	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 41987

FusionGeneSummary for WHSC1_FOXP1

Fusion gene summary

Fusion gene information	Fusion gene name: WHSC1_FOXP1
	Fusion gene ID: 41987
		Hgene	Tgene
	Gene symbol	WHSC1	FOXP1
	Gene ID	7468	27086
	Gene name	nuclear receptor binding SET domain protein 2	forkhead box P1
	Synonyms	KMT3F\|KMT3G\|MMSET\|REIIBP\|TRX5\|WHS\|WHSC1	12CC4\|HSPC215\|MFH\|QRF1\|hFKH1B
	Cytomap	4p16.3	3p13
	Type of gene	protein-coding	protein-coding
	Description	histone-lysine N-methyltransferase NSD2IL5 promoter REII region-binding proteinWolf-Hirschhorn syndrome candidate 1multiple myeloma SET domain containing protein type IIInuclear SET domain-containing protein 2probable histone-lysine N-methyltransfera	forkhead box protein P1fork head-related protein like Bglutamine-rich factor 1mac-1-regulated forkhead
	Modification date	20180519	20180522
	UniProtAcc		Q9H334
	Ensembl transtripts involved in fusion gene	ENST00000508803, ENST00000382892, ENST00000382891, ENST00000382895, ENST00000482415, ENST00000382888, ENST00000514045, ENST00000436793, ENST00000420906, ENST00000503128, ENST00000398261,	ENST00000318789, ENST00000475937, ENST00000493089, ENST00000484350, ENST00000318779, ENST00000491238, ENST00000498215, ENST00000468577, ENST00000472382,
Fusion gene scores	* DoF score	11 X 9 X 5=495	37 X 16 X 17=10064
	# samples	11	40
	** MAII score	log2(11/495*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(40/10064*10)=-4.65306001710456 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: WHSC1 [Title/Abstract] AND FOXP1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	FOXP1	GO:0002903	negative regulation of B cell apoptotic process	25267198
Tgene	FOXP1	GO:0030316	osteoclast differentiation	18799727
Tgene	FOXP1	GO:0032496	response to lipopolysaccharide	18799727
Tgene	FOXP1	GO:0032680	regulation of tumor necrosis factor production	18799727
Tgene	FOXP1	GO:0035926	chemokine (C-C motif) ligand 2 secretion	18799727
Tgene	FOXP1	GO:0036035	osteoclast development	18799727
Tgene	FOXP1	GO:0042116	macrophage activation	18799727
Tgene	FOXP1	GO:0042117	monocyte activation	18799727
Tgene	FOXP1	GO:0045655	regulation of monocyte differentiation	15286807
Tgene	FOXP1	GO:0045892	negative regulation of transcription, DNA-templated	20950788
Tgene	FOXP1	GO:0050706	regulation of interleukin-1 beta secretion	18799727
Tgene	FOXP1	GO:0050727	regulation of inflammatory response	18799727
Tgene	FOXP1	GO:0060766	negative regulation of androgen receptor signaling pathway	18640093
Tgene	FOXP1	GO:1900424	regulation of defense response to bacterium	18799727
Tgene	FOXP1	GO:1901256	regulation of macrophage colony-stimulating factor production	18799727
Tgene	FOXP1	GO:2001182	regulation of interleukin-12 secretion	18799727

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			U73662	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000508803	ENST00000318789	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000508803	ENST00000475937	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000508803	ENST00000493089	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000508803	ENST00000484350	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000508803	ENST00000318779	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000508803	ENST00000491238	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000508803	ENST00000498215	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000508803	ENST00000468577	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000508803	ENST00000472382	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382892	ENST00000318789	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382892	ENST00000475937	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382892	ENST00000493089	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382892	ENST00000484350	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382892	ENST00000318779	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382892	ENST00000491238	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382892	ENST00000498215	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382892	ENST00000468577	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382892	ENST00000472382	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382891	ENST00000318789	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382891	ENST00000475937	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382891	ENST00000493089	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382891	ENST00000484350	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382891	ENST00000318779	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382891	ENST00000491238	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382891	ENST00000498215	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382891	ENST00000468577	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382891	ENST00000472382	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382895	ENST00000318789	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382895	ENST00000475937	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382895	ENST00000493089	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382895	ENST00000484350	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382895	ENST00000318779	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382895	ENST00000491238	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382895	ENST00000498215	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382895	ENST00000468577	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382895	ENST00000472382	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000482415	ENST00000318789	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000482415	ENST00000475937	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000482415	ENST00000493089	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000482415	ENST00000484350	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000482415	ENST00000318779	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000482415	ENST00000491238	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000482415	ENST00000498215	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000482415	ENST00000468577	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000482415	ENST00000472382	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382888	ENST00000318789	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382888	ENST00000475937	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382888	ENST00000493089	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382888	ENST00000484350	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382888	ENST00000318779	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382888	ENST00000491238	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382888	ENST00000498215	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382888	ENST00000468577	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000382888	ENST00000472382	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000514045	ENST00000318789	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000514045	ENST00000475937	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000514045	ENST00000493089	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000514045	ENST00000484350	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000514045	ENST00000318779	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000514045	ENST00000491238	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000514045	ENST00000498215	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000514045	ENST00000468577	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000514045	ENST00000472382	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000436793	ENST00000318789	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000436793	ENST00000475937	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000436793	ENST00000493089	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000436793	ENST00000484350	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000436793	ENST00000318779	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000436793	ENST00000491238	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000436793	ENST00000498215	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000436793	ENST00000468577	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000436793	ENST00000472382	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000420906	ENST00000318789	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000420906	ENST00000475937	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000420906	ENST00000493089	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000420906	ENST00000484350	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000420906	ENST00000318779	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000420906	ENST00000491238	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000420906	ENST00000498215	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000420906	ENST00000468577	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000420906	ENST00000472382	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000503128	ENST00000318789	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000503128	ENST00000475937	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000503128	ENST00000493089	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000503128	ENST00000484350	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000503128	ENST00000318779	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000503128	ENST00000491238	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000503128	ENST00000498215	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000503128	ENST00000468577	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000503128	ENST00000472382	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000398261	ENST00000318789	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000398261	ENST00000475937	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000398261	ENST00000493089	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000398261	ENST00000484350	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000398261	ENST00000318779	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000398261	ENST00000491238	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000398261	ENST00000498215	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000398261	ENST00000468577	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+
intron-intron	ENST00000398261	ENST00000472382	WHSC1	chr4	1904709	-	FOXP1	chr3	71227176	+

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FusionProtFeatures for WHSC1_FOXP1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
WHSC1	FOXP1 Q9H334
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269\|PubMed:10224141, ECO:0000269\|PubMed:28301481}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for WHSC1_FOXP1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WHSC1_FOXP1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for WHSC1_FOXP1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for WHSC1_FOXP1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	FOXP1	C0024232	Lymphatic Metastasis	1	CTD_human
Tgene	FOXP1	C0027626	Neoplasm Invasiveness	1	CTD_human
Tgene	FOXP1	C0030297	Pancreatic Neoplasm	1	CTD_human
Tgene	FOXP1	C0042900	Vitiligo	1	CTD_human
Tgene	FOXP1	C0279628	Adenocarcinoma Of Esophagus	1	CTD_human
Tgene	FOXP1	C1510586	Autism Spectrum Disorders	1	CTD_human
Tgene	FOXP1	C3495559	Juvenile arthritis	1	CTD_human
Tgene	FOXP1	C4013764	MENTAL RETARDATION WITH LANGUAGE IMPAIRMENT AND WITH OR WITHOUT AUTISTIC FEATURES	1	CTD_human;ORPHANET;UNIPROT

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Fusion gene ID: 41987

FusionGeneSummary for WHSC1_FOXP1

FusionProtFeatures for WHSC1_FOXP1

FusionGeneSequence for WHSC1_FOXP1

FusionGenePPI for WHSC1_FOXP1

RelatedDrugs for WHSC1_FOXP1

RelatedDiseases for WHSC1_FOXP1