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Fusion gene ID: 4194 |
FusionGeneSummary for BIRC6_MYCNOS |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BIRC6_MYCNOS | Fusion gene ID: 4194 | Hgene | Tgene | Gene symbol | BIRC6 | MYCNOS | Gene ID | 57448 | 10408 |
| Gene name | baculoviral IAP repeat containing 6 | MYCN opposite strand | |
| Synonyms | APOLLON|BRUCE | MYCN-AS1|N-CYM|NCYM|NYCM | |
| Cytomap | 2p22.3 | 2p24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | baculoviral IAP repeat-containing protein 6BIR repeat-containing ubiquitin-conjugating enzymeRING-type E3 ubiquitin transferase BIRC6ubiquitin-conjugating BIR-domain enzyme apollon | N-cym proteinDNA-binding transcriptional activator NCYMMYCN antisense RNA 1MYCN opposite strand/antisense RNA (non-protein coding)N-myc opposite strandv-myc myelocytomatosis viral related oncogene, neuroblastoma derived opposite strand | |
| Modification date | 20180523 | 20180329 | |
| UniProtAcc | Q9NR09 | ||
| Ensembl transtripts involved in fusion gene | ENST00000421745, | ENST00000453400, ENST00000420452, ENST00000419083, ENST00000439180, ENST00000448719, | |
| Fusion gene scores | * DoF score | 16 X 15 X 12=2880 | 1 X 1 X 1=1 |
| # samples | 19 | 1 | |
| ** MAII score | log2(19/2880*10)=-3.92199748799873 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: BIRC6 [Title/Abstract] AND MYCNOS [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MYCNOS | GO:0033673 | negative regulation of kinase activity | 24391509 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-GU-AATO-01A | BIRC6 | chr2 | 32774548 | + | MYCNOS | chr2 | 16081219 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000421745 | ENST00000453400 | BIRC6 | chr2 | 32774548 | + | MYCNOS | chr2 | 16081219 | - |
| 5CDS-5UTR | ENST00000421745 | ENST00000420452 | BIRC6 | chr2 | 32774548 | + | MYCNOS | chr2 | 16081219 | - |
| 5CDS-5UTR | ENST00000421745 | ENST00000419083 | BIRC6 | chr2 | 32774548 | + | MYCNOS | chr2 | 16081219 | - |
| 5CDS-5UTR | ENST00000421745 | ENST00000439180 | BIRC6 | chr2 | 32774548 | + | MYCNOS | chr2 | 16081219 | - |
| 5CDS-5UTR | ENST00000421745 | ENST00000448719 | BIRC6 | chr2 | 32774548 | + | MYCNOS | chr2 | 16081219 | - |
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FusionProtFeatures for BIRC6_MYCNOS |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BIRC6 | MYCNOS |
| Anti-apoptotic protein which can regulate cell death bycontrolling caspases and by acting as an E3 ubiquitin-proteinligase. Has an unusual ubiquitin conjugation system in that itcould combine in a single polypeptide, ubiquitin conjugating (E2)with ubiquitin ligase (E3) activity, forming a chimeric E2/E3ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Actsas an inhibitor of CASP3, CASP7 and CASP9. Important regulator forthe final stages of cytokinesis. Crucial for normal vesicletargeting to the site of abscission, but also for the integrity ofthe midbody and the midbody ring, and its striking ubiquitinmodification. {ECO:0000269|PubMed:14765125,ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BIRC6_MYCNOS |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BIRC6_MYCNOS |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| BIRC6 | RNF41, KIF23, USP8, DIABLO, CASP9, HTRA2, UBC, VAV2, SIRT7, CASP3, CASP7, BIRC6, CASP8, UBE2D1, CSNK2A1, RASSF2, EPS15L1, GBF1, CCNA2, CDC27, ANAPC11, TEX35, PRSS45, RTBDN, C3orf20, WDR4, DFNA5, FAM175B, CA11, FIGF, MOS, HERC2, CHIA, CLEC11A, INTS4P2, TBC1D22A, FAM58A, MCPH1, TP53, UNK, RPGR, KIF22, LLGL2, PLK1, MYH13, SSH3, AGRP, ANGPTL3, UGGT2, AKAP9, DCAF12, FERMT2, PSMC5, MGST3, CCDC22, OSBPL2, ADAMTS4, HEY1 | MYCNOS |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BIRC6_MYCNOS |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BIRC6_MYCNOS |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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