|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 41956 |
FusionGeneSummary for WEE1_CHRNA3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: WEE1_CHRNA3 | Fusion gene ID: 41956 | Hgene | Tgene | Gene symbol | WEE1 | CHRNA3 | Gene ID | 7465 | 1136 |
| Gene name | WEE1 G2 checkpoint kinase | cholinergic receptor nicotinic alpha 3 subunit | |
| Synonyms | WEE1A|WEE1hu | LNCR2|NACHRA3|PAOD2 | |
| Cytomap | 11p15.4 | 15q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | wee1-like protein kinaseWEE1 homologWEE1+ homologwee1A kinase | neuronal acetylcholine receptor subunit alpha-3cholinergic receptor, nicotinic alpha 3cholinergic receptor, nicotinic, alpha 3 (neuronal)cholinergic receptor, nicotinic, alpha polypeptide 3neuronal nicotinic acetylcholine receptor, alpha3 subunit | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P30291 | P32297 | |
| Ensembl transtripts involved in fusion gene | ENST00000450114, ENST00000299613, | ENST00000348639, ENST00000326828, ENST00000559941, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 3 X 3=36 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: WEE1 [Title/Abstract] AND CHRNA3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CHRNA3 | GO:0007165 | signal transduction | 8906617 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | CESC | TCGA-C5-A7X3-01A | WEE1 | chr11 | 9608403 | + | CHRNA3 | chr15 | 78894606 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000450114 | ENST00000348639 | WEE1 | chr11 | 9608403 | + | CHRNA3 | chr15 | 78894606 | - |
| In-frame | ENST00000450114 | ENST00000326828 | WEE1 | chr11 | 9608403 | + | CHRNA3 | chr15 | 78894606 | - |
| 5CDS-intron | ENST00000450114 | ENST00000559941 | WEE1 | chr11 | 9608403 | + | CHRNA3 | chr15 | 78894606 | - |
| In-frame | ENST00000299613 | ENST00000348639 | WEE1 | chr11 | 9608403 | + | CHRNA3 | chr15 | 78894606 | - |
| In-frame | ENST00000299613 | ENST00000326828 | WEE1 | chr11 | 9608403 | + | CHRNA3 | chr15 | 78894606 | - |
| 5CDS-intron | ENST00000299613 | ENST00000559941 | WEE1 | chr11 | 9608403 | + | CHRNA3 | chr15 | 78894606 | - |
Top |
FusionProtFeatures for WEE1_CHRNA3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| WEE1 | CHRNA3 |
| Acts as a negative regulator of entry into mitosis (G2to M transition) by protecting the nucleus from cytoplasmicallyactivated cyclin B1-complexed CDK1 before the onset of mitosis bymediating phosphorylation of CDK1 on 'Tyr-15'. Specificallyphosphorylates and inactivates cyclin B1-complexed CDK1 reaching amaximum during G2 phase and a minimum as cells enter M phase.Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15'and phosphorylation of monomeric CDK1 does not occur. Its activityincreases during S and G2 phases and decreases at M phase when itis hyperphosphorylated. A correlated decrease in protein leveloccurs at M/G1 phase, probably due to its degradation. | After binding acetylcholine, the AChR responds by anextensive change in conformation that affects all subunits andleads to opening of an ion-conducting channel across the plasmamembrane. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | WEE1 | chr11:9608403 | chr15:78894606 | ENST00000299613 | + | 10 | 11 | 34_43 | 381 | 433 | Compositional bias | Note=Poly-Glu |
| Hgene | WEE1 | chr11:9608403 | chr15:78894606 | ENST00000299613 | + | 10 | 11 | 9_12 | 381 | 433 | Compositional bias | Note=Poly-Pro |
| Hgene | WEE1 | chr11:9608403 | chr15:78894606 | ENST00000450114 | + | 10 | 11 | 34_43 | 595 | 647 | Compositional bias | Note=Poly-Glu |
| Hgene | WEE1 | chr11:9608403 | chr15:78894606 | ENST00000450114 | + | 10 | 11 | 9_12 | 595 | 647 | Compositional bias | Note=Poly-Pro |
| Hgene | WEE1 | chr11:9608403 | chr15:78894606 | ENST00000450114 | + | 10 | 11 | 299_569 | 595 | 647 | Domain | Protein kinase |
| Hgene | WEE1 | chr11:9608403 | chr15:78894606 | ENST00000299613 | + | 10 | 11 | 305_313 | 381 | 433 | Nucleotide binding | ATP |
| Hgene | WEE1 | chr11:9608403 | chr15:78894606 | ENST00000450114 | + | 10 | 11 | 305_313 | 595 | 647 | Nucleotide binding | ATP |
| Tgene | >CHRNA3 | chr11:9608403 | chr15:78894606 | ENST00000326828 | - | 3 | 6 | 329_477 | 125 | 506 | Topological domain | Cytoplasmic |
| Tgene | >CHRNA3 | chr11:9608403 | chr15:78894606 | ENST00000348639 | - | 3 | 6 | 329_477 | 125 | 490 | Topological domain | Cytoplasmic |
| Tgene | >CHRNA3 | chr11:9608403 | chr15:78894606 | ENST00000326828 | - | 3 | 6 | 241_265 | 125 | 506 | Transmembrane | Helical |
| Tgene | >CHRNA3 | chr11:9608403 | chr15:78894606 | ENST00000326828 | - | 3 | 6 | 273_291 | 125 | 506 | Transmembrane | Helical |
| Tgene | >CHRNA3 | chr11:9608403 | chr15:78894606 | ENST00000326828 | - | 3 | 6 | 307_328 | 125 | 506 | Transmembrane | Helical |
| Tgene | >CHRNA3 | chr11:9608403 | chr15:78894606 | ENST00000326828 | - | 3 | 6 | 478_497 | 125 | 506 | Transmembrane | Helical |
| Tgene | >CHRNA3 | chr11:9608403 | chr15:78894606 | ENST00000348639 | - | 3 | 6 | 241_265 | 125 | 490 | Transmembrane | Helical |
| Tgene | >CHRNA3 | chr11:9608403 | chr15:78894606 | ENST00000348639 | - | 3 | 6 | 273_291 | 125 | 490 | Transmembrane | Helical |
| Tgene | >CHRNA3 | chr11:9608403 | chr15:78894606 | ENST00000348639 | - | 3 | 6 | 307_328 | 125 | 490 | Transmembrane | Helical |
| Tgene | >CHRNA3 | chr11:9608403 | chr15:78894606 | ENST00000348639 | - | 3 | 6 | 478_497 | 125 | 490 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >WEE1 | chr11:9608403 | chr15:78894606 | ENST00000299613 | + | 10 | 11 | 299_569 | 381 | 433 | Domain | Protein kinase |
| Tgene | CHRNA3 | chr11:9608403 | chr15:78894606 | ENST00000326828 | - | 3 | 6 | 32_240 | 125 | 506 | Topological domain | Extracellular |
| Tgene | CHRNA3 | chr11:9608403 | chr15:78894606 | ENST00000348639 | - | 3 | 6 | 32_240 | 125 | 490 | Topological domain | Extracellular |
Top |
FusionGeneSequence for WEE1_CHRNA3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_WEE1_ENST00000450114_chr11_9608403_+_CHRNA3_ENST00000348639_chr15_78894606_-_960aa MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDSPLPPARSPTEPGPERRRSPGPAPGSPGELE EDLLLPGACPGADEAGGGAEGDSWEEEGFGSSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFR KLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTPDSLLLHSSGQCRRRKRTYWNDSCGEDMEAS DYELEDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVV RYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDED DWASNKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQ EFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCK IDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLII PCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPS WVKTVFLNLLPRVMFMTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDA >In-frame_WEE1_ENST00000450114_chr11_9608403_+_CHRNA3_ENST00000326828_chr15_78894606_-_976aa MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDSPLPPARSPTEPGPERRRSPGPAPGSPGELE EDLLLPGACPGADEAGGGAEGDSWEEEGFGSSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFR KLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTPDSLLLHSSGQCRRRKRTYWNDSCGEDMEAS DYELEDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVV RYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDED DWASNKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQ EFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCK IDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLII PCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPS WVKTVFLNLLPRVMFMTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDA >In-frame_WEE1_ENST00000299613_chr11_9608403_+_CHRNA3_ENST00000348639_chr15_78894606_-_746aa MDTEKSGKREFDVRQTPQVNINPFTPDSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFHELEK IGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRI MSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDSRFLA NEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASR KSAEQLRIELNAEKFKNSLLQNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGS SMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLT VFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPRPLYG AELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEE >In-frame_WEE1_ENST00000299613_chr11_9608403_+_CHRNA3_ENST00000326828_chr15_78894606_-_762aa MDTEKSGKREFDVRQTPQVNINPFTPDSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFHELEK IGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRI MSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDSRFLA NEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASR KSAEQLRIELNAEKFKNSLLQNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGS SMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLT VFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPRPLYG AELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_WEE1_ENST00000450114_chr11_9608403_+_CHRNA3_ENST00000348639_chr15_78894606_-_2880nt ATGAGCTTCCTGAGCCGACAGCAGCCGCCGCCACCCCGCCGCGCCGGGGCGGCCTGCACCTTGCGGCAGAAGCTGATCTTCTCGCCCTGC AGCGACTGTGAGGAGGAGGAAGAAGAGGAGGAGGAGGAGGGCAGCGGCCACAGCACCGGGGAGGACTCGGCCTTTCAAGAGCCCGACTCG CCGCTGCCGCCCGCGCGGAGCCCCACGGAGCCCGGGCCCGAGCGCCGCCGCTCGCCCGGGCCGGCCCCCGGCAGCCCCGGCGAGCTGGAG GAGGACCTGTTGCTGCCCGGCGCCTGCCCGGGCGCGGACGAGGCGGGCGGTGGGGCGGAGGGCGACTCGTGGGAGGAGGAGGGCTTCGGC TCCTCGTCGCCGGTCAAGTCGCCGGCGGCCCCCTACTTCCTGGGTAGCTCTTTCTCGCCGGTGCGCTGCGGCGGCCCAGGAGATGCGTCG CCGCGGGGTTGCGGGGCGCGCCGGGCGGGCGAAGGCCGCCGCTCGCCGCGGCCGGACCACCCGGGCACCCCGCCACACAAGACCTTCCGC AAGCTGCGACTCTTCGACACCCCGCACACGCCCAAGAGTTTGCTCTCCAAAGCTCGGGGAATTGATTCCAGCTCTGTTAAACTCCGGGGT AGTTCTCTCTTCATGGATACAGAAAAATCAGGAAAAAGGGAATTTGATGTGCGACAGACTCCTCAAGTGAATATTAATCCTTTTACTCCG GATTCTTTGTTGCTTCATTCCTCAGGACAGTGTCGTCGTAGAAAGAGAACGTATTGGAATGATTCCTGTGGTGAAGACATGGAAGCCAGT GATTATGAGCTTGAAGATGAAACAAGACCTGCTAAGAGAATTACAATTACTGAAAGCAATATGAAGTCCCGGTATACAACAGAATTTCAT GAGCTAGAGAAAATCGGCTCTGGAGAATTTGGTTCTGTATTTAAGTGTGTGAAGAGGCTGGATGGATGCATTTATGCCATTAAGCGATCA AAAAAGCCATTGGCGGGCTCTGTTGATGAGCAGAACGCTTTGAGAGAAGTATATGCTCATGCAGTGCTTGGACAGCATTCTCATGTAGTT CGATATTTCTCTGCGTGGGCAGAAGATGATCATATGCTTATACAGAATGAATATTGTAATGGTGGAAGTTTAGCTGATGCTATAAGTGAA AACTACAGAATCATGAGTTACTTTAAAGAAGCAGAGTTGAAGGATCTCCTTTTGCAAGTTGGCCGAGGCTTGAGGTATATTCATTCAATG TCTTTGGTTCACATGGATATAAAACCTAGTAATATTTTCATATCTCGAACCTCAATCCCAAATGCTGCCTCTGAAGAAGGAGACGAAGAT GATTGGGCATCCAACAAAGTTATGTTTAAAATAGGTGATCTTGGGCATGTAACAAGGATCTCCAGTCCACAAGTTGAAGAGGGCGATAGT CGTTTTCTTGCAAATGAAGTTTTACAGGAGAATTATACCCATCTACCAAAAGCAGATATTTTTGCGCTTGCCCTCACAGTGGTATGTGCT GCTGGTGCTGAACCTCTTCCGAGAAATGGAGATCAATGGCATGAAATCAGACAGGGTAGATTACCTCGGATACCACAAGTGCTTTCCCAA GAATTTACAGAGTTGCTAAAAGTTATGATTCATCCAGATCCAGAGAGAAGACCTTCAGCAATGGCACTGGTAAAGCATTCAGTATTGCTG TCCGCTTCTAGAAAGAGTGCAGAACAATTACGAATAGAATTGAATGCCGAAAAGTTCAAAAATTCACTTTTACAAAATGCTGTTGGGGAT TTCCAGGTGGACGACAAGACCAAAGCCTTACTCAAGTACACTGGGGAGGTGACTTGGATACCTCCGGCCATCTTTAAGAGCTCCTGTAAA ATCGACGTGACCTACTTCCCGTTTGATTACCAAAACTGTACCATGAAGTTCGGTTCCTGGTCCTACGATAAGGCGAAAATCGATCTGGTC CTGATCGGCTCTTCCATGAACCTCAAGGACTATTGGGAGAGCGGCGAGTGGGCCATCATCAAAGCCCCAGGCTACAAACACGACATCAAG TACAACTGCTGCGAGGAGATCTACCCCGACATCACATACTCGCTGTACATCCGGCGCCTGCCCTTGTTCTACACCATCAACCTCATCATC CCCTGCCTGCTCATCTCCTTCCTCACTGTGCTCGTCTTCTACCTGCCCTCCGACTGCGGTGAGAAGGTGACCCTGTGCATTTCTGTCCTC CTCTCCCTGACGGTGTTTCTCCTGGTGATCACTGAGACCATCCCTTCCACCTCGCTGGTCATCCCCCTGATTGGAGAGTACCTCCTGTTC ACCATGATTTTTGTAACCTTGTCCATCGTCATCACCGTCTTCGTGCTCAACGTGCACTACAGAACCCCGACGACACACACAATGCCCTCA TGGGTGAAGACTGTATTCTTGAACCTGCTCCCCAGGGTCATGTTCATGACCAGGCCAACAAGCAACGAGGGCAACGCTCAGAAGCCGAGG CCCCTCTACGGTGCCGAGCTCTCAAATCTGAATTGCTTCAGCCGCGCAGAGTCCAAAGGCTGCAAGGAGGGCTACCCCTGCCAGGACGGG ATGTGTGGTTACTGCCACCACCGCAGGATAAAAATCTCCAATTTCAGTGCTAACCTCACGAGAAGCTCTAGTTCTGAATCTGTTGATGCT GTGCTGTCCCTCTCTGCTTTGTCACCAGAAATCAAAGAAGCCATCCAAAGTGTCAAGTATATTGCTGAAAATATGAAAGCACAAAATGAA GCCAAAGAGGAACAAAAAGCCCAAGAGATCCAACAATTGAAACGAAAAGAAAAGTCCACAGAAACATCCGATCAAGAACCTGGGCTATGA >In-frame_WEE1_ENST00000450114_chr11_9608403_+_CHRNA3_ENST00000326828_chr15_78894606_-_2928nt ATGAGCTTCCTGAGCCGACAGCAGCCGCCGCCACCCCGCCGCGCCGGGGCGGCCTGCACCTTGCGGCAGAAGCTGATCTTCTCGCCCTGC AGCGACTGTGAGGAGGAGGAAGAAGAGGAGGAGGAGGAGGGCAGCGGCCACAGCACCGGGGAGGACTCGGCCTTTCAAGAGCCCGACTCG CCGCTGCCGCCCGCGCGGAGCCCCACGGAGCCCGGGCCCGAGCGCCGCCGCTCGCCCGGGCCGGCCCCCGGCAGCCCCGGCGAGCTGGAG GAGGACCTGTTGCTGCCCGGCGCCTGCCCGGGCGCGGACGAGGCGGGCGGTGGGGCGGAGGGCGACTCGTGGGAGGAGGAGGGCTTCGGC TCCTCGTCGCCGGTCAAGTCGCCGGCGGCCCCCTACTTCCTGGGTAGCTCTTTCTCGCCGGTGCGCTGCGGCGGCCCAGGAGATGCGTCG CCGCGGGGTTGCGGGGCGCGCCGGGCGGGCGAAGGCCGCCGCTCGCCGCGGCCGGACCACCCGGGCACCCCGCCACACAAGACCTTCCGC AAGCTGCGACTCTTCGACACCCCGCACACGCCCAAGAGTTTGCTCTCCAAAGCTCGGGGAATTGATTCCAGCTCTGTTAAACTCCGGGGT AGTTCTCTCTTCATGGATACAGAAAAATCAGGAAAAAGGGAATTTGATGTGCGACAGACTCCTCAAGTGAATATTAATCCTTTTACTCCG GATTCTTTGTTGCTTCATTCCTCAGGACAGTGTCGTCGTAGAAAGAGAACGTATTGGAATGATTCCTGTGGTGAAGACATGGAAGCCAGT GATTATGAGCTTGAAGATGAAACAAGACCTGCTAAGAGAATTACAATTACTGAAAGCAATATGAAGTCCCGGTATACAACAGAATTTCAT GAGCTAGAGAAAATCGGCTCTGGAGAATTTGGTTCTGTATTTAAGTGTGTGAAGAGGCTGGATGGATGCATTTATGCCATTAAGCGATCA AAAAAGCCATTGGCGGGCTCTGTTGATGAGCAGAACGCTTTGAGAGAAGTATATGCTCATGCAGTGCTTGGACAGCATTCTCATGTAGTT CGATATTTCTCTGCGTGGGCAGAAGATGATCATATGCTTATACAGAATGAATATTGTAATGGTGGAAGTTTAGCTGATGCTATAAGTGAA AACTACAGAATCATGAGTTACTTTAAAGAAGCAGAGTTGAAGGATCTCCTTTTGCAAGTTGGCCGAGGCTTGAGGTATATTCATTCAATG TCTTTGGTTCACATGGATATAAAACCTAGTAATATTTTCATATCTCGAACCTCAATCCCAAATGCTGCCTCTGAAGAAGGAGACGAAGAT GATTGGGCATCCAACAAAGTTATGTTTAAAATAGGTGATCTTGGGCATGTAACAAGGATCTCCAGTCCACAAGTTGAAGAGGGCGATAGT CGTTTTCTTGCAAATGAAGTTTTACAGGAGAATTATACCCATCTACCAAAAGCAGATATTTTTGCGCTTGCCCTCACAGTGGTATGTGCT GCTGGTGCTGAACCTCTTCCGAGAAATGGAGATCAATGGCATGAAATCAGACAGGGTAGATTACCTCGGATACCACAAGTGCTTTCCCAA GAATTTACAGAGTTGCTAAAAGTTATGATTCATCCAGATCCAGAGAGAAGACCTTCAGCAATGGCACTGGTAAAGCATTCAGTATTGCTG TCCGCTTCTAGAAAGAGTGCAGAACAATTACGAATAGAATTGAATGCCGAAAAGTTCAAAAATTCACTTTTACAAAATGCTGTTGGGGAT TTCCAGGTGGACGACAAGACCAAAGCCTTACTCAAGTACACTGGGGAGGTGACTTGGATACCTCCGGCCATCTTTAAGAGCTCCTGTAAA ATCGACGTGACCTACTTCCCGTTTGATTACCAAAACTGTACCATGAAGTTCGGTTCCTGGTCCTACGATAAGGCGAAAATCGATCTGGTC CTGATCGGCTCTTCCATGAACCTCAAGGACTATTGGGAGAGCGGCGAGTGGGCCATCATCAAAGCCCCAGGCTACAAACACGACATCAAG TACAACTGCTGCGAGGAGATCTACCCCGACATCACATACTCGCTGTACATCCGGCGCCTGCCCTTGTTCTACACCATCAACCTCATCATC