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Fusion gene ID: 42022 |
FusionGeneSummary for WIPF2_USP32 |
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Fusion gene information | Fusion gene name: WIPF2_USP32 | Fusion gene ID: 42022 | Hgene | Tgene | Gene symbol | WIPF2 | USP32 | Gene ID | 147179 | 84669 |
Gene name | WAS/WASL interacting protein family member 2 | ubiquitin specific peptidase 32 | |
Synonyms | WICH|WIRE | NY-REN-60|USP10 | |
Cytomap | 17q21.2 | 17q23.1-q23.2 | |
Type of gene | protein-coding | protein-coding | |
Description | WAS/WASL-interacting protein family member 2WASP-binding proteinWASP-interacting protein-related proteinWIP- and CR16-homologous proteinWIP-related protein | ubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8TF74 | Q8NFA0 | |
Ensembl transtripts involved in fusion gene | ENST00000494757, ENST00000323571, ENST00000585043, ENST00000394103, ENST00000536600, ENST00000583130, | ENST00000300896, ENST00000592339, ENST00000393003, ENST00000586881, | |
Fusion gene scores | * DoF score | 28 X 7 X 15=2940 | 12 X 7 X 6=504 |
# samples | 28 | 12 | |
** MAII score | log2(28/2940*10)=-3.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/504*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: WIPF2 [Title/Abstract] AND USP32 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-BH-A18R-01A | WIPF2 | chr17 | 38375744 | + | USP32 | chr17 | 58422969 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000494757 | ENST00000300896 | WIPF2 | chr17 | 38375744 | + | USP32 | chr17 | 58422969 | - |
3UTR-intron | ENST00000494757 | ENST00000592339 | WIPF2 | chr17 | 38375744 | + | USP32 | chr17 | 58422969 | - |
3UTR-intron | ENST00000494757 | ENST00000393003 | WIPF2 | chr17 | 38375744 | + | USP32 | chr17 | 58422969 | - |
3UTR-intron | ENST00000494757 | ENST00000586881 | WIPF2 | chr17 | 38375744 | + | USP32 | chr17 | 58422969 | - |
5UTR-3CDS | ENST00000323571 | ENST00000300896 | WIPF2 | chr17 | 38375744 | + | USP32 | chr17 | 58422969 | - |
5UTR-intron | ENST00000323571 | ENST00000592339 | WIPF2 | chr17 | 38375744 | + | USP32 | chr17 | 58422969 | - |
5UTR-intron | ENST00000323571 | ENST00000393003 | WIPF2 | chr17 | 38375744 | + | USP32 | chr17 | 58422969 | - |
5UTR-intron | ENST00000323571 | ENST00000586881 | WIPF2 | chr17 | 38375744 | + | USP32 | chr17 | 58422969 | - |
5UTR-3CDS | ENST00000585043 | ENST00000300896 | WIPF2 | chr17 | 38375744 | + | USP32 | chr17 | 58422969 | - |
5UTR-intron | ENST00000585043 | ENST00000592339 | WIPF2 | chr17 | 38375744 | + | USP32 | chr17 | 58422969 | - |
5UTR-intron | ENST00000585043 | ENST00000393003 | WIPF2 | chr17 | 38375744 | + | USP32 | chr17 | 58422969 | - |
5UTR-intron | ENST00000585043 | ENST00000586881 | WIPF2 | chr17 | 38375744 | + | USP32 | chr17 | 58422969 | - |
5UTR-3CDS | ENST00000394103 | ENST00000300896 | WIPF2 | chr17 | 38375744 | + | USP32 | chr17 | 58422969 | - |
5UTR-intron | ENST00000394103 | ENST00000592339 | WIPF2 | chr17 | 38375744 | + | USP32 | chr17 | 58422969 | - |
5UTR-intron | ENST00000394103 | ENST00000393003 | WIPF2 | chr17 | 38375744 | + | USP32 | chr17 | 58422969 | - |
5UTR-intron | ENST00000394103 | ENST00000586881 | WIPF2 | chr17 | 38375744 | + | USP32 | chr17 | 58422969 | - |
5UTR-3CDS | ENST00000536600 | ENST00000300896 | WIPF2 | chr17 | 38375744 | + | USP32 | chr17 | 58422969 | - |
5UTR-intron | ENST00000536600 | ENST00000592339 | WIPF2 | chr17 | 38375744 | + | USP32 | chr17 | 58422969 | - |
5UTR-intron | ENST00000536600 | ENST00000393003 | WIPF2 | chr17 | 38375744 | + | USP32 | chr17 | 58422969 | - |
5UTR-intron | ENST00000536600 | ENST00000586881 | WIPF2 | chr17 | 38375744 | + | USP32 | chr17 | 58422969 | - |
intron-3CDS | ENST00000583130 | ENST00000300896 | WIPF2 | chr17 | 38375744 | + | USP32 | chr17 | 58422969 | - |
intron-intron | ENST00000583130 | ENST00000592339 | WIPF2 | chr17 | 38375744 | + | USP32 | chr17 | 58422969 | - |
intron-intron | ENST00000583130 | ENST00000393003 | WIPF2 | chr17 | 38375744 | + | USP32 | chr17 | 58422969 | - |
intron-intron | ENST00000583130 | ENST00000586881 | WIPF2 | chr17 | 38375744 | + | USP32 | chr17 | 58422969 | - |
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FusionProtFeatures for WIPF2_USP32 |
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Hgene | Tgene |
WIPF2 | USP32 |
Plays an active role in the formation of cell surfaceprotrusions downstream of activated PDGFB receptors. Plays animportant role in actin-microspike formation through cooperationwith WASL. May cooperate with WASP and WASL to induce mobilizationand reorganization of the actin filament system.{ECO:0000269|PubMed:11829459, ECO:0000269|PubMed:12213210}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for WIPF2_USP32 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for WIPF2_USP32 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
WIPF2 | DNMBP, WAS, NCK2, GRB2, ITSN2, SH3KBP1, WASL, EIF4A3, TXLNG, SLC4A1AP, HNRNPDL, ZFAND5, ZNF830, TCERG1, APBB1, WWOX, PACSIN2, NCK1, CDH1, TRIM25 | USP32 | CDK1, FARSA, KRT8, KRT18, KRT19, ABCD3, YWHAB, TUBA1A, SMC1A, USP6, TRIP13, ERP44, UBXN1, MRPL39, VPS35, LRRC47, USP32P2, USP4, CUL3, CAND1, RBCK1, TRIM46, RNF144A, TRIM74, ZDHHC17, RAP1B, SORT1, SYNCRIP, BAG6, FDFT1, RAB6B, TPCN2, MANSC1, ENTPD7, ALDH3B1, CD83, NME4, HSPA12A, UBC, MTNR1A, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for WIPF2_USP32 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WIPF2_USP32 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |