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Fusion gene ID: 41931 |
FusionGeneSummary for WDR76_IDH3A |
Fusion gene summary |
Fusion gene information | Fusion gene name: WDR76_IDH3A | Fusion gene ID: 41931 | Hgene | Tgene | Gene symbol | WDR76 | IDH3A | Gene ID | 79968 | 3419 |
Gene name | WD repeat domain 76 | isocitrate dehydrogenase 3 (NAD(+)) alpha | |
Synonyms | CDW14 | - | |
Cytomap | 15q15.3 | 15q25.1 | |
Type of gene | protein-coding | protein-coding | |
Description | WD repeat-containing protein 76 | isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialH-IDH alphaNAD(+)-specific ICDH subunit alphaNAD(H)-specific isocitrate dehydrogenase alpha subunitNAD+-specific ICDHisocitrate dehydrogenase (NAD+) alpha chainisocitrate dehydrogenase 3 (NA | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q9H967 | P50213 | |
Ensembl transtripts involved in fusion gene | ENST00000263795, ENST00000381246, ENST00000478130, | ENST00000299518, ENST00000558554, ENST00000559205, ENST00000441490, ENST00000558535, ENST00000561366, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 3 X 2=12 |
# samples | 4 | 3 | |
** MAII score | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: WDR76 [Title/Abstract] AND IDH3A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SKCM | TCGA-WE-A8K1-06A | WDR76 | chr15 | 44120564 | + | IDH3A | chr15 | 78461264 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000263795 | ENST00000299518 | WDR76 | chr15 | 44120564 | + | IDH3A | chr15 | 78461264 | + |
In-frame | ENST00000263795 | ENST00000558554 | WDR76 | chr15 | 44120564 | + | IDH3A | chr15 | 78461264 | + |
Frame-shift | ENST00000263795 | ENST00000559205 | WDR76 | chr15 | 44120564 | + | IDH3A | chr15 | 78461264 | + |
Frame-shift | ENST00000263795 | ENST00000441490 | WDR76 | chr15 | 44120564 | + | IDH3A | chr15 | 78461264 | + |
5CDS-3UTR | ENST00000263795 | ENST00000558535 | WDR76 | chr15 | 44120564 | + | IDH3A | chr15 | 78461264 | + |
5CDS-intron | ENST00000263795 | ENST00000561366 | WDR76 | chr15 | 44120564 | + | IDH3A | chr15 | 78461264 | + |
Frame-shift | ENST00000381246 | ENST00000299518 | WDR76 | chr15 | 44120564 | + | IDH3A | chr15 | 78461264 | + |
In-frame | ENST00000381246 | ENST00000558554 | WDR76 | chr15 | 44120564 | + | IDH3A | chr15 | 78461264 | + |
Frame-shift | ENST00000381246 | ENST00000559205 | WDR76 | chr15 | 44120564 | + | IDH3A | chr15 | 78461264 | + |
Frame-shift | ENST00000381246 | ENST00000441490 | WDR76 | chr15 | 44120564 | + | IDH3A | chr15 | 78461264 | + |
5CDS-3UTR | ENST00000381246 | ENST00000558535 | WDR76 | chr15 | 44120564 | + | IDH3A | chr15 | 78461264 | + |
5CDS-intron | ENST00000381246 | ENST00000561366 | WDR76 | chr15 | 44120564 | + | IDH3A | chr15 | 78461264 | + |
intron-3CDS | ENST00000478130 | ENST00000299518 | WDR76 | chr15 | 44120564 | + | IDH3A | chr15 | 78461264 | + |
intron-3CDS | ENST00000478130 | ENST00000558554 | WDR76 | chr15 | 44120564 | + | IDH3A | chr15 | 78461264 | + |
intron-3CDS | ENST00000478130 | ENST00000559205 | WDR76 | chr15 | 44120564 | + | IDH3A | chr15 | 78461264 | + |
intron-3CDS | ENST00000478130 | ENST00000441490 | WDR76 | chr15 | 44120564 | + | IDH3A | chr15 | 78461264 | + |
intron-3UTR | ENST00000478130 | ENST00000558535 | WDR76 | chr15 | 44120564 | + | IDH3A | chr15 | 78461264 | + |
intron-intron | ENST00000478130 | ENST00000561366 | WDR76 | chr15 | 44120564 | + | IDH3A | chr15 | 78461264 | + |
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FusionProtFeatures for WDR76_IDH3A |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
WDR76 | IDH3A |
Specifically binds 5-hydroxymethylcytosine (5hmC),suggesting that it acts as a specific reader of 5hmC.{ECO:0000250}. | Catalytic subunit of the enzyme which catalyzes thedecarboxylation of isocitrate (ICT) into alpha-ketoglutarate. Theheterodimer composed of the alpha (IDH3A) and beta (IDH3B)subunits and the heterodimer composed of the alpha (IDH3A) andgamma (IDH3G) subunits, have considerable basal activity but thefull activity of the heterotetramer (containing two subunits ofIDH3A, one of IDH3B and one of IDH3G) requires the assembly andcooperative function of both heterodimers.{ECO:0000269|PubMed:28139779}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for WDR76_IDH3A |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_WDR76_ENST00000263795_chr15_44120564_+_IDH3A_ENST00000558554_chr15_78461264_+_182aa MSRSGAAAEKADSRQRPQMKVNEYKENQNIAYVSLRPAQTTVLIKTAKVYLAPFSLSNYQLDQLMCPKSLSEKNSNNEVACKKTKIKKTC RRIIPPKMKNTSSKAESTLQNSSSAVHTESNKLQPKRTADAMNLSVDVESSQDGDSDEDTTPSLSLTKDLGGNAKCSDFTEEICRRVKDL >In-frame_WDR76_ENST00000381246_chr15_44120564_+_IDH3A_ENST00000558554_chr15_78461264_+_118aa MCPKSLSEKNSNNEVACKKTKIKKTCRRIIPPKMKNTSSKAESTLQNSSSAVHTESNKLQPKRTADAMNLSVDVESSQDGDSDEDTTPSL |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_WDR76_ENST00000263795_chr15_44120564_+_IDH3A_ENST00000558554_chr15_78461264_+_546nt ATGTCCAGGTCGGGCGCGGCGGCTGAGAAGGCGGACTCCAGACAGCGACCCCAGATGAAGGTAAATGAATATAAAGAAAATCAAAACATC GCTTATGTGTCTCTGAGACCAGCACAGACTACAGTTTTAATAAAAACAGCTAAGGTCTATCTTGCCCCCTTTTCACTCAGTAATTACCAG CTAGACCAGCTTATGTGCCCCAAATCCCTATCAGAAAAGAATTCTAACAATGAAGTGGCGTGTAAGAAGACTAAAATAAAGAAAACTTGC AGAAGGATTATACCTCCAAAGATGAAAAACACATCTTCCAAGGCAGAATCCACGCTGCAAAATTCATCCTCAGCTGTTCATACTGAAAGT AACAAGCTACAACCCAAGAGAACGGCAGATGCGATGAATCTCAGTGTTGATGTGGAAAGTAGTCAGGATGGAGACAGTGATGAAGATACC ACACCATCCCTGAGCTTGACAAAAGATTTGGGAGGCAATGCAAAATGCTCAGACTTCACAGAGGAAATCTGTCGCCGAGTAAAAGATTTA >In-frame_WDR76_ENST00000381246_chr15_44120564_+_IDH3A_ENST00000558554_chr15_78461264_+_354nt ATGTGCCCCAAATCCCTATCAGAAAAGAATTCTAACAATGAAGTGGCGTGTAAGAAGACTAAAATAAAGAAAACTTGCAGAAGGATTATA CCTCCAAAGATGAAAAACACATCTTCCAAGGCAGAATCCACGCTGCAAAATTCATCCTCAGCTGTTCATACTGAAAGTAACAAGCTACAA CCCAAGAGAACGGCAGATGCGATGAATCTCAGTGTTGATGTGGAAAGTAGTCAGGATGGAGACAGTGATGAAGATACCACACCATCCCTG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_WDR76_ENST00000263795_chr15_44120564_+_IDH3A_ENST00000558554_chr15_78461264_+_1171nt TCGGACCCGCCCCTCCCGGCCTCCCGCCGCAATCTTGGCGGGAAGGCGCCGGCCGCTAAGAAGCCGAAAGATGTCCAGGTCGGGCGCGGC GGCTGAGAAGGCGGACTCCAGACAGCGACCCCAGATGAAGGTAAATGAATATAAAGAAAATCAAAACATCGCTTATGTGTCTCTGAGACC AGCACAGACTACAGTTTTAATAAAAACAGCTAAGGTCTATCTTGCCCCCTTTTCACTCAGTAATTACCAGCTAGACCAGCTTATGTGCCC CAAATCCCTATCAGAAAAGAATTCTAACAATGAAGTGGCGTGTAAGAAGACTAAAATAAAGAAAACTTGCAGAAGGATTATACCTCCAAA GATGAAAAACACATCTTCCAAGGCAGAATCCACGCTGCAAAATTCATCCTCAGCTGTTCATACTGAAAGTAACAAGCTACAACCCAAGAG AACGGCAGATGCGATGAATCTCAGTGTTGATGTGGAAAGTAGTCAGGATGGAGACAGTGATGAAGATACCACACCATCCCTGAGCTTGAC AAAAGATTTGGGAGGCAATGCAAAATGCTCAGACTTCACAGAGGAAATCTGTCGCCGAGTAAAAGATTTAGATTAACACTTCTACAACTG GCATTTACATCAGTCACTCTAAATGGACACCACATGAACCTCTGTTTAGAATACCTACGTATGTATGCATTGGTTTGCTTGTTTCTTGAC AGTACATTTTTAGATCTGGCCTTTTCTTAACAAAATCTGTGCAAAAGATGCAGGTGGATGTCCCTAGGTCTGTTTTCAAAGAACTTTTTC CAAGTGCTTGTTTTATTTATTAAGTGTCTACCTGGTAAATGTTTTTTTTGTAAACTCTGAGTGGACTGTATCATTTGCTATTCTAAACCA TTTTACACTTAAGTTAAAATAGTTTCTCTTCAGCTGTAAATAACAGGATACAGAATTAACAAGAGAAAATGTCTAACTTTTTAAGAAAAA CCTTATTTTCTTCGGTTTTTGAAAAACATAATGGAAATAAAACAGGATATTGACATAATAGCACAAAATGACACTCTTCTAAAACTAAAT GGGCACAAGAGAATTTTCCTGGGAAAGTTCACATCAAAAAGAGTGAATGTGGTATATTTCTAAATGATATGGAAAATAGAGACAGATTTG >In-frame_WDR76_ENST00000381246_chr15_44120564_+_IDH3A_ENST00000558554_chr15_78461264_+_1180nt GGCCTCCCGCCGCAATCTTGGCGGGAAGGCGCCGGCCGCTAAGAAGCCGAAAGATGTCCAGGTCGGGCGCGGCGGCTGAGAAGGCGGACT CCAGACAGCGACCCCAGATGAAGGTGAGAAACGGACTGGTGCTTCCAAGGTAAATGAATATAAAGAAAATCAAAACATCGCTTATGTGTC TCTGAGACCAGCACAGACTACAGTTTTAATAAAAACAGCTAAGGTCTATCTTGCCCCCTTTTCACTCAGTAATTACCAGCTAGACCAGCT TATGTGCCCCAAATCCCTATCAGAAAAGAATTCTAACAATGAAGTGGCGTGTAAGAAGACTAAAATAAAGAAAACTTGCAGAAGGATTAT ACCTCCAAAGATGAAAAACACATCTTCCAAGGCAGAATCCACGCTGCAAAATTCATCCTCAGCTGTTCATACTGAAAGTAACAAGCTACA ACCCAAGAGAACGGCAGATGCGATGAATCTCAGTGTTGATGTGGAAAGTAGTCAGGATGGAGACAGTGATGAAGATACCACACCATCCCT GAGCTTGACAAAAGATTTGGGAGGCAATGCAAAATGCTCAGACTTCACAGAGGAAATCTGTCGCCGAGTAAAAGATTTAGATTAACACTT CTACAACTGGCATTTACATCAGTCACTCTAAATGGACACCACATGAACCTCTGTTTAGAATACCTACGTATGTATGCATTGGTTTGCTTG TTTCTTGACAGTACATTTTTAGATCTGGCCTTTTCTTAACAAAATCTGTGCAAAAGATGCAGGTGGATGTCCCTAGGTCTGTTTTCAAAG AACTTTTTCCAAGTGCTTGTTTTATTTATTAAGTGTCTACCTGGTAAATGTTTTTTTTGTAAACTCTGAGTGGACTGTATCATTTGCTAT TCTAAACCATTTTACACTTAAGTTAAAATAGTTTCTCTTCAGCTGTAAATAACAGGATACAGAATTAACAAGAGAAAATGTCTAACTTTT TAAGAAAAACCTTATTTTCTTCGGTTTTTGAAAAACATAATGGAAATAAAACAGGATATTGACATAATAGCACAAAATGACACTCTTCTA AAACTAAATGGGCACAAGAGAATTTTCCTGGGAAAGTTCACATCAAAAAGAGTGAATGTGGTATATTTCTAAATGATATGGAAAATAGAG |
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FusionGenePPI for WDR76_IDH3A |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
WDR76 | CUL4A, CUL4B, CUL3, HELLS, SRRM2, CCT2, XRCC6, XRCC5, ZC3HAV1, GNB2L1, SUGT1, RPSA, HSP90AA1, PARP1, BAG2, CCT7, CCT8, CCT5, CCT3, PPIB, LRRC59, CCT4, NUDT21, FXR1, C1QBP, HMGB1, RPS23, RPL22, SSRP1, RPS18, RPS25, FEN1, RPS17, SPIN2B, PCGF6, GFOD1, HIST1H2BG, HIST1H3A, CAPZA2, EZH2, MYH9, AP4M1, C10orf12, GAN, CAMK2D, IKZF1, IMPDH1, PARP2, SUPT16H, HIST2H3PS2, XPC, SSSCA1, LIG3 | IDH3A | DMWD, DDA1, PSMD4, TERF1, TERF2, MYC, S100A16, UQCRFS1P1, SUCLA2, ADRB2, MBNL1, RAB4A, STAU1, HUWE1, CUL7, EGFR, IDH3B, RDH13, IDH3G, ABCC1, ABCC3, ACO2, ACTN4, ATP2B1, CCT8, HDHD1, IDH1, ACADM, CAD, CANX, CCT6A, CCT6B, CLTCL1, CS, EPRS, ETFA, IDH2, MDH2, PPP2R1A, PSMC5, RPLP0, RPN1, SLC25A3, SUCLG2, IPO9, PSMD2, UBE2N, UQCRC2, NFATC2, DLD, SDHA, SOD1 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for WDR76_IDH3A |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | IDH3A | P50213 | DB09092 | Xanthinol | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | small molecule | approved|withdrawn |
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RelatedDiseases for WDR76_IDH3A |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | IDH3A | C0029408 | Degenerative polyarthritis | 1 | CTD_human |