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Fusion gene ID: 42031 |
FusionGeneSummary for WLS_TBX3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: WLS_TBX3 | Fusion gene ID: 42031 | Hgene | Tgene | Gene symbol | WLS | TBX3 | Gene ID | 79971 | 6926 |
| Gene name | wntless Wnt ligand secretion mediator | T-box 3 | |
| Synonyms | C1orf139|EVI|GPR177|MRP|mig-14 | TBX3-ISO|UMS|XHL | |
| Cytomap | 1p31.3 | 12q24.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein wntless homologG protein-coupled receptor 177integral membrane protein GPR177protein evenness interrupted homologputative NF-kappa-B-activating protein 373putative NFkB activating protein 373 | T-box transcription factor TBX3T-box protein 3bladder cancer related protein XHL | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | Q5T9L3 | O15119 | |
| Ensembl transtripts involved in fusion gene | ENST00000540432, ENST00000354777, ENST00000262348, ENST00000370976, ENST00000370971, ENST00000491811, | ENST00000349155, ENST00000257566, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: WLS [Title/Abstract] AND TBX3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TBX3 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 11689487 |
| Tgene | TBX3 | GO:0007569 | cell aging | 11689487|11748239 |
| Tgene | TBX3 | GO:0008284 | positive regulation of cell proliferation | 11689487|11748239|12032820 |
| Tgene | TBX3 | GO:0009887 | animal organ morphogenesis | 9207801 |
| Tgene | TBX3 | GO:0035136 | forelimb morphogenesis | 9207801 |
| Tgene | TBX3 | GO:0043066 | negative regulation of apoptotic process | 12032820 |
| Tgene | TBX3 | GO:0045662 | negative regulation of myoblast differentiation | 12032820 |
| Tgene | TBX3 | GO:0045787 | positive regulation of cell cycle | 12032820 |
| Tgene | TBX3 | GO:0045892 | negative regulation of transcription, DNA-templated | 10468588|11689487 |
| Tgene | TBX3 | GO:0090398 | cellular senescence | 22002537 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-EJ-5525-01A | WLS | chr1 | 68603463 | - | TBX3 | chr12 | 115110107 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000540432 | ENST00000349155 | WLS | chr1 | 68603463 | - | TBX3 | chr12 | 115110107 | - |
| In-frame | ENST00000540432 | ENST00000257566 | WLS | chr1 | 68603463 | - | TBX3 | chr12 | 115110107 | - |
| Frame-shift | ENST00000354777 | ENST00000349155 | WLS | chr1 | 68603463 | - | TBX3 | chr12 | 115110107 | - |
| In-frame | ENST00000354777 | ENST00000257566 | WLS | chr1 | 68603463 | - | TBX3 | chr12 | 115110107 | - |
| Frame-shift | ENST00000262348 | ENST00000349155 | WLS | chr1 | 68603463 | - | TBX3 | chr12 | 115110107 | - |
| In-frame | ENST00000262348 | ENST00000257566 | WLS | chr1 | 68603463 | - | TBX3 | chr12 | 115110107 | - |
| Frame-shift | ENST00000370976 | ENST00000349155 | WLS | chr1 | 68603463 | - | TBX3 | chr12 | 115110107 | - |
| In-frame | ENST00000370976 | ENST00000257566 | WLS | chr1 | 68603463 | - | TBX3 | chr12 | 115110107 | - |
| intron-3CDS | ENST00000370971 | ENST00000349155 | WLS | chr1 | 68603463 | - | TBX3 | chr12 | 115110107 | - |
| intron-3CDS | ENST00000370971 | ENST00000257566 | WLS | chr1 | 68603463 | - | TBX3 | chr12 | 115110107 | - |
| intron-3CDS | ENST00000491811 | ENST00000349155 | WLS | chr1 | 68603463 | - | TBX3 | chr12 | 115110107 | - |
| intron-3CDS | ENST00000491811 | ENST00000257566 | WLS | chr1 | 68603463 | - | TBX3 | chr12 | 115110107 | - |
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FusionProtFeatures for WLS_TBX3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| WLS | TBX3 |
