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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41934

FusionGeneSummary for WDR77_WDR77

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR77_WDR77
Fusion gene ID: 41934
HgeneTgene
Gene symbol

WDR77

WDR77

Gene ID

79084

79084

Gene nameWD repeat domain 77WD repeat domain 77
SynonymsHKMT1069|MEP-50|MEP50|Nbla10071|p44|p44/Mep50HKMT1069|MEP-50|MEP50|Nbla10071|p44|p44/Mep50
Cytomap

1p13.2

1p13.2

Type of geneprotein-codingprotein-coding
Descriptionmethylosome protein 50WD repeat-containing protein 77androgen receptor cofactor p44testis tissue sperm-binding protein Li 44amethylosome protein 50WD repeat-containing protein 77androgen receptor cofactor p44testis tissue sperm-binding protein Li 44a
Modification date2018052220180522
UniProtAcc

Q9BQA1

Q9BQA1

Ensembl transtripts involved in fusion geneENST00000235090, ENST00000411751, 
ENST00000497278, 
ENST00000235090, 
ENST00000411751, ENST00000497278, 
Fusion gene scores* DoF score2 X 2 X 1=41 X 1 X 1=1
# samples 21
** MAII scorelog2(2/4*10)=2.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: WDR77 [Title/Abstract] AND WDR77 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA428438WDR77chr1

111985982

+WDR77chr1

111984662

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000235090ENST00000235090WDR77chr1

111985982

+WDR77chr1

111984662

-
intron-3CDSENST00000235090ENST00000411751WDR77chr1

111985982

+WDR77chr1

111984662

-
intron-5UTRENST00000235090ENST00000497278WDR77chr1

111985982

+WDR77chr1

111984662

-
intron-3CDSENST00000411751ENST00000235090WDR77chr1

111985982

+WDR77chr1

111984662

-
intron-3CDSENST00000411751ENST00000411751WDR77chr1

111985982

+WDR77chr1

111984662

-
intron-5UTRENST00000411751ENST00000497278WDR77chr1

111985982

+WDR77chr1

111984662

-
intron-3CDSENST00000497278ENST00000235090WDR77chr1

111985982

+WDR77chr1

111984662

-
intron-3CDSENST00000497278ENST00000411751WDR77chr1

111985982

+WDR77chr1

111984662

-
intron-5UTRENST00000497278ENST00000497278WDR77chr1

111985982

+WDR77chr1

111984662

-

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FusionProtFeatures for WDR77_WDR77


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WDR77

Q9BQA1

WDR77

Q9BQA1

Non-catalytic component of the methylosome complex,composed of PRMT5, WDR77 and CLNS1A, which modifies specificarginines to dimethylarginines in several spliceosomal Sm proteinsand histones (PubMed:11756452). This modification targets Smproteins to the survival of motor neurons (SMN) complex forassembly into small nuclear ribonucleoprotein core particles.Might play a role in transcription regulation. The methylosomecomplex also methylates the Piwi proteins (PIWIL1, PIWIL2 andPIWIL4), methylation of Piwi proteins being required for theinteraction with Tudor domain-containing proteins and subsequentlocalization to the meiotic nuage (PubMed:23071334).{ECO:0000269|PubMed:11756452, ECO:0000269|PubMed:23071334}. Non-catalytic component of the methylosome complex,composed of PRMT5, WDR77 and CLNS1A, which modifies specificarginines to dimethylarginines in several spliceosomal Sm proteinsand histones (PubMed:11756452). This modification targets Smproteins to the survival of motor neurons (SMN) complex forassembly into small nuclear ribonucleoprotein core particles.Might play a role in transcription regulation. The methylosomecomplex also methylates the Piwi proteins (PIWIL1, PIWIL2 andPIWIL4), methylation of Piwi proteins being required for theinteraction with Tudor domain-containing proteins and subsequentlocalization to the meiotic nuage (PubMed:23071334).{ECO:0000269|PubMed:11756452, ECO:0000269|PubMed:23071334}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WDR77_WDR77


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WDR77_WDR77


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WDR77_WDR77


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WDR77_WDR77


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneWDR77C0919267ovarian neoplasm1CTD_human
TgeneWDR77C0919267ovarian neoplasm1CTD_human