CCCTGCCTGCTCATCTCCTTCCTCACTGTGCTCGTCTTCTACCTGCCCTCCGACTGCGGTGAGAAGGTGACCCTGTGCATTTCTGTCCTC CTCTCCCTGACGGTGTTTCTCCTGGTGATCACTGAGACCATCCCTTCCACCTCGCTGGTCATCCCCCTGATTGGAGAGTACCTCCTGTTC ACCATGATTTTTGTAACCTTGTCCATCGTCATCACCGTCTTCGTGCTCAACGTGCACTACAGAACCCCGACGACACACACAATGCCCTCA TGGGTGAAGACTGTATTCTTGAACCTGCTCCCCAGGGTCATGTTCATGACCAGGCCAACAAGCAACGAGGGCAACGCTCAGAAGCCGAGG CCCCTCTACGGTGCCGAGCTCTCAAATCTGAATTGCTTCAGCCGCGCAGAGTCCAAAGGCTGCAAGGAGGGCTACCCCTGCCAGGACGGG ATGTGTGGTTACTGCCACCACCGCAGGATAAAAATCTCCAATTTCAGTGCTAACCTCACGAGAAGCTCTAGTTCTGAATCTGTTGATGCT GTGCTGTCCCTCTCTGCTTTGTCACCAGAAATCAAAGAAGCCATCCAAAGTGTCAAGTATATTGCTGAAAATATGAAAGCACAAAATGAA GCCAAAGAGATTCAAGATGATTGGAAGTATGTTGCCATGGTGATTGATCGTATTTTTCTGTGGGTTTTCACCCTGGTGTGCATTCTAGGG >In-frame_WEE1_ENST00000299613_chr11_9608403_+_CHRNA3_ENST00000348639_chr15_78894606_-_2238nt ATGGATACAGAAAAATCAGGAAAAAGGGAATTTGATGTGCGACAGACTCCTCAAGTGAATATTAATCCTTTTACTCCGGATTCTTTGTTG CTTCATTCCTCAGGACAGTGTCGTCGTAGAAAGAGAACGTATTGGAATGATTCCTGTGGTGAAGACATGGAAGCCAGTGATTATGAGCTT GAAGATGAAACAAGACCTGCTAAGAGAATTACAATTACTGAAAGCAATATGAAGTCCCGGTATACAACAGAATTTCATGAGCTAGAGAAA ATCGGCTCTGGAGAATTTGGTTCTGTATTTAAGTGTGTGAAGAGGCTGGATGGATGCATTTATGCCATTAAGCGATCAAAAAAGCCATTG GCGGGCTCTGTTGATGAGCAGAACGCTTTGAGAGAAGTATATGCTCATGCAGTGCTTGGACAGCATTCTCATGTAGTTCGATATTTCTCT GCGTGGGCAGAAGATGATCATATGCTTATACAGAATGAATATTGTAATGGTGGAAGTTTAGCTGATGCTATAAGTGAAAACTACAGAATC ATGAGTTACTTTAAAGAAGCAGAGTTGAAGGATCTCCTTTTGCAAGTTGGCCGAGGCTTGAGGTATATTCATTCAATGTCTTTGGTTCAC ATGGATATAAAACCTAGTAATATTTTCATATCTCGAACCTCAATCCCAAATGCTGCCTCTGAAGAAGGAGACGAAGATGATTGGGCATCC AACAAAGTTATGTTTAAAATAGGTGATCTTGGGCATGTAACAAGGATCTCCAGTCCACAAGTTGAAGAGGGCGATAGTCGTTTTCTTGCA AATGAAGTTTTACAGGAGAATTATACCCATCTACCAAAAGCAGATATTTTTGCGCTTGCCCTCACAGTGGTATGTGCTGCTGGTGCTGAA CCTCTTCCGAGAAATGGAGATCAATGGCATGAAATCAGACAGGGTAGATTACCTCGGATACCACAAGTGCTTTCCCAAGAATTTACAGAG TTGCTAAAAGTTATGATTCATCCAGATCCAGAGAGAAGACCTTCAGCAATGGCACTGGTAAAGCATTCAGTATTGCTGTCCGCTTCTAGA AAGAGTGCAGAACAATTACGAATAGAATTGAATGCCGAAAAGTTCAAAAATTCACTTTTACAAAATGCTGTTGGGGATTTCCAGGTGGAC GACAAGACCAAAGCCTTACTCAAGTACACTGGGGAGGTGACTTGGATACCTCCGGCCATCTTTAAGAGCTCCTGTAAAATCGACGTGACC TACTTCCCGTTTGATTACCAAAACTGTACCATGAAGTTCGGTTCCTGGTCCTACGATAAGGCGAAAATCGATCTGGTCCTGATCGGCTCT TCCATGAACCTCAAGGACTATTGGGAGAGCGGCGAGTGGGCCATCATCAAAGCCCCAGGCTACAAACACGACATCAAGTACAACTGCTGC GAGGAGATCTACCCCGACATCACATACTCGCTGTACATCCGGCGCCTGCCCTTGTTCTACACCATCAACCTCATCATCCCCTGCCTGCTC ATCTCCTTCCTCACTGTGCTCGTCTTCTACCTGCCCTCCGACTGCGGTGAGAAGGTGACCCTGTGCATTTCTGTCCTCCTCTCCCTGACG GTGTTTCTCCTGGTGATCACTGAGACCATCCCTTCCACCTCGCTGGTCATCCCCCTGATTGGAGAGTACCTCCTGTTCACCATGATTTTT GTAACCTTGTCCATCGTCATCACCGTCTTCGTGCTCAACGTGCACTACAGAACCCCGACGACACACACAATGCCCTCATGGGTGAAGACT GTATTCTTGAACCTGCTCCCCAGGGTCATGTTCATGACCAGGCCAACAAGCAACGAGGGCAACGCTCAGAAGCCGAGGCCCCTCTACGGT GCCGAGCTCTCAAATCTGAATTGCTTCAGCCGCGCAGAGTCCAAAGGCTGCAAGGAGGGCTACCCCTGCCAGGACGGGATGTGTGGTTAC TGCCACCACCGCAGGATAAAAATCTCCAATTTCAGTGCTAACCTCACGAGAAGCTCTAGTTCTGAATCTGTTGATGCTGTGCTGTCCCTC TCTGCTTTGTCACCAGAAATCAAAGAAGCCATCCAAAGTGTCAAGTATATTGCTGAAAATATGAAAGCACAAAATGAAGCCAAAGAGGAA >In-frame_WEE1_ENST00000299613_chr11_9608403_+_CHRNA3_ENST00000326828_chr15_78894606_-_2286nt ATGGATACAGAAAAATCAGGAAAAAGGGAATTTGATGTGCGACAGACTCCTCAAGTGAATATTAATCCTTTTACTCCGGATTCTTTGTTG CTTCATTCCTCAGGACAGTGTCGTCGTAGAAAGAGAACGTATTGGAATGATTCCTGTGGTGAAGACATGGAAGCCAGTGATTATGAGCTT GAAGATGAAACAAGACCTGCTAAGAGAATTACAATTACTGAAAGCAATATGAAGTCCCGGTATACAACAGAATTTCATGAGCTAGAGAAA ATCGGCTCTGGAGAATTTGGTTCTGTATTTAAGTGTGTGAAGAGGCTGGATGGATGCATTTATGCCATTAAGCGATCAAAAAAGCCATTG GCGGGCTCTGTTGATGAGCAGAACGCTTTGAGAGAAGTATATGCTCATGCAGTGCTTGGACAGCATTCTCATGTAGTTCGATATTTCTCT GCGTGGGCAGAAGATGATCATATGCTTATACAGAATGAATATTGTAATGGTGGAAGTTTAGCTGATGCTATAAGTGAAAACTACAGAATC ATGAGTTACTTTAAAGAAGCAGAGTTGAAGGATCTCCTTTTGCAAGTTGGCCGAGGCTTGAGGTATATTCATTCAATGTCTTTGGTTCAC ATGGATATAAAACCTAGTAATATTTTCATATCTCGAACCTCAATCCCAAATGCTGCCTCTGAAGAAGGAGACGAAGATGATTGGGCATCC AACAAAGTTATGTTTAAAATAGGTGATCTTGGGCATGTAACAAGGATCTCCAGTCCACAAGTTGAAGAGGGCGATAGTCGTTTTCTTGCA AATGAAGTTTTACAGGAGAATTATACCCATCTACCAAAAGCAGATATTTTTGCGCTTGCCCTCACAGTGGTATGTGCTGCTGGTGCTGAA CCTCTTCCGAGAAATGGAGATCAATGGCATGAAATCAGACAGGGTAGATTACCTCGGATACCACAAGTGCTTTCCCAAGAATTTACAGAG TTGCTAAAAGTTATGATTCATCCAGATCCAGAGAGAAGACCTTCAGCAATGGCACTGGTAAAGCATTCAGTATTGCTGTCCGCTTCTAGA AAGAGTGCAGAACAATTACGAATAGAATTGAATGCCGAAAAGTTCAAAAATTCACTTTTACAAAATGCTGTTGGGGATTTCCAGGTGGAC GACAAGACCAAAGCCTTACTCAAGTACACTGGGGAGGTGACTTGGATACCTCCGGCCATCTTTAAGAGCTCCTGTAAAATCGACGTGACC TACTTCCCGTTTGATTACCAAAACTGTACCATGAAGTTCGGTTCCTGGTCCTACGATAAGGCGAAAATCGATCTGGTCCTGATCGGCTCT TCCATGAACCTCAAGGACTATTGGGAGAGCGGCGAGTGGGCCATCATCAAAGCCCCAGGCTACAAACACGACATCAAGTACAACTGCTGC GAGGAGATCTACCCCGACATCACATACTCGCTGTACATCCGGCGCCTGCCCTTGTTCTACACCATCAACCTCATCATCCCCTGCCTGCTC ATCTCCTTCCTCACTGTGCTCGTCTTCTACCTGCCCTCCGACTGCGGTGAGAAGGTGACCCTGTGCATTTCTGTCCTCCTCTCCCTGACG GTGTTTCTCCTGGTGATCACTGAGACCATCCCTTCCACCTCGCTGGTCATCCCCCTGATTGGAGAGTACCTCCTGTTCACCATGATTTTT GTAACCTTGTCCATCGTCATCACCGTCTTCGTGCTCAACGTGCACTACAGAACCCCGACGACACACACAATGCCCTCATGGGTGAAGACT GTATTCTTGAACCTGCTCCCCAGGGTCATGTTCATGACCAGGCCAACAAGCAACGAGGGCAACGCTCAGAAGCCGAGGCCCCTCTACGGT GCCGAGCTCTCAAATCTGAATTGCTTCAGCCGCGCAGAGTCCAAAGGCTGCAAGGAGGGCTACCCCTGCCAGGACGGGATGTGTGGTTAC TGCCACCACCGCAGGATAAAAATCTCCAATTTCAGTGCTAACCTCACGAGAAGCTCTAGTTCTGAATCTGTTGATGCTGTGCTGTCCCTC TCTGCTTTGTCACCAGAAATCAAAGAAGCCATCCAAAGTGTCAAGTATATTGCTGAAAATATGAAAGCACAAAATGAAGCCAAAGAGATT CAAGATGATTGGAAGTATGTTGCCATGGTGATTGATCGTATTTTTCTGTGGGTTTTCACCCTGGTGTGCATTCTAGGGACAGCAGGATTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_WEE1_ENST00000450114_chr11_9608403_+_CHRNA3_ENST00000348639_chr15_78894606_-_3192nt CTGAGACTGGACCTGAGGAGACCTCAGCCTCGGTGCTCGGGCCGCCCCGCCTCTGCCGGAAAGTCCGCGCCGCCGCTGCCGCCACCGTCC GCAGCCCGAGCGCCCCGGAGCCGCAGGCCGCCGCCGCGCAGAGACGCCGCGGCTGCGACTAGGCGCGCCCAGCCGCACGTGGCGGACCCG CCCCCAGGCCCGCAGTGTCCTGGACCCCGCAGGCCTCCGCTCTCCTGTCCTCGGCCCCGTCCCCAGGGCCGCGATGAGCTTCCTGAGCCG ACAGCAGCCGCCGCCACCCCGCCGCGCCGGGGCGGCCTGCACCTTGCGGCAGAAGCTGATCTTCTCGCCCTGCAGCGACTGTGAGGAGGA GGAAGAAGAGGAGGAGGAGGAGGGCAGCGGCCACAGCACCGGGGAGGACTCGGCCTTTCAAGAGCCCGACTCGCCGCTGCCGCCCGCGCG GAGCCCCACGGAGCCCGGGCCCGAGCGCCGCCGCTCGCCCGGGCCGGCCCCCGGCAGCCCCGGCGAGCTGGAGGAGGACCTGTTGCTGCC CGGCGCCTGCCCGGGCGCGGACGAGGCGGGCGGTGGGGCGGAGGGCGACTCGTGGGAGGAGGAGGGCTTCGGCTCCTCGTCGCCGGTCAA GTCGCCGGCGGCCCCCTACTTCCTGGGTAGCTCTTTCTCGCCGGTGCGCTGCGGCGGCCCAGGAGATGCGTCGCCGCGGGGTTGCGGGGC GCGCCGGGCGGGCGAAGGCCGCCGCTCGCCGCGGCCGGACCACCCGGGCACCCCGCCACACAAGACCTTCCGCAAGCTGCGACTCTTCGA CACCCCGCACACGCCCAAGAGTTTGCTCTCCAAAGCTCGGGGAATTGATTCCAGCTCTGTTAAACTCCGGGGTAGTTCTCTCTTCATGGA TACAGAAAAATCAGGAAAAAGGGAATTTGATGTGCGACAGACTCCTCAAGTGAATATTAATCCTTTTACTCCGGATTCTTTGTTGCTTCA TTCCTCAGGACAGTGTCGTCGTAGAAAGAGAACGTATTGGAATGATTCCTGTGGTGAAGACATGGAAGCCAGTGATTATGAGCTTGAAGA TGAAACAAGACCTGCTAAGAGAATTACAATTACTGAAAGCAATATGAAGTCCCGGTATACAACAGAATTTCATGAGCTAGAGAAAATCGG CTCTGGAGAATTTGGTTCTGTATTTAAGTGTGTGAAGAGGCTGGATGGATGCATTTATGCCATTAAGCGATCAAAAAAGCCATTGGCGGG CTCTGTTGATGAGCAGAACGCTTTGAGAGAAGTATATGCTCATGCAGTGCTTGGACAGCATTCTCATGTAGTTCGATATTTCTCTGCGTG GGCAGAAGATGATCATATGCTTATACAGAATGAATATTGTAATGGTGGAAGTTTAGCTGATGCTATAAGTGAAAACTACAGAATCATGAG TTACTTTAAAGAAGCAGAGTTGAAGGATCTCCTTTTGCAAGTTGGCCGAGGCTTGAGGTATATTCATTCAATGTCTTTGGTTCACATGGA TATAAAACCTAGTAATATTTTCATATCTCGAACCTCAATCCCAAATGCTGCCTCTGAAGAAGGAGACGAAGATGATTGGGCATCCAACAA AGTTATGTTTAAAATAGGTGATCTTGGGCATGTAACAAGGATCTCCAGTCCACAAGTTGAAGAGGGCGATAGTCGTTTTCTTGCAAATGA AGTTTTACAGGAGAATTATACCCATCTACCAAAAGCAGATATTTTTGCGCTTGCCCTCACAGTGGTATGTGCTGCTGGTGCTGAACCTCT TCCGAGAAATGGAGATCAATGGCATGAAATCAGACAGGGTAGATTACCTCGGATACCACAAGTGCTTTCCCAAGAATTTACAGAGTTGCT AAAAGTTATGATTCATCCAGATCCAGAGAGAAGACCTTCAGCAATGGCACTGGTAAAGCATTCAGTATTGCTGTCCGCTTCTAGAAAGAG TGCAGAACAATTACGAATAGAATTGAATGCCGAAAAGTTCAAAAATTCACTTTTACAAAATGCTGTTGGGGATTTCCAGGTGGACGACAA GACCAAAGCCTTACTCAAGTACACTGGGGAGGTGACTTGGATACCTCCGGCCATCTTTAAGAGCTCCTGTAAAATCGACGTGACCTACTT CCCGTTTGATTACCAAAACTGTACCATGAAGTTCGGTTCCTGGTCCTACGATAAGGCGAAAATCGATCTGGTCCTGATCGGCTCTTCCAT GAACCTCAAGGACTATTGGGAGAGCGGCGAGTGGGCCATCATCAAAGCCCCAGGCTACAAACACGACATCAAGTACAACTGCTGCGAGGA GATCTACCCCGACATCACATACTCGCTGTACATCCGGCGCCTGCCCTTGTTCTACACCATCAACCTCATCATCCCCTGCCTGCTCATCTC CTTCCTCACTGTGCTCGTCTTCTACCTGCCCTCCGACTGCGGTGAGAAGGTGACCCTGTGCATTTCTGTCCTCCTCTCCCTGACGGTGTT TCTCCTGGTGATCACTGAGACCATCCCTTCCACCTCGCTGGTCATCCCCCTGATTGGAGAGTACCTCCTGTTCACCATGATTTTTGTAAC CTTGTCCATCGTCATCACCGTCTTCGTGCTCAACGTGCACTACAGAACCCCGACGACACACACAATGCCCTCATGGGTGAAGACTGTATT CTTGAACCTGCTCCCCAGGGTCATGTTCATGACCAGGCCAACAAGCAACGAGGGCAACGCTCAGAAGCCGAGGCCCCTCTACGGTGCCGA GCTCTCAAATCTGAATTGCTTCAGCCGCGCAGAGTCCAAAGGCTGCAAGGAGGGCTACCCCTGCCAGGACGGGATGTGTGGTTACTGCCA CCACCGCAGGATAAAAATCTCCAATTTCAGTGCTAACCTCACGAGAAGCTCTAGTTCTGAATCTGTTGATGCTGTGCTGTCCCTCTCTGC TTTGTCACCAGAAATCAAAGAAGCCATCCAAAGTGTCAAGTATATTGCTGAAAATATGAAAGCACAAAATGAAGCCAAAGAGGAACAAAA AGCCCAAGAGATCCAACAATTGAAACGAAAAGAAAAGTCCACAGAAACATCCGATCAAGAACCTGGGCTATGAATTTCCAATCTTCAACA >In-frame_WEE1_ENST00000450114_chr11_9608403_+_CHRNA3_ENST00000326828_chr15_78894606_-_4480nt CTGAGACTGGACCTGAGGAGACCTCAGCCTCGGTGCTCGGGCCGCCCCGCCTCTGCCGGAAAGTCCGCGCCGCCGCTGCCGCCACCGTCC GCAGCCCGAGCGCCCCGGAGCCGCAGGCCGCCGCCGCGCAGAGACGCCGCGGCTGCGACTAGGCGCGCCCAGCCGCACGTGGCGGACCCG CCCCCAGGCCCGCAGTGTCCTGGACCCCGCAGGCCTCCGCTCTCCTGTCCTCGGCCCCGTCCCCAGGGCCGCGATGAGCTTCCTGAGCCG ACAGCAGCCGCCGCCACCCCGCCGCGCCGGGGCGGCCTGCACCTTGCGGCAGAAGCTGATCTTCTCGCCCTGCAGCGACTGTGAGGAGGA GGAAGAAGAGGAGGAGGAGGAGGGCAGCGGCCACAGCACCGGGGAGGACTCGGCCTTTCAAGAGCCCGACTCGCCGCTGCCGCCCGCGCG GAGCCCCACGGAGCCCGGGCCCGAGCGCCGCCGCTCGCCCGGGCCGGCCCCCGGCAGCCCCGGCGAGCTGGAGGAGGACCTGTTGCTGCC CGGCGCCTGCCCGGGCGCGGACGAGGCGGGCGGTGGGGCGGAGGGCGACTCGTGGGAGGAGGAGGGCTTCGGCTCCTCGTCGCCGGTCAA GTCGCCGGCGGCCCCCTACTTCCTGGGTAGCTCTTTCTCGCCGGTGCGCTGCGGCGGCCCAGGAGATGCGTCGCCGCGGGGTTGCGGGGC GCGCCGGGCGGGCGAAGGCCGCCGCTCGCCGCGGCCGGACCACCCGGGCACCCCGCCACACAAGACCTTCCGCAAGCTGCGACTCTTCGA CACCCCGCACACGCCCAAGAGTTTGCTCTCCAAAGCTCGGGGAATTGATTCCAGCTCTGTTAAACTCCGGGGTAGTTCTCTCTTCATGGA TACAGAAAAATCAGGAAAAAGGGAATTTGATGTGCGACAGACTCCTCAAGTGAATATTAATCCTTTTACTCCGGATTCTTTGTTGCTTCA TTCCTCAGGACAGTGTCGTCGTAGAAAGAGAACGTATTGGAATGATTCCTGTGGTGAAGACATGGAAGCCAGTGATTATGAGCTTGAAGA TGAAACAAGACCTGCTAAGAGAATTACAATTACTGAAAGCAATATGAAGTCCCGGTATACAACAGAATTTCATGAGCTAGAGAAAATCGG CTCTGGAGAATTTGGTTCTGTATTTAAGTGTGTGAAGAGGCTGGATGGATGCATTTATGCCATTAAGCGATCAAAAAAGCCATTGGCGGG CTCTGTTGATGAGCAGAACGCTTTGAGAGAAGTATATGCTCATGCAGTGCTTGGACAGCATTCTCATGTAGTTCGATATTTCTCTGCGTG GGCAGAAGATGATCATATGCTTATACAGAATGAATATTGTAATGGTGGAAGTTTAGCTGATGCTATAAGTGAAAACTACAGAATCATGAG TTACTTTAAAGAAGCAGAGTTGAAGGATCTCCTTTTGCAAGTTGGCCGAGGCTTGAGGTATATTCATTCAATGTCTTTGGTTCACATGGA TATAAAACCTAGTAATATTTTCATATCTCGAACCTCAATCCCAAATGCTGCCTCTGAAGAAGGAGACGAAGATGATTGGGCATCCAACAA AGTTATGTTTAAAATAGGTGATCTTGGGCATGTAACAAGGATCTCCAGTCCACAAGTTGAAGAGGGCGATAGTCGTTTTCTTGCAAATGA AGTTTTACAGGAGAATTATACCCATCTACCAAAAGCAGATATTTTTGCGCTTGCCCTCACAGTGGTATGTGCTGCTGGTGCTGAACCTCT TCCGAGAAATGGAGATCAATGGCATGAAATCAGACAGGGTAGATTACCTCGGATACCACAAGTGCTTTCCCAAGAATTTACAGAGTTGCT AAAAGTTATGATTCATCCAGATCCAGAGAGAAGACCTTCAGCAATGGCACTGGTAAAGCATTCAGTATTGCTGTCCGCTTCTAGAAAGAG TGCAGAACAATTACGAATAGAATTGAATGCCGAAAAGTTCAAAAATTCACTTTTACAAAATGCTGTTGGGGATTTCCAGGTGGACGACAA GACCAAAGCCTTACTCAAGTACACTGGGGAGGTGACTTGGATACCTCCGGCCATCTTTAAGAGCTCCTGTAAAATCGACGTGACCTACTT CCCGTTTGATTACCAAAACTGTACCATGAAGTTCGGTTCCTGGTCCTACGATAAGGCGAAAATCGATCTGGTCCTGATCGGCTCTTCCAT GAACCTCAAGGACTATTGGGAGAGCGGCGAGTGGGCCATCATCAAAGCCCCAGGCTACAAACACGACATCAAGTACAACTGCTGCGAGGA GATCTACCCCGACATCACATACTCGCTGTACATCCGGCGCCTGCCCTTGTTCTACACCATCAACCTCATCATCCCCTGCCTGCTCATCTC CTTCCTCACTGTGCTCGTCTTCTACCTGCCCTCCGACTGCGGTGAGAAGGTGACCCTGTGCATTTCTGTCCTCCTCTCCCTGACGGTGTT TCTCCTGGTGATCACTGAGACCATCCCTTCCACCTCGCTGGTCATCCCCCTGATTGGAGAGTACCTCCTGTTCACCATGATTTTTGTAAC CTTGTCCATCGTCATCACCGTCTTCGTGCTCAACGTGCACTACAGAACCCCGACGACACACACAATGCCCTCATGGGTGAAGACTGTATT CTTGAACCTGCTCCCCAGGGTCATGTTCATGACCAGGCCAACAAGCAACGAGGGCAACGCTCAGAAGCCGAGGCCCCTCTACGGTGCCGA GCTCTCAAATCTGAATTGCTTCAGCCGCGCAGAGTCCAAAGGCTGCAAGGAGGGCTACCCCTGCCAGGACGGGATGTGTGGTTACTGCCA CCACCGCAGGATAAAAATCTCCAATTTCAGTGCTAACCTCACGAGAAGCTCTAGTTCTGAATCTGTTGATGCTGTGCTGTCCCTCTCTGC TTTGTCACCAGAAATCAAAGAAGCCATCCAAAGTGTCAAGTATATTGCTGAAAATATGAAAGCACAAAATGAAGCCAAAGAGATTCAAGA TGATTGGAAGTATGTTGCCATGGTGATTGATCGTATTTTTCTGTGGGTTTTCACCCTGGTGTGCATTCTAGGGACAGCAGGATTGTTTCT GCAACCCCTGATGGCCAGGGAAGATGCATAAGCACTAAGCTGTGTGCCTGCCTGGGAGACTTCCTTGTGTCAGGGCAGGAGGAGGCTGCT TCCTAGTAAGAACGTACTTTCTGTTATCAAGCTACCAGCTTTGTTTTTGGCATTTCGAGGTTTACTTATTTTCCACTTATCTTGGAATCA TGCAAAAAAAAAAATGTCAAGAGTATTTATTACCGATAAATGAACATTTAACTAGCCTTTTTGGTATGGTAAAGAGATGTCAAAATGTGA TTCTATGTGATTAGTATGCTATGCTATGGAATATACATGTAAAAATGTTTCCTTTTAGTTGTTGAAACAAAACTGGATAGAAAAATGCTG TTCAGAAATATGAAAAGTCATTCAGTTATCACTACAGATCTCCCAGTAATTTTTCTTATTTAGCCCATAATCTCTTTGAAGGTTTATACT AATTCAGCAATCCCCCATCGTTACCCATTTCTTACCATGCATTTCTCGTTCTTTACTGGGTCTAAAGGGCTATGCCTCCATTTCAGAGAG CTTCAACTACTTCTCTTGCATACTTCTAAATTATACCATGAGAAATCATGCCTAGTTATTCATTGTTAATATAACTGTCTTAGTACACCA TAAACTGGGTGGATTATAAACAACAGAAACTTCTCAGTTTTGGAGGTTGGGAGGTCCAAGGTCAAGGCACCAGCAAATTTGGTGTCTGGT GAGGGTCCTCTTCCTCAAAGGGTGCCTTCTAGCTGTGTCCTCACATGACTGAAGGGACTAGCTATCTCTGTGGGGTCTATTTTATAAGGG CACTAACCCCATTCATGAGAGCAGAGCCCCCATGGCCTAATCACCTTTCCAAGGCCCCACCTTCTATCTAAGACAATCACGCTGGGAATA GGTTTCAACATATGAATTGGGGGAGGACACATTTGGACCACAGCATGAACCTTTAGAACAGGGTTTCTCAGCCTTAGCACTATGGACATT TTGGGCTGGATAAATATGTGTTGGTACAGAATGGGGGTATCCTGTGCATTGTAGGATCTTTAGCAGTACCCTAGCCTCAACTCACTAGAT GCCAATGACATACCTTGCTTCTTCACCAGTTATGATAACCAAGAATGTCTCCATTGTTAAATGTTCCCTTAGGAGCAAAATTGCCCCTGG TTGAGAAACATTGCTTTAGACAAATTGTTAAGAGTATCATGTACTACACTTCTGAAACTTAACGTGATCATCACCACTGACAGATGATTC >In-frame_WEE1_ENST00000299613_chr11_9608403_+_CHRNA3_ENST00000348639_chr15_78894606_-_3052nt ATGTAACTGAACAATGGGCCTCGTCTGGAACTTCATCTTACAAAGGGGCCGATCGGCCCGTCCGGGTGGCCAAGGATTTGCCGCCCGTTG AGTCCGGGCCGCCCCGAGCGTGTCAGCCCCGAGTGCGGCACCGATAACGCGGTTCGCGAGGATGCTGGAGGGTGCCGGCCCGGCCACCTG ACACTCCCGAGCCATAGGATGCCTTTTAAACGCGGCGATCGGGCCTGTAATTTGGGCGGCGCGGGCAGAAGGAGTTTAAAGAAAAATAAT TGTCCCGCCCTGATCGTGTCGTGTCGTGTGGCGTGGATGGGGGAAAGGTCTGGGGCATGCAGGGAGACTACGCTTGGACTTGGGAGTAAA GGCTGGCCTTCCAAGCATTTACAGTCCTACAGACTCATCCTAAGTCCAGGCAGTACTGAGGCCTGTTTCTGGACAAGGTCTTGGCCCAGC ATTTGTTTTTATCGTGGGTTTGCGGTGCCCAGAGTTTGGCCGGCCTCCGTGTGATTAGGAACATCCTACCGTAGATAAGGTATCTTAAAG AAGGAGGTGTTCAGCACCTGTGTTTTGAAAGGCCTTCGAGTACTGCGCAGATGACCACTTTTAAAACTGCAGATTTTAAAGCTGATACTT CCAGAGATTAAGACAAGCCTCGCATTTGTAAGGTTAACAGGGAAGATGCACCTTTTAAAAGTTTGCTCTCCAAAGCTCGGGGAATTGATT