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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42032

FusionGeneSummary for WNK1_ALDOC

check button Fusion gene summary
Fusion gene informationFusion gene name: WNK1_ALDOC
Fusion gene ID: 42032
HgeneTgene
Gene symbol

WNK1

ALDOC

Gene ID

65125

230

Gene nameWNK lysine deficient protein kinase 1aldolase, fructose-bisphosphate C
SynonymsHSAN2|HSN2|KDP|PPP1R167|PRKWNK1|PSK|p65ALDC
Cytomap

12p13.33

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase WNK1WNK lysine deficient protein kinase 1 isoformerythrocyte 65 kDa proteinprostate-derived sterile 20-like kinaseprotein kinase with no lysine 1protein phosphatase 1, regulatory subunit 167serine/threonine-protein kifructose-bisphosphate aldolase Caldolase 3aldolase C, fructose-bisphosphatebrain-type aldolasefructoaldolase Cfructose-1,6-biphosphate triosephosphate lyase
Modification date2018052320180519
UniProtAcc

Q9H4A3

P09972

Ensembl transtripts involved in fusion geneENST00000535572, ENST00000537687, 
ENST00000315939, ENST00000447667, 
ENST00000530271, ENST00000540360, 
ENST00000340908, ENST00000574564, 
ENST00000395319, ENST00000395321, 
ENST00000226253, 
Fusion gene scores* DoF score15 X 10 X 10=15006 X 6 X 2=72
# samples 196
** MAII scorelog2(19/1500*10)=-2.9808911770523
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WNK1 [Title/Abstract] AND ALDOC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWNK1

GO:0006468

protein phosphorylation

10660600

HgeneWNK1

GO:0010923

negative regulation of phosphatase activity

19389623

HgeneWNK1

GO:0023016

signal transduction by trans-phosphorylation

16669787

HgeneWNK1

GO:0035556

intracellular signal transduction

10660600

TgeneALDOC

GO:0030388

fructose 1,6-bisphosphate metabolic process

9244396|15537755


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA088736WNK1chr12

987436

+ALDOCchr17

26903883

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000535572ENST00000395319WNK1chr12

987436

+ALDOCchr17

26903883

-
5CDS-5UTRENST00000535572ENST00000395321WNK1chr12

987436

+ALDOCchr17

26903883

-
5CDS-5UTRENST00000535572ENST00000226253WNK1chr12

987436

+ALDOCchr17

26903883

-
5CDS-5UTRENST00000537687ENST00000395319WNK1chr12

987436

+ALDOCchr17

26903883

-
5CDS-5UTRENST00000537687ENST00000395321WNK1chr12

987436

+ALDOCchr17

26903883

-
5CDS-5UTRENST00000537687ENST00000226253WNK1chr12

987436

+ALDOCchr17

26903883

-
5CDS-5UTRENST00000315939ENST00000395319WNK1chr12

987436

+ALDOCchr17

26903883

-
5CDS-5UTRENST00000315939ENST00000395321WNK1chr12

987436

+ALDOCchr17

26903883

-
5CDS-5UTRENST00000315939ENST00000226253WNK1chr12

987436

+ALDOCchr17

26903883

-
intron-5UTRENST00000447667ENST00000395319WNK1chr12

987436

+ALDOCchr17

26903883

-
intron-5UTRENST00000447667ENST00000395321WNK1chr12

987436

+ALDOCchr17

26903883

-
intron-5UTRENST00000447667ENST00000226253WNK1chr12

987436

+ALDOCchr17

26903883

-
5CDS-5UTRENST00000530271ENST00000395319WNK1chr12

987436

+ALDOCchr17

26903883

-
5CDS-5UTRENST00000530271ENST00000395321WNK1chr12

987436

+ALDOCchr17

26903883

-
5CDS-5UTRENST00000530271ENST00000226253WNK1chr12

987436

+ALDOCchr17

26903883

-
intron-5UTRENST00000540360ENST00000395319WNK1chr12

987436

+ALDOCchr17

26903883

-
intron-5UTRENST00000540360ENST00000395321WNK1chr12

987436

+ALDOCchr17

26903883

-
intron-5UTRENST00000540360ENST00000226253WNK1chr12

987436

+ALDOCchr17

26903883

-
5CDS-5UTRENST00000340908ENST00000395319WNK1chr12

987436

+ALDOCchr17

26903883

-
5CDS-5UTRENST00000340908ENST00000395321WNK1chr12

987436

+ALDOCchr17

26903883

-
5CDS-5UTRENST00000340908ENST00000226253WNK1chr12

987436

+ALDOCchr17

26903883

-
intron-5UTRENST00000574564ENST00000395319WNK1chr12

987436

+ALDOCchr17

26903883

-
intron-5UTRENST00000574564ENST00000395321WNK1chr12

987436

+ALDOCchr17

26903883

-
intron-5UTRENST00000574564ENST00000226253WNK1chr12

987436

+ALDOCchr17

26903883

-

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FusionProtFeatures for WNK1_ALDOC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WNK1

Q9H4A3

ALDOC

P09972


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WNK1_ALDOC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WNK1_ALDOC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WNK1_ALDOC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WNK1_ALDOC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneWNK1C0020538Hypertensive disease1CTD_human
HgeneWNK1C0022658Kidney Diseases1CTD_human
HgeneWNK1C0033805Pseudohypoaldosteronism1CTD_human