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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41994

FusionGeneSummary for WHSC1_WHSC1

check button Fusion gene summary
Fusion gene informationFusion gene name: WHSC1_WHSC1
Fusion gene ID: 41994
HgeneTgene
Gene symbol

WHSC1

WHSC1

Gene ID

7468

7468

Gene namenuclear receptor binding SET domain protein 2nuclear receptor binding SET domain protein 2
SynonymsKMT3F|KMT3G|MMSET|REIIBP|TRX5|WHS|WHSC1KMT3F|KMT3G|MMSET|REIIBP|TRX5|WHS|WHSC1
Cytomap

4p16.3

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase NSD2IL5 promoter REII region-binding proteinWolf-Hirschhorn syndrome candidate 1multiple myeloma SET domain containing protein type IIInuclear SET domain-containing protein 2probable histone-lysine N-methyltransferahistone-lysine N-methyltransferase NSD2IL5 promoter REII region-binding proteinWolf-Hirschhorn syndrome candidate 1multiple myeloma SET domain containing protein type IIInuclear SET domain-containing protein 2probable histone-lysine N-methyltransfera
Modification date2018051920180519
UniProtAcc

Ensembl transtripts involved in fusion geneENST00000508803, ENST00000382892, 
ENST00000382891, ENST00000382895, 
ENST00000482415, ENST00000382888, 
ENST00000514045, ENST00000436793, 
ENST00000420906, ENST00000503128, 
ENST00000398261, 		ENST00000508803, 
ENST00000382892, ENST00000382891, 
ENST00000382895, ENST00000482415, 
ENST00000382888, ENST00000514045, 
ENST00000436793, ENST00000420906, 
ENST00000503128, ENST00000398261, 
Fusion gene scores* DoF score11 X 9 X 5=4955 X 5 X 1=25
# samples 116
** MAII scorelog2(11/495*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/25*10)=1.26303440583379
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: WHSC1 [Title/Abstract] AND WHSC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE079790WHSC1chr4

1919940

-WHSC1chr4

1902816

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000508803ENST00000508803WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000508803ENST00000382892WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000508803ENST00000382891WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000508803ENST00000382895WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000508803ENST00000482415WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000508803ENST00000382888WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000508803ENST00000514045WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000508803ENST00000436793WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000508803ENST00000420906WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000508803ENST00000503128WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000508803ENST00000398261WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000382892ENST00000508803WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000382892ENST00000382892WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000382892ENST00000382891WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000382892ENST00000382895WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000382892ENST00000482415WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000382892ENST00000382888WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000382892ENST00000514045WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000382892ENST00000436793WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000382892ENST00000420906WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000382892ENST00000503128WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000382892ENST00000398261WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000382891ENST00000508803WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000382891ENST00000382892WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000382891ENST00000382891WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000382891ENST00000382895WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000382891ENST00000482415WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000382891ENST00000382888WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000382891ENST00000514045WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000382891ENST00000436793WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000382891ENST00000420906WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000382891ENST00000503128WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000382891ENST00000398261WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000382895ENST00000508803WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000382895ENST00000382892WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000382895ENST00000382891WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000382895ENST00000382895WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000382895ENST00000482415WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000382895ENST00000382888WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000382895ENST00000514045WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000382895ENST00000436793WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000382895ENST00000420906WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000382895ENST00000503128WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000382895ENST00000398261WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-3CDSENST00000482415ENST00000508803WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-3CDSENST00000482415ENST00000382892WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-3CDSENST00000482415ENST00000382891WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-3CDSENST00000482415ENST00000382895WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-intronENST00000482415ENST00000482415WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-intronENST00000482415ENST00000382888WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-intronENST00000482415ENST00000514045WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-intronENST00000482415ENST00000436793WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-intronENST00000482415ENST00000420906WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-intronENST00000482415ENST00000503128WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-intronENST00000482415ENST00000398261WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-3CDSENST00000382888ENST00000508803WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-3CDSENST00000382888ENST00000382892WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-3CDSENST00000382888ENST00000382891WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-3CDSENST00000382888ENST00000382895WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-intronENST00000382888ENST00000482415WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-intronENST00000382888ENST00000382888WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-intronENST00000382888ENST00000514045WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-intronENST00000382888ENST00000436793WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-intronENST00000382888ENST00000420906WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-intronENST00000382888ENST00000503128WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-intronENST00000382888ENST00000398261WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000514045ENST00000508803WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000514045ENST00000382892WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000514045ENST00000382891WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000514045ENST00000382895WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000514045ENST00000482415WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000514045ENST00000382888WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000514045ENST00000514045WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000514045ENST00000436793WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000514045ENST00000420906WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000514045ENST00000503128WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000514045ENST00000398261WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-3CDSENST00000436793ENST00000508803WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-3CDSENST00000436793ENST00000382892WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-3CDSENST00000436793ENST00000382891WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-3CDSENST00000436793ENST00000382895WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-intronENST00000436793ENST00000482415WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-intronENST00000436793ENST00000382888WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-intronENST00000436793ENST00000514045WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-intronENST00000436793ENST00000436793WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-intronENST00000436793ENST00000420906WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-intronENST00000436793ENST00000503128WHSC1chr4

1919940

-WHSC1chr4

1902816

+
intron-intronENST00000436793ENST00000398261WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000420906ENST00000508803WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000420906ENST00000382892WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000420906ENST00000382891WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000420906ENST00000382895WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000420906ENST00000482415WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000420906ENST00000382888WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000420906ENST00000514045WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000420906ENST00000436793WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000420906ENST00000420906WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000420906ENST00000503128WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000420906ENST00000398261WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000503128ENST00000508803WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000503128ENST00000382892WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000503128ENST00000382891WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000503128ENST00000382895WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000503128ENST00000482415WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000503128ENST00000382888WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000503128ENST00000514045WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000503128ENST00000436793WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000503128ENST00000420906WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000503128ENST00000503128WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000503128ENST00000398261WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000398261ENST00000508803WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000398261ENST00000382892WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000398261ENST00000382891WHSC1chr4

1919940

-WHSC1chr4

1902816

+
Frame-shiftENST00000398261ENST00000382895WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000398261ENST00000482415WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000398261ENST00000382888WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000398261ENST00000514045WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000398261ENST00000436793WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000398261ENST00000420906WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000398261ENST00000503128WHSC1chr4

1919940

-WHSC1chr4

1902816

+
5CDS-intronENST00000398261ENST00000398261WHSC1chr4

1919940

-WHSC1chr4

1902816

+

Top

FusionProtFeatures for WHSC1_WHSC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WHSC1

WHSC1

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for WHSC1_WHSC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for WHSC1_WHSC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for WHSC1_WHSC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for WHSC1_WHSC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource