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Fusion gene ID: 41983 |
FusionGeneSummary for WHSC1L1_ZNF721 |
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Fusion gene information | Fusion gene name: WHSC1L1_ZNF721 | Fusion gene ID: 41983 | Hgene | Tgene | Gene symbol | WHSC1L1 | ZNF721 | Gene ID | 54904 | 170960 |
Gene name | nuclear receptor binding SET domain protein 3 | zinc finger protein 721 | |
Synonyms | KMT3F|KMT3G|WHISTLE|WHSC1L1|pp14328 | - | |
Cytomap | 8p11.23 | 4p16.3 | |
Type of gene | protein-coding | protein-coding | |
Description | histone-lysine N-methyltransferase NSD3WHSC1-like 1 isoform 9 with methyltransferase activity to lysineWolf-Hirschhorn syndrome candidate 1-like 1nuclear SET domain-containing protein 3protein whistle | zinc finger protein 721 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q8TF20 | ||
Ensembl transtripts involved in fusion gene | ENST00000317025, ENST00000433384, ENST00000527502, ENST00000316985, ENST00000525081, | ENST00000506646, ENST00000507078, ENST00000338977, ENST00000511833, | |
Fusion gene scores | * DoF score | 19 X 10 X 10=1900 | 2 X 2 X 2=8 |
# samples | 22 | 2 | |
** MAII score | log2(22/1900*10)=-3.11042398969365 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: WHSC1L1 [Title/Abstract] AND ZNF721 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | WHSC1L1 | GO:0016571 | histone methylation | 16682010 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LIHC | TCGA-G3-A25X-01A | WHSC1L1 | chr8 | 38239317 | - | ZNF721 | chr4 | 438221 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000317025 | ENST00000506646 | WHSC1L1 | chr8 | 38239317 | - | ZNF721 | chr4 | 438221 | - |
5UTR-intron | ENST00000317025 | ENST00000507078 | WHSC1L1 | chr8 | 38239317 | - | ZNF721 | chr4 | 438221 | - |
5UTR-5UTR | ENST00000317025 | ENST00000338977 | WHSC1L1 | chr8 | 38239317 | - | ZNF721 | chr4 | 438221 | - |
5UTR-5UTR | ENST00000317025 | ENST00000511833 | WHSC1L1 | chr8 | 38239317 | - | ZNF721 | chr4 | 438221 | - |
5UTR-3CDS | ENST00000433384 | ENST00000506646 | WHSC1L1 | chr8 | 38239317 | - | ZNF721 | chr4 | 438221 | - |
5UTR-intron | ENST00000433384 | ENST00000507078 | WHSC1L1 | chr8 | 38239317 | - | ZNF721 | chr4 | 438221 | - |
5UTR-5UTR | ENST00000433384 | ENST00000338977 | WHSC1L1 | chr8 | 38239317 | - | ZNF721 | chr4 | 438221 | - |
5UTR-5UTR | ENST00000433384 | ENST00000511833 | WHSC1L1 | chr8 | 38239317 | - | ZNF721 | chr4 | 438221 | - |
5UTR-3CDS | ENST00000527502 | ENST00000506646 | WHSC1L1 | chr8 | 38239317 | - | ZNF721 | chr4 | 438221 | - |
5UTR-intron | ENST00000527502 | ENST00000507078 | WHSC1L1 | chr8 | 38239317 | - | ZNF721 | chr4 | 438221 | - |
5UTR-5UTR | ENST00000527502 | ENST00000338977 | WHSC1L1 | chr8 | 38239317 | - | ZNF721 | chr4 | 438221 | - |
5UTR-5UTR | ENST00000527502 | ENST00000511833 | WHSC1L1 | chr8 | 38239317 | - | ZNF721 | chr4 | 438221 | - |
5UTR-3CDS | ENST00000316985 | ENST00000506646 | WHSC1L1 | chr8 | 38239317 | - | ZNF721 | chr4 | 438221 | - |
5UTR-intron | ENST00000316985 | ENST00000507078 | WHSC1L1 | chr8 | 38239317 | - | ZNF721 | chr4 | 438221 | - |
5UTR-5UTR | ENST00000316985 | ENST00000338977 | WHSC1L1 | chr8 | 38239317 | - | ZNF721 | chr4 | 438221 | - |
5UTR-5UTR | ENST00000316985 | ENST00000511833 | WHSC1L1 | chr8 | 38239317 | - | ZNF721 | chr4 | 438221 | - |
intron-3CDS | ENST00000525081 | ENST00000506646 | WHSC1L1 | chr8 | 38239317 | - | ZNF721 | chr4 | 438221 | - |
intron-intron | ENST00000525081 | ENST00000507078 | WHSC1L1 | chr8 | 38239317 | - | ZNF721 | chr4 | 438221 | - |
intron-5UTR | ENST00000525081 | ENST00000338977 | WHSC1L1 | chr8 | 38239317 | - | ZNF721 | chr4 | 438221 | - |
intron-5UTR | ENST00000525081 | ENST00000511833 | WHSC1L1 | chr8 | 38239317 | - | ZNF721 | chr4 | 438221 | - |
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FusionProtFeatures for WHSC1L1_ZNF721 |
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Hgene | Tgene |
WHSC1L1 | ZNF721 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | May be involved in transcriptional regulation.{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for WHSC1L1_ZNF721 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for WHSC1L1_ZNF721 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
WHSC1L1 | CBX3, KDM1B, CCNT1, BRD4, H2AFY, CRNN, BRD9, SMARCC1, BCL7C, SMARCA4, BCL7A, SS18L1, SMARCA2, DAXX, HOXC4, MNDA, SLU7, DOCK7, ETV3, GLYR1, H3F3C, HIST1H1A, SEPT6, SPAG8, STAC3, UBE2I, ZNF557, HIST3H3, MLLT6, CBX5, AKT1, ATM, BCAR3, CASP8, CDKN2A, CHEK2, ESR1, FGFR4, PAX2, PPM1D, RAD51, RB1CC1, TGFB1, HIST1H2BG, LSM3, YEATS4, BRD2, HIST1H3A, HIST1H4A, BPTF, BOD1L1, CHD8, CDC14B | ZNF721 | TRIM28 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for WHSC1L1_ZNF721 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WHSC1L1_ZNF721 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |