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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41931

FusionGeneSummary for WDR76_IDH3A

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR76_IDH3A
Fusion gene ID: 41931
HgeneTgene
Gene symbol

WDR76

IDH3A

Gene ID

79968

3419

Gene nameWD repeat domain 76isocitrate dehydrogenase 3 (NAD(+)) alpha
SynonymsCDW14-
Cytomap

15q15.3

15q25.1

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing protein 76isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialH-IDH alphaNAD(+)-specific ICDH subunit alphaNAD(H)-specific isocitrate dehydrogenase alpha subunitNAD+-specific ICDHisocitrate dehydrogenase (NAD+) alpha chainisocitrate dehydrogenase 3 (NA
Modification date2018052320180522
UniProtAcc

Q9H967

P50213

Ensembl transtripts involved in fusion geneENST00000263795, ENST00000381246, 
ENST00000478130, 
ENST00000299518, 
ENST00000558554, ENST00000559205, 
ENST00000441490, ENST00000558535, 
ENST00000561366, 
Fusion gene scores* DoF score3 X 3 X 3=272 X 3 X 2=12
# samples 43
** MAII scorelog2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: WDR76 [Title/Abstract] AND IDH3A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-WE-A8K1-06AWDR76chr15

44120564

+IDH3Achr15

78461264

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000263795ENST00000299518WDR76chr15

44120564

+IDH3Achr15

78461264

+
In-frameENST00000263795ENST00000558554WDR76chr15

44120564

+IDH3Achr15

78461264

+
Frame-shiftENST00000263795ENST00000559205WDR76chr15

44120564

+IDH3Achr15

78461264

+
Frame-shiftENST00000263795ENST00000441490WDR76chr15

44120564

+IDH3Achr15

78461264

+
5CDS-3UTRENST00000263795ENST00000558535WDR76chr15

44120564

+IDH3Achr15

78461264

+
5CDS-intronENST00000263795ENST00000561366WDR76chr15

44120564

+IDH3Achr15

78461264

+
Frame-shiftENST00000381246ENST00000299518WDR76chr15

44120564

+IDH3Achr15

78461264

+
In-frameENST00000381246ENST00000558554WDR76chr15

44120564

+IDH3Achr15

78461264

+
Frame-shiftENST00000381246ENST00000559205WDR76chr15

44120564

+IDH3Achr15

78461264

+
Frame-shiftENST00000381246ENST00000441490WDR76chr15

44120564

+IDH3Achr15

78461264

+
5CDS-3UTRENST00000381246ENST00000558535WDR76chr15

44120564

+IDH3Achr15

78461264

+
5CDS-intronENST00000381246ENST00000561366WDR76chr15

44120564

+IDH3Achr15

78461264

+
intron-3CDSENST00000478130ENST00000299518WDR76chr15

44120564

+IDH3Achr15

78461264

+
intron-3CDSENST00000478130ENST00000558554WDR76chr15

44120564

+IDH3Achr15

78461264

+
intron-3CDSENST00000478130ENST00000559205WDR76