![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 41934 |
FusionGeneSummary for WDR77_WDR77 |
![]() |
Fusion gene information | Fusion gene name: WDR77_WDR77 | Fusion gene ID: 41934 | Hgene | Tgene | Gene symbol | WDR77 | WDR77 | Gene ID | 79084 | 79084 |
Gene name | WD repeat domain 77 | WD repeat domain 77 | |
Synonyms | HKMT1069|MEP-50|MEP50|Nbla10071|p44|p44/Mep50 | HKMT1069|MEP-50|MEP50|Nbla10071|p44|p44/Mep50 | |
Cytomap | 1p13.2 | 1p13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | methylosome protein 50WD repeat-containing protein 77androgen receptor cofactor p44testis tissue sperm-binding protein Li 44a | methylosome protein 50WD repeat-containing protein 77androgen receptor cofactor p44testis tissue sperm-binding protein Li 44a | |
Modification date | 20180522 | 20180522 | |
UniProtAcc | Q9BQA1 | Q9BQA1 | |
Ensembl transtripts involved in fusion gene | ENST00000235090, ENST00000411751, ENST00000497278, | ENST00000235090, ENST00000411751, ENST00000497278, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 1 X 1 X 1=1 |
# samples | 2 | 1 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: WDR77 [Title/Abstract] AND WDR77 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA428438 | WDR77 | chr1 | 111985982 | + | WDR77 | chr1 | 111984662 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000235090 | ENST00000235090 | WDR77 | chr1 | 111985982 | + | WDR77 | chr1 | 111984662 | - |
intron-3CDS | ENST00000235090 | ENST00000411751 | WDR77 | chr1 | 111985982 | + | WDR77 | chr1 | 111984662 | - |
intron-5UTR | ENST00000235090 | ENST00000497278 | WDR77 | chr1 | 111985982 | + | WDR77 | chr1 | 111984662 | - |
intron-3CDS | ENST00000411751 | ENST00000235090 | WDR77 | chr1 | 111985982 | + | WDR77 | chr1 | 111984662 | - |
intron-3CDS | ENST00000411751 | ENST00000411751 | WDR77 | chr1 | 111985982 | + | WDR77 | chr1 | 111984662 | - |
intron-5UTR | ENST00000411751 | ENST00000497278 | WDR77 | chr1 | 111985982 | + | WDR77 | chr1 | 111984662 | - |
intron-3CDS | ENST00000497278 | ENST00000235090 | WDR77 | chr1 | 111985982 | + | WDR77 | chr1 | 111984662 | - |
intron-3CDS | ENST00000497278 | ENST00000411751 | WDR77 | chr1 | 111985982 | + | WDR77 | chr1 | 111984662 | - |
intron-5UTR | ENST00000497278 | ENST00000497278 | WDR77 | chr1 | 111985982 | + | WDR77 | chr1 | 111984662 | - |
Top |
FusionProtFeatures for WDR77_WDR77 |
![]() |
Hgene | Tgene |
WDR77 | WDR77 |
Non-catalytic component of the methylosome complex,composed of PRMT5, WDR77 and CLNS1A, which modifies specificarginines to dimethylarginines in several spliceosomal Sm proteinsand histones (PubMed:11756452). This modification targets Smproteins to the survival of motor neurons (SMN) complex forassembly into small nuclear ribonucleoprotein core particles.Might play a role in transcription regulation. The methylosomecomplex also methylates the Piwi proteins (PIWIL1, PIWIL2 andPIWIL4), methylation of Piwi proteins being required for theinteraction with Tudor domain-containing proteins and subsequentlocalization to the meiotic nuage (PubMed:23071334).{ECO:0000269|PubMed:11756452, ECO:0000269|PubMed:23071334}. | Non-catalytic component of the methylosome complex,composed of PRMT5, WDR77 and CLNS1A, which modifies specificarginines to dimethylarginines in several spliceosomal Sm proteinsand histones (PubMed:11756452). This modification targets Smproteins to the survival of motor neurons (SMN) complex forassembly into small nuclear ribonucleoprotein core particles.Might play a role in transcription regulation. The methylosomecomplex also methylates the Piwi proteins (PIWIL1, PIWIL2 andPIWIL4), methylation of Piwi proteins being required for theinteraction with Tudor domain-containing proteins and subsequentlocalization to the meiotic nuage (PubMed:23071334).{ECO:0000269|PubMed:11756452, ECO:0000269|PubMed:23071334}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for WDR77_WDR77 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for WDR77_WDR77 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for WDR77_WDR77 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for WDR77_WDR77 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | WDR77 | C0919267 | ovarian neoplasm | 1 | CTD_human |
Tgene | WDR77 | C0919267 | ovarian neoplasm | 1 | CTD_human |