| Regulates Wnt proteins sorting and secretion in afeedback regulatory mechanism. This reciprocal interaction plays akey role in the regulation of expression, subcellular location,binding and organelle-specific association of Wnt proteins. Playsalso an important role in establishment of the anterior-posteriorbody axis formation during development (By similarity).{ECO:0000250, ECO:0000269|PubMed:16678095,ECO:0000269|PubMed:16678096}. | Transcriptional repressor involved in developmentalprocesses. Probably plays a role in limb pattern formation. Actsas a negative regulator of PML function in cellular senescence.{ECO:0000269|PubMed:10468588, ECO:0000269|PubMed:22002537}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for WLS_TBX3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_WLS_ENST00000540432_chr1_68603463_-_TBX3_ENST00000257566_chr12_115110107_-_659aa MAGAIIENMSTKKLCIVGGILLVFQIIAFLVGGLIAPGPTTAVSYMSVKCVDARKNHHKTKWFVPWGPNHCDKIRDIEEAIPREIEANDI VFSVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSLAYRDDAFAEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYECD VLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVI FALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQ LTNPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFF IVSQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGPGHVPFRKPVPLPLHVHGRSGGRLLCGSLQLGAP PPLPQSEHHAPAAALQPLLHPGAGPGRQQSAHHRPALHGGGRGAPGRQSRRPGRQPGLGGSGLGLXTQQPLLHALLQLHVLVAQTLRGER >In-frame_WLS_ENST00000354777_chr1_68603463_-_TBX3_ENST00000257566_chr12_115110107_-_657aa MAGAIIENMSTKKLCIVGGILLVFQIIAFLVGGLIGPTTAVSYMSVKCVDARKNHHKTKWFVPWGPNHCDKIRDIEEAIPREIEANDIVF SVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSLAYRDDAFAEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYECDVL PFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVIFA LGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQLT NPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFFIV SQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGPGHVPFRKPVPLPLHVHGRSGGRLLCGSLQLGAPPP LPQSEHHAPAAALQPLLHPGAGPGRQQSAHHRPALHGGGRGAPGRQSRRPGRQPGLGGSGLGLXTQQPLLHALLQLHVLVAQTLRGERGG >In-frame_WLS_ENST00000262348_chr1_68603463_-_TBX3_ENST00000257566_chr12_115110107_-_659aa MAGAIIENMSTKKLCIVGGILLVFQIIAFLVGGLIAPGPTTAVSYMSVKCVDARKNHHKTKWFVPWGPNHCDKIRDIEEAIPREIEANDI VFSVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSLAYRDDAFAEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYECD VLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVI FALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQ LTNPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFF IVSQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGPGHVPFRKPVPLPLHVHGRSGGRLLCGSLQLGAP PPLPQSEHHAPAAALQPLLHPGAGPGRQQSAHHRPALHGGGRGAPGRQSRRPGRQPGLGGSGLGLXTQQPLLHALLQLHVLVAQTLRGER >In-frame_WLS_ENST00000370976_chr1_68603463_-_TBX3_ENST00000257566_chr12_115110107_-_568aa MAGAIIENMSTKKLCIVGGILLVFQIIAFLVGGLIGENAEVSMDVSLAYRDDAFAEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYECDV LPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVIF ALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQL TNPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFFI VSQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGPGHVPFRKPVPLPLHVHGRSGGRLLCGSLQLGAPP PLPQSEHHAPAAALQPLLHPGAGPGRQQSAHHRPALHGGGRGAPGRQSRRPGRQPGLGGSGLGLXTQQPLLHALLQLHVLVAQTLRGERG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_WLS_ENST00000540432_chr1_68603463_-_TBX3_ENST00000257566_chr12_115110107_-_1978nt ATGGCTGGGGCAATTATAGAAAACATGAGCACCAAGAAGCTGTGCATTGTTGGTGGGATTCTGCTCGTGTTCCAAATCATCGCCTTTCTG GTGGGAGGCTTGATTGCTCCAGGGCCCACAACGGCAGTGTCCTACATGTCGGTGAAATGTGTGGATGCCCGTAAGAACCATCACAAGACA AAATGGTTCGTGCCTTGGGGACCCAATCATTGTGACAAGATCCGAGACATTGAAGAGGCAATTCCAAGGGAAATTGAAGCCAATGACATC GTGTTTTCTGTTCACATTCCCCTCCCCCACATGGAGATGAGTCCTTGGTTCCAATTCATGCTGTTTATCCTGCAGCTGGACATTGCCTTC AAGCTAAACAACCAAATCAGAGAAAATGCAGAAGTCTCCATGGACGTTTCCCTGGCTTACCGTGATGACGCGTTTGCTGAGTGGACTGAA ATGGCCCATGAAAGAGTACCACGGAAACTCAAATGCACCTTCACATCTCCCAAGACTCCAGAGCATGAGGGCCGTTACTATGAATGTGAT GTCCTTCCTTTCATGGAAATTGGGTCTGTGGCCCATAAGTTTTACCTTTTAAACATCCGGCTGCCTGTGAATGAGAAGAAGAAAATCAAT GTGGGAATTGGGGAGATAAAGGATATCCGGTTGGTGGGGATCCACCAAAATGGAGGCTTCACCAAGGTGTGGTTTGCCATGAAGACCTTC CTTACGCCCAGCATCTTCATCATTATGGTGTGGTATTGGAGGAGGATCACCATGATGTCCCGACCCCCAGTGCTTCTGGAAAAAGTCATC TTTGCCCTTGGGATTTCCATGACCTTTATCAATATCCCAGTGGAATGGTTTTCCATCGGGTTTGACTGGACCTGGATGCTGCTGTTTGGT GACATCCGACAGGGCATCTTCTATGCGATGCTTCTGTCCTTCTGGATCATCTTCTGTGGCGAGCACATGATGGATCAGCACGAGCGGAAC CACATCGCAGGGTATTGGAAGCAAGTCGGACCCATTGCCGTTGGCTCCTTCTGCCTCTTCATATTTGACATGTGTGAGAGAGGGGTACAA CTCACGAATCCCTTCTACAGTATCTGGACTACAGACATTGGAACAGAGCTGGCCATGGCCTTCATCATCGTGGCTGGAATCTGCCTCTGC CTCTACTTCCTGTTTCTATGCTTCATGGTATTTCAGGTGTTTCGGAACATCAGTGGGAAGCAGTCCAGCCTGCCAGCTATGAGCAAAGTC CGGCGGCTACACTATGAGGGGCTAATTTTTAGGTTCAAGTTCCTCATGCTTATCACCTTGGCCTGCGCTGCCATGACTGTCATCTTCTTC ATCGTTAGTCAGGTAACGGAAGGCCATTGGAAATGGGGCGGCGTCACAGTCCAAGTGAACAGTGCCTTTTTCACAGGCATCTATGGGATG TGGAATCTGTATGTCTTTGCTCTGATGTTCTTGTATGCACCATCCCATAAAAACTATGGAGAAGACCAGTCCAATGGGCCTGGCCATGTC CCCTTTCGGAAGCCTGTTCCCTTACCCCTACACGTACATGGCCGCAGCGGCGGCCGCCTCCTCTGCGGCAGCCTCCAGCTCGGTGCACCG CCACCCCTTCCTCAATCTGAACACCATGCGCCCGCGGCTGCGCTACAGCCCCTACTCCATCCCGGTGCCGGTCCCGGACGGCAGCAGTCT GCTCACCACCGCCCTGCCCTCCATGGCGGCGGCCGCGGGGCCCCTGGACGGCAAAGTCGCCGCCCTGGCCGCCAGCCCGGCCTCGGTGGC AGTGGACTCGGGCTCTGAACTCAACAGCCGCTCCTCCACGCTCTCCTCCAGCTCCATGTCCTTGTCGCCCAAACTCTGCGCGGAGAAAGA >In-frame_WLS_ENST00000354777_chr1_68603463_-_TBX3_ENST00000257566_chr12_115110107_-_1972nt ATGGCTGGGGCAATTATAGAAAACATGAGCACCAAGAAGCTGTGCATTGTTGGTGGGATTCTGCTCGTGTTCCAAATCATCGCCTTTCTG GTGGGAGGCTTGATTGGGCCCACAACGGCAGTGTCCTACATGTCGGTGAAATGTGTGGATGCCCGTAAGAACCATCACAAGACAAAATGG TTCGTGCCTTGGGGACCCAATCATTGTGACAAGATCCGAGACATTGAAGAGGCAATTCCAAGGGAAATTGAAGCCAATGACATCGTGTTT TCTGTTCACATTCCCCTCCCCCACATGGAGATGAGTCCTTGGTTCCAATTCATGCTGTTTATCCTGCAGCTGGACATTGCCTTCAAGCTA AACAACCAAATCAGAGAAAATGCAGAAGTCTCCATGGACGTTTCCCTGGCTTACCGTGATGACGCGTTTGCTGAGTGGACTGAAATGGCC CATGAAAGAGTACCACGGAAACTCAAATGCACCTTCACATCTCCCAAGACTCCAGAGCATGAGGGCCGTTACTATGAATGTGATGTCCTT CCTTTCATGGAAATTGGGTCTGTGGCCCATAAGTTTTACCTTTTAAACATCCGGCTGCCTGTGAATGAGAAGAAGAAAATCAATGTGGGA ATTGGGGAGATAAAGGATATCCGGTTGGTGGGGATCCACCAAAATGGAGGCTTCACCAAGGTGTGGTTTGCCATGAAGACCTTCCTTACG CCCAGCATCTTCATCATTATGGTGTGGTATTGGAGGAGGATCACCATGATGTCCCGACCCCCAGTGCTTCTGGAAAAAGTCATCTTTGCC CTTGGGATTTCCATGACCTTTATCAATATCCCAGTGGAATGGTTTTCCATCGGGTTTGACTGGACCTGGATGCTGCTGTTTGGTGACATC CGACAGGGCATCTTCTATGCGATGCTTCTGTCCTTCTGGATCATCTTCTGTGGCGAGCACATGATGGATCAGCACGAGCGGAACCACATC GCAGGGTATTGGAAGCAAGTCGGACCCATTGCCGTTGGCTCCTTCTGCCTCTTCATATTTGACATGTGTGAGAGAGGGGTACAACTCACG AATCCCTTCTACAGTATCTGGACTACAGACATTGGAACAGAGCTGGCCATGGCCTTCATCATCGTGGCTGGAATCTGCCTCTGCCTCTAC TTCCTGTTTCTATGCTTCATGGTATTTCAGGTGTTTCGGAACATCAGTGGGAAGCAGTCCAGCCTGCCAGCTATGAGCAAAGTCCGGCGG CTACACTATGAGGGGCTAATTTTTAGGTTCAAGTTCCTCATGCTTATCACCTTGGCCTGCGCTGCCATGACTGTCATCTTCTTCATCGTT AGTCAGGTAACGGAAGGCCATTGGAAATGGGGCGGCGTCACAGTCCAAGTGAACAGTGCCTTTTTCACAGGCATCTATGGGATGTGGAAT CTGTATGTCTTTGCTCTGATGTTCTTGTATGCACCATCCCATAAAAACTATGGAGAAGACCAGTCCAATGGGCCTGGCCATGTCCCCTTT CGGAAGCCTGTTCCCTTACCCCTACACGTACATGGCCGCAGCGGCGGCCGCCTCCTCTGCGGCAGCCTCCAGCTCGGTGCACCGCCACCC CTTCCTCAATCTGAACACCATGCGCCCGCGGCTGCGCTACAGCCCCTACTCCATCCCGGTGCCGGTCCCGGACGGCAGCAGTCTGCTCAC CACCGCCCTGCCCTCCATGGCGGCGGCCGCGGGGCCCCTGGACGGCAAAGTCGCCGCCCTGGCCGCCAGCCCGGCCTCGGTGGCAGTGGA CTCGGGCTCTGAACTCAACAGCCGCTCCTCCACGCTCTCCTCCAGCTCCATGTCCTTGTCGCCCAAACTCTGCGCGGAGAAAGAGGCGGC >In-frame_WLS_ENST00000262348_chr1_68603463_-_TBX3_ENST00000257566_chr12_115110107_-_1978nt ATGGCTGGGGCAATTATAGAAAACATGAGCACCAAGAAGCTGTGCATTGTTGGTGGGATTCTGCTCGTGTTCCAAATCATCGCCTTTCTG GTGGGAGGCTTGATTGCTCCAGGGCCCACAACGGCAGTGTCCTACATGTCGGTGAAATGTGTGGATGCCCGTAAGAACCATCACAAGACA AAATGGTTCGTGCCTTGGGGACCCAATCATTGTGACAAGATCCGAGACATTGAAGAGGCAATTCCAAGGGAAATTGAAGCCAATGACATC GTGTTTTCTGTTCACATTCCCCTCCCCCACATGGAGATGAGTCCTTGGTTCCAATTCATGCTGTTTATCCTGCAGCTGGACATTGCCTTC AAGCTAAACAACCAAATCAGAGAAAATGCAGAAGTCTCCATGGACGTTTCCCTGGCTTACCGTGATGACGCGTTTGCTGAGTGGACTGAA ATGGCCCATGAAAGAGTACCACGGAAACTCAAATGCACCTTCACATCTCCCAAGACTCCAGAGCATGAGGGCCGTTACTATGAATGTGAT GTCCTTCCTTTCATGGAAATTGGGTCTGTGGCCCATAAGTTTTACCTTTTAAACATCCGGCTGCCTGTGAATGAGAAGAAGAAAATCAAT