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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 42072

FusionGeneSummary for WRB_BACE2

check button Fusion gene summary
Fusion gene informationFusion gene name: WRB_BACE2
Fusion gene ID: 42072
HgeneTgene
Gene symbol

WRB

BACE2

Gene ID

7485

25825

Gene nametryptophan rich basic proteinbeta-secretase 2
SynonymsCHD5|GET1AEPLC|ALP56|ASP1|ASP21|BAE2|CDA13|CEAP1|DRAP
Cytomap

21q22.2

21q22.2-q22.3

Type of geneprotein-codingprotein-coding
Descriptiontail-anchored protein insertion receptor WRBcongenital heart disease 5 proteinbeta-secretase 256 kDa aspartic-like proteaseDown syndrome region aspartic proteaseSLCO3A1/BACE2 fusionaspartyl protease 1beta-site APP-cleaving enzyme 2beta-site amyloid beta A4 precursor protein-cleaving enzyme 2memapsin-1membrane-associated asp
Modification date2018051920180523
UniProtAcc

O00258

Q9Y5Z0

Ensembl transtripts involved in fusion geneENST00000333781, ENST00000541890, 
ENST00000398753, ENST00000380708, 
ENST00000466787, 		ENST00000328735, 
ENST00000330333, ENST00000347667, 
ENST00000466122, 
Fusion gene scores* DoF score4 X 3 X 4=486 X 4 X 5=120
# samples 46
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WRB [Title/Abstract] AND BACE2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBACE2

GO:0006509

membrane protein ectodomain proteolysis

10591213


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-G9-6353-01AWRBchr21

40763762

+BACE2chr21

42647298

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000333781ENST00000328735WRBchr21

40763762

+BACE2chr21

42647298

+
Frame-shiftENST00000333781ENST00000330333WRBchr21

40763762

+BACE2chr21

42647298

+
In-frameENST00000333781ENST00000347667WRBchr21

40763762

+BACE2chr21

42647298

+
5CDS-3UTRENST00000333781ENST00000466122WRBchr21

40763762

+BACE2chr21

42647298

+
In-frameENST00000541890ENST00000328735WRBchr21

40763762

+BACE2chr21

42647298

+
Frame-shiftENST00000541890ENST00000330333WRBchr21

40763762

+BACE2chr21

42647298

+
In-frameENST00000541890ENST00000347667WRBchr21

40763762

+BACE2chr21

42647298

+
5CDS-3UTRENST00000541890ENST00000466122WRBchr21

40763762

+BACE2chr21

42647298

+
In-frameENST00000398753ENST00000328735WRBchr21

40763762

+BACE2chr21

42647298

+
Frame-shiftENST00000398753ENST00000330333WRBchr21

40763762

+BACE2chr21

42647298

+
In-frameENST00000398753ENST00000347667WRBchr21

40763762

+BACE2chr21

42647298

+
5CDS-3UTRENST00000398753ENST00000466122WRBchr21

40763762

+BACE2chr21

42647298

+
In-frameENST00000380708ENST00000328735WRBchr21

40763762

+BACE2chr21

42647298

+
Frame-shiftENST00000380708ENST00000330333WRBchr21

40763762

+BACE2chr21

42647298

+
In-frameENST00000380708ENST00000347667WRBchr21

40763762

+BACE2chr21

42647298

+
5CDS-3UTRENST00000380708ENST00000466122WRBchr21

40763762

+BACE2chr21

42647298

+
3UTR-3CDSENST00000466787ENST00000328735WRBchr21

40763762

+BACE2chr21

42647298

+
3UTR-3CDSENST00000466787ENST00000330333WRBchr21

40763762

+BACE2chr21

42647298

+
3UTR-3CDSENST00000466787ENST00000347667WRBchr21

40763762

+BACE2chr21

42647298

+
3UTR-3UTRENST00000466787ENST00000466122WRBchr21

40763762

+BACE2chr21

42647298

+

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FusionProtFeatures for WRB_BACE2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WRB

O00258

BACE2

Q9Y5Z0

Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane.{ECO:0000269|PubMed:21444755}. Responsible for the proteolytic processing of theamyloid precursor protein (APP). Cleaves APP, between residues 690and 691, leading to the generation and extracellular release ofbeta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. Ithas also been shown that it can cleave APP between residues 671and 672. {ECO:0000269|PubMed:10591213,ECO:0000269|PubMed:11083922, ECO:0000269|PubMed:11423558,ECO:0000269|PubMed:15857888, ECO:0000269|PubMed:16816112}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWRBchr21:40763762chr21:42647298ENST00000333781+3539_94112175Coiled coilOntology_term=ECO:0000255
HgeneWRBchr21:40763762chr21:42647298ENST00000333781+351_8112175Topological domainLumenal
HgeneWRBchr21:40763762chr21:42647298ENST00000333781+3530_99112175Topological domainCytoplasmic
HgeneWRBchr21:40763762chr21:42647298ENST00000380708+351_878141Topological domainLumenal
HgeneWRBchr21:40763762chr21:42647298ENST00000398753+351_878141Topological domainLumenal
HgeneWRBchr21:40763762chr21:42647298ENST00000333781+359_29112175TransmembraneHelical
HgeneWRBchr21:40763762chr21:42647298ENST00000380708+359_2978141TransmembraneHelical
HgeneWRBchr21:40763762chr21:42647298ENST00000398753+359_2978141TransmembraneHelical
TgeneBACE2chr21:40763762chr21:42647298ENST00000328735+68495_518378397Topological domainCytoplasmic
TgeneBACE2chr21:40763762chr21:42647298ENST00000330333+79495_518434519Topological domainCytoplasmic
TgeneBACE2chr21:40763762chr21:42647298ENST00000347667+68495_518384469Topological domainCytoplasmic
TgeneBACE2chr21:40763762chr21:42647298ENST00000328735+68474_494378397TransmembraneHelical
TgeneBACE2chr21:40763762chr21:42647298ENST00000330333+79474_494434519TransmembraneHelical
TgeneBACE2chr21:40763762chr21:42647298ENST00000347667+68474_494384469TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWRBchr21:40763762chr21:42647298ENST00000380708+3539_9478141Coiled coilOntology_term=ECO:0000255
HgeneWRBchr21:40763762chr21:42647298ENST00000398753+3539_9478141Coiled coilOntology_term=ECO:0000255
HgeneWRBchr21:40763762chr21:42647298ENST00000333781+35121_148112175Topological domainLumenal
HgeneWRBchr21:40763762chr21:42647298ENST00000333781+35170_174112175Topological domainCytoplasmic
HgeneWRBchr21:40763762chr21:42647298ENST00000380708+35121_14878141Topological domainLumenal
HgeneWRBchr21:40763762chr21:42647298ENST00000380708+35170_17478141Topological domainCytoplasmic
HgeneWRBchr21:40763762chr21:42647298ENST00000380708+3530_9978141Topological domainCytoplasmic
HgeneWRBchr21:40763762chr21:42647298ENST00000398753+35121_14878141Topological domainLumenal
HgeneWRBchr21:40763762chr21:42647298ENST00000398753+35170_17478141Topological domainCytoplasmic
HgeneWRBchr21:40763762chr21:42647298ENST00000398753+3530_9978141Topological domainCytoplasmic
HgeneWRBchr21:40763762chr21:42647298ENST00000333781+35100_120112175TransmembraneHelical
HgeneWRBchr21:40763762chr21:42647298ENST00000333781+35149_169112175TransmembraneHelical
HgeneWRBchr21:40763762chr21:42647298ENST00000380708+35100_12078141TransmembraneHelical
HgeneWRBchr21:40763762chr21:42647298ENST00000380708+35149_16978141TransmembraneHelical
HgeneWRBchr21:40763762chr21:42647298ENST00000398753+35100_12078141TransmembraneHelical
HgeneWRBchr21:40763762chr21:42647298ENST00000398753+35149_16978141TransmembraneHelical
TgeneBACE2chr21:40763762chr21:42647298ENST00000328735+6892_429378397DomainPeptidase A1
TgeneBACE2chr21:40763762chr21:42647298ENST00000330333+7992_429434519DomainPeptidase A1
TgeneBACE2chr21:40763762chr21:42647298ENST00000347667+6892_429384469DomainPeptidase A1
TgeneBACE2chr21:40763762chr21:42647298ENST00000328735+6821_473378397Topological domainExtracellular
TgeneBACE2chr21:40763762chr21:42647298ENST00000330333+7921_473434519Topological domainExtracellular
TgeneBACE2chr21:40763762chr21:42647298ENST00000347667+6821_473384469Topological domainExtracellular


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FusionGeneSequence for WRB_BACE2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_WRB_ENST00000333781_chr21_40763762_+_BACE2_ENST00000328735_chr21_42647298_+_131aa
MSSAAADHWAWLLVLSFVFGCNVLRILLPSFSSFMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKLKTHV

>In-frame_WRB_ENST00000333781_chr21_40763762_+_BACE2_ENST00000347667_chr21_42647298_+_196aa
MSSAAADHWAWLLVLSFVFGCNVLRILLPSFSSFMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKLKTHV
KARTAQLAKIKWVISVAFYVLQKLQVLQCLKFPGLSQQRMXPATVSPLSLXASPFCGLCPMRSXASVEPSSLSXSSCCCCRSGVSVAPVT

>In-frame_WRB_ENST00000541890_chr21_40763762_+_BACE2_ENST00000328735_chr21_42647298_+_131aa
MSSAAADHWAWLLVLSFVFGCNVLRILLPSFSSFMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKLKTHV

>In-frame_WRB_ENST00000541890_chr21_40763762_+_BACE2_ENST00000347667_chr21_42647298_+_196aa
MSSAAADHWAWLLVLSFVFGCNVLRILLPSFSSFMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKLKTHV
KARTAQLAKIKWVISVAFYVLQKLQVLQCLKFPGLSQQRMXPATVSPLSLXASPFCGLCPMRSXASVEPSSLSXSSCCCCRSGVSVAPVT

>In-frame_WRB_ENST00000398753_chr21_40763762_+_BACE2_ENST00000328735_chr21_42647298_+_97aa
MSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIKWVISVAFYVLQKLQVLQCLKFPG

>In-frame_WRB_ENST00000398753_chr21_40763762_+_BACE2_ENST00000347667_chr21_42647298_+_162aa
MSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIKWVISVAFYVLQKLQVLQCLKFPG

>In-frame_WRB_ENST00000380708_chr21_40763762_+_BACE2_ENST00000328735_chr21_42647298_+_97aa
MSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIKWVISVAFYVLQKLQVLQCLKFPG

>In-frame_WRB_ENST00000380708_chr21_40763762_+_BACE2_ENST00000347667_chr21_42647298_+_162aa
MSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIKWVISVAFYVLQKLQVLQCLKFPG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_WRB_ENST00000333781_chr21_40763762_+_BACE2_ENST00000328735_chr21_42647298_+_393nt
ATGAGCTCAGCCGCGGCCGACCACTGGGCGTGGTTGCTGGTGCTCAGCTTCGTGTTTGGATGCAATGTTCTTAGGATCCTCCTCCCGTCC
TTCTCATCCTTCATGTCCAGGGTGCTGCAGAAGGACGCGGAGCAGGAGTCACAGATGAGAGCGGAGATCCAGGACATGAAGCAGGAGCTC
TCCACAGTCAACATGATGGACGAGTTTGCCAGATATGCCAGGCTGGAAAGAAAGATCAACAAGATGACGGATAAGCTCAAAACCCATGTG
AAAGCTCGGACAGCTCAATTAGCCAAGATAAAATGGGTGATAAGTGTCGCTTTCTACGTATTGCAGAAATTGCAGGTGCTGCAGTGTCTG

>In-frame_WRB_ENST00000333781_chr21_40763762_+_BACE2_ENST00000347667_chr21_42647298_+_590nt
ATGAGCTCAGCCGCGGCCGACCACTGGGCGTGGTTGCTGGTGCTCAGCTTCGTGTTTGGATGCAATGTTCTTAGGATCCTCCTCCCGTCC
TTCTCATCCTTCATGTCCAGGGTGCTGCAGAAGGACGCGGAGCAGGAGTCACAGATGAGAGCGGAGATCCAGGACATGAAGCAGGAGCTC
TCCACAGTCAACATGATGGACGAGTTTGCCAGATATGCCAGGCTGGAAAGAAAGATCAACAAGATGACGGATAAGCTCAAAACCCATGTG
AAAGCTCGGACAGCTCAATTAGCCAAGATAAAATGGGTGATAAGTGTCGCTTTCTACGTATTGCAGAAATTGCAGGTGCTGCAGTGTCTG
AAATTTCCGGGCCTTTCTCAACAGAGGATGTAGCCAGCAACTGTGTCCCCGCTCAGTCTTTGAGCGAGCCCATTTTGTGGATTGTGTCCT
ATGCGCTCATGAGCGTCTGTGGAGCCATCCTCCTTGTCTTAATCGTCCTGCTGCTGCTGCCGTTCCGGTGTCAGCGTCGCCCCCGTGACC

>In-frame_WRB_ENST00000541890_chr21_40763762_+_BACE2_ENST00000328735_chr21_42647298_+_393nt
ATGAGCTCAGCCGCGGCCGACCACTGGGCGTGGTTGCTGGTGCTCAGCTTCGTGTTTGGATGCAATGTTCTTAGGATCCTCCTCCCGTCC
TTCTCATCCTTCATGTCCAGGGTGCTGCAGAAGGACGCGGAGCAGGAGTCACAGATGAGAGCGGAGATCCAGGACATGAAGCAGGAGCTC
TCCACAGTCAACATGATGGACGAGTTTGCCAGATATGCCAGGCTGGAAAGAAAGATCAACAAGATGACGGATAAGCTCAAAACCCATGTG
AAAGCTCGGACAGCTCAATTAGCCAAGATAAAATGGGTGATAAGTGTCGCTTTCTACGTATTGCAGAAATTGCAGGTGCTGCAGTGTCTG

>In-frame_WRB_ENST00000541890_chr21_40763762_+_BACE2_ENST00000347667_chr21_42647298_+_590nt
ATGAGCTCAGCCGCGGCCGACCACTGGGCGTGGTTGCTGGTGCTCAGCTTCGTGTTTGGATGCAATGTTCTTAGGATCCTCCTCCCGTCC
TTCTCATCCTTCATGTCCAGGGTGCTGCAGAAGGACGCGGAGCAGGAGTCACAGATGAGAGCGGAGATCCAGGACATGAAGCAGGAGCTC
TCCACAGTCAACATGATGGACGAGTTTGCCAGATATGCCAGGCTGGAAAGAAAGATCAACAAGATGACGGATAAGCTCAAAACCCATGTG
AAAGCTCGGACAGCTCAATTAGCCAAGATAAAATGGGTGATAAGTGTCGCTTTCTACGTATTGCAGAAATTGCAGGTGCTGCAGTGTCTG
AAATTTCCGGGCCTTTCTCAACAGAGGATGTAGCCAGCAACTGTGTCCCCGCTCAGTCTTTGAGCGAGCCCATTTTGTGGATTGTGTCCT
ATGCGCTCATGAGCGTCTGTGGAGCCATCCTCCTTGTCTTAATCGTCCTGCTGCTGCTGCCGTTCCGGTGTCAGCGTCGCCCCCGTGACC

>In-frame_WRB_ENST00000398753_chr21_40763762_+_BACE2_ENST00000328735_chr21_42647298_+_291nt
ATGTCCAGGGTGCTGCAGAAGGACGCGGAGCAGGAGTCACAGATGAGAGCGGAGATCCAGGACATGAAGCAGGAGCTCTCCACAGTCAAC
ATGATGGACGAGTTTGCCAGATATGCCAGGCTGGAAAGAAAGATCAACAAGATGACGGATAAGCTCAAAACCCATGTGAAAGCTCGGACA
GCTCAATTAGCCAAGATAAAATGGGTGATAAGTGTCGCTTTCTACGTATTGCAGAAATTGCAGGTGCTGCAGTGTCTGAAATTTCCGGGC

>In-frame_WRB_ENST00000398753_chr21_40763762_+_BACE2_ENST00000347667_chr21_42647298_+_488nt
ATGTCCAGGGTGCTGCAGAAGGACGCGGAGCAGGAGTCACAGATGAGAGCGGAGATCCAGGACATGAAGCAGGAGCTCTCCACAGTCAAC
ATGATGGACGAGTTTGCCAGATATGCCAGGCTGGAAAGAAAGATCAACAAGATGACGGATAAGCTCAAAACCCATGTGAAAGCTCGGACA
GCTCAATTAGCCAAGATAAAATGGGTGATAAGTGTCGCTTTCTACGTATTGCAGAAATTGCAGGTGCTGCAGTGTCTGAAATTTCCGGGC
CTTTCTCAACAGAGGATGTAGCCAGCAACTGTGTCCCCGCTCAGTCTTTGAGCGAGCCCATTTTGTGGATTGTGTCCTATGCGCTCATGA
GCGTCTGTGGAGCCATCCTCCTTGTCTTAATCGTCCTGCTGCTGCTGCCGTTCCGGTGTCAGCGTCGCCCCCGTGACCCTGAGGTCGTCA

>In-frame_WRB_ENST00000380708_chr21_40763762_+_BACE2_ENST00000328735_chr21_42647298_+_291nt
ATGTCCAGGGTGCTGCAGAAGGACGCGGAGCAGGAGTCACAGATGAGAGCGGAGATCCAGGACATGAAGCAGGAGCTCTCCACAGTCAAC
ATGATGGACGAGTTTGCCAGATATGCCAGGCTGGAAAGAAAGATCAACAAGATGACGGATAAGCTCAAAACCCATGTGAAAGCTCGGACA
GCTCAATTAGCCAAGATAAAATGGGTGATAAGTGTCGCTTTCTACGTATTGCAGAAATTGCAGGTGCTGCAGTGTCTGAAATTTCCGGGC

>In-frame_WRB_ENST00000380708_chr21_40763762_+_BACE2_ENST00000347667_chr21_42647298_+_488nt
ATGTCCAGGGTGCTGCAGAAGGACGCGGAGCAGGAGTCACAGATGAGAGCGGAGATCCAGGACATGAAGCAGGAGCTCTCCACAGTCAAC
ATGATGGACGAGTTTGCCAGATATGCCAGGCTGGAAAGAAAGATCAACAAGATGACGGATAAGCTCAAAACCCATGTGAAAGCTCGGACA
GCTCAATTAGCCAAGATAAAATGGGTGATAAGTGTCGCTTTCTACGTATTGCAGAAATTGCAGGTGCTGCAGTGTCTGAAATTTCCGGGC
CTTTCTCAACAGAGGATGTAGCCAGCAACTGTGTCCCCGCTCAGTCTTTGAGCGAGCCCATTTTGTGGATTGTGTCCTATGCGCTCATGA
GCGTCTGTGGAGCCATCCTCCTTGTCTTAATCGTCCTGCTGCTGCTGCCGTTCCGGTGTCAGCGTCGCCCCCGTGACCCTGAGGTCGTCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_WRB_ENST00000333781_chr21_40763762_+_BACE2_ENST00000328735_chr21_42647298_+_1704nt
CGCGAGGGCGACGCAGTTCGCAGGCGCGTCGGCGCGCCTGTTCTGGGGCGCTTGGCTTCACCGCGCAGGCGCGGTCGCCGCTGTTGTTGT
GGTCCCCATGGAGCTGCCGTAGCGGACCCAGCACAGCCAGGAGCGTCCGGGATGAGCTCAGCCGCGGCCGACCACTGGGCGTGGTTGCTG
GTGCTCAGCTTCGTGTTTGGATGCAATGTTCTTAGGATCCTCCTCCCGTCCTTCTCATCCTTCATGTCCAGGGTGCTGCAGAAGGACGCG
GAGCAGGAGTCACAGATGAGAGCGGAGATCCAGGACATGAAGCAGGAGCTCTCCACAGTCAACATGATGGACGAGTTTGCCAGATATGCC
AGGCTGGAAAGAAAGATCAACAAGATGACGGATAAGCTCAAAACCCATGTGAAAGCTCGGACAGCTCAATTAGCCAAGATAAAATGGGTG
ATAAGTGTCGCTTTCTACGTATTGCAGAAATTGCAGGTGCTGCAGTGTCTGAAATTTCCGGGCCTTTCTCAACAGAGGATGTAGCCAGCA
ACTGTGTCCCCGCTCAGTCTTTGAGCGAGCCCATTTTGTGGATTGTGTCCTATGCGCTCATGAGCGTCTGTGGAGCCATCCTCCTTGTCT
TAATCGTCCTGCTGCTGCTGCCGTTCCGGTGTCAGCGTCGCCCCCGTGACCCTGAGGTCGTCAATGATGAGTCCTCTCTGGTCAGACATC
GCTGGAAATGAATAGCCAGGCCTGACCTCAAGCAACCATGAACTCAGCTATTAAGAAAATCACATTTCCAGGGCAGCAGCCGGGATCGAT
GGTGGCGCTTTCTCCTGTGCCCACCCGTCTTCAATCTCTGTTCTGCTCCCAGATGCCTTCTAGATTCACTGTCTTTTGATTCTTGATTTT
CAAGCTTTCAAATCCTCCCTACTTCCAAGAAAAATAATTAAAAAAAAAACTTCATTCTAAACCAAAACAGAGTGGATTGGGCTGCAGGCT
CTATGGGGTTCGTTATGCCAAAGTGTCTACATGTGCCACCAACATAAAACAAAACCAAGCCTTGGCTCGTTCTCTTCTCTCTTCAATCTC
TGGAAAAATAAGTACATATAGTTGATAACCCCTCTTAGCTTACAGGAAGCTTTTTGTATTAATTGCCTTTGAGGTTATTTTCCGCCAGAC
CTCAACCTGGGTCAAAGTGGTACAGGAAGGCTTGCAGTATGATGGCAGGAGAATCAGCCTGGGGCCTGGGGATGTAACCAAGCTGTACCC
TTGAGACCTGGAACCAGAGCCACAGGCCCCTTTTGTGGGTTTCTCTGTGCTCTGAATGGGAGCCAGAATTCACTAGGAGGTCATCAACCG
ATGGTCCTCACAAGCCTCTTCTGAAGATGGAAGGCCTTTTGCCCGTTGAGGTAGAGGGGAAGGAAATCTCCTCTTTTGTACCCAATACTT
ATGTTGTATTGTTGGTGCGAAAGTAAAAACACTACCTCTTTTGAGACTTTGCCCAGGGTCCTGTGCCTGGATGGGGGTGCAGGCAGCCTT
GACCACGGCTGTTCCCCTCACCCAAAAGAATTATCATCCCAACAGCCAAGACCCAACAGGTGCTGAACTGTGCATCAACCAGGAAGAGTT

>In-frame_WRB_ENST00000333781_chr21_40763762_+_BACE2_ENST00000347667_chr21_42647298_+_7625nt
CGCGAGGGCGACGCAGTTCGCAGGCGCGTCGGCGCGCCTGTTCTGGGGCGCTTGGCTTCACCGCGCAGGCGCGGTCGCCGCTGTTGTTGT
GGTCCCCATGGAGCTGCCGTAGCGGACCCAGCACAGCCAGGAGCGTCCGGGATGAGCTCAGCCGCGGCCGACCACTGGGCGTGGTTGCTG
GTGCTCAGCTTCGTGTTTGGATGCAATGTTCTTAGGATCCTCCTCCCGTCCTTCTCATCCTTCATGTCCAGGGTGCTGCAGAAGGACGCG
GAGCAGGAGTCACAGATGAGAGCGGAGATCCAGGACATGAAGCAGGAGCTCTCCACAGTCAACATGATGGACGAGTTTGCCAGATATGCC
AGGCTGGAAAGAAAGATCAACAAGATGACGGATAAGCTCAAAACCCATGTGAAAGCTCGGACAGCTCAATTAGCCAAGATAAAATGGGTG
ATAAGTGTCGCTTTCTACGTATTGCAGAAATTGCAGGTGCTGCAGTGTCTGAAATTTCCGGGCCTTTCTCAACAGAGGATGTAGCCAGCA
ACTGTGTCCCCGCTCAGTCTTTGAGCGAGCCCATTTTGTGGATTGTGTCCTATGCGCTCATGAGCGTCTGTGGAGCCATCCTCCTTGTCT
TAATCGTCCTGCTGCTGCTGCCGTTCCGGTGTCAGCGTCGCCCCCGTGACCCTGAGGTCGTCAATGATGAGTCCTCTCTGGTCAGACATC
GCTGGAAATGAATAGCCAGGCCTGACCTCAAGCAACCATGAACTCAGCTATTAAGAAAATCACATTTCCAGGGCAGCAGCCGGGATCGAT
GGTGGCGCTTTCTCCTGTGCCCACCCGTCTTCAATCTCTGTTCTGCTCCCAGATGCCTTCTAGATTCACTGTCTTTTGATTCTTGATTTT
CAAGCTTTCAAATCCTCCCTACTTCCAAGAAAAATAATTAAAAAAAAAACTTCATTCTAAACCAAAACAGAGTGGATTGGGCTGCAGGCT
CTATGGGGTTCGTTATGCCAAAGTGTCTACATGTGCCACCAACATAAAACAAAACCAAGCCTTGGCTCGTTCTCTTCTCTCTTCAATCTC
TGGAAAAATAAGTACATATAGTTGATAACCCCTCTTAGCTTACAGGAAGCTTTTTGTATTAATTGCCTTTGAGGTTATTTTCCGCCAGAC
CTCAACCTGGGTCAAAGTGGTACAGGAAGGCTTGCAGTATGATGGCAGGAGAATCAGCCTGGGGCCTGGGGATGTAACCAAGCTGTACCC
TTGAGACCTGGAACCAGAGCCACAGGCCCCTTTTGTGGGTTTCTCTGTGCTCTGAATGGGAGCCAGAATTCACTAGGAGGTCATCAACCG
ATGGTCCTCACAAGCCTCTTCTGAAGATGGAAGGCCTTTTGCCCGTTGAGGTAGAGGGGAAGGAAATCTCCTCTTTTGTACCCAATACTT
ATGTTGTATTGTTGGTGCGAAAGTAAAAACACTACCTCTTTTGAGACTTTGCCCAGGGTCCTGTGCCTGGATGGGGGTGCAGGCAGCCTT
GACCACGGCTGTTCCCCTCACCCAAAAGAATTATCATCCCAACAGCCAAGACCCAACAGGTGCTGAACTGTGCATCAACCAGGAAGAGTT
CTATCCCCAAGCTGGCCACTATCACATATGCTTACTCTTGCTTAAAATTAATAAATCATGTTTTGATGAGAAAAAACTATTCTATTTCAC
TAGCTTAGTTGTCTCTTTTTCCAAATCTTCTCTGGAAGTAGGTTGGCTATTACCCTGTTGGGAAACAGGGAAATGGCCTGATGCCCCTAT
TTCTGACCAGCTGTCAGGGAAGGAAGATGCAAGATGTGCAGAAGACACAAGGTAACGTCTACTTATCCCCGTGCTTCGAAACCGTGTGTT
TCCCTTTGCAGAACTGGTTAGCCTCAAGCATACCCATCCAATCAGCTTAAATTGTTCAGCAGTTGACCTCTGTGCTTCTTCCTTTGGGGG
TGTTTAATCTTTGGTAACAGTTGTGCAGTGGTAGCCTTATTTCGGGGGGCAGTCCCTACTTTCTGTCACTTATCGAGGCCTTTGCCAAAG
AAAAGTGGAAGCCGTTTCCTTGACATAGCCTTATATGACCTGATGTCATTAGGAGAAGAGTTAAAAGACAGTATCCCCTCTCTCCTGCTT
GTGTGCCAAGTTCAGTGTTCCCTTTGCATTTTTTTGGGGTGGGTTGGCTATATTACAGAATTCCACCAAAAGTGCTAAGTGTCCCCTCCT
GCAGAAGTATCGTTTGTATTCACAGTAGGCTACGTGTGGATGTTTCAGCCATCTGCTCTGCTCCCTGGGTCCCCGGGTCACCACCATACT
GAGAAATATAGGACTCTGCCAAAGAGACGTGGAGGCCACGTCGGCTTGTCATGGTGTCCTGGAAGACTCTCCAGCAGCCAGAAGAACCTT
CTGTGCTGTTTTCACTAGAGAAGATTTGAGTTGCAGCCTCTTGGAAAGAACATGACGGCACGGAACGGGAGGAGGGGGCTCTTGTATCAG
GGCCCGTTGTCACATCCGCTCTCAGCTTGTTGAAAACTCATAATCTCAGAATGCATTTCACACGGAGAGATGTCTGGAAGTCCAATTCTC
ATCCCATTGGCTTTTTCCGTGGTTGCTGTTTTGTGGGCCGCTTTGCACAGGAGTGAAGCCAACACCCCTAGATTGTGCCTTCACCCTTGC
TGTGAAAAATTCAAAGCCCTGAAATAAGAGGAGGGAATCGCAGACATGCCCTGATTAGTTTTCCTGCTTATTTCTTCATACAGGCATCTT
CTGTTCCGTTGTATTGTGTTAGGTTTCAGAGGCGGGGAGCTTCCTCCTGCAGCAGATGAACAGGCATAGTTCTTAAAATACAGGAAAGTA
ACAAGTGAGGTTTCCAGGTAGAGTAGGTGAATGAAGTTTGCCGTCATGCTCTGTATTTCATATCAGATTTCTTTATCTTTTCATATCGCA
TGTCATTGGATGTGACATTTTGATGAAAATACTGAAACTACAAAAGCATAACTTCGCAACAAGAATGAGATAGACAATTGAATGTGGGAC
ATTTTTCTGGCATGTCTTGCTGCTGAGAATCGGACTTCCAGTCAAAACCCTGTTAGTGACACCCACCTCCTCCAGTTATGCAAATTGATG
CTTAGCTTGGCAAGCTTTCAAGGAGGTTTGCTTGGAACAGGAAAGGAATTAACAACCCTTTGAGGGTGTCATTTTTACCTTGTAATACAC
TGTGGAAAATTCTGGAAGACGGTCCTTGCCTGAAAAGGTGCAACTTAGCATTAGGTTGTTATCAGAAACCTTGTCAAGTCTGATGGGAAA
TGAATAGATGCTGCTTTATTTCCTTGATAACTTCTTTGGAAGTCTGAAATAAATCCTGCCTTCAGTAACTGAAACCATTTATTAAAAATA
GCAAGAAACAAGATGGGGACCAATTCTATTTTTATTCTTGGGAATTTGAAAGAGCCACAAGTGATTGGTGTCCGATCTCCCAGCATATAC
TGTACACTATTTTGTATTTCTCCTGAACCAAAACCAAGTACTTAGCACTCAAGAAACAGATGCCCTGTGTGTGACCGAGGGGAGTGTTTT
TCCACAACAGGTTCCACTTCTGAACACTTGGAAGGACCTTGCCTGATTCATGGTGAAACACAGAGGTTTTGGTTGGAGATAAATTTGGGG
TCAGTTACTGTTCAAAATTGTGAAAGTAGTTCCCAGGAAGACAGCATTAGTGACTCCGCAGTGCTTTGGGTAATAGATTTTGAAAAGCAA
TTGTGAGTTGGGGATTCCATCATTTCATTTAAGAGGTGAAGAGGGATTTAATTATTTAATACGCCGGGTGCAAACTTGTTAAATTCCTCT
TTCCCTGTCCCTGCTTGGTGGAGCTGCCACGTGTGGTTCAGTTCTAAGTTCTGGACTAGTGCCACTCGATATCATTGGGAATAAATCGTT
GTTCAACAGTCTGTTCCACAAACAACAGTAATTGAATTTCACAGACTTTATCCTGATTAGTGGAAATCAAATAATGGAGTGGAATCCCCA
TGTGTTTTCTCTTGCACAAACTTATTAGACTTGATTAGAAAACTGTTTGGAGGAAAAACTTGCCAGTAAGTTTTTTGGTTGTTGTTTTGT
TTTTTTTGAAAAACGACGCAACACCATAAAGTGTAAAATTAGGGGTTCTGGCCAAGAGAGGTACTAGATTTTTTTAATGCCGAGAAAAGT
CCATGCCACAGAAGTTATTGTGTATGTCTCTAGGGAGCTTTAAGAATTTCACGTTTGAACTTTACAGCTGTTTACCAATTAAATGGCAAG
CTGGAAAAATACATTTTGAGAGGGGTAGAAAGAATAAGAATATAATTAAAAGTATGCTAACAAAATAAGCAGTACATATTTTTTTAGAAA
ATGCAGTTTAGGCCAGGCACGGTAGCTCGTGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTT
GAGACCAGCCTGGACAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCAACGATGGTGATGCCTGTCTGTAATCCCAG
CTACTCTGGAGGCTGAGGCAGGAGAATCGCTTGAACCGGGGAGGCAGAGGTTGTAGTGAGCCAAGATTGCGCCACTGCACTCCAGCCTGG
GCAACAGAGCAAGACTCCGTCTCAAAAAAGGAAAGAAAATGCAGTTTCATTCCAGCCATCCTTAGATTTCTTTTCCCCTTAAAGTGGCTG
AATCCATTGGAGATGTGATTTATTTTGCAGATCCACCAATTCCAAACTTCAGGAATATTCAAGCGGGAGTCATGTGTAAGTGACAGCTTT
GACAAAGAGAGACTGTGGCTGGGTGGCCCGGGTGTTGCCCACGCGGAGCAAGGATTGGTTCATTCAACGGATGGAGAGTACAGGATGGCT
GGGACCTGGGAAGTTCCAGAATCTGAAAAGAGGGCAGGGCAAGAAGGAGCCAGAAGAGAGGTCCCACCCCTCAGTTGGCAGTGGGGCACG
GAGGTCCGCATCAGCCAAGAACGTCCCCAGGATGCCGTGGGCACCTCATTTCACCCCACGTTTTTGGCACAGTCTACTTTTTAGGTATTT
TGTAAAGGAACTTCTCAGGATTGATTATTTGCCAGAGGAACAATTAGGCCAAGAGAAACTTGCTTGACAGCCATGTGTAAAACACGTCTG
TCCTAATCAAACTAGAGATGCCTCAAGGCCCACGCAGGACACAGGCAGGTTCAAGGTCATGCACCTGGAAATTTGTAGGGGAGGGTCAAG
CAACTGAGGCCAAAGGGGGCCGGTAAAGTGGCTTCTGGGGTCTGAGCATCTGGAAGGCTCCTGGCAGCAGTTACCTGACAGTGTCGTTGA
GGGGCACGGCAGCTGGGCCCTCACCGTTTCCGCCAGCTCTGCTGAGCCAGCCCAGCCCATGCATTCCGAACATCCGACAGCTTCTTTCTC
CAGAATGTCTTCTGTCAGAGACTTCCAGGAAAGGAGCTCCCTCCTGTCTCACTGCTGTCAGCGTGGGAGCCCTGCTCCCCAGGCTCCACG
TCCCCGGAAGGTCCATCTTGTCCTGGAGCACACCCAGCCCCATTCAGGGTCAGTGCAGGAGGGAACAGGGAATCTGCATTTCAGTAAGCT
CCCCAGGTGAGGCTGCAGAGCAGAAACCACGGCTTTCAGACGTGAGCAGGCTCCCTGGGCTCTTGGTGTCACCCTGTTAGCCACATCTGC
GGAATGTGGAAGGCAGAACATAGCCACGCTGCTTAGTGCTGCCAGCGAACCTCAGGTTGCATCAGTGGCTGGAATCTATCACAGCTGTTG
GGGATACGTAACTCCCAGCAATAAATCCAGTATTTTCTTCCCTGCCCTGAGCTTCCTCTGGGTTTCTTATCAGCAGCTATTACACACAGA
TGTCCAGTGCTTCTAAACTAAATTGTACTGTGTAACTTTTACATCACACTTGTGTGCTTAAAAAGCACACCGTGGGTAGTGACTGGGCCA
AGAGACATCACAAAGCTTCCTGATAAATTTGAATCCAGCCACGGCAAGAGCGACGTGCGGGTACCTGGTCCCTGATGCTTGGGTGCCCCG
TTGAGCCTCGGGTACTTCTTGGACACTATTGTGAGAGCAGCCATCCTGGTGTCTCTGCCAGCATCTTGGGGAACGCTGTGATGGTAAAAT
ATCTGTCTCTCCTCTGGGAATCAGGGCAGCCCTGAGAAGTGAGCAGTTCCCTTTACAGATGGATAATTGTTTGTGTAAGACCAACCAGAT
AAAGTCCAAACTGTGTAGAACACACGTGTGCCTCACACATAGCCATCTGAGTAAAATATTTTTTCCAATGTAGATTTATAATTAGAAATG
ACAGATTTATAATATAGACTTCAGTAAGTTGGGCACAGCTGTCACTTTCGTGGTATCAATAAAAGGCTAGAAACCTTGGGTGTCCTTGGC
AACCTAGCCTTTGACATTGATGTTTTTCCATAGGATTTTCTTCATTTGGGTTGGAATAAAAATGCATTTTTATTCACAAGGCACAGACAG
ATAAGAATATCATAAGCAGGGAAGTGTCTCCAAAGGTCAGGACATATGTTTTTCTGTTGAGTGCTATATGTGGAGGTCATTGCAAGTTCC
CTGATATGAGTATGGTTTCGCTTGCTACATTGTGCCTATTAAAGTAAAATTTTACACAAGCCTCGCATTTCTAAGATTAGTGTTCCTGAA
TGAAATGTTAAGAAAACATTAAAAGATTATCTCTTTTTAAGATGGAGGAAAAAAAGTGAACAAAGCTAATTAATCTATCATGAAAATTGC
ACAAAATAACATTTCTTAACAAATTTAATACAATTTTGTGTTCTTTGTTGCTAGTGGTATAAAACGAGATTTTTTTCCCTCATTTTTCTC
ATTGTAGATGTCATCTCTCACATTTATATCAGTGAGGTTTGAAATTCTGTGTAGCAGTTACTCAGCACATATGAGAGGGCAGCGAATGAA
TGAGATTTGTCATGTGCTAATAAAAGCTGAATTTTTGTAATCTAAAATGATGTATTTTCTACTATTGCTGTTAATTTGCATTGTTAAAAA
TTCTTAAAGTTTAATATGTTATGTTCAGTCATTGAAAGCGACCACTCATTTTTTTCTTAAAGTTGATGCCTTTTCTGCTGTGCTAGAGTC
AGTATTTTGCTTCTGGCAGGAGAGCTGCAAACTGTGTATCCTCAAACAGATGCAAAAAGTAGTGCTTTGCAAAACGTTTGTTTTCTGTTT
ATCTCAGATTAACATCCTTTAATACAAGTTTCTTAAGTGTAACTTGTATTTCTGAAAATGCTTAAAATTATTTTATATTTCCCTTTGGGA
ATTTTTCTCTATTTCCAGCACGCTGATTTGATTTAAAAATGTAATAAGACCAAGAGTTGGAGTAAAGGGATATTCATTCCATGTTAAAAG
TGGCTTCATAGCTACTGACAAATGTCTGAACTATTGTCGTGCCCTTCAAAACTGGAGTTTTCTAAAATAATCTTATTTTTATACTTGTAT

>In-frame_WRB_ENST00000541890_chr21_40763762_+_BACE2_ENST00000328735_chr21_42647298_+_1594nt
AGCGGACCCAGCACAGCCAGGAGCGTCCGGGATGAGCTCAGCCGCGGCCGACCACTGGGCGTGGTTGCTGGTGCTCAGCTTCGTGTTTGG
ATGCAATGTTCTTAGGATCCTCCTCCCGTCCTTCTCATCCTTCATGTCCAGGGTGCTGCAGAAGGACGCGGAGCAGGAGTCACAGATGAG
AGCGGAGATCCAGGACATGAAGCAGGAGCTCTCCACAGTCAACATGATGGACGAGTTTGCCAGATATGCCAGGCTGGAAAGAAAGATCAA
CAAGATGACGGATAAGCTCAAAACCCATGTGAAAGCTCGGACAGCTCAATTAGCCAAGATAAAATGGGTGATAAGTGTCGCTTTCTACGT
ATTGCAGAAATTGCAGGTGCTGCAGTGTCTGAAATTTCCGGGCCTTTCTCAACAGAGGATGTAGCCAGCAACTGTGTCCCCGCTCAGTCT
TTGAGCGAGCCCATTTTGTGGATTGTGTCCTATGCGCTCATGAGCGTCTGTGGAGCCATCCTCCTTGTCTTAATCGTCCTGCTGCTGCTG
CCGTTCCGGTGTCAGCGTCGCCCCCGTGACCCTGAGGTCGTCAATGATGAGTCCTCTCTGGTCAGACATCGCTGGAAATGAATAGCCAGG
CCTGACCTCAAGCAACCATGAACTCAGCTATTAAGAAAATCACATTTCCAGGGCAGCAGCCGGGATCGATGGTGGCGCTTTCTCCTGTGC
CCACCCGTCTTCAATCTCTGTTCTGCTCCCAGATGCCTTCTAGATTCACTGTCTTTTGATTCTTGATTTTCAAGCTTTCAAATCCTCCCT
ACTTCCAAGAAAAATAATTAAAAAAAAAACTTCATTCTAAACCAAAACAGAGTGGATTGGGCTGCAGGCTCTATGGGGTTCGTTATGCCA
AAGTGTCTACATGTGCCACCAACATAAAACAAAACCAAGCCTTGGCTCGTTCTCTTCTCTCTTCAATCTCTGGAAAAATAAGTACATATA
GTTGATAACCCCTCTTAGCTTACAGGAAGCTTTTTGTATTAATTGCCTTTGAGGTTATTTTCCGCCAGACCTCAACCTGGGTCAAAGTGG
TACAGGAAGGCTTGCAGTATGATGGCAGGAGAATCAGCCTGGGGCCTGGGGATGTAACCAAGCTGTACCCTTGAGACCTGGAACCAGAGC
CACAGGCCCCTTTTGTGGGTTTCTCTGTGCTCTGAATGGGAGCCAGAATTCACTAGGAGGTCATCAACCGATGGTCCTCACAAGCCTCTT
CTGAAGATGGAAGGCCTTTTGCCCGTTGAGGTAGAGGGGAAGGAAATCTCCTCTTTTGTACCCAATACTTATGTTGTATTGTTGGTGCGA
AAGTAAAAACACTACCTCTTTTGAGACTTTGCCCAGGGTCCTGTGCCTGGATGGGGGTGCAGGCAGCCTTGACCACGGCTGTTCCCCTCA
CCCAAAAGAATTATCATCCCAACAGCCAAGACCCAACAGGTGCTGAACTGTGCATCAACCAGGAAGAGTTCTATCCCCAAGCTGGCCACT

