|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 4200 |
FusionGeneSummary for BIRC7_ZNF200 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BIRC7_ZNF200 | Fusion gene ID: 4200 | Hgene | Tgene | Gene symbol | BIRC7 | ZNF200 | Gene ID | 79444 | 7752 |
| Gene name | baculoviral IAP repeat containing 7 | zinc finger protein 200 | |
| Synonyms | KIAP|LIVIN|ML-IAP|MLIAP|RNF50 | - | |
| Cytomap | 20q13.33 | 16p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | baculoviral IAP repeat-containing protein 7RING finger protein 50RING-type E3 ubiquitin transferase BIRC7kidney inhibitor of apoptosis proteinlivin inhibitor of apoptosismelanoma inhibitor of apoptosis protein | zinc finger protein 200 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q96CA5 | P98182 | |
| Ensembl transtripts involved in fusion gene | ENST00000342412, ENST00000217169, ENST00000395306, | ENST00000396868, ENST00000414144, ENST00000396871, ENST00000431561, ENST00000396870, ENST00000575948, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 1 X 2=4 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: BIRC7 [Title/Abstract] AND ZNF200 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BIRC7 | GO:0016567 | protein ubiquitination | 16729033 |
| Hgene | BIRC7 | GO:0042127 | regulation of cell proliferation | 21617971 |
| Hgene | BIRC7 | GO:0070247 | regulation of natural killer cell apoptotic process | 18034418 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-EE-A2GK-06A | BIRC7 | chr20 | 61870962 | + | ZNF200 | chr16 | 3285360 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000342412 | ENST00000396868 | BIRC7 | chr20 | 61870962 | + | ZNF200 | chr16 | 3285360 | - |
| 3UTR-5UTR | ENST00000342412 | ENST00000414144 | BIRC7 | chr20 | 61870962 | + | ZNF200 | chr16 | 3285360 | - |
| 3UTR-5UTR | ENST00000342412 | ENST00000396871 | BIRC7 | chr20 | 61870962 | + | ZNF200 | chr16 | 3285360 | - |
| 3UTR-intron | ENST00000342412 | ENST00000431561 | BIRC7 | chr20 | 61870962 | + | ZNF200 | chr16 | 3285360 | - |
| 3UTR-intron | ENST00000342412 | ENST00000396870 | BIRC7 | chr20 | 61870962 | + | ZNF200 | chr16 | 3285360 | - |
| 3UTR-intron | ENST00000342412 | ENST00000575948 | BIRC7 | chr20 | 61870962 | + | ZNF200 | chr16 | 3285360 | - |
| 3UTR-3CDS | ENST00000217169 | ENST00000396868 | BIRC7 | chr20 | 61870962 | + | ZNF200 | chr16 | 3285360 | - |
| 3UTR-5UTR | ENST00000217169 | ENST00000414144 | BIRC7 | chr20 | 61870962 | + | ZNF200 | chr16 | 3285360 | - |
| 3UTR-5UTR | ENST00000217169 | ENST00000396871 | BIRC7 | chr20 | 61870962 | + | ZNF200 | chr16 | 3285360 | - |
| 3UTR-intron | ENST00000217169 | ENST00000431561 | BIRC7 | chr20 | 61870962 | + | ZNF200 | chr16 | 3285360 | - |
| 3UTR-intron | ENST00000217169 | ENST00000396870 | BIRC7 | chr20 | 61870962 | + | ZNF200 | chr16 | 3285360 | - |
| 3UTR-intron | ENST00000217169 | ENST00000575948 | BIRC7 | chr20 | 61870962 | + | ZNF200 | chr16 | 3285360 | - |
| Frame-shift | ENST00000395306 | ENST00000396868 | BIRC7 | chr20 | 61870962 | + | ZNF200 | chr16 | 3285360 | - |
| 5CDS-5UTR | ENST00000395306 | ENST00000414144 | BIRC7 | chr20 | 61870962 | + | ZNF200 | chr16 | 3285360 | - |
| 5CDS-5UTR | ENST00000395306 | ENST00000396871 | BIRC7 | chr20 | 61870962 | + | ZNF200 | chr16 | 3285360 | - |
| 5CDS-intron | ENST00000395306 | ENST00000431561 | BIRC7 | chr20 | 61870962 | + | ZNF200 | chr16 | 3285360 | - |
| 5CDS-intron | ENST00000395306 | ENST00000396870 | BIRC7 | chr20 | 61870962 | + | ZNF200 | chr16 | 3285360 | - |
| 5CDS-intron | ENST00000395306 | ENST00000575948 | BIRC7 | chr20 | 61870962 | + | ZNF200 | chr16 | 3285360 | - |
Top |
FusionProtFeatures for BIRC7_ZNF200 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BIRC7 | ZNF200 |
| Apoptotic regulator capable of exerting proapoptotic andanti-apoptotic activities and plays crucial roles in apoptosis,cell proliferation, and cell cycle control. Its anti-apoptoticactivity is mediated through the inhibition of CASP3, CASP7 andCASP9, as well as by its E3 ubiquitin-protein ligase activity. Asit is a weak caspase inhibitor, its anti-apoptotic activity isthought to be due to its ability to ubiquitinate DIABLO/SMACtargeting it for degradation thereby promoting cell survival. Maycontribute to caspase inhibition, by blocking the ability ofDIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protectsagainst apoptosis induced by TNF or by chemical agents such asadriamycin, etoposide or staurosporine. Suppression of apoptosisis mediated by activation of MAPK8/JNK1, and possibly also ofMAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. Invitro, inhibits CASP3 and proteolytic activation of pro-CASP9.Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocksetoposide-induced apoptosis. Isoform 2 protects against naturalkiller (NK) cell killing whereas isoform 1 augments killing.{ECO:0000269|PubMed:11084335, ECO:0000269|PubMed:16729033,ECO:0000269|PubMed:17294084, ECO:0000269|PubMed:18034418}. | Could have a role in spermatogenesis. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for BIRC7_ZNF200 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for BIRC7_ZNF200 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| BIRC7 | CASP9, CASP7, CASP3, XAF1, DIABLO, UBE2K, UBE2E1, UBE2D1, UBE2D2, UBE2D3, UBE2I, BIRC2, BIRC7, UBC, HTRA2, RAF1, XIAP, TAB1, AES, DDX6, PHF1, POLR1C, FAM124B, PCNT, ZC3H7A, NFKBIB, OSTM1, DHRS4, WIZ, CLCN7, PTCD3, SPAG9 | ZNF200 | PPARGC1B, ELAVL1, SKIL, FAM208B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for BIRC7_ZNF200 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for BIRC7_ZNF200 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | BIRC7 | C0007134 | Renal Cell Carcinoma | 2 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|