GTGGGAATTGGGGAGATAAAGGATATCCGGTTGGTGGGGATCCACCAAAATGGAGGCTTCACCAAGGTGTGGTTTGCCATGAAGACCTTC CTTACGCCCAGCATCTTCATCATTATGGTGTGGTATTGGAGGAGGATCACCATGATGTCCCGACCCCCAGTGCTTCTGGAAAAAGTCATC TTTGCCCTTGGGATTTCCATGACCTTTATCAATATCCCAGTGGAATGGTTTTCCATCGGGTTTGACTGGACCTGGATGCTGCTGTTTGGT GACATCCGACAGGGCATCTTCTATGCGATGCTTCTGTCCTTCTGGATCATCTTCTGTGGCGAGCACATGATGGATCAGCACGAGCGGAAC CACATCGCAGGGTATTGGAAGCAAGTCGGACCCATTGCCGTTGGCTCCTTCTGCCTCTTCATATTTGACATGTGTGAGAGAGGGGTACAA CTCACGAATCCCTTCTACAGTATCTGGACTACAGACATTGGAACAGAGCTGGCCATGGCCTTCATCATCGTGGCTGGAATCTGCCTCTGC CTCTACTTCCTGTTTCTATGCTTCATGGTATTTCAGGTGTTTCGGAACATCAGTGGGAAGCAGTCCAGCCTGCCAGCTATGAGCAAAGTC CGGCGGCTACACTATGAGGGGCTAATTTTTAGGTTCAAGTTCCTCATGCTTATCACCTTGGCCTGCGCTGCCATGACTGTCATCTTCTTC ATCGTTAGTCAGGTAACGGAAGGCCATTGGAAATGGGGCGGCGTCACAGTCCAAGTGAACAGTGCCTTTTTCACAGGCATCTATGGGATG TGGAATCTGTATGTCTTTGCTCTGATGTTCTTGTATGCACCATCCCATAAAAACTATGGAGAAGACCAGTCCAATGGGCCTGGCCATGTC CCCTTTCGGAAGCCTGTTCCCTTACCCCTACACGTACATGGCCGCAGCGGCGGCCGCCTCCTCTGCGGCAGCCTCCAGCTCGGTGCACCG CCACCCCTTCCTCAATCTGAACACCATGCGCCCGCGGCTGCGCTACAGCCCCTACTCCATCCCGGTGCCGGTCCCGGACGGCAGCAGTCT GCTCACCACCGCCCTGCCCTCCATGGCGGCGGCCGCGGGGCCCCTGGACGGCAAAGTCGCCGCCCTGGCCGCCAGCCCGGCCTCGGTGGC AGTGGACTCGGGCTCTGAACTCAACAGCCGCTCCTCCACGCTCTCCTCCAGCTCCATGTCCTTGTCGCCCAAACTCTGCGCGGAGAAAGA >In-frame_WLS_ENST00000370976_chr1_68603463_-_TBX3_ENST00000257566_chr12_115110107_-_1705nt ATGGCTGGGGCAATTATAGAAAACATGAGCACCAAGAAGCTGTGCATTGTTGGTGGGATTCTGCTCGTGTTCCAAATCATCGCCTTTCTG GTGGGAGGCTTGATTGGAGAAAATGCAGAAGTCTCCATGGACGTTTCCCTGGCTTACCGTGATGACGCGTTTGCTGAGTGGACTGAAATG GCCCATGAAAGAGTACCACGGAAACTCAAATGCACCTTCACATCTCCCAAGACTCCAGAGCATGAGGGCCGTTACTATGAATGTGATGTC CTTCCTTTCATGGAAATTGGGTCTGTGGCCCATAAGTTTTACCTTTTAAACATCCGGCTGCCTGTGAATGAGAAGAAGAAAATCAATGTG GGAATTGGGGAGATAAAGGATATCCGGTTGGTGGGGATCCACCAAAATGGAGGCTTCACCAAGGTGTGGTTTGCCATGAAGACCTTCCTT ACGCCCAGCATCTTCATCATTATGGTGTGGTATTGGAGGAGGATCACCATGATGTCCCGACCCCCAGTGCTTCTGGAAAAAGTCATCTTT GCCCTTGGGATTTCCATGACCTTTATCAATATCCCAGTGGAATGGTTTTCCATCGGGTTTGACTGGACCTGGATGCTGCTGTTTGGTGAC ATCCGACAGGGCATCTTCTATGCGATGCTTCTGTCCTTCTGGATCATCTTCTGTGGCGAGCACATGATGGATCAGCACGAGCGGAACCAC ATCGCAGGGTATTGGAAGCAAGTCGGACCCATTGCCGTTGGCTCCTTCTGCCTCTTCATATTTGACATGTGTGAGAGAGGGGTACAACTC ACGAATCCCTTCTACAGTATCTGGACTACAGACATTGGAACAGAGCTGGCCATGGCCTTCATCATCGTGGCTGGAATCTGCCTCTGCCTC TACTTCCTGTTTCTATGCTTCATGGTATTTCAGGTGTTTCGGAACATCAGTGGGAAGCAGTCCAGCCTGCCAGCTATGAGCAAAGTCCGG CGGCTACACTATGAGGGGCTAATTTTTAGGTTCAAGTTCCTCATGCTTATCACCTTGGCCTGCGCTGCCATGACTGTCATCTTCTTCATC GTTAGTCAGGTAACGGAAGGCCATTGGAAATGGGGCGGCGTCACAGTCCAAGTGAACAGTGCCTTTTTCACAGGCATCTATGGGATGTGG AATCTGTATGTCTTTGCTCTGATGTTCTTGTATGCACCATCCCATAAAAACTATGGAGAAGACCAGTCCAATGGGCCTGGCCATGTCCCC TTTCGGAAGCCTGTTCCCTTACCCCTACACGTACATGGCCGCAGCGGCGGCCGCCTCCTCTGCGGCAGCCTCCAGCTCGGTGCACCGCCA CCCCTTCCTCAATCTGAACACCATGCGCCCGCGGCTGCGCTACAGCCCCTACTCCATCCCGGTGCCGGTCCCGGACGGCAGCAGTCTGCT CACCACCGCCCTGCCCTCCATGGCGGCGGCCGCGGGGCCCCTGGACGGCAAAGTCGCCGCCCTGGCCGCCAGCCCGGCCTCGGTGGCAGT GGACTCGGGCTCTGAACTCAACAGCCGCTCCTCCACGCTCTCCTCCAGCTCCATGTCCTTGTCGCCCAAACTCTGCGCGGAGAAAGAGGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_WLS_ENST00000540432_chr1_68603463_-_TBX3_ENST00000257566_chr12_115110107_-_3848nt GGCGGCGTCATGTGATCCGCTTCCCTGCTCCTTTAAGCGTCCACAGGCGGCGGAGCGGCCACAATCACAGCTCCGGGCATTGGGGGAACC CGAGCCGGCTGCGCCGGGGGAATCCGTGCGGGCGCCTTCCGTCCCGGTCCCATCCTCGCCGCGCTCCAGCACCTCTGAAGTTTTGCAGCG CCCAGAAAGGAGGCGAGGAAGGAGGGAGTGTGTGAGAGGAGGGAGCAAAAAGCTCACCCTAAAACATTTATTTCAAGGAGAAAAGAAAAA GGGGGGGCGCAAAAATGGCTGGGGCAATTATAGAAAACATGAGCACCAAGAAGCTGTGCATTGTTGGTGGGATTCTGCTCGTGTTCCAAA TCATCGCCTTTCTGGTGGGAGGCTTGATTGCTCCAGGGCCCACAACGGCAGTGTCCTACATGTCGGTGAAATGTGTGGATGCCCGTAAGA ACCATCACAAGACAAAATGGTTCGTGCCTTGGGGACCCAATCATTGTGACAAGATCCGAGACATTGAAGAGGCAATTCCAAGGGAAATTG AAGCCAATGACATCGTGTTTTCTGTTCACATTCCCCTCCCCCACATGGAGATGAGTCCTTGGTTCCAATTCATGCTGTTTATCCTGCAGC TGGACATTGCCTTCAAGCTAAACAACCAAATCAGAGAAAATGCAGAAGTCTCCATGGACGTTTCCCTGGCTTACCGTGATGACGCGTTTG CTGAGTGGACTGAAATGGCCCATGAAAGAGTACCACGGAAACTCAAATGCACCTTCACATCTCCCAAGACTCCAGAGCATGAGGGCCGTT ACTATGAATGTGATGTCCTTCCTTTCATGGAAATTGGGTCTGTGGCCCATAAGTTTTACCTTTTAAACATCCGGCTGCCTGTGAATGAGA AGAAGAAAATCAATGTGGGAATTGGGGAGATAAAGGATATCCGGTTGGTGGGGATCCACCAAAATGGAGGCTTCACCAAGGTGTGGTTTG CCATGAAGACCTTCCTTACGCCCAGCATCTTCATCATTATGGTGTGGTATTGGAGGAGGATCACCATGATGTCCCGACCCCCAGTGCTTC TGGAAAAAGTCATCTTTGCCCTTGGGATTTCCATGACCTTTATCAATATCCCAGTGGAATGGTTTTCCATCGGGTTTGACTGGACCTGGA TGCTGCTGTTTGGTGACATCCGACAGGGCATCTTCTATGCGATGCTTCTGTCCTTCTGGATCATCTTCTGTGGCGAGCACATGATGGATC AGCACGAGCGGAACCACATCGCAGGGTATTGGAAGCAAGTCGGACCCATTGCCGTTGGCTCCTTCTGCCTCTTCATATTTGACATGTGTG AGAGAGGGGTACAACTCACGAATCCCTTCTACAGTATCTGGACTACAGACATTGGAACAGAGCTGGCCATGGCCTTCATCATCGTGGCTG GAATCTGCCTCTGCCTCTACTTCCTGTTTCTATGCTTCATGGTATTTCAGGTGTTTCGGAACATCAGTGGGAAGCAGTCCAGCCTGCCAG CTATGAGCAAAGTCCGGCGGCTACACTATGAGGGGCTAATTTTTAGGTTCAAGTTCCTCATGCTTATCACCTTGGCCTGCGCTGCCATGA CTGTCATCTTCTTCATCGTTAGTCAGGTAACGGAAGGCCATTGGAAATGGGGCGGCGTCACAGTCCAAGTGAACAGTGCCTTTTTCACAG GCATCTATGGGATGTGGAATCTGTATGTCTTTGCTCTGATGTTCTTGTATGCACCATCCCATAAAAACTATGGAGAAGACCAGTCCAATG GGCCTGGCCATGTCCCCTTTCGGAAGCCTGTTCCCTTACCCCTACACGTACATGGCCGCAGCGGCGGCCGCCTCCTCTGCGGCAGCCTCC AGCTCGGTGCACCGCCACCCCTTCCTCAATCTGAACACCATGCGCCCGCGGCTGCGCTACAGCCCCTACTCCATCCCGGTGCCGGTCCCG GACGGCAGCAGTCTGCTCACCACCGCCCTGCCCTCCATGGCGGCGGCCGCGGGGCCCCTGGACGGCAAAGTCGCCGCCCTGGCCGCCAGC CCGGCCTCGGTGGCAGTGGACTCGGGCTCTGAACTCAACAGCCGCTCCTCCACGCTCTCCTCCAGCTCCATGTCCTTGTCGCCCAAACTC TGCGCGGAGAAAGAGGCGGCCACCAGCGAACTGCAGAGCATCCAGCGGTTGGTTAGCGGCTTGGAAGCCAAGCCGGACAGGTCCCGCAGC GCGTCCCCGTAGACCCGTCCCAGACACGTCTTTTCATTCCAGTCCAGTTCAGGCTGCCGTGCACTTTGTCGGATATAAAATAAACCACGG GCCCGCCATGGCGTTAGCCCTTCCTTTTGCAGTTGCGTCTGGGAAGGGGCCCCGGACTCCCTCGAGAGAATGTGCTAGAGACAGCCCCTG TCTTCTTGGCGTGGTTTATATGTCCGGGATCTGGATCAGATTCTGGGGGCTCAGAAACGTCGGTTGCATTGAGCTACTGGGGGTAGGAGT TCCAACATTTATGTCCAGAGCAACTTCCAGCAAGGCTGGTCTGGGTCTCTGCCCACCAGGCGGGGAGGTGTTCAAAGACATCTCCCTCAG TGCGGATTTATATATATATTTTTCCTTCACTGTGTCAAGTGGAAACAAAAACAAAATCTTTCAAAAAAAAAATCGGGACAAGTGAACACA TTAACATGATTCTGTTTGTGCAGATTAAAAACTTTATAGGGACTTGCATTATCGGTTCTCAATAAATTACTGAGCAGCTTTGTTTGGGGA GGGAAGTCCCTACCATCCTTGTTTAGTCTATATTAAGAAAATCTGTGTCTTTTTAATATTCTTGTGATGTTTTCAGAGCCGCTGTAGGTC TCTTCTTGCATGTCCACAGTAATGTATTTGTGGTTTTTATTTTGAACGCTTGCTTTTAGAGAGAAAACAATATAGCCCCCTACCCTTTTC CCAATCCTTTGCCCTCAAATCAGTGACCCAAGGGAGGGGGGGATTTAAAGGGAAGGAGTGGGCAAAACACATAAAATGAATTTATTATAT CTAAGCTCTGTAGCAGGATTCATGTCGTTCTTTGACAGTTCTTTCTCTTTCCTGTATATGCAATAACAAGGTTTTAAAAAAATAATAAAG AAGTGAGACTATTAGACAAAGTATTTATGTAATTATTTGATAACTCTTGTAAATAGGTGGAATATGAATGCTTGGAAAATTAAACTTTAA TTTATTGACATTGTACATAGCTCTGTGTAAATAGAATTGCAACTGTCAGGTTTTGTGTTCTTGTTTTCCTTTAGTTGGGTTTATTTCCAG GTCACAGAATTGCTGTTAACACTAGAAAACACACTTCCTGCACCAACACCAATACCCTTTCAAAAGAGTTGTCTGCAACATTTTTGTTTT CTTTTTTAATGTCCAAAAGTGGGGGAAAGTGCTATTTCCTATTTTCACCAAAATTGGGGAAGGAGTGCCACTTTCCAGCTCCACTTCAAA TTCCTTAAAATATAACTGAGATTGCTGTGGGGAGGGAGGAGGGCAGAGGCTGCGGTTTGACTTTTTAATTTTTCTTTTGTTATTTGTATT TGCTAGTCTCTGATTTCCTCAAAACGAAGTGGAATTTACTACTGTTGTCAGTATCGGTGTTTTGAATTGGTGCCTGCCTATAGAGATATA TTCACAGTTCAAAAGTCAGGTGCTGAGAGATGGTTTAAAGACAAATTCATGAAGGTATATTTTGTGTTATAGTTGTTGATGAGTTCTTTG >In-frame_WLS_ENST00000354777_chr1_68603463_-_TBX3_ENST00000257566_chr12_115110107_-_3804nt GTCCACAGGCGGCGGAGCGGCCACAATCACAGCTCCGGGCATTGGGGGAACCCGAGCCGGCTGCGCCGGGGGAATCCGTGCGGGCGCCTT CCGTCCCGGTCCCATCCTCGCCGCGCTCCAGCACCTCTGAAGTTTTGCAGCGCCCAGAAAGGAGGCGAGGAAGGAGGGAGTGTGTGAGAG GAGGGAGCAAAAAGCTCACCCTAAAACATTTATTTCAAGGAGAAAAGAAAAAGGGGGGGCGCAAAAATGGCTGGGGCAATTATAGAAAAC ATGAGCACCAAGAAGCTGTGCATTGTTGGTGGGATTCTGCTCGTGTTCCAAATCATCGCCTTTCTGGTGGGAGGCTTGATTGGGCCCACA ACGGCAGTGTCCTACATGTCGGTGAAATGTGTGGATGCCCGTAAGAACCATCACAAGACAAAATGGTTCGTGCCTTGGGGACCCAATCAT TGTGACAAGATCCGAGACATTGAAGAGGCAATTCCAAGGGAAATTGAAGCCAATGACATCGTGTTTTCTGTTCACATTCCCCTCCCCCAC ATGGAGATGAGTCCTTGGTTCCAATTCATGCTGTTTATCCTGCAGCTGGACATTGCCTTCAAGCTAAACAACCAAATCAGAGAAAATGCA GAAGTCTCCATGGACGTTTCCCTGGCTTACCGTGATGACGCGTTTGCTGAGTGGACTGAAATGGCCCATGAAAGAGTACCACGGAAACTC AAATGCACCTTCACATCTCCCAAGACTCCAGAGCATGAGGGCCGTTACTATGAATGTGATGTCCTTCCTTTCATGGAAATTGGGTCTGTG GCCCATAAGTTTTACCTTTTAAACATCCGGCTGCCTGTGAATGAGAAGAAGAAAATCAATGTGGGAATTGGGGAGATAAAGGATATCCGG TTGGTGGGGATCCACCAAAATGGAGGCTTCACCAAGGTGTGGTTTGCCATGAAGACCTTCCTTACGCCCAGCATCTTCATCATTATGGTG TGGTATTGGAGGAGGATCACCATGATGTCCCGACCCCCAGTGCTTCTGGAAAAAGTCATCTTTGCCCTTGGGATTTCCATGACCTTTATC AATATCCCAGTGGAATGGTTTTCCATCGGGTTTGACTGGACCTGGATGCTGCTGTTTGGTGACATCCGACAGGGCATCTTCTATGCGATG CTTCTGTCCTTCTGGATCATCTTCTGTGGCGAGCACATGATGGATCAGCACGAGCGGAACCACATCGCAGGGTATTGGAAGCAAGTCGGA CCCATTGCCGTTGGCTCCTTCTGCCTCTTCATATTTGACATGTGTGAGAGAGGGGTACAACTCACGAATCCCTTCTACAGTATCTGGACT ACAGACATTGGAACAGAGCTGGCCATGGCCTTCATCATCGTGGCTGGAATCTGCCTCTGCCTCTACTTCCTGTTTCTATGCTTCATGGTA TTTCAGGTGTTTCGGAACATCAGTGGGAAGCAGTCCAGCCTGCCAGCTATGAGCAAAGTCCGGCGGCTACACTATGAGGGGCTAATTTTT AGGTTCAAGTTCCTCATGCTTATCACCTTGGCCTGCGCTGCCATGACTGTCATCTTCTTCATCGTTAGTCAGGTAACGGAAGGCCATTGG AAATGGGGCGGCGTCACAGTCCAAGTGAACAGTGCCTTTTTCACAGGCATCTATGGGATGTGGAATCTGTATGTCTTTGCTCTGATGTTC TTGTATGCACCATCCCATAAAAACTATGGAGAAGACCAGTCCAATGGGCCTGGCCATGTCCCCTTTCGGAAGCCTGTTCCCTTACCCCTA CACGTACATGGCCGCAGCGGCGGCCGCCTCCTCTGCGGCAGCCTCCAGCTCGGTGCACCGCCACCCCTTCCTCAATCTGAACACCATGCG CCCGCGGCTGCGCTACAGCCCCTACTCCATCCCGGTGCCGGTCCCGGACGGCAGCAGTCTGCTCACCACCGCCCTGCCCTCCATGGCGGC GGCCGCGGGGCCCCTGGACGGCAAAGTCGCCGCCCTGGCCGCCAGCCCGGCCTCGGTGGCAGTGGACTCGGGCTCTGAACTCAACAGCCG CTCCTCCACGCTCTCCTCCAGCTCCATGTCCTTGTCGCCCAAACTCTGCGCGGAGAAAGAGGCGGCCACCAGCGAACTGCAGAGCATCCA GCGGTTGGTTAGCGGCTTGGAAGCCAAGCCGGACAGGTCCCGCAGCGCGTCCCCGTAGACCCGTCCCAGACACGTCTTTTCATTCCAGTC CAGTTCAGGCTGCCGTGCACTTTGTCGGATATAAAATAAACCACGGGCCCGCCATGGCGTTAGCCCTTCCTTTTGCAGTTGCGTCTGGGA AGGGGCCCCGGACTCCCTCGAGAGAATGTGCTAGAGACAGCCCCTGTCTTCTTGGCGTGGTTTATATGTCCGGGATCTGGATCAGATTCT GGGGGCTCAGAAACGTCGGTTGCATTGAGCTACTGGGGGTAGGAGTTCCAACATTTATGTCCAGAGCAACTTCCAGCAAGGCTGGTCTGG GTCTCTGCCCACCAGGCGGGGAGGTGTTCAAAGACATCTCCCTCAGTGCGGATTTATATATATATTTTTCCTTCACTGTGTCAAGTGGAA ACAAAAACAAAATCTTTCAAAAAAAAAATCGGGACAAGTGAACACATTAACATGATTCTGTTTGTGCAGATTAAAAACTTTATAGGGACT TGCATTATCGGTTCTCAATAAATTACTGAGCAGCTTTGTTTGGGGAGGGAAGTCCCTACCATCCTTGTTTAGTCTATATTAAGAAAATCT GTGTCTTTTTAATATTCTTGTGATGTTTTCAGAGCCGCTGTAGGTCTCTTCTTGCATGTCCACAGTAATGTATTTGTGGTTTTTATTTTG AACGCTTGCTTTTAGAGAGAAAACAATATAGCCCCCTACCCTTTTCCCAATCCTTTGCCCTCAAATCAGTGACCCAAGGGAGGGGGGGAT TTAAAGGGAAGGAGTGGGCAAAACACATAAAATGAATTTATTATATCTAAGCTCTGTAGCAGGATTCATGTCGTTCTTTGACAGTTCTTT CTCTTTCCTGTATATGCAATAACAAGGTTTTAAAAAAATAATAAAGAAGTGAGACTATTAGACAAAGTATTTATGTAATTATTTGATAAC TCTTGTAAATAGGTGGAATATGAATGCTTGGAAAATTAAACTTTAATTTATTGACATTGTACATAGCTCTGTGTAAATAGAATTGCAACT GTCAGGTTTTGTGTTCTTGTTTTCCTTTAGTTGGGTTTATTTCCAGGTCACAGAATTGCTGTTAACACTAGAAAACACACTTCCTGCACC AACACCAATACCCTTTCAAAAGAGTTGTCTGCAACATTTTTGTTTTCTTTTTTAATGTCCAAAAGTGGGGGAAAGTGCTATTTCCTATTT TCACCAAAATTGGGGAAGGAGTGCCACTTTCCAGCTCCACTTCAAATTCCTTAAAATATAACTGAGATTGCTGTGGGGAGGGAGGAGGGC AGAGGCTGCGGTTTGACTTTTTAATTTTTCTTTTGTTATTTGTATTTGCTAGTCTCTGATTTCCTCAAAACGAAGTGGAATTTACTACTG TTGTCAGTATCGGTGTTTTGAATTGGTGCCTGCCTATAGAGATATATTCACAGTTCAAAAGTCAGGTGCTGAGAGATGGTTTAAAGACAA ATTCATGAAGGTATATTTTGTGTTATAGTTGTTGATGAGTTCTTTGGTTTTCTGTATTTTTCCCCCTCTCTTTAAAACATCACTGAAATT >In-frame_WLS_ENST00000262348_chr1_68603463_-_TBX3_ENST00000257566_chr12_115110107_-_3818nt CTTTAAGCGTCCACAGGCGGCGGAGCGGCCACAATCACAGCTCCGGGCATTGGGGGAACCCGAGCCGGCTGCGCCGGGGGAATCCGTGCG GGCGCCTTCCGTCCCGGTCCCATCCTCGCCGCGCTCCAGCACCTCTGAAGTTTTGCAGCGCCCAGAAAGGAGGCGAGGAAGGAGGGAGTG TGTGAGAGGAGGGAGCAAAAAGCTCACCCTAAAACATTTATTTCAAGGAGAAAAGAAAAAGGGGGGGCGCAAAAATGGCTGGGGCAATTA TAGAAAACATGAGCACCAAGAAGCTGTGCATTGTTGGTGGGATTCTGCTCGTGTTCCAAATCATCGCCTTTCTGGTGGGAGGCTTGATTG CTCCAGGGCCCACAACGGCAGTGTCCTACATGTCGGTGAAATGTGTGGATGCCCGTAAGAACCATCACAAGACAAAATGGTTCGTGCCTT GGGGACCCAATCATTGTGACAAGATCCGAGACATTGAAGAGGCAATTCCAAGGGAAATTGAAGCCAATGACATCGTGTTTTCTGTTCACA TTCCCCTCCCCCACATGGAGATGAGTCCTTGGTTCCAATTCATGCTGTTTATCCTGCAGCTGGACATTGCCTTCAAGCTAAACAACCAAA TCAGAGAAAATGCAGAAGTCTCCATGGACGTTTCCCTGGCTTACCGTGATGACGCGTTTGCTGAGTGGACTGAAATGGCCCATGAAAGAG TACCACGGAAACTCAAATGCACCTTCACATCTCCCAAGACTCCAGAGCATGAGGGCCGTTACTATGAATGTGATGTCCTTCCTTTCATGG AAATTGGGTCTGTGGCCCATAAGTTTTACCTTTTAAACATCCGGCTGCCTGTGAATGAGAAGAAGAAAATCAATGTGGGAATTGGGGAGA TAAAGGATATCCGGTTGGTGGGGATCCACCAAAATGGAGGCTTCACCAAGGTGTGGTTTGCCATGAAGACCTTCCTTACGCCCAGCATCT TCATCATTATGGTGTGGTATTGGAGGAGGATCACCATGATGTCCCGACCCCCAGTGCTTCTGGAAAAAGTCATCTTTGCCCTTGGGATTT CCATGACCTTTATCAATATCCCAGTGGAATGGTTTTCCATCGGGTTTGACTGGACCTGGATGCTGCTGTTTGGTGACATCCGACAGGGCA TCTTCTATGCGATGCTTCTGTCCTTCTGGATCATCTTCTGTGGCGAGCACATGATGGATCAGCACGAGCGGAACCACATCGCAGGGTATT GGAAGCAAGTCGGACCCATTGCCGTTGGCTCCTTCTGCCTCTTCATATTTGACATGTGTGAGAGAGGGGTACAACTCACGAATCCCTTCT ACAGTATCTGGACTACAGACATTGGAACAGAGCTGGCCATGGCCTTCATCATCGTGGCTGGAATCTGCCTCTGCCTCTACTTCCTGTTTC TATGCTTCATGGTATTTCAGGTGTTTCGGAACATCAGTGGGAAGCAGTCCAGCCTGCCAGCTATGAGCAAAGTCCGGCGGCTACACTATG AGGGGCTAATTTTTAGGTTCAAGTTCCTCATGCTTATCACCTTGGCCTGCGCTGCCATGACTGTCATCTTCTTCATCGTTAGTCAGGTAA CGGAAGGCCATTGGAAATGGGGCGGCGTCACAGTCCAAGTGAACAGTGCCTTTTTCACAGGCATCTATGGGATGTGGAATCTGTATGTCT TTGCTCTGATGTTCTTGTATGCACCATCCCATAAAAACTATGGAGAAGACCAGTCCAATGGGCCTGGCCATGTCCCCTTTCGGAAGCCTG TTCCCTTACCCCTACACGTACATGGCCGCAGCGGCGGCCGCCTCCTCTGCGGCAGCCTCCAGCTCGGTGCACCGCCACCCCTTCCTCAAT CTGAACACCATGCGCCCGCGGCTGCGCTACAGCCCCTACTCCATCCCGGTGCCGGTCCCGGACGGCAGCAGTCTGCTCACCACCGCCCTG CCCTCCATGGCGGCGGCCGCGGGGCCCCTGGACGGCAAAGTCGCCGCCCTGGCCGCCAGCCCGGCCTCGGTGGCAGTGGACTCGGGCTCT GAACTCAACAGCCGCTCCTCCACGCTCTCCTCCAGCTCCATGTCCTTGTCGCCCAAACTCTGCGCGGAGAAAGAGGCGGCCACCAGCGAA CTGCAGAGCATCCAGCGGTTGGTTAGCGGCTTGGAAGCCAAGCCGGACAGGTCCCGCAGCGCGTCCCCGTAGACCCGTCCCAGACACGTC TTTTCATTCCAGTCCAGTTCAGGCTGCCGTGCACTTTGTCGGATATAAAATAAACCACGGGCCCGCCATGGCGTTAGCCCTTCCTTTTGC AGTTGCGTCTGGGAAGGGGCCCCGGACTCCCTCGAGAGAATGTGCTAGAGACAGCCCCTGTCTTCTTGGCGTGGTTTATATGTCCGGGAT CTGGATCAGATTCTGGGGGCTCAGAAACGTCGGTTGCATTGAGCTACTGGGGGTAGGAGTTCCAACATTTATGTCCAGAGCAACTTCCAG CAAGGCTGGTCTGGGTCTCTGCCCACCAGGCGGGGAGGTGTTCAAAGACATCTCCCTCAGTGCGGATTTATATATATATTTTTCCTTCAC TGTGTCAAGTGGAAACAAAAACAAAATCTTTCAAAAAAAAAATCGGGACAAGTGAACACATTAACATGATTCTGTTTGTGCAGATTAAAA ACTTTATAGGGACTTGCATTATCGGTTCTCAATAAATTACTGAGCAGCTTTGTTTGGGGAGGGAAGTCCCTACCATCCTTGTTTAGTCTA TATTAAGAAAATCTGTGTCTTTTTAATATTCTTGTGATGTTTTCAGAGCCGCTGTAGGTCTCTTCTTGCATGTCCACAGTAATGTATTTG TGGTTTTTATTTTGAACGCTTGCTTTTAGAGAGAAAACAATATAGCCCCCTACCCTTTTCCCAATCCTTTGCCCTCAAATCAGTGACCCA AGGGAGGGGGGGATTTAAAGGGAAGGAGTGGGCAAAACACATAAAATGAATTTATTATATCTAAGCTCTGTAGCAGGATTCATGTCGTTC TTTGACAGTTCTTTCTCTTTCCTGTATATGCAATAACAAGGTTTTAAAAAAATAATAAAGAAGTGAGACTATTAGACAAAGTATTTATGT AATTATTTGATAACTCTTGTAAATAGGTGGAATATGAATGCTTGGAAAATTAAACTTTAATTTATTGACATTGTACATAGCTCTGTGTAA ATAGAATTGCAACTGTCAGGTTTTGTGTTCTTGTTTTCCTTTAGTTGGGTTTATTTCCAGGTCACAGAATTGCTGTTAACACTAGAAAAC ACACTTCCTGCACCAACACCAATACCCTTTCAAAAGAGTTGTCTGCAACATTTTTGTTTTCTTTTTTAATGTCCAAAAGTGGGGGAAAGT GCTATTTCCTATTTTCACCAAAATTGGGGAAGGAGTGCCACTTTCCAGCTCCACTTCAAATTCCTTAAAATATAACTGAGATTGCTGTGG GGAGGGAGGAGGGCAGAGGCTGCGGTTTGACTTTTTAATTTTTCTTTTGTTATTTGTATTTGCTAGTCTCTGATTTCCTCAAAACGAAGT GGAATTTACTACTGTTGTCAGTATCGGTGTTTTGAATTGGTGCCTGCCTATAGAGATATATTCACAGTTCAAAAGTCAGGTGCTGAGAGA TGGTTTAAAGACAAATTCATGAAGGTATATTTTGTGTTATAGTTGTTGATGAGTTCTTTGGTTTTCTGTATTTTTCCCCCTCTCTTTAAA >In-frame_WLS_ENST00000370976_chr1_68603463_-_TBX3_ENST00000257566_chr12_115110107_-_3536nt TCCACAGGCGGCGGAGCGGCCACAATCACAGCTCCGGGCATTGGGGGAACCCGAGCCGGCTGCGCCGGGGGAATCCGTGCGGGCGCCTTC CGTCCCGGTCCCATCCTCGCCGCGCTCCAGCACCTCTGAAGTTTTGCAGCGCCCAGAAAGGAGGCGAGGAAGGAGGGAGTGTGTGAGAGG AGGGAGCAAAAAGCTCACCCTAAAACATTTATTTCAAGGAGAAAAGAAAAAGGGGGGGCGCAAAAATGGCTGGGGCAATTATAGAAAACA TGAGCACCAAGAAGCTGTGCATTGTTGGTGGGATTCTGCTCGTGTTCCAAATCATCGCCTTTCTGGTGGGAGGCTTGATTGGAGAAAATG CAGAAGTCTCCATGGACGTTTCCCTGGCTTACCGTGATGACGCGTTTGCTGAGTGGACTGAAATGGCCCATGAAAGAGTACCACGGAAAC TCAAATGCACCTTCACATCTCCCAAGACTCCAGAGCATGAGGGCCGTTACTATGAATGTGATGTCCTTCCTTTCATGGAAATTGGGTCTG TGGCCCATAAGTTTTACCTTTTAAACATCCGGCTGCCTGTGAATGAGAAGAAGAAAATCAATGTGGGAATTGGGGAGATAAAGGATATCC GGTTGGTGGGGATCCACCAAAATGGAGGCTTCACCAAGGTGTGGTTTGCCATGAAGACCTTCCTTACGCCCAGCATCTTCATCATTATGG TGTGGTATTGGAGGAGGATCACCATGATGTCCCGACCCCCAGTGCTTCTGGAAAAAGTCATCTTTGCCCTTGGGATTTCCATGACCTTTA TCAATATCCCAGTGGAATGGTTTTCCATCGGGTTTGACTGGACCTGGATGCTGCTGTTTGGTGACATCCGACAGGGCATCTTCTATGCGA TGCTTCTGTCCTTCTGGATCATCTTCTGTGGCGAGCACATGATGGATCAGCACGAGCGGAACCACATCGCAGGGTATTGGAAGCAAGTCG GACCCATTGCCGTTGGCTCCTTCTGCCTCTTCATATTTGACATGTGTGAGAGAGGGGTACAACTCACGAATCCCTTCTACAGTATCTGGA CTACAGACATTGGAACAGAGCTGGCCATGGCCTTCATCATCGTGGCTGGAATCTGCCTCTGCCTCTACTTCCTGTTTCTATGCTTCATGG TATTTCAGGTGTTTCGGAACATCAGTGGGAAGCAGTCCAGCCTGCCAGCTATGAGCAAAGTCCGGCGGCTACACTATGAGGGGCTAATTT TTAGGTTCAAGTTCCTCATGCTTATCACCTTGGCCTGCGCTGCCATGACTGTCATCTTCTTCATCGTTAGTCAGGTAACGGAAGGCCATT GGAAATGGGGCGGCGTCACAGTCCAAGTGAACAGTGCCTTTTTCACAGGCATCTATGGGATGTGGAATCTGTATGTCTTTGCTCTGATGT TCTTGTATGCACCATCCCATAAAAACTATGGAGAAGACCAGTCCAATGGGCCTGGCCATGTCCCCTTTCGGAAGCCTGTTCCCTTACCCC TACACGTACATGGCCGCAGCGGCGGCCGCCTCCTCTGCGGCAGCCTCCAGCTCGGTGCACCGCCACCCCTTCCTCAATCTGAACACCATG CGCCCGCGGCTGCGCTACAGCCCCTACTCCATCCCGGTGCCGGTCCCGGACGGCAGCAGTCTGCTCACCACCGCCCTGCCCTCCATGGCG GCGGCCGCGGGGCCCCTGGACGGCAAAGTCGCCGCCCTGGCCGCCAGCCCGGCCTCGGTGGCAGTGGACTCGGGCTCTGAACTCAACAGC CGCTCCTCCACGCTCTCCTCCAGCTCCATGTCCTTGTCGCCCAAACTCTGCGCGGAGAAAGAGGCGGCCACCAGCGAACTGCAGAGCATC CAGCGGTTGGTTAGCGGCTTGGAAGCCAAGCCGGACAGGTCCCGCAGCGCGTCCCCGTAGACCCGTCCCAGACACGTCTTTTCATTCCAG TCCAGTTCAGGCTGCCGTGCACTTTGTCGGATATAAAATAAACCACGGGCCCGCCATGGCGTTAGCCCTTCCTTTTGCAGTTGCGTCTGG GAAGGGGCCCCGGACTCCCTCGAGAGAATGTGCTAGAGACAGCCCCTGTCTTCTTGGCGTGGTTTATATGTCCGGGATCTGGATCAGATT CTGGGGGCTCAGAAACGTCGGTTGCATTGAGCTACTGGGGGTAGGAGTTCCAACATTTATGTCCAGAGCAACTTCCAGCAAGGCTGGTCT GGGTCTCTGCCCACCAGGCGGGGAGGTGTTCAAAGACATCTCCCTCAGTGCGGATTTATATATATATTTTTCCTTCACTGTGTCAAGTGG AAACAAAAACAAAATCTTTCAAAAAAAAAATCGGGACAAGTGAACACATTAACATGATTCTGTTTGTGCAGATTAAAAACTTTATAGGGA CTTGCATTATCGGTTCTCAATAAATTACTGAGCAGCTTTGTTTGGGGAGGGAAGTCCCTACCATCCTTGTTTAGTCTATATTAAGAAAAT CTGTGTCTTTTTAATATTCTTGTGATGTTTTCAGAGCCGCTGTAGGTCTCTTCTTGCATGTCCACAGTAATGTATTTGTGGTTTTTATTT TGAACGCTTGCTTTTAGAGAGAAAACAATATAGCCCCCTACCCTTTTCCCAATCCTTTGCCCTCAAATCAGTGACCCAAGGGAGGGGGGG ATTTAAAGGGAAGGAGTGGGCAAAACACATAAAATGAATTTATTATATCTAAGCTCTGTAGCAGGATTCATGTCGTTCTTTGACAGTTCT TTCTCTTTCCTGTATATGCAATAACAAGGTTTTAAAAAAATAATAAAGAAGTGAGACTATTAGACAAAGTATTTATGTAATTATTTGATA ACTCTTGTAAATAGGTGGAATATGAATGCTTGGAAAATTAAACTTTAATTTATTGACATTGTACATAGCTCTGTGTAAATAGAATTGCAA CTGTCAGGTTTTGTGTTCTTGTTTTCCTTTAGTTGGGTTTATTTCCAGGTCACAGAATTGCTGTTAACACTAGAAAACACACTTCCTGCA CCAACACCAATACCCTTTCAAAAGAGTTGTCTGCAACATTTTTGTTTTCTTTTTTAATGTCCAAAAGTGGGGGAAAGTGCTATTTCCTAT TTTCACCAAAATTGGGGAAGGAGTGCCACTTTCCAGCTCCACTTCAAATTCCTTAAAATATAACTGAGATTGCTGTGGGGAGGGAGGAGG GCAGAGGCTGCGGTTTGACTTTTTAATTTTTCTTTTGTTATTTGTATTTGCTAGTCTCTGATTTCCTCAAAACGAAGTGGAATTTACTAC TGTTGTCAGTATCGGTGTTTTGAATTGGTGCCTGCCTATAGAGATATATTCACAGTTCAAAAGTCAGGTGCTGAGAGATGGTTTAAAGAC AAATTCATGAAGGTATATTTTGTGTTATAGTTGTTGATGAGTTCTTTGGTTTTCTGTATTTTTCCCCCTCTCTTTAAAACATCACTGAAA |
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FusionGenePPI for WLS_TBX3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| WLS | MOV10, NXF1, OPRM1, OPRD1, OPRK1, WNT4, HTR3C, TCTN2, TCTN3, NCSTN, WNT7A, CHRND, WNT5A, HTR3A, GABRA3, WNT16, TMED6, TRIM25 | TBX3 | TBX3, TOLLIP, HDAC1, HDAC2, HDAC3, HDAC5, ELAVL1, SOX2, AES, CA8, PML, PLEKHF2, CDK8, MAPK3, KIF21B, KIF21A, DNAJC11, DCP1A, CDCA5, HNRNPLL |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for WLS_TBX3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WLS_TBX3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | WLS | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | WLS | C0858355 | addicted to cocaine | 1 | PSYGENET |
| Tgene | TBX3 | C1866994 | Ulnar-mammary syndrome | 2 | CTD_human;ORPHANET;UNIPROT |
| Tgene | TBX3 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Tgene | TBX3 | C0040128 | Thyroid Diseases | 1 | CTD_human |
| Tgene | TBX3 | C0040427 | Tooth Abnormalities | 1 | CTD_human |
| Tgene | TBX3 | C0206762 | Limb Deformities, Congenital | 1 | CTD_human |
| Tgene | TBX3 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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