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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42051

FusionGeneSummary for WNK2_SECISBP2

check button Fusion gene summary
Fusion gene informationFusion gene name: WNK2_SECISBP2
Fusion gene ID: 42051
HgeneTgene
Gene symbol

WNK2

SECISBP2

Gene ID

65268

79048

Gene nameWNK lysine deficient protein kinase 2SECIS binding protein 2
SynonymsNY-CO-43|P/OKcl.13|PRKWNK2|SDCCAG43SBP2
Cytomap

9q22.31

9q22.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase WNK2antigen NY-CO-43mitogen-activated protein kinase kinase kinaseprotein kinase lysine-deficient 2protein kinase with no lysine 2serologically defined colon cancer antigen 43selenocysteine insertion sequence-binding protein 2Sec insertion sequence-binding protein 2
Modification date2018052320180523
UniProtAcc

Q9Y3S1

Q96T21

Ensembl transtripts involved in fusion geneENST00000427277, ENST00000297954, 
ENST00000395475, ENST00000356055, 
ENST00000349097, ENST00000395477, 
ENST00000471076, 		ENST00000375807, 
ENST00000339901, ENST00000534113, 
ENST00000470305, 
Fusion gene scores* DoF score6 X 7 X 8=3364 X 4 X 2=32
# samples 96
** MAII scorelog2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/32*10)=0.906890595608518
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: WNK2 [Title/Abstract] AND SECISBP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWNK2

GO:0006468

protein phosphorylation

21733846

HgeneWNK2

GO:0046777

protein autophosphorylation

17667937


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-22-5483-01AWNK2chr9

96026315

+SECISBP2chr9

91972326

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000427277ENST00000375807WNK2chr9

96026315

+SECISBP2chr9

91972326

+
Frame-shitENST00000427277ENST00000339901WNK2chr9

96026315

+SECISBP2chr9

91972326

+
Frame-shitENST00000427277ENST00000534113WNK2chr9

96026315

+SECISBP2chr9

91972326

+
5CDS-intronENST00000427277ENST00000470305WNK2chr9

96026315

+SECISBP2chr9

91972326

+
Frame-shitENST00000297954ENST00000375807WNK2chr9

96026315

+SECISBP2chr9

91972326

+
Frame-shitENST00000297954ENST00000339901WNK2chr9

96026315

+SECISBP2chr9

91972326

+
Frame-shitENST00000297954ENST00000534113WNK2chr9

96026315

+SECISBP2chr9

91972326

+
5CDS-intronENST00000297954ENST00000470305WNK2chr9

96026315

+SECISBP2chr9

91972326

+
3UTR-3CDSENST00000395475ENST00000375807WNK2chr9

96026315

+SECISBP2chr9

91972326

+
3UTR-3CDSENST00000395475ENST00000339901WNK2chr9

96026315

+SECISBP2chr9

91972326

+
3UTR-3CDSENST00000395475ENST00000534113WNK2chr9

96026315

+SECISBP2chr9

91972326

+
3UTR-intronENST00000395475ENST00000470305WNK2chr9

96026315

+SECISBP2chr9

91972326

+
5UTR-3CDSENST00000356055ENST00000375807WNK2chr9

96026315

+SECISBP2chr9

91972326

+
5UTR-3CDSENST00000356055ENST00000339901WNK2chr9

96026315

+SECISBP2chr9

91972326

+
5UTR-3CDSENST00000356055ENST00000534113WNK2chr9

96026315

+SECISBP2chr9

91972326

+
5UTR-intronENST00000356055ENST00000470305WNK2chr9

96026315

+SECISBP2chr9

91972326

+
Frame-shitENST00000349097ENST00000375807WNK2chr9

96026315

+SECISBP2chr9

91972326

+
Frame-shitENST00000349097ENST00000339901WNK2chr9

96026315

+SECISBP2chr9

91972326

+
Frame-shitENST00000349097ENST00000534113WNK2chr9

96026315

+SECISBP2chr9

91972326

+
5CDS-intronENST00000349097ENST00000470305WNK2chr9

96026315

+SECISBP2chr9

91972326

+
Frame-shitENST00000395477ENST00000375807WNK2chr9

96026315

+SECISBP2chr9

91972326

+
Frame-shitENST00000395477ENST00000339901WNK2chr9

96026315

+SECISBP2chr9

91972326

+
Frame-shitENST00000395477ENST00000534113WNK2chr9

96026315

+SECISBP2chr9

91972326

+
5CDS-intronENST00000395477ENST00000470305WNK2chr9

96026315

+SECISBP2chr9

91972326

+
intron-3CDSENST00000471076ENST00000375807WNK2chr9

96026315

+SECISBP2chr9

91972326

+
intron-3CDSENST00000471076ENST00000339901WNK2chr9

96026315

+SECISBP2chr9

91972326

+
intron-3CDSENST00000471076ENST00000534113WNK2chr9

96026315

+SECISBP2chr9

91972326

+
intron-intronENST00000471076ENST00000470305WNK2chr9

96026315

+SECISBP2chr9

91972326

+

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FusionProtFeatures for WNK2_SECISBP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WNK2

Q9Y3S1

SECISBP2

Q96T21

Serine/threonine kinase which plays an important role inthe regulation of electrolyte homeostasis, cell signaling,survival, and proliferation. Acts as an activator and inhibitor ofsodium-coupled chloride cotransporters and potassium-coupledchloride cotransporters respectively. Activates SLC12A2, SCNN1A,SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulatesthe EGF-induced activation of the ERK/MAPK-pathway and thedownstream cell cycle progression. Affects MAPK3/MAPK1 activity bymodulating the activity of MAP2K1 and this modulation depends onphosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering withthe activity of PAK1 by controlling the balance of the activity ofupstream regulators of PAK1 activity, RHOA and RAC1, which displayreciprocal activity. {ECO:0000269|PubMed:17667937,ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. Binds to the SECIS element in the 3'-UTR of some mRNAsencoding selenoproteins. Binding is stimulated by SELB.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WNK2_SECISBP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WNK2_SECISBP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WNK2YWHAZ, WNK1, SGK1, ATXN1, KLHL3, KLHL2, DGCR14, TSC22D4, PSMC3, SPATA1, TRIM25SECISBP2ATXN7L3, APP, SMAD9, GOLGA2, PCM1, SPICE1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WNK2_SECISBP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WNK2_SECISBP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSECISBP2C0002514Amino Acid Metabolism, Inborn Errors1CTD_human
TgeneSECISBP2C0018273Growth Disorders1CTD_human
TgeneSECISBP2C1864761Thyroid Hormone Metabolism, Abnormal1CTD_human;ORPHANET;UNIPROT