CCAGCTCTGTTAAACTCCGGGGTAGTTCTCTCTTCATGGATACAGAAAAATCAGGAAAAAGGGAATTTGATGTGCGACAGACTCCTCAAG TGAATATTAATCCTTTTACTCCGGATTCTTTGTTGCTTCATTCCTCAGGACAGTGTCGTCGTAGAAAGAGAACGTATTGGAATGATTCCT GTGGTGAAGACATGGAAGCCAGTGATTATGAGCTTGAAGATGAAACAAGACCTGCTAAGAGAATTACAATTACTGAAAGCAATATGAAGT CCCGGTATACAACAGAATTTCATGAGCTAGAGAAAATCGGCTCTGGAGAATTTGGTTCTGTATTTAAGTGTGTGAAGAGGCTGGATGGAT GCATTTATGCCATTAAGCGATCAAAAAAGCCATTGGCGGGCTCTGTTGATGAGCAGAACGCTTTGAGAGAAGTATATGCTCATGCAGTGC TTGGACAGCATTCTCATGTAGTTCGATATTTCTCTGCGTGGGCAGAAGATGATCATATGCTTATACAGAATGAATATTGTAATGGTGGAA GTTTAGCTGATGCTATAAGTGAAAACTACAGAATCATGAGTTACTTTAAAGAAGCAGAGTTGAAGGATCTCCTTTTGCAAGTTGGCCGAG GCTTGAGGTATATTCATTCAATGTCTTTGGTTCACATGGATATAAAACCTAGTAATATTTTCATATCTCGAACCTCAATCCCAAATGCTG CCTCTGAAGAAGGAGACGAAGATGATTGGGCATCCAACAAAGTTATGTTTAAAATAGGTGATCTTGGGCATGTAACAAGGATCTCCAGTC CACAAGTTGAAGAGGGCGATAGTCGTTTTCTTGCAAATGAAGTTTTACAGGAGAATTATACCCATCTACCAAAAGCAGATATTTTTGCGC TTGCCCTCACAGTGGTATGTGCTGCTGGTGCTGAACCTCTTCCGAGAAATGGAGATCAATGGCATGAAATCAGACAGGGTAGATTACCTC GGATACCACAAGTGCTTTCCCAAGAATTTACAGAGTTGCTAAAAGTTATGATTCATCCAGATCCAGAGAGAAGACCTTCAGCAATGGCAC TGGTAAAGCATTCAGTATTGCTGTCCGCTTCTAGAAAGAGTGCAGAACAATTACGAATAGAATTGAATGCCGAAAAGTTCAAAAATTCAC TTTTACAAAATGCTGTTGGGGATTTCCAGGTGGACGACAAGACCAAAGCCTTACTCAAGTACACTGGGGAGGTGACTTGGATACCTCCGG CCATCTTTAAGAGCTCCTGTAAAATCGACGTGACCTACTTCCCGTTTGATTACCAAAACTGTACCATGAAGTTCGGTTCCTGGTCCTACG ATAAGGCGAAAATCGATCTGGTCCTGATCGGCTCTTCCATGAACCTCAAGGACTATTGGGAGAGCGGCGAGTGGGCCATCATCAAAGCCC CAGGCTACAAACACGACATCAAGTACAACTGCTGCGAGGAGATCTACCCCGACATCACATACTCGCTGTACATCCGGCGCCTGCCCTTGT TCTACACCATCAACCTCATCATCCCCTGCCTGCTCATCTCCTTCCTCACTGTGCTCGTCTTCTACCTGCCCTCCGACTGCGGTGAGAAGG TGACCCTGTGCATTTCTGTCCTCCTCTCCCTGACGGTGTTTCTCCTGGTGATCACTGAGACCATCCCTTCCACCTCGCTGGTCATCCCCC TGATTGGAGAGTACCTCCTGTTCACCATGATTTTTGTAACCTTGTCCATCGTCATCACCGTCTTCGTGCTCAACGTGCACTACAGAACCC CGACGACACACACAATGCCCTCATGGGTGAAGACTGTATTCTTGAACCTGCTCCCCAGGGTCATGTTCATGACCAGGCCAACAAGCAACG AGGGCAACGCTCAGAAGCCGAGGCCCCTCTACGGTGCCGAGCTCTCAAATCTGAATTGCTTCAGCCGCGCAGAGTCCAAAGGCTGCAAGG AGGGCTACCCCTGCCAGGACGGGATGTGTGGTTACTGCCACCACCGCAGGATAAAAATCTCCAATTTCAGTGCTAACCTCACGAGAAGCT CTAGTTCTGAATCTGTTGATGCTGTGCTGTCCCTCTCTGCTTTGTCACCAGAAATCAAAGAAGCCATCCAAAGTGTCAAGTATATTGCTG AAAATATGAAAGCACAAAATGAAGCCAAAGAGGAACAAAAAGCCCAAGAGATCCAACAATTGAAACGAAAAGAAAAGTCCACAGAAACAT >In-frame_WEE1_ENST00000299613_chr11_9608403_+_CHRNA3_ENST00000326828_chr15_78894606_-_4340nt ATGTAACTGAACAATGGGCCTCGTCTGGAACTTCATCTTACAAAGGGGCCGATCGGCCCGTCCGGGTGGCCAAGGATTTGCCGCCCGTTG AGTCCGGGCCGCCCCGAGCGTGTCAGCCCCGAGTGCGGCACCGATAACGCGGTTCGCGAGGATGCTGGAGGGTGCCGGCCCGGCCACCTG ACACTCCCGAGCCATAGGATGCCTTTTAAACGCGGCGATCGGGCCTGTAATTTGGGCGGCGCGGGCAGAAGGAGTTTAAAGAAAAATAAT TGTCCCGCCCTGATCGTGTCGTGTCGTGTGGCGTGGATGGGGGAAAGGTCTGGGGCATGCAGGGAGACTACGCTTGGACTTGGGAGTAAA GGCTGGCCTTCCAAGCATTTACAGTCCTACAGACTCATCCTAAGTCCAGGCAGTACTGAGGCCTGTTTCTGGACAAGGTCTTGGCCCAGC ATTTGTTTTTATCGTGGGTTTGCGGTGCCCAGAGTTTGGCCGGCCTCCGTGTGATTAGGAACATCCTACCGTAGATAAGGTATCTTAAAG AAGGAGGTGTTCAGCACCTGTGTTTTGAAAGGCCTTCGAGTACTGCGCAGATGACCACTTTTAAAACTGCAGATTTTAAAGCTGATACTT CCAGAGATTAAGACAAGCCTCGCATTTGTAAGGTTAACAGGGAAGATGCACCTTTTAAAAGTTTGCTCTCCAAAGCTCGGGGAATTGATT CCAGCTCTGTTAAACTCCGGGGTAGTTCTCTCTTCATGGATACAGAAAAATCAGGAAAAAGGGAATTTGATGTGCGACAGACTCCTCAAG TGAATATTAATCCTTTTACTCCGGATTCTTTGTTGCTTCATTCCTCAGGACAGTGTCGTCGTAGAAAGAGAACGTATTGGAATGATTCCT GTGGTGAAGACATGGAAGCCAGTGATTATGAGCTTGAAGATGAAACAAGACCTGCTAAGAGAATTACAATTACTGAAAGCAATATGAAGT CCCGGTATACAACAGAATTTCATGAGCTAGAGAAAATCGGCTCTGGAGAATTTGGTTCTGTATTTAAGTGTGTGAAGAGGCTGGATGGAT GCATTTATGCCATTAAGCGATCAAAAAAGCCATTGGCGGGCTCTGTTGATGAGCAGAACGCTTTGAGAGAAGTATATGCTCATGCAGTGC TTGGACAGCATTCTCATGTAGTTCGATATTTCTCTGCGTGGGCAGAAGATGATCATATGCTTATACAGAATGAATATTGTAATGGTGGAA GTTTAGCTGATGCTATAAGTGAAAACTACAGAATCATGAGTTACTTTAAAGAAGCAGAGTTGAAGGATCTCCTTTTGCAAGTTGGCCGAG GCTTGAGGTATATTCATTCAATGTCTTTGGTTCACATGGATATAAAACCTAGTAATATTTTCATATCTCGAACCTCAATCCCAAATGCTG CCTCTGAAGAAGGAGACGAAGATGATTGGGCATCCAACAAAGTTATGTTTAAAATAGGTGATCTTGGGCATGTAACAAGGATCTCCAGTC CACAAGTTGAAGAGGGCGATAGTCGTTTTCTTGCAAATGAAGTTTTACAGGAGAATTATACCCATCTACCAAAAGCAGATATTTTTGCGC TTGCCCTCACAGTGGTATGTGCTGCTGGTGCTGAACCTCTTCCGAGAAATGGAGATCAATGGCATGAAATCAGACAGGGTAGATTACCTC GGATACCACAAGTGCTTTCCCAAGAATTTACAGAGTTGCTAAAAGTTATGATTCATCCAGATCCAGAGAGAAGACCTTCAGCAATGGCAC TGGTAAAGCATTCAGTATTGCTGTCCGCTTCTAGAAAGAGTGCAGAACAATTACGAATAGAATTGAATGCCGAAAAGTTCAAAAATTCAC TTTTACAAAATGCTGTTGGGGATTTCCAGGTGGACGACAAGACCAAAGCCTTACTCAAGTACACTGGGGAGGTGACTTGGATACCTCCGG CCATCTTTAAGAGCTCCTGTAAAATCGACGTGACCTACTTCCCGTTTGATTACCAAAACTGTACCATGAAGTTCGGTTCCTGGTCCTACG ATAAGGCGAAAATCGATCTGGTCCTGATCGGCTCTTCCATGAACCTCAAGGACTATTGGGAGAGCGGCGAGTGGGCCATCATCAAAGCCC CAGGCTACAAACACGACATCAAGTACAACTGCTGCGAGGAGATCTACCCCGACATCACATACTCGCTGTACATCCGGCGCCTGCCCTTGT