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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41993

FusionGeneSummary for WHSC1_QKI

check button Fusion gene summary
Fusion gene informationFusion gene name: WHSC1_QKI
Fusion gene ID: 41993
HgeneTgene
Gene symbol

WHSC1

QKI

Gene ID

7468

9444

Gene namenuclear receptor binding SET domain protein 2QKI, KH domain containing RNA binding
SynonymsKMT3F|KMT3G|MMSET|REIIBP|TRX5|WHS|WHSC1Hqk|QK|QK1|QK3|hqkI
Cytomap

4p16.3

6q26

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase NSD2IL5 promoter REII region-binding proteinWolf-Hirschhorn syndrome candidate 1multiple myeloma SET domain containing protein type IIInuclear SET domain-containing protein 2probable histone-lysine N-methyltransferaprotein quakingQKI/LOC100132735 fusionRNA binding protein HQKhomolog of mouse quaking QKI (KH domain RNA binding protein)quaking homolog, KH domain RNA binding
Modification date2018051920180522
UniProtAcc

Q96PU8

Ensembl transtripts involved in fusion geneENST00000508803, ENST00000382892, 
ENST00000382891, ENST00000382895, 
ENST00000482415, ENST00000382888, 
ENST00000514045, ENST00000436793, 
ENST00000420906, ENST00000503128, 
ENST00000398261, 		ENST00000275262, 
ENST00000392127, ENST00000453779, 
ENST00000361752, ENST00000361195, 
ENST00000424802, 
Fusion gene scores* DoF score11 X 9 X 5=49513 X 14 X 6=1092
# samples 1118
** MAII scorelog2(11/495*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1092*10)=-2.60090404459018
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WHSC1 [Title/Abstract] AND QKI [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-WY-A859-01AWHSC1chr4

1959763

+QKIchr6

163876311

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000508803ENST00000275262WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000508803ENST00000392127WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000508803ENST00000453779WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000508803ENST00000361752WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000508803ENST00000361195WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000508803ENST00000424802WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000382892ENST00000275262WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000382892ENST00000392127WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000382892ENST00000453779WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000382892ENST00000361752WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000382892ENST00000361195WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000382892ENST00000424802WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000382891ENST00000275262WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000382891ENST00000392127WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000382891ENST00000453779WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000382891ENST00000361752WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000382891ENST00000361195WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000382891ENST00000424802WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000382895ENST00000275262WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000382895ENST00000392127WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000382895ENST00000453779WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000382895ENST00000361752WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000382895ENST00000361195WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000382895ENST00000424802WHSC1chr4

1959763

+QKIchr6

163876311

+
3UTR-3CDSENST00000482415ENST00000275262WHSC1chr4

1959763

+QKIchr6

163876311

+
3UTR-3CDSENST00000482415ENST00000392127WHSC1chr4

1959763

+QKIchr6

163876311

+
3UTR-3CDSENST00000482415ENST00000453779WHSC1chr4

1959763

+QKIchr6

163876311

+
3UTR-3CDSENST00000482415ENST00000361752WHSC1chr4

1959763

+QKIchr6

163876311

+
3UTR-3CDSENST00000482415ENST00000361195WHSC1chr4

1959763

+QKIchr6

163876311

+
3UTR-3CDSENST00000482415ENST00000424802WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000382888ENST00000275262WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000382888ENST00000392127WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000382888ENST00000453779WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000382888ENST00000361752WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000382888ENST00000361195WHSC1chr4

1959763

+QKIchr6

163876311

+
Frame-shiftENST00000382888ENST00000424802WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000514045ENST00000275262WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000514045ENST00000392127WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000514045ENST00000453779WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000514045ENST00000361752WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000514045ENST00000361195WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000514045ENST00000424802WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000436793ENST00000275262WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000436793ENST00000392127WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000436793ENST00000453779WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000436793ENST00000361752WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000436793ENST00000361195WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000436793ENST00000424802WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000420906ENST00000275262WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000420906ENST00000392127WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000420906ENST00000453779WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000420906ENST00000361752WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000420906ENST00000361195WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000420906ENST00000424802WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000503128ENST00000275262WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000503128ENST00000392127WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000503128ENST00000453779WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000503128ENST00000361752WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000503128ENST00000361195WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000503128ENST00000424802WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000398261ENST00000275262WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000398261ENST00000392127WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000398261ENST00000453779WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000398261ENST00000361752WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000398261ENST00000361195WHSC1chr4

1959763

+QKIchr6

163876311

+
intron-3CDSENST00000398261ENST00000424802WHSC1chr4

1959763

+QKIchr6

163876311

+

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FusionProtFeatures for WHSC1_QKI


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WHSC1

QKI

Q96PU8

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WHSC1_QKI


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WHSC1_QKI


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WHSC1AR, HDAC1, SIN3B, WHSC1, HDAC2, SIN3A, KDM1A, BRD4, SIRT7, HIST2H3C, IQGAP1, TIAM1, CTNNB1, MDC1, APP, LSM1, TRIM28, HIST3H3, HIST1H3A, ESR1, RPL14, RPL8, ZC3H3, PRR11, RBM4B, GEMIN4, GEMIN5, DDX20, GOLGA3, MYBBP1A, PLEC, CCDC88C, RPL6, RBM10, PRPSAP2, THRAP3, RPLP0, PTPN13, SMN1, KIF11, WDR77, MYCBP2, MAP1B, SKIV2L2, IFI16, HIST1H4A, DTL, PCNA, CDC14B, WDR46, DGCR8, RPL30, HIST1H1E, PRDM5, ZNF2, CNBP, ZNF692, RPL28, RPL37A, RRP8, CPNE4, KNOP1, GLTSCR2, GPATCH4, ZC3HAV1, TRIM25QKIHNRNPK, USP30, MED12, MED13, MED25, MED16, MED17, MED1, MED24, MED23, MED4, MED29, MED31, MED15, MED14, MED26, MED10, POLR2A, MED27, ELAVL1, PSMF1, C10orf10, FUBP3, HCLS1, PCBP2, PTBP1, PTBP2, RBM14, RBFOX2, RBPMS, RNF138, SERF2, THAP1, USH1C, RBFOX1, PCBP1, PCBP4, APP, NDUFA7, CDV3, ATXN1, FN1, U2AF2, RBM23, RALY, WDR77, HNRNPH2, QKI, DAZ1, IL7R, CARM1, SNRPA, RBM11, NABP1, HNRNPLL, OIP5, RBMX, ZACN, CYP1A1, NTRK1, EWSR1, HYPK, DUSP22, DUSP4, ATE1, RBM42, FBXW11, SLC39A12, VAC14, TRIM11, SYNCRIP, SNRNP27


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WHSC1_QKI


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WHSC1_QKI


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneQKIC0036341Schizophrenia5PSYGENET
TgeneQKIC0017638Glioma1CTD_human
TgeneQKIC0041696Unipolar Depression1PSYGENET
TgeneQKIC1269683Major Depressive Disorder1PSYGENET