1|WSB-1 | ST15 | |
| Cytomap | 17q11.1 | 9p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | WD repeat and SOCS box-containing protein 1SOCS box-containing WD protein SWiP-1 | reversion-inducing cysteine-rich protein with Kazal motifsmembrane-anchored glycoprotein (metastasis and invasion)suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs)suppression of tumorigenicity 5 (reversion-in | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9Y6I7 | O95980 | |
| Ensembl transtripts involved in fusion gene | ENST00000578312, ENST00000262394, ENST00000579733, ENST00000583193, ENST00000581185, ENST00000427287, ENST00000348811, | ENST00000377966, ENST00000479053, | |
| Fusion gene scores | * DoF score | 7 X 4 X 4=112 | 4 X 4 X 4=64 |
| # samples | 7 | 4 | |
| ** MAII score | log2(7/112*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: WSB1 [Title/Abstract] AND RECK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI472026 | WSB1 | chr17 | 25622072 | - | RECK | chr9 | 36083764 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000578312 | ENST00000377966 | WSB1 | chr17 | 25622072 | - | RECK | chr9 | 36083764 | - |
| intron-intron | ENST00000578312 | ENST00000479053 | WSB1 | chr17 | 25622072 | - | RECK | chr9 | 36083764 | - |
| intron-intron | ENST00000262394 | ENST00000377966 | WSB1 | chr17 | 25622072 | - | RECK | chr9 | 36083764 | - |
| intron-intron | ENST00000262394 | ENST00000479053 | WSB1 | chr17 | 25622072 | - | RECK | chr9 | 36083764 | - |
| intron-intron | ENST00000579733 | ENST00000377966 | WSB1 | chr17 | 25622072 | - | RECK | chr9 | 36083764 | - |
| intron-intron | ENST00000579733 | ENST00000479053 | WSB1 | chr17 | 25622072 | - | RECK | chr9 | 36083764 | - |
| intron-intron | ENST00000583193 | ENST00000377966 | WSB1 | chr17 | 25622072 | - | RECK | chr9 | 36083764 | - |
| intron-intron | ENST00000583193 | ENST00000479053 | WSB1 | chr17 | 25622072 | - | RECK | chr9 | 36083764 | - |
| intron-intron | ENST00000581185 | ENST00000377966 | WSB1 | chr17 | 25622072 | - | RECK | chr9 | 36083764 | - |
| intron-intron | ENST00000581185 | ENST00000479053 | WSB1 | chr17 | 25622072 | - | RECK | chr9 | 36083764 | - |
| intron-intron | ENST00000427287 | ENST00000377966 | WSB1 | chr17 | 25622072 | - | RECK | chr9 | 36083764 | - |
| intron-intron | ENST00000427287 | ENST00000479053 | WSB1 | chr17 | 25622072 | - | RECK | chr9 | 36083764 | - |
| intron-intron | ENST00000348811 | ENST00000377966 | WSB1 | chr17 | 25622072 | - | RECK | chr9 | 36083764 | - |
| intron-intron | ENST00000348811 | ENST00000479053 | WSB1 | chr17 | 25622072 | - | RECK | chr9 | 36083764 | - |
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FusionProtFeatures for WSB1_RECK |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| WSB1 | RECK |
| Probable substrate-recognition component of a SCF-likeECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complexwhich mediates the ubiquitination and subsequent proteasomaldegradation of target proteins. Recognizes type II iodothyroninedeiodinase/DIO2. Confers constitutive instability to HIPK2 throughproteasomal degradation. {ECO:0000269|PubMed:15601820,ECO:0000269|PubMed:15965468, ECO:0000269|PubMed:18093972}. | Negatively regulates matrix metalloproteinase-9 (MMP-9)by suppressing MMP-9 secretion and by direct inhibition of itsenzymatic activity. RECK down-regulation by oncogenic signals mayfacilitate tumor invasion and metastasis. Appears to also regulateMMP-2 and MT1-MMP, which are involved in cancer progression. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for WSB1_RECK |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for WSB1_RECK |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for WSB1_RECK |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WSB1_RECK |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | RECK | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Tgene | RECK | C0009171 | Cocaine Abuse | 1 | PSYGENET |
| Tgene | RECK | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| Tgene | RECK | C0017636 | Glioblastoma | 1 | CTD_human |
| Tgene | RECK | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | RECK | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Tgene | RECK | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
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