TCTACACCATCAACCTCATCATCCCCTGCCTGCTCATCTCCTTCCTCACTGTGCTCGTCTTCTACCTGCCCTCCGACTGCGGTGAGAAGG TGACCCTGTGCATTTCTGTCCTCCTCTCCCTGACGGTGTTTCTCCTGGTGATCACTGAGACCATCCCTTCCACCTCGCTGGTCATCCCCC TGATTGGAGAGTACCTCCTGTTCACCATGATTTTTGTAACCTTGTCCATCGTCATCACCGTCTTCGTGCTCAACGTGCACTACAGAACCC CGACGACACACACAATGCCCTCATGGGTGAAGACTGTATTCTTGAACCTGCTCCCCAGGGTCATGTTCATGACCAGGCCAACAAGCAACG AGGGCAACGCTCAGAAGCCGAGGCCCCTCTACGGTGCCGAGCTCTCAAATCTGAATTGCTTCAGCCGCGCAGAGTCCAAAGGCTGCAAGG AGGGCTACCCCTGCCAGGACGGGATGTGTGGTTACTGCCACCACCGCAGGATAAAAATCTCCAATTTCAGTGCTAACCTCACGAGAAGCT CTAGTTCTGAATCTGTTGATGCTGTGCTGTCCCTCTCTGCTTTGTCACCAGAAATCAAAGAAGCCATCCAAAGTGTCAAGTATATTGCTG AAAATATGAAAGCACAAAATGAAGCCAAAGAGATTCAAGATGATTGGAAGTATGTTGCCATGGTGATTGATCGTATTTTTCTGTGGGTTT TCACCCTGGTGTGCATTCTAGGGACAGCAGGATTGTTTCTGCAACCCCTGATGGCCAGGGAAGATGCATAAGCACTAAGCTGTGTGCCTG CCTGGGAGACTTCCTTGTGTCAGGGCAGGAGGAGGCTGCTTCCTAGTAAGAACGTACTTTCTGTTATCAAGCTACCAGCTTTGTTTTTGG CATTTCGAGGTTTACTTATTTTCCACTTATCTTGGAATCATGCAAAAAAAAAAATGTCAAGAGTATTTATTACCGATAAATGAACATTTA ACTAGCCTTTTTGGTATGGTAAAGAGATGTCAAAATGTGATTCTATGTGATTAGTATGCTATGCTATGGAATATACATGTAAAAATGTTT CCTTTTAGTTGTTGAAACAAAACTGGATAGAAAAATGCTGTTCAGAAATATGAAAAGTCATTCAGTTATCACTACAGATCTCCCAGTAAT TTTTCTTATTTAGCCCATAATCTCTTTGAAGGTTTATACTAATTCAGCAATCCCCCATCGTTACCCATTTCTTACCATGCATTTCTCGTT CTTTACTGGGTCTAAAGGGCTATGCCTCCATTTCAGAGAGCTTCAACTACTTCTCTTGCATACTTCTAAATTATACCATGAGAAATCATG CCTAGTTATTCATTGTTAATATAACTGTCTTAGTACACCATAAACTGGGTGGATTATAAACAACAGAAACTTCTCAGTTTTGGAGGTTGG GAGGTCCAAGGTCAAGGCACCAGCAAATTTGGTGTCTGGTGAGGGTCCTCTTCCTCAAAGGGTGCCTTCTAGCTGTGTCCTCACATGACT GAAGGGACTAGCTATCTCTGTGGGGTCTATTTTATAAGGGCACTAACCCCATTCATGAGAGCAGAGCCCCCATGGCCTAATCACCTTTCC AAGGCCCCACCTTCTATCTAAGACAATCACGCTGGGAATAGGTTTCAACATATGAATTGGGGGAGGACACATTTGGACCACAGCATGAAC CTTTAGAACAGGGTTTCTCAGCCTTAGCACTATGGACATTTTGGGCTGGATAAATATGTGTTGGTACAGAATGGGGGTATCCTGTGCATT GTAGGATCTTTAGCAGTACCCTAGCCTCAACTCACTAGATGCCAATGACATACCTTGCTTCTTCACCAGTTATGATAACCAAGAATGTCT CCATTGTTAAATGTTCCCTTAGGAGCAAAATTGCCCCTGGTTGAGAAACATTGCTTTAGACAAATTGTTAAGAGTATCATGTACTACACT TCTGAAACTTAACGTGATCATCACCACTGACAGATGATTCACAGAGACTGTTTGAATCTTGTCTCACTAGTTTTTCCTGTGCAAAAATAA |
Top |
FusionGenePPI for WEE1_CHRNA3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| WEE1 | SFN, CDCA3, YWHAB, PIN1, CRK, FBXW11, BTRC, SKP2, NEDD4, ARRB2, MYC, MUS81, CSNK2B, CSNK2A1, BRSK2, PLK1, CDK1, PAXIP1, YWHAQ, CNBP, EEF2, PCBP1, SPTBN1, YEATS4, NUP160, XPO1, RUSC2, CEP350, WDFY3, BRPF3, CCNYL1, BRCA1, KDM5C, SMAD4, GATA3, RRM2, PIK3R1, HSP90AA1, CSNK1A1, KCTD3, BCR, USP15, KIF13B, SPAG9, MCM2, MCM4, CGN, DENND4C, CBY1, CHEK2, CHEK1, ADA, TOP1, TOP2A, TOP3A, DHFR, CDC73, TTN, RB1, ING4, FZR1, WRN, BLM, ATAD5, BRD4, FH, WEE1, CDKN1B, XRCC3, CDK12, CDC6, IMPDH1, TUBA1A, MTOR, TRIM25 | CHRNA3 | GLT8D2, TMEM231, EDA, GLRB, TMEM219, LEMD2, TMEM143, CNNM1, TPST2, ENTPD7, ITPR2, FAM69A, TMEM223, MIB1, APOL2, DSE, EXTL2, C1QL4, ST3GAL6, GRAMD1A, GHDC, FAR2, FAM20B, ITPR3, MFAP3, HTR3A, TMPPE |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for WEE1_CHRNA3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | CHRNA3 | P32297 | DB00184 | Nicotine | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved |
| Tgene | CHRNA3 | P32297 | DB00514 | Dextromethorphan | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved |
| Tgene | CHRNA3 | P32297 | DB00674 | Galantamine | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved |
| Tgene | CHRNA3 | P32297 | DB00898 | Ethanol | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved |
| Tgene | CHRNA3 | P32297 | DB01156 | Bupropion | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved |
| Tgene | CHRNA3 | P32297 | DB01227 | Levomethadyl Acetate | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved|investigational |
| Tgene | CHRNA3 | P32297 | DB01273 | Varenicline | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved|investigational |
| Tgene | CHRNA3 | P32297 | DB00848 | Levamisole | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved|investigational|vet_approved|withdrawn |
Top |
RelatedDiseases for WEE1_CHRNA3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | WEE1 | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human |
| Tgene | CHRNA3 | C0001973 | Alcoholic Intoxication, Chronic | 4 | CTD_human;PSYGENET |
| Tgene | CHRNA3 | C0600427 | Cocaine Dependence | 2 | PSYGENET |
| Tgene | CHRNA3 | C1861063 | TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding) | 2 | CTD_human |
| Tgene | CHRNA3 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Tgene | CHRNA3 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | CHRNA3 | C0036572 | Seizures | 1 | CTD_human |
| Tgene | CHRNA3 | C0040336 | Tobacco Use Disorder | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|