	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 41984

FusionGeneSummary for WHSC1_CHN2

Fusion gene summary

Fusion gene information	Fusion gene name: WHSC1_CHN2
	Fusion gene ID: 41984
		Hgene	Tgene
	Gene symbol	WHSC1	CHN2
	Gene ID	7468	1124
	Gene name	nuclear receptor binding SET domain protein 2	chimerin 2
	Synonyms	KMT3F\|KMT3G\|MMSET\|REIIBP\|TRX5\|WHS\|WHSC1	ARHGAP3\|BCH\|CHN2-3\|RHOGAP3
	Cytomap	4p16.3	7p14.3
	Type of gene	protein-coding	protein-coding
	Description	histone-lysine N-methyltransferase NSD2IL5 promoter REII region-binding proteinWolf-Hirschhorn syndrome candidate 1multiple myeloma SET domain containing protein type IIInuclear SET domain-containing protein 2probable histone-lysine N-methyltransfera	beta-chimaerinbeta-chimerinbeta3-chimaerinchimerin (chimaerin) 2chimerin, beta-2chimerin, testis-specificrho-GTPase-activating protein 3
	Modification date	20180519	20180519
	UniProtAcc		P52757
	Ensembl transtripts involved in fusion gene	ENST00000508803, ENST00000382892, ENST00000382891, ENST00000382895, ENST00000482415, ENST00000382888, ENST00000514045, ENST00000436793, ENST00000420906, ENST00000503128, ENST00000398261,	ENST00000539406, ENST00000222792, ENST00000435288, ENST00000495789, ENST00000539389, ENST00000546235, ENST00000409041, ENST00000424025, ENST00000439711, ENST00000421775, ENST00000410098,
Fusion gene scores	* DoF score	11 X 9 X 5=495	6 X 5 X 4=120
	# samples	11	6
	** MAII score	log2(11/495*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: WHSC1 [Title/Abstract] AND CHN2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AW935679	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000508803	ENST00000539406	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000508803	ENST00000222792	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000508803	ENST00000435288	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000508803	ENST00000495789	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000508803	ENST00000539389	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000508803	ENST00000546235	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000508803	ENST00000409041	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000508803	ENST00000424025	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000508803	ENST00000439711	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000508803	ENST00000421775	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000508803	ENST00000410098	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382892	ENST00000539406	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382892	ENST00000222792	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382892	ENST00000435288	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382892	ENST00000495789	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382892	ENST00000539389	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382892	ENST00000546235	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382892	ENST00000409041	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382892	ENST00000424025	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382892	ENST00000439711	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382892	ENST00000421775	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382892	ENST00000410098	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382891	ENST00000539406	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382891	ENST00000222792	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382891	ENST00000435288	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382891	ENST00000495789	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382891	ENST00000539389	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382891	ENST00000546235	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382891	ENST00000409041	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382891	ENST00000424025	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382891	ENST00000439711	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382891	ENST00000421775	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382891	ENST00000410098	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382895	ENST00000539406	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382895	ENST00000222792	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382895	ENST00000435288	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382895	ENST00000495789	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382895	ENST00000539389	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382895	ENST00000546235	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382895	ENST00000409041	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382895	ENST00000424025	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382895	ENST00000439711	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382895	ENST00000421775	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
3UTR-intron	ENST00000382895	ENST00000410098	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000482415	ENST00000539406	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000482415	ENST00000222792	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000482415	ENST00000435288	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000482415	ENST00000495789	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000482415	ENST00000539389	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000482415	ENST00000546235	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000482415	ENST00000409041	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000482415	ENST00000424025	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000482415	ENST00000439711	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000482415	ENST00000421775	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000482415	ENST00000410098	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000382888	ENST00000539406	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000382888	ENST00000222792	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000382888	ENST00000435288	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000382888	ENST00000495789	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000382888	ENST00000539389	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000382888	ENST00000546235	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000382888	ENST00000409041	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000382888	ENST00000424025	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000382888	ENST00000439711	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000382888	ENST00000421775	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000382888	ENST00000410098	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000514045	ENST00000539406	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000514045	ENST00000222792	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000514045	ENST00000435288	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000514045	ENST00000495789	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000514045	ENST00000539389	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000514045	ENST00000546235	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000514045	ENST00000409041	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000514045	ENST00000424025	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000514045	ENST00000439711	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000514045	ENST00000421775	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000514045	ENST00000410098	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000436793	ENST00000539406	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000436793	ENST00000222792	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000436793	ENST00000435288	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000436793	ENST00000495789	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000436793	ENST00000539389	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000436793	ENST00000546235	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000436793	ENST00000409041	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000436793	ENST00000424025	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000436793	ENST00000439711	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000436793	ENST00000421775	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000436793	ENST00000410098	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000420906	ENST00000539406	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000420906	ENST00000222792	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000420906	ENST00000435288	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000420906	ENST00000495789	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000420906	ENST00000539389	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000420906	ENST00000546235	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000420906	ENST00000409041	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000420906	ENST00000424025	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000420906	ENST00000439711	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000420906	ENST00000421775	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000420906	ENST00000410098	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000503128	ENST00000539406	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000503128	ENST00000222792	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000503128	ENST00000435288	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000503128	ENST00000495789	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000503128	ENST00000539389	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000503128	ENST00000546235	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000503128	ENST00000409041	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000503128	ENST00000424025	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000503128	ENST00000439711	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000503128	ENST00000421775	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000503128	ENST00000410098	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000398261	ENST00000539406	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000398261	ENST00000222792	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000398261	ENST00000435288	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000398261	ENST00000495789	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000398261	ENST00000539389	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000398261	ENST00000546235	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000398261	ENST00000409041	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000398261	ENST00000424025	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000398261	ENST00000439711	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000398261	ENST00000421775	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+
intron-intron	ENST00000398261	ENST00000410098	WHSC1	chr4	1982890	+	CHN2	chr7	29249708	+

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FusionProtFeatures for WHSC1_CHN2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
WHSC1	CHN2 P52757
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269\|PubMed:10224141, ECO:0000269\|PubMed:28301481}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for WHSC1_CHN2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WHSC1_CHN2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for WHSC1_CHN2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for WHSC1_CHN2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	CHN2	C0023903	Liver neoplasms	1	CTD_human
Tgene	CHN2	C0032927	Precancerous Conditions	1	CTD_human

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Fusion gene ID: 41984

FusionGeneSummary for WHSC1_CHN2

FusionProtFeatures for WHSC1_CHN2

FusionGeneSequence for WHSC1_CHN2

FusionGenePPI for WHSC1_CHN2

RelatedDrugs for WHSC1_CHN2

RelatedDiseases for WHSC1_CHN2