>In-frame_WRB_ENST00000541890_chr21_40763762_+_BACE2_ENST00000347667_chr21_42647298_+_7515nt
AGCGGACCCAGCACAGCCAGGAGCGTCCGGGATGAGCTCAGCCGCGGCCGACCACTGGGCGTGGTTGCTGGTGCTCAGCTTCGTGTTTGG
ATGCAATGTTCTTAGGATCCTCCTCCCGTCCTTCTCATCCTTCATGTCCAGGGTGCTGCAGAAGGACGCGGAGCAGGAGTCACAGATGAG
AGCGGAGATCCAGGACATGAAGCAGGAGCTCTCCACAGTCAACATGATGGACGAGTTTGCCAGATATGCCAGGCTGGAAAGAAAGATCAA
CAAGATGACGGATAAGCTCAAAACCCATGTGAAAGCTCGGACAGCTCAATTAGCCAAGATAAAATGGGTGATAAGTGTCGCTTTCTACGT
ATTGCAGAAATTGCAGGTGCTGCAGTGTCTGAAATTTCCGGGCCTTTCTCAACAGAGGATGTAGCCAGCAACTGTGTCCCCGCTCAGTCT
TTGAGCGAGCCCATTTTGTGGATTGTGTCCTATGCGCTCATGAGCGTCTGTGGAGCCATCCTCCTTGTCTTAATCGTCCTGCTGCTGCTG
CCGTTCCGGTGTCAGCGTCGCCCCCGTGACCCTGAGGTCGTCAATGATGAGTCCTCTCTGGTCAGACATCGCTGGAAATGAATAGCCAGG
CCTGACCTCAAGCAACCATGAACTCAGCTATTAAGAAAATCACATTTCCAGGGCAGCAGCCGGGATCGATGGTGGCGCTTTCTCCTGTGC
CCACCCGTCTTCAATCTCTGTTCTGCTCCCAGATGCCTTCTAGATTCACTGTCTTTTGATTCTTGATTTTCAAGCTTTCAAATCCTCCCT
ACTTCCAAGAAAAATAATTAAAAAAAAAACTTCATTCTAAACCAAAACAGAGTGGATTGGGCTGCAGGCTCTATGGGGTTCGTTATGCCA
AAGTGTCTACATGTGCCACCAACATAAAACAAAACCAAGCCTTGGCTCGTTCTCTTCTCTCTTCAATCTCTGGAAAAATAAGTACATATA
GTTGATAACCCCTCTTAGCTTACAGGAAGCTTTTTGTATTAATTGCCTTTGAGGTTATTTTCCGCCAGACCTCAACCTGGGTCAAAGTGG
TACAGGAAGGCTTGCAGTATGATGGCAGGAGAATCAGCCTGGGGCCTGGGGATGTAACCAAGCTGTACCCTTGAGACCTGGAACCAGAGC
CACAGGCCCCTTTTGTGGGTTTCTCTGTGCTCTGAATGGGAGCCAGAATTCACTAGGAGGTCATCAACCGATGGTCCTCACAAGCCTCTT
CTGAAGATGGAAGGCCTTTTGCCCGTTGAGGTAGAGGGGAAGGAAATCTCCTCTTTTGTACCCAATACTTATGTTGTATTGTTGGTGCGA
AAGTAAAAACACTACCTCTTTTGAGACTTTGCCCAGGGTCCTGTGCCTGGATGGGGGTGCAGGCAGCCTTGACCACGGCTGTTCCCCTCA
CCCAAAAGAATTATCATCCCAACAGCCAAGACCCAACAGGTGCTGAACTGTGCATCAACCAGGAAGAGTTCTATCCCCAAGCTGGCCACT
ATCACATATGCTTACTCTTGCTTAAAATTAATAAATCATGTTTTGATGAGAAAAAACTATTCTATTTCACTAGCTTAGTTGTCTCTTTTT
CCAAATCTTCTCTGGAAGTAGGTTGGCTATTACCCTGTTGGGAAACAGGGAAATGGCCTGATGCCCCTATTTCTGACCAGCTGTCAGGGA
AGGAAGATGCAAGATGTGCAGAAGACACAAGGTAACGTCTACTTATCCCCGTGCTTCGAAACCGTGTGTTTCCCTTTGCAGAACTGGTTA
GCCTCAAGCATACCCATCCAATCAGCTTAAATTGTTCAGCAGTTGACCTCTGTGCTTCTTCCTTTGGGGGTGTTTAATCTTTGGTAACAG
TTGTGCAGTGGTAGCCTTATTTCGGGGGGCAGTCCCTACTTTCTGTCACTTATCGAGGCCTTTGCCAAAGAAAAGTGGAAGCCGTTTCCT
TGACATAGCCTTATATGACCTGATGTCATTAGGAGAAGAGTTAAAAGACAGTATCCCCTCTCTCCTGCTTGTGTGCCAAGTTCAGTGTTC
CCTTTGCATTTTTTTGGGGTGGGTTGGCTATATTACAGAATTCCACCAAAAGTGCTAAGTGTCCCCTCCTGCAGAAGTATCGTTTGTATT
CACAGTAGGCTACGTGTGGATGTTTCAGCCATCTGCTCTGCTCCCTGGGTCCCCGGGTCACCACCATACTGAGAAATATAGGACTCTGCC
AAAGAGACGTGGAGGCCACGTCGGCTTGTCATGGTGTCCTGGAAGACTCTCCAGCAGCCAGAAGAACCTTCTGTGCTGTTTTCACTAGAG
AAGATTTGAGTTGCAGCCTCTTGGAAAGAACATGACGGCACGGAACGGGAGGAGGGGGCTCTTGTATCAGGGCCCGTTGTCACATCCGCT
CTCAGCTTGTTGAAAACTCATAATCTCAGAATGCATTTCACACGGAGAGATGTCTGGAAGTCCAATTCTCATCCCATTGGCTTTTTCCGT
GGTTGCTGTTTTGTGGGCCGCTTTGCACAGGAGTGAAGCCAACACCCCTAGATTGTGCCTTCACCCTTGCTGTGAAAAATTCAAAGCCCT
GAAATAAGAGGAGGGAATCGCAGACATGCCCTGATTAGTTTTCCTGCTTATTTCTTCATACAGGCATCTTCTGTTCCGTTGTATTGTGTT
AGGTTTCAGAGGCGGGGAGCTTCCTCCTGCAGCAGATGAACAGGCATAGTTCTTAAAATACAGGAAAGTAACAAGTGAGGTTTCCAGGTA
GAGTAGGTGAATGAAGTTTGCCGTCATGCTCTGTATTTCATATCAGATTTCTTTATCTTTTCATATCGCATGTCATTGGATGTGACATTT
TGATGAAAATACTGAAACTACAAAAGCATAACTTCGCAACAAGAATGAGATAGACAATTGAATGTGGGACATTTTTCTGGCATGTCTTGC
TGCTGAGAATCGGACTTCCAGTCAAAACCCTGTTAGTGACACCCACCTCCTCCAGTTATGCAAATTGATGCTTAGCTTGGCAAGCTTTCA
AGGAGGTTTGCTTGGAACAGGAAAGGAATTAACAACCCTTTGAGGGTGTCATTTTTACCTTGTAATACACTGTGGAAAATTCTGGAAGAC
GGTCCTTGCCTGAAAAGGTGCAACTTAGCATTAGGTTGTTATCAGAAACCTTGTCAAGTCTGATGGGAAATGAATAGATGCTGCTTTATT
TCCTTGATAACTTCTTTGGAAGTCTGAAATAAATCCTGCCTTCAGTAACTGAAACCATTTATTAAAAATAGCAAGAAACAAGATGGGGAC
CAATTCTATTTTTATTCTTGGGAATTTGAAAGAGCCACAAGTGATTGGTGTCCGATCTCCCAGCATATACTGTACACTATTTTGTATTTC
TCCTGAACCAAAACCAAGTACTTAGCACTCAAGAAACAGATGCCCTGTGTGTGACCGAGGGGAGTGTTTTTCCACAACAGGTTCCACTTC
TGAACACTTGGAAGGACCTTGCCTGATTCATGGTGAAACACAGAGGTTTTGGTTGGAGATAAATTTGGGGTCAGTTACTGTTCAAAATTG
TGAAAGTAGTTCCCAGGAAGACAGCATTAGTGACTCCGCAGTGCTTTGGGTAATAGATTTTGAAAAGCAATTGTGAGTTGGGGATTCCAT
CATTTCATTTAAGAGGTGAAGAGGGATTTAATTATTTAATACGCCGGGTGCAAACTTGTTAAATTCCTCTTTCCCTGTCCCTGCTTGGTG
GAGCTGCCACGTGTGGTTCAGTTCTAAGTTCTGGACTAGTGCCACTCGATATCATTGGGAATAAATCGTTGTTCAACAGTCTGTTCCACA
AACAACAGTAATTGAATTTCACAGACTTTATCCTGATTAGTGGAAATCAAATAATGGAGTGGAATCCCCATGTGTTTTCTCTTGCACAAA
CTTATTAGACTTGATTAGAAAACTGTTTGGAGGAAAAACTTGCCAGTAAGTTTTTTGGTTGTTGTTTTGTTTTTTTTGAAAAACGACGCA
ACACCATAAAGTGTAAAATTAGGGGTTCTGGCCAAGAGAGGTACTAGATTTTTTTAATGCCGAGAAAAGTCCATGCCACAGAAGTTATTG
TGTATGTCTCTAGGGAGCTTTAAGAATTTCACGTTTGAACTTTACAGCTGTTTACCAATTAAATGGCAAGCTGGAAAAATACATTTTGAG
AGGGGTAGAAAGAATAAGAATATAATTAAAAGTATGCTAACAAAATAAGCAGTACATATTTTTTTAGAAAATGCAGTTTAGGCCAGGCAC
GGTAGCTCGTGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGACAACAT
GGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCAACGATGGTGATGCCTGTCTGTAATCCCAGCTACTCTGGAGGCTGAGGCA
GGAGAATCGCTTGAACCGGGGAGGCAGAGGTTGTAGTGAGCCAAGATTGCGCCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCCGT
CTCAAAAAAGGAAAGAAAATGCAGTTTCATTCCAGCCATCCTTAGATTTCTTTTCCCCTTAAAGTGGCTGAATCCATTGGAGATGTGATT
TATTTTGCAGATCCACCAATTCCAAACTTCAGGAATATTCAAGCGGGAGTCATGTGTAAGTGACAGCTTTGACAAAGAGAGACTGTGGCT
GGGTGGCCCGGGTGTTGCCCACGCGGAGCAAGGATTGGTTCATTCAACGGATGGAGAGTACAGGATGGCTGGGACCTGGGAAGTTCCAGA
ATCTGAAAAGAGGGCAGGGCAAGAAGGAGCCAGAAGAGAGGTCCCACCCCTCAGTTGGCAGTGGGGCACGGAGGTCCGCATCAGCCAAGA
ACGTCCCCAGGATGCCGTGGGCACCTCATTTCACCCCACGTTTTTGGCACAGTCTACTTTTTAGGTATTTTGTAAAGGAACTTCTCAGGA
TTGATTATTTGCCAGAGGAACAATTAGGCCAAGAGAAACTTGCTTGACAGCCATGTGTAAAACACGTCTGTCCTAATCAAACTAGAGATG
CCTCAAGGCCCACGCAGGACACAGGCAGGTTCAAGGTCATGCACCTGGAAATTTGTAGGGGAGGGTCAAGCAACTGAGGCCAAAGGGGGC
CGGTAAAGTGGCTTCTGGGGTCTGAGCATCTGGAAGGCTCCTGGCAGCAGTTACCTGACAGTGTCGTTGAGGGGCACGGCAGCTGGGCCC
TCACCGTTTCCGCCAGCTCTGCTGAGCCAGCCCAGCCCATGCATTCCGAACATCCGACAGCTTCTTTCTCCAGAATGTCTTCTGTCAGAG
ACTTCCAGGAAAGGAGCTCCCTCCTGTCTCACTGCTGTCAGCGTGGGAGCCCTGCTCCCCAGGCTCCACGTCCCCGGAAGGTCCATCTTG
TCCTGGAGCACACCCAGCCCCATTCAGGGTCAGTGCAGGAGGGAACAGGGAATCTGCATTTCAGTAAGCTCCCCAGGTGAGGCTGCAGAG
CAGAAACCACGGCTTTCAGACGTGAGCAGGCTCCCTGGGCTCTTGGTGTCACCCTGTTAGCCACATCTGCGGAATGTGGAAGGCAGAACA
TAGCCACGCTGCTTAGTGCTGCCAGCGAACCTCAGGTTGCATCAGTGGCTGGAATCTATCACAGCTGTTGGGGATACGTAACTCCCAGCA
ATAAATCCAGTATTTTCTTCCCTGCCCTGAGCTTCCTCTGGGTTTCTTATCAGCAGCTATTACACACAGATGTCCAGTGCTTCTAAACTA
AATTGTACTGTGTAACTTTTACATCACACTTGTGTGCTTAAAAAGCACACCGTGGGTAGTGACTGGGCCAAGAGACATCACAAAGCTTCC
TGATAAATTTGAATCCAGCCACGGCAAGAGCGACGTGCGGGTACCTGGTCCCTGATGCTTGGGTGCCCCGTTGAGCCTCGGGTACTTCTT
GGACACTATTGTGAGAGCAGCCATCCTGGTGTCTCTGCCAGCATCTTGGGGAACGCTGTGATGGTAAAATATCTGTCTCTCCTCTGGGAA
TCAGGGCAGCCCTGAGAAGTGAGCAGTTCCCTTTACAGATGGATAATTGTTTGTGTAAGACCAACCAGATAAAGTCCAAACTGTGTAGAA
CACACGTGTGCCTCACACATAGCCATCTGAGTAAAATATTTTTTCCAATGTAGATTTATAATTAGAAATGACAGATTTATAATATAGACT
TCAGTAAGTTGGGCACAGCTGTCACTTTCGTGGTATCAATAAAAGGCTAGAAACCTTGGGTGTCCTTGGCAACCTAGCCTTTGACATTGA
TGTTTTTCCATAGGATTTTCTTCATTTGGGTTGGAATAAAAATGCATTTTTATTCACAAGGCACAGACAGATAAGAATATCATAAGCAGG
GAAGTGTCTCCAAAGGTCAGGACATATGTTTTTCTGTTGAGTGCTATATGTGGAGGTCATTGCAAGTTCCCTGATATGAGTATGGTTTCG
CTTGCTACATTGTGCCTATTAAAGTAAAATTTTACACAAGCCTCGCATTTCTAAGATTAGTGTTCCTGAATGAAATGTTAAGAAAACATT
AAAAGATTATCTCTTTTTAAGATGGAGGAAAAAAAGTGAACAAAGCTAATTAATCTATCATGAAAATTGCACAAAATAACATTTCTTAAC
AAATTTAATACAATTTTGTGTTCTTTGTTGCTAGTGGTATAAAACGAGATTTTTTTCCCTCATTTTTCTCATTGTAGATGTCATCTCTCA
CATTTATATCAGTGAGGTTTGAAATTCTGTGTAGCAGTTACTCAGCACATATGAGAGGGCAGCGAATGAATGAGATTTGTCATGTGCTAA
TAAAAGCTGAATTTTTGTAATCTAAAATGATGTATTTTCTACTATTGCTGTTAATTTGCATTGTTAAAAATTCTTAAAGTTTAATATGTT
ATGTTCAGTCATTGAAAGCGACCACTCATTTTTTTCTTAAAGTTGATGCCTTTTCTGCTGTGCTAGAGTCAGTATTTTGCTTCTGGCAGG
AGAGCTGCAAACTGTGTATCCTCAAACAGATGCAAAAAGTAGTGCTTTGCAAAACGTTTGTTTTCTGTTTATCTCAGATTAACATCCTTT
AATACAAGTTTCTTAAGTGTAACTTGTATTTCTGAAAATGCTTAAAATTATTTTATATTTCCCTTTGGGAATTTTTCTCTATTTCCAGCA
CGCTGATTTGATTTAAAAATGTAATAAGACCAAGAGTTGGAGTAAAGGGATATTCATTCCATGTTAAAAGTGGCTTCATAGCTACTGACA
AATGTCTGAACTATTGTCGTGCCCTTCAAAACTGGAGTTTTCTAAAATAATCTTATTTTTATACTTGTATGTTCCAGCAATTTAAGATAT

>In-frame_WRB_ENST00000398753_chr21_40763762_+_BACE2_ENST00000328735_chr21_42647298_+_1560nt
GGATCCTCCTCCCGTCCTTCTCATCCTTCGTAAGTGGCTGCCTGGCCTCCCAAGGGCCGGTGGGGATGCCGCCCCAGTCCCCCGGCGGGT
CTGGCGTAGATGTCCAGGGTGCTGCAGAAGGACGCGGAGCAGGAGTCACAGATGAGAGCGGAGATCCAGGACATGAAGCAGGAGCTCTCC
ACAGTCAACATGATGGACGAGTTTGCCAGATATGCCAGGCTGGAAAGAAAGATCAACAAGATGACGGATAAGCTCAAAACCCATGTGAAA
GCTCGGACAGCTCAATTAGCCAAGATAAAATGGGTGATAAGTGTCGCTTTCTACGTATTGCAGAAATTGCAGGTGCTGCAGTGTCTGAAA
TTTCCGGGCCTTTCTCAACAGAGGATGTAGCCAGCAACTGTGTCCCCGCTCAGTCTTTGAGCGAGCCCATTTTGTGGATTGTGTCCTATG
CGCTCATGAGCGTCTGTGGAGCCATCCTCCTTGTCTTAATCGTCCTGCTGCTGCTGCCGTTCCGGTGTCAGCGTCGCCCCCGTGACCCTG
AGGTCGTCAATGATGAGTCCTCTCTGGTCAGACATCGCTGGAAATGAATAGCCAGGCCTGACCTCAAGCAACCATGAACTCAGCTATTAA
GAAAATCACATTTCCAGGGCAGCAGCCGGGATCGATGGTGGCGCTTTCTCCTGTGCCCACCCGTCTTCAATCTCTGTTCTGCTCCCAGAT
GCCTTCTAGATTCACTGTCTTTTGATTCTTGATTTTCAAGCTTTCAAATCCTCCCTACTTCCAAGAAAAATAATTAAAAAAAAAACTTCA
TTCTAAACCAAAACAGAGTGGATTGGGCTGCAGGCTCTATGGGGTTCGTTATGCCAAAGTGTCTACATGTGCCACCAACATAAAACAAAA
CCAAGCCTTGGCTCGTTCTCTTCTCTCTTCAATCTCTGGAAAAATAAGTACATATAGTTGATAACCCCTCTTAGCTTACAGGAAGCTTTT
TGTATTAATTGCCTTTGAGGTTATTTTCCGCCAGACCTCAACCTGGGTCAAAGTGGTACAGGAAGGCTTGCAGTATGATGGCAGGAGAAT
CAGCCTGGGGCCTGGGGATGTAACCAAGCTGTACCCTTGAGACCTGGAACCAGAGCCACAGGCCCCTTTTGTGGGTTTCTCTGTGCTCTG
AATGGGAGCCAGAATTCACTAGGAGGTCATCAACCGATGGTCCTCACAAGCCTCTTCTGAAGATGGAAGGCCTTTTGCCCGTTGAGGTAG
AGGGGAAGGAAATCTCCTCTTTTGTACCCAATACTTATGTTGTATTGTTGGTGCGAAAGTAAAAACACTACCTCTTTTGAGACTTTGCCC
AGGGTCCTGTGCCTGGATGGGGGTGCAGGCAGCCTTGACCACGGCTGTTCCCCTCACCCAAAAGAATTATCATCCCAACAGCCAAGACCC
AACAGGTGCTGAACTGTGCATCAACCAGGAAGAGTTCTATCCCCAAGCTGGCCACTATCACATATGCTTACTCTTGCTTAAAATTAATAA

>In-frame_WRB_ENST00000398753_chr21_40763762_+_BACE2_ENST00000347667_chr21_42647298_+_7481nt
GGATCCTCCTCCCGTCCTTCTCATCCTTCGTAAGTGGCTGCCTGGCCTCCCAAGGGCCGGTGGGGATGCCGCCCCAGTCCCCCGGCGGGT
CTGGCGTAGATGTCCAGGGTGCTGCAGAAGGACGCGGAGCAGGAGTCACAGATGAGAGCGGAGATCCAGGACATGAAGCAGGAGCTCTCC
ACAGTCAACATGATGGACGAGTTTGCCAGATATGCCAGGCTGGAAAGAAAGATCAACAAGATGACGGATAAGCTCAAAACCCATGTGAAA
GCTCGGACAGCTCAATTAGCCAAGATAAAATGGGTGATAAGTGTCGCTTTCTACGTATTGCAGAAATTGCAGGTGCTGCAGTGTCTGAAA
TTTCCGGGCCTTTCTCAACAGAGGATGTAGCCAGCAACTGTGTCCCCGCTCAGTCTTTGAGCGAGCCCATTTTGTGGATTGTGTCCTATG
CGCTCATGAGCGTCTGTGGAGCCATCCTCCTTGTCTTAATCGTCCTGCTGCTGCTGCCGTTCCGGTGTCAGCGTCGCCCCCGTGACCCTG
AGGTCGTCAATGATGAGTCCTCTCTGGTCAGACATCGCTGGAAATGAATAGCCAGGCCTGACCTCAAGCAACCATGAACTCAGCTATTAA
GAAAATCACATTTCCAGGGCAGCAGCCGGGATCGATGGTGGCGCTTTCTCCTGTGCCCACCCGTCTTCAATCTCTGTTCTGCTCCCAGAT
GCCTTCTAGATTCACTGTCTTTTGATTCTTGATTTTCAAGCTTTCAAATCCTCCCTACTTCCAAGAAAAATAATTAAAAAAAAAACTTCA
TTCTAAACCAAAACAGAGTGGATTGGGCTGCAGGCTCTATGGGGTTCGTTATGCCAAAGTGTCTACATGTGCCACCAACATAAAACAAAA
CCAAGCCTTGGCTCGTTCTCTTCTCTCTTCAATCTCTGGAAAAATAAGTACATATAGTTGATAACCCCTCTTAGCTTACAGGAAGCTTTT
TGTATTAATTGCCTTTGAGGTTATTTTCCGCCAGACCTCAACCTGGGTCAAAGTGGTACAGGAAGGCTTGCAGTATGATGGCAGGAGAAT
CAGCCTGGGGCCTGGGGATGTAACCAAGCTGTACCCTTGAGACCTGGAACCAGAGCCACAGGCCCCTTTTGTGGGTTTCTCTGTGCTCTG
AATGGGAGCCAGAATTCACTAGGAGGTCATCAACCGATGGTCCTCACAAGCCTCTTCTGAAGATGGAAGGCCTTTTGCCCGTTGAGGTAG
AGGGGAAGGAAATCTCCTCTTTTGTACCCAATACTTATGTTGTATTGTTGGTGCGAAAGTAAAAACACTACCTCTTTTGAGACTTTGCCC
AGGGTCCTGTGCCTGGATGGGGGTGCAGGCAGCCTTGACCACGGCTGTTCCCCTCACCCAAAAGAATTATCATCCCAACAGCCAAGACCC
AACAGGTGCTGAACTGTGCATCAACCAGGAAGAGTTCTATCCCCAAGCTGGCCACTATCACATATGCTTACTCTTGCTTAAAATTAATAA
ATCATGTTTTGATGAGAAAAAACTATTCTATTTCACTAGCTTAGTTGTCTCTTTTTCCAAATCTTCTCTGGAAGTAGGTTGGCTATTACC
CTGTTGGGAAACAGGGAAATGGCCTGATGCCCCTATTTCTGACCAGCTGTCAGGGAAGGAAGATGCAAGATGTGCAGAAGACACAAGGTA
ACGTCTACTTATCCCCGTGCTTCGAAACCGTGTGTTTCCCTTTGCAGAACTGGTTAGCCTCAAGCATACCCATCCAATCAGCTTAAATTG
TTCAGCAGTTGACCTCTGTGCTTCTTCCTTTGGGGGTGTTTAATCTTTGGTAACAGTTGTGCAGTGGTAGCCTTATTTCGGGGGGCAGTC
CCTACTTTCTGTCACTTATCGAGGCCTTTGCCAAAGAAAAGTGGAAGCCGTTTCCTTGACATAGCCTTATATGACCTGATGTCATTAGGA
GAAGAGTTAAAAGACAGTATCCCCTCTCTCCTGCTTGTGTGCCAAGTTCAGTGTTCCCTTTGCATTTTTTTGGGGTGGGTTGGCTATATT
ACAGAATTCCACCAAAAGTGCTAAGTGTCCCCTCCTGCAGAAGTATCGTTTGTATTCACAGTAGGCTACGTGTGGATGTTTCAGCCATCT
GCTCTGCTCCCTGGGTCCCCGGGTCACCACCATACTGAGAAATATAGGACTCTGCCAAAGAGACGTGGAGGCCACGTCGGCTTGTCATGG
TGTCCTGGAAGACTCTCCAGCAGCCAGAAGAACCTTCTGTGCTGTTTTCACTAGAGAAGATTTGAGTTGCAGCCTCTTGGAAAGAACATG
ACGGCACGGAACGGGAGGAGGGGGCTCTTGTATCAGGGCCCGTTGTCACATCCGCTCTCAGCTTGTTGAAAACTCATAATCTCAGAATGC
ATTTCACACGGAGAGATGTCTGGAAGTCCAATTCTCATCCCATTGGCTTTTTCCGTGGTTGCTGTTTTGTGGGCCGCTTTGCACAGGAGT
GAAGCCAACACCCCTAGATTGTGCCTTCACCCTTGCTGTGAAAAATTCAAAGCCCTGAAATAAGAGGAGGGAATCGCAGACATGCCCTGA
TTAGTTTTCCTGCTTATTTCTTCATACAGGCATCTTCTGTTCCGTTGTATTGTGTTAGGTTTCAGAGGCGGGGAGCTTCCTCCTGCAGCA
GATGAACAGGCATAGTTCTTAAAATACAGGAAAGTAACAAGTGAGGTTTCCAGGTAGAGTAGGTGAATGAAGTTTGCCGTCATGCTCTGT
ATTTCATATCAGATTTCTTTATCTTTTCATATCGCATGTCATTGGATGTGACATTTTGATGAAAATACTGAAACTACAAAAGCATAACTT
CGCAACAAGAATGAGATAGACAATTGAATGTGGGACATTTTTCTGGCATGTCTTGCTGCTGAGAATCGGACTTCCAGTCAAAACCCTGTT
AGTGACACCCACCTCCTCCAGTTATGCAAATTGATGCTTAGCTTGGCAAGCTTTCAAGGAGGTTTGCTTGGAACAGGAAAGGAATTAACA
ACCCTTTGAGGGTGTCATTTTTACCTTGTAATACACTGTGGAAAATTCTGGAAGACGGTCCTTGCCTGAAAAGGTGCAACTTAGCATTAG
GTTGTTATCAGAAACCTTGTCAAGTCTGATGGGAAATGAATAGATGCTGCTTTATTTCCTTGATAACTTCTTTGGAAGTCTGAAATAAAT
CCTGCCTTCAGTAACTGAAACCATTTATTAAAAATAGCAAGAAACAAGATGGGGACCAATTCTATTTTTATTCTTGGGAATTTGAAAGAG
CCACAAGTGATTGGTGTCCGATCTCCCAGCATATACTGTACACTATTTTGTATTTCTCCTGAACCAAAACCAAGTACTTAGCACTCAAGA
AACAGATGCCCTGTGTGTGACCGAGGGGAGTGTTTTTCCACAACAGGTTCCACTTCTGAACACTTGGAAGGACCTTGCCTGATTCATGGT
GAAACACAGAGGTTTTGGTTGGAGATAAATTTGGGGTCAGTTACTGTTCAAAATTGTGAAAGTAGTTCCCAGGAAGACAGCATTAGTGAC
TCCGCAGTGCTTTGGGTAATAGATTTTGAAAAGCAATTGTGAGTTGGGGATTCCATCATTTCATTTAAGAGGTGAAGAGGGATTTAATTA
TTTAATACGCCGGGTGCAAACTTGTTAAATTCCTCTTTCCCTGTCCCTGCTTGGTGGAGCTGCCACGTGTGGTTCAGTTCTAAGTTCTGG
ACTAGTGCCACTCGATATCATTGGGAATAAATCGTTGTTCAACAGTCTGTTCCACAAACAACAGTAATTGAATTTCACAGACTTTATCCT
GATTAGTGGAAATCAAATAATGGAGTGGAATCCCCATGTGTTTTCTCTTGCACAAACTTATTAGACTTGATTAGAAAACTGTTTGGAGGA
AAAACTTGCCAGTAAGTTTTTTGGTTGTTGTTTTGTTTTTTTTGAAAAACGACGCAACACCATAAAGTGTAAAATTAGGGGTTCTGGCCA
AGAGAGGTACTAGATTTTTTTAATGCCGAGAAAAGTCCATGCCACAGAAGTTATTGTGTATGTCTCTAGGGAGCTTTAAGAATTTCACGT
TTGAACTTTACAGCTGTTTACCAATTAAATGGCAAGCTGGAAAAATACATTTTGAGAGGGGTAGAAAGAATAAGAATATAATTAAAAGTA
TGCTAACAAAATAAGCAGTACATATTTTTTTAGAAAATGCAGTTTAGGCCAGGCACGGTAGCTCGTGCCTGTAATCCCAGCACTTTGGGA
GGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGACAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAA
TTAGCCAACGATGGTGATGCCTGTCTGTAATCCCAGCTACTCTGGAGGCTGAGGCAGGAGAATCGCTTGAACCGGGGAGGCAGAGGTTGT
AGTGAGCCAAGATTGCGCCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCCGTCTCAAAAAAGGAAAGAAAATGCAGTTTCATTCCA
GCCATCCTTAGATTTCTTTTCCCCTTAAAGTGGCTGAATCCATTGGAGATGTGATTTATTTTGCAGATCCACCAATTCCAAACTTCAGGA
ATATTCAAGCGGGAGTCATGTGTAAGTGACAGCTTTGACAAAGAGAGACTGTGGCTGGGTGGCCCGGGTGTTGCCCACGCGGAGCAAGGA
TTGGTTCATTCAACGGATGGAGAGTACAGGATGGCTGGGACCTGGGAAGTTCCAGAATCTGAAAAGAGGGCAGGGCAAGAAGGAGCCAGA
AGAGAGGTCCCACCCCTCAGTTGGCAGTGGGGCACGGAGGTCCGCATCAGCCAAGAACGTCCCCAGGATGCCGTGGGCACCTCATTTCAC
CCCACGTTTTTGGCACAGTCTACTTTTTAGGTATTTTGTAAAGGAACTTCTCAGGATTGATTATTTGCCAGAGGAACAATTAGGCCAAGA
GAAACTTGCTTGACAGCCATGTGTAAAACACGTCTGTCCTAATCAAACTAGAGATGCCTCAAGGCCCACGCAGGACACAGGCAGGTTCAA
GGTCATGCACCTGGAAATTTGTAGGGGAGGGTCAAGCAACTGAGGCCAAAGGGGGCCGGTAAAGTGGCTTCTGGGGTCTGAGCATCTGGA
AGGCTCCTGGCAGCAGTTACCTGACAGTGTCGTTGAGGGGCACGGCAGCTGGGCCCTCACCGTTTCCGCCAGCTCTGCTGAGCCAGCCCA
GCCCATGCATTCCGAACATCCGACAGCTTCTTTCTCCAGAATGTCTTCTGTCAGAGACTTCCAGGAAAGGAGCTCCCTCCTGTCTCACTG
CTGTCAGCGTGGGAGCCCTGCTCCCCAGGCTCCACGTCCCCGGAAGGTCCATCTTGTCCTGGAGCACACCCAGCCCCATTCAGGGTCAGT
GCAGGAGGGAACAGGGAATCTGCATTTCAGTAAGCTCCCCAGGTGAGGCTGCAGAGCAGAAACCACGGCTTTCAGACGTGAGCAGGCTCC
CTGGGCTCTTGGTGTCACCCTGTTAGCCACATCTGCGGAATGTGGAAGGCAGAACATAGCCACGCTGCTTAGTGCTGCCAGCGAACCTCA
GGTTGCATCAGTGGCTGGAATCTATCACAGCTGTTGGGGATACGTAACTCCCAGCAATAAATCCAGTATTTTCTTCCCTGCCCTGAGCTT
CCTCTGGGTTTCTTATCAGCAGCTATTACACACAGATGTCCAGTGCTTCTAAACTAAATTGTACTGTGTAACTTTTACATCACACTTGTG
TGCTTAAAAAGCACACCGTGGGTAGTGACTGGGCCAAGAGACATCACAAAGCTTCCTGATAAATTTGAATCCAGCCACGGCAAGAGCGAC
GTGCGGGTACCTGGTCCCTGATGCTTGGGTGCCCCGTTGAGCCTCGGGTACTTCTTGGACACTATTGTGAGAGCAGCCATCCTGGTGTCT
CTGCCAGCATCTTGGGGAACGCTGTGATGGTAAAATATCTGTCTCTCCTCTGGGAATCAGGGCAGCCCTGAGAAGTGAGCAGTTCCCTTT
ACAGATGGATAATTGTTTGTGTAAGACCAACCAGATAAAGTCCAAACTGTGTAGAACACACGTGTGCCTCACACATAGCCATCTGAGTAA
AATATTTTTTCCAATGTAGATTTATAATTAGAAATGACAGATTTATAATATAGACTTCAGTAAGTTGGGCACAGCTGTCACTTTCGTGGT
ATCAATAAAAGGCTAGAAACCTTGGGTGTCCTTGGCAACCTAGCCTTTGACATTGATGTTTTTCCATAGGATTTTCTTCATTTGGGTTGG
AATAAAAATGCATTTTTATTCACAAGGCACAGACAGATAAGAATATCATAAGCAGGGAAGTGTCTCCAAAGGTCAGGACATATGTTTTTC
TGTTGAGTGCTATATGTGGAGGTCATTGCAAGTTCCCTGATATGAGTATGGTTTCGCTTGCTACATTGTGCCTATTAAAGTAAAATTTTA
CACAAGCCTCGCATTTCTAAGATTAGTGTTCCTGAATGAAATGTTAAGAAAACATTAAAAGATTATCTCTTTTTAAGATGGAGGAAAAAA
AGTGAACAAAGCTAATTAATCTATCATGAAAATTGCACAAAATAACATTTCTTAACAAATTTAATACAATTTTGTGTTCTTTGTTGCTAG
TGGTATAAAACGAGATTTTTTTCCCTCATTTTTCTCATTGTAGATGTCATCTCTCACATTTATATCAGTGAGGTTTGAAATTCTGTGTAG
CAGTTACTCAGCACATATGAGAGGGCAGCGAATGAATGAGATTTGTCATGTGCTAATAAAAGCTGAATTTTTGTAATCTAAAATGATGTA
TTTTCTACTATTGCTGTTAATTTGCATTGTTAAAAATTCTTAAAGTTTAATATGTTATGTTCAGTCATTGAAAGCGACCACTCATTTTTT
TCTTAAAGTTGATGCCTTTTCTGCTGTGCTAGAGTCAGTATTTTGCTTCTGGCAGGAGAGCTGCAAACTGTGTATCCTCAAACAGATGCA
AAAAGTAGTGCTTTGCAAAACGTTTGTTTTCTGTTTATCTCAGATTAACATCCTTTAATACAAGTTTCTTAAGTGTAACTTGTATTTCTG
AAAATGCTTAAAATTATTTTATATTTCCCTTTGGGAATTTTTCTCTATTTCCAGCACGCTGATTTGATTTAAAAATGTAATAAGACCAAG
AGTTGGAGTAAAGGGATATTCATTCCATGTTAAAAGTGGCTTCATAGCTACTGACAAATGTCTGAACTATTGTCGTGCCCTTCAAAACTG
GAGTTTTCTAAAATAATCTTATTTTTATACTTGTATGTTCCAGCAATTTAAGATATATACCATTGAAAGGGAAATAAAACATTTTTGTTT

>In-frame_WRB_ENST00000380708_chr21_40763762_+_BACE2_ENST00000328735_chr21_42647298_+_1552nt
ATGCGCAGACACCCTCAGGCGACTGGCGGGTCGCGGCTTCCAAGCTCTAAATGGAGAGTTGTCCCTACTGTGCGGCAGGCGGAGGAGACC
TATGTCCAGGGTGCTGCAGAAGGACGCGGAGCAGGAGTCACAGATGAGAGCGGAGATCCAGGACATGAAGCAGGAGCTCTCCACAGTCAA
CATGATGGACGAGTTTGCCAGATATGCCAGGCTGGAAAGAAAGATCAACAAGATGACGGATAAGCTCAAAACCCATGTGAAAGCTCGGAC
AGCTCAATTAGCCAAGATAAAATGGGTGATAAGTGTCGCTTTCTACGTATTGCAGAAATTGCAGGTGCTGCAGTGTCTGAAATTTCCGGG
CCTTTCTCAACAGAGGATGTAGCCAGCAACTGTGTCCCCGCTCAGTCTTTGAGCGAGCCCATTTTGTGGATTGTGTCCTATGCGCTCATG
AGCGTCTGTGGAGCCATCCTCCTTGTCTTAATCGTCCTGCTGCTGCTGCCGTTCCGGTGTCAGCGTCGCCCCCGTGACCCTGAGGTCGTC
AATGATGAGTCCTCTCTGGTCAGACATCGCTGGAAATGAATAGCCAGGCCTGACCTCAAGCAACCATGAACTCAGCTATTAAGAAAATCA
CATTTCCAGGGCAGCAGCCGGGATCGATGGTGGCGCTTTCTCCTGTGCCCACCCGTCTTCAATCTCTGTTCTGCTCCCAGATGCCTTCTA
GATTCACTGTCTTTTGATTCTTGATTTTCAAGCTTTCAAATCCTCCCTACTTCCAAGAAAAATAATTAAAAAAAAAACTTCATTCTAAAC
CAAAACAGAGTGGATTGGGCTGCAGGCTCTATGGGGTTCGTTATGCCAAAGTGTCTACATGTGCCACCAACATAAAACAAAACCAAGCCT
TGGCTCGTTCTCTTCTCTCTTCAATCTCTGGAAAAATAAGTACATATAGTTGATAACCCCTCTTAGCTTACAGGAAGCTTTTTGTATTAA
TTGCCTTTGAGGTTATTTTCCGCCAGACCTCAACCTGGGTCAAAGTGGTACAGGAAGGCTTGCAGTATGATGGCAGGAGAATCAGCCTGG
GGCCTGGGGATGTAACCAAGCTGTACCCTTGAGACCTGGAACCAGAGCCACAGGCCCCTTTTGTGGGTTTCTCTGTGCTCTGAATGGGAG
CCAGAATTCACTAGGAGGTCATCAACCGATGGTCCTCACAAGCCTCTTCTGAAGATGGAAGGCCTTTTGCCCGTTGAGGTAGAGGGGAAG
GAAATCTCCTCTTTTGTACCCAATACTTATGTTGTATTGTTGGTGCGAAAGTAAAAACACTACCTCTTTTGAGACTTTGCCCAGGGTCCT
GTGCCTGGATGGGGGTGCAGGCAGCCTTGACCACGGCTGTTCCCCTCACCCAAAAGAATTATCATCCCAACAGCCAAGACCCAACAGGTG
CTGAACTGTGCATCAACCAGGAAGAGTTCTATCCCCAAGCTGGCCACTATCACATATGCTTACTCTTGCTTAAAATTAATAAATCATGTT

>In-frame_WRB_ENST00000380708_chr21_40763762_+_BACE2_ENST00000347667_chr21_42647298_+_7473nt
ATGCGCAGACACCCTCAGGCGACTGGCGGGTCGCGGCTTCCAAGCTCTAAATGGAGAGTTGTCCCTACTGTGCGGCAGGCGGAGGAGACC
TATGTCCAGGGTGCTGCAGAAGGACGCGGAGCAGGAGTCACAGATGAGAGCGGAGATCCAGGACATGAAGCAGGAGCTCTCCACAGTCAA
CATGATGGACGAGTTTGCCAGATATGCCAGGCTGGAAAGAAAGATCAACAAGATGACGGATAAGCTCAAAACCCATGTGAAAGCTCGGAC
AGCTCAATTAGCCAAGATAAAATGGGTGATAAGTGTCGCTTTCTACGTATTGCAGAAATTGCAGGTGCTGCAGTGTCTGAAATTTCCGGG
CCTTTCTCAACAGAGGATGTAGCCAGCAACTGTGTCCCCGCTCAGTCTTTGAGCGAGCCCATTTTGTGGATTGTGTCCTATGCGCTCATG
AGCGTCTGTGGAGCCATCCTCCTTGTCTTAATCGTCCTGCTGCTGCTGCCGTTCCGGTGTCAGCGTCGCCCCCGTGACCCTGAGGTCGTC
AATGATGAGTCCTCTCTGGTCAGACATCGCTGGAAATGAATAGCCAGGCCTGACCTCAAGCAACCATGAACTCAGCTATTAAGAAAATCA
CATTTCCAGGGCAGCAGCCGGGATCGATGGTGGCGCTTTCTCCTGTGCCCACCCGTCTTCAATCTCTGTTCTGCTCCCAGATGCCTTCTA
GATTCACTGTCTTTTGATTCTTGATTTTCAAGCTTTCAAATCCTCCCTACTTCCAAGAAAAATAATTAAAAAAAAAACTTCATTCTAAAC
CAAAACAGAGTGGATTGGGCTGCAGGCTCTATGGGGTTCGTTATGCCAAAGTGTCTACATGTGCCACCAACATAAAACAAAACCAAGCCT
TGGCTCGTTCTCTTCTCTCTTCAATCTCTGGAAAAATAAGTACATATAGTTGATAACCCCTCTTAGCTTACAGGAAGCTTTTTGTATTAA
TTGCCTTTGAGGTTATTTTCCGCCAGACCTCAACCTGGGTCAAAGTGGTACAGGAAGGCTTGCAGTATGATGGCAGGAGAATCAGCCTGG
GGCCTGGGGATGTAACCAAGCTGTACCCTTGAGACCTGGAACCAGAGCCACAGGCCCCTTTTGTGGGTTTCTCTGTGCTCTGAATGGGAG
CCAGAATTCACTAGGAGGTCATCAACCGATGGTCCTCACAAGCCTCTTCTGAAGATGGAAGGCCTTTTGCCCGTTGAGGTAGAGGGGAAG
GAAATCTCCTCTTTTGTACCCAATACTTATGTTGTATTGTTGGTGCGAAAGTAAAAACACTACCTCTTTTGAGACTTTGCCCAGGGTCCT
GTGCCTGGATGGGGGTGCAGGCAGCCTTGACCACGGCTGTTCCCCTCACCCAAAAGAATTATCATCCCAACAGCCAAGACCCAACAGGTG
CTGAACTGTGCATCAACCAGGAAGAGTTCTATCCCCAAGCTGGCCACTATCACATATGCTTACTCTTGCTTAAAATTAATAAATCATGTT
TTGATGAGAAAAAACTATTCTATTTCACTAGCTTAGTTGTCTCTTTTTCCAAATCTTCTCTGGAAGTAGGTTGGCTATTACCCTGTTGGG
AAACAGGGAAATGGCCTGATGCCCCTATTTCTGACCAGCTGTCAGGGAAGGAAGATGCAAGATGTGCAGAAGACACAAGGTAACGTCTAC
TTATCCCCGTGCTTCGAAACCGTGTGTTTCCCTTTGCAGAACTGGTTAGCCTCAAGCATACCCATCCAATCAGCTTAAATTGTTCAGCAG
TTGACCTCTGTGCTTCTTCCTTTGGGGGTGTTTAATCTTTGGTAACAGTTGTGCAGTGGTAGCCTTATTTCGGGGGGCAGTCCCTACTTT
CTGTCACTTATCGAGGCCTTTGCCAAAGAAAAGTGGAAGCCGTTTCCTTGACATAGCCTTATATGACCTGATGTCATTAGGAGAAGAGTT
AAAAGACAGTATCCCCTCTCTCCTGCTTGTGTGCCAAGTTCAGTGTTCCCTTTGCATTTTTTTGGGGTGGGTTGGCTATATTACAGAATT
CCACCAAAAGTGCTAAGTGTCCCCTCCTGCAGAAGTATCGTTTGTATTCACAGTAGGCTACGTGTGGATGTTTCAGCCATCTGCTCTGCT
CCCTGGGTCCCCGGGTCACCACCATACTGAGAAATATAGGACTCTGCCAAAGAGACGTGGAGGCCACGTCGGCTTGTCATGGTGTCCTGG
AAGACTCTCCAGCAGCCAGAAGAACCTTCTGTGCTGTTTTCACTAGAGAAGATTTGAGTTGCAGCCTCTTGGAAAGAACATGACGGCACG
GAACGGGAGGAGGGGGCTCTTGTATCAGGGCCCGTTGTCACATCCGCTCTCAGCTTGTTGAAAACTCATAATCTCAGAATGCATTTCACA
CGGAGAGATGTCTGGAAGTCCAATTCTCATCCCATTGGCTTTTTCCGTGGTTGCTGTTTTGTGGGCCGCTTTGCACAGGAGTGAAGCCAA
CACCCCTAGATTGTGCCTTCACCCTTGCTGTGAAAAATTCAAAGCCCTGAAATAAGAGGAGGGAATCGCAGACATGCCCTGATTAGTTTT
CCTGCTTATTTCTTCATACAGGCATCTTCTGTTCCGTTGTATTGTGTTAGGTTTCAGAGGCGGGGAGCTTCCTCCTGCAGCAGATGAACA
GGCATAGTTCTTAAAATACAGGAAAGTAACAAGTGAGGTTTCCAGGTAGAGTAGGTGAATGAAGTTTGCCGTCATGCTCTGTATTTCATA
TCAGATTTCTTTATCTTTTCATATCGCATGTCATTGGATGTGACATTTTGATGAAAATACTGAAACTACAAAAGCATAACTTCGCAACAA
GAATGAGATAGACAATTGAATGTGGGACATTTTTCTGGCATGTCTTGCTGCTGAGAATCGGACTTCCAGTCAAAACCCTGTTAGTGACAC
CCACCTCCTCCAGTTATGCAAATTGATGCTTAGCTTGGCAAGCTTTCAAGGAGGTTTGCTTGGAACAGGAAAGGAATTAACAACCCTTTG
AGGGTGTCATTTTTACCTTGTAATACACTGTGGAAAATTCTGGAAGACGGTCCTTGCCTGAAAAGGTGCAACTTAGCATTAGGTTGTTAT
CAGAAACCTTGTCAAGTCTGATGGGAAATGAATAGATGCTGCTTTATTTCCTTGATAACTTCTTTGGAAGTCTGAAATAAATCCTGCCTT
CAGTAACTGAAACCATTTATTAAAAATAGCAAGAAACAAGATGGGGACCAATTCTATTTTTATTCTTGGGAATTTGAAAGAGCCACAAGT
GATTGGTGTCCGATCTCCCAGCATATACTGTACACTATTTTGTATTTCTCCTGAACCAAAACCAAGTACTTAGCACTCAAGAAACAGATG
CCCTGTGTGTGACCGAGGGGAGTGTTTTTCCACAACAGGTTCCACTTCTGAACACTTGGAAGGACCTTGCCTGATTCATGGTGAAACACA
GAGGTTTTGGTTGGAGATAAATTTGGGGTCAGTTACTGTTCAAAATTGTGAAAGTAGTTCCCAGGAAGACAGCATTAGTGACTCCGCAGT
GCTTTGGGTAATAGATTTTGAAAAGCAATTGTGAGTTGGGGATTCCATCATTTCATTTAAGAGGTGAAGAGGGATTTAATTATTTAATAC
GCCGGGTGCAAACTTGTTAAATTCCTCTTTCCCTGTCCCTGCTTGGTGGAGCTGCCACGTGTGGTTCAGTTCTAAGTTCTGGACTAGTGC
CACTCGATATCATTGGGAATAAATCGTTGTTCAACAGTCTGTTCCACAAACAACAGTAATTGAATTTCACAGACTTTATCCTGATTAGTG
GAAATCAAATAATGGAGTGGAATCCCCATGTGTTTTCTCTTGCACAAACTTATTAGACTTGATTAGAAAACTGTTTGGAGGAAAAACTTG
CCAGTAAGTTTTTTGGTTGTTGTTTTGTTTTTTTTGAAAAACGACGCAACACCATAAAGTGTAAAATTAGGGGTTCTGGCCAAGAGAGGT
ACTAGATTTTTTTAATGCCGAGAAAAGTCCATGCCACAGAAGTTATTGTGTATGTCTCTAGGGAGCTTTAAGAATTTCACGTTTGAACTT
TACAGCTGTTTACCAATTAAATGGCAAGCTGGAAAAATACATTTTGAGAGGGGTAGAAAGAATAAGAATATAATTAAAAGTATGCTAACA
AAATAAGCAGTACATATTTTTTTAGAAAATGCAGTTTAGGCCAGGCACGGTAGCTCGTGCCTGTAATCCCAGCACTTTGGGAGGCCGAGG
CAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGACAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCAA
CGATGGTGATGCCTGTCTGTAATCCCAGCTACTCTGGAGGCTGAGGCAGGAGAATCGCTTGAACCGGGGAGGCAGAGGTTGTAGTGAGCC
AAGATTGCGCCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCCGTCTCAAAAAAGGAAAGAAAATGCAGTTTCATTCCAGCCATCCT
TAGATTTCTTTTCCCCTTAAAGTGGCTGAATCCATTGGAGATGTGATTTATTTTGCAGATCCACCAATTCCAAACTTCAGGAATATTCAA
GCGGGAGTCATGTGTAAGTGACAGCTTTGACAAAGAGAGACTGTGGCTGGGTGGCCCGGGTGTTGCCCACGCGGAGCAAGGATTGGTTCA
TTCAACGGATGGAGAGTACAGGATGGCTGGGACCTGGGAAGTTCCAGAATCTGAAAAGAGGGCAGGGCAAGAAGGAGCCAGAAGAGAGGT
CCCACCCCTCAGTTGGCAGTGGGGCACGGAGGTCCGCATCAGCCAAGAACGTCCCCAGGATGCCGTGGGCACCTCATTTCACCCCACGTT
TTTGGCACAGTCTACTTTTTAGGTATTTTGTAAAGGAACTTCTCAGGATTGATTATTTGCCAGAGGAACAATTAGGCCAAGAGAAACTTG
CTTGACAGCCATGTGTAAAACACGTCTGTCCTAATCAAACTAGAGATGCCTCAAGGCCCACGCAGGACACAGGCAGGTTCAAGGTCATGC
ACCTGGAAATTTGTAGGGGAGGGTCAAGCAACTGAGGCCAAAGGGGGCCGGTAAAGTGGCTTCTGGGGTCTGAGCATCTGGAAGGCTCCT
GGCAGCAGTTACCTGACAGTGTCGTTGAGGGGCACGGCAGCTGGGCCCTCACCGTTTCCGCCAGCTCTGCTGAGCCAGCCCAGCCCATGC
ATTCCGAACATCCGACAGCTTCTTTCTCCAGAATGTCTTCTGTCAGAGACTTCCAGGAAAGGAGCTCCCTCCTGTCTCACTGCTGTCAGC
GTGGGAGCCCTGCTCCCCAGGCTCCACGTCCCCGGAAGGTCCATCTTGTCCTGGAGCACACCCAGCCCCATTCAGGGTCAGTGCAGGAGG
GAACAGGGAATCTGCATTTCAGTAAGCTCCCCAGGTGAGGCTGCAGAGCAGAAACCACGGCTTTCAGACGTGAGCAGGCTCCCTGGGCTC
TTGGTGTCACCCTGTTAGCCACATCTGCGGAATGTGGAAGGCAGAACATAGCCACGCTGCTTAGTGCTGCCAGCGAACCTCAGGTTGCAT
CAGTGGCTGGAATCTATCACAGCTGTTGGGGATACGTAACTCCCAGCAATAAATCCAGTATTTTCTTCCCTGCCCTGAGCTTCCTCTGGG
TTTCTTATCAGCAGCTATTACACACAGATGTCCAGTGCTTCTAAACTAAATTGTACTGTGTAACTTTTACATCACACTTGTGTGCTTAAA
AAGCACACCGTGGGTAGTGACTGGGCCAAGAGACATCACAAAGCTTCCTGATAAATTTGAATCCAGCCACGGCAAGAGCGACGTGCGGGT
ACCTGGTCCCTGATGCTTGGGTGCCCCGTTGAGCCTCGGGTACTTCTTGGACACTATTGTGAGAGCAGCCATCCTGGTGTCTCTGCCAGC
ATCTTGGGGAACGCTGTGATGGTAAAATATCTGTCTCTCCTCTGGGAATCAGGGCAGCCCTGAGAAGTGAGCAGTTCCCTTTACAGATGG
ATAATTGTTTGTGTAAGACCAACCAGATAAAGTCCAAACTGTGTAGAACACACGTGTGCCTCACACATAGCCATCTGAGTAAAATATTTT
TTCCAATGTAGATTTATAATTAGAAATGACAGATTTATAATATAGACTTCAGTAAGTTGGGCACAGCTGTCACTTTCGTGGTATCAATAA
AAGGCTAGAAACCTTGGGTGTCCTTGGCAACCTAGCCTTTGACATTGATGTTTTTCCATAGGATTTTCTTCATTTGGGTTGGAATAAAAA
TGCATTTTTATTCACAAGGCACAGACAGATAAGAATATCATAAGCAGGGAAGTGTCTCCAAAGGTCAGGACATATGTTTTTCTGTTGAGT
GCTATATGTGGAGGTCATTGCAAGTTCCCTGATATGAGTATGGTTTCGCTTGCTACATTGTGCCTATTAAAGTAAAATTTTACACAAGCC
TCGCATTTCTAAGATTAGTGTTCCTGAATGAAATGTTAAGAAAACATTAAAAGATTATCTCTTTTTAAGATGGAGGAAAAAAAGTGAACA
AAGCTAATTAATCTATCATGAAAATTGCACAAAATAACATTTCTTAACAAATTTAATACAATTTTGTGTTCTTTGTTGCTAGTGGTATAA
AACGAGATTTTTTTCCCTCATTTTTCTCATTGTAGATGTCATCTCTCACATTTATATCAGTGAGGTTTGAAATTCTGTGTAGCAGTTACT
CAGCACATATGAGAGGGCAGCGAATGAATGAGATTTGTCATGTGCTAATAAAAGCTGAATTTTTGTAATCTAAAATGATGTATTTTCTAC
TATTGCTGTTAATTTGCATTGTTAAAAATTCTTAAAGTTTAATATGTTATGTTCAGTCATTGAAAGCGACCACTCATTTTTTTCTTAAAG
TTGATGCCTTTTCTGCTGTGCTAGAGTCAGTATTTTGCTTCTGGCAGGAGAGCTGCAAACTGTGTATCCTCAAACAGATGCAAAAAGTAG
TGCTTTGCAAAACGTTTGTTTTCTGTTTATCTCAGATTAACATCCTTTAATACAAGTTTCTTAAGTGTAACTTGTATTTCTGAAAATGCT
TAAAATTATTTTATATTTCCCTTTGGGAATTTTTCTCTATTTCCAGCACGCTGATTTGATTTAAAAATGTAATAAGACCAAGAGTTGGAG
TAAAGGGATATTCATTCCATGTTAAAAGTGGCTTCATAGCTACTGACAAATGTCTGAACTATTGTCGTGCCCTTCAAAACTGGAGTTTTC
TAAAATAATCTTATTTTTATACTTGTATGTTCCAGCAATTTAAGATATATACCATTGAAAGGGAAATAAAACATTTTTGTTTATTTGAAT


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FusionGenePPI for WRB_BACE2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WRBCAMLG, MCOLN3, FAS, SERPINA6, LPAR6, TOR3A, DPEP2, ERGIC3, ITGB8, HTR3C, CNDP1, DUSP6, ASNA1, SLC39A12, SLC22A9BACE2GGA1, GGA2, ATP1B3, TMEM30A, HLA-E, MPPE1, ST8SIA4, CHST6, TCTN2, CD1E, CLEC2D, TMPRSS11B, IFNE, ARSG, CD97, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneWRBchr21:40763762chr21:42647298ENST00000333781+3539_97112175ASNA1/TRC40


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneWRBchr21:40763762chr21:42647298ENST00000380708+3539_9778141ASNA1/TRC40
HgeneWRBchr21:40763762chr21:42647298ENST00000398753+3539_9778141ASNA1/TRC40


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WRB_BACE2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WRB_BACE2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneWRBC0023893Liver Cirrhosis, Experimental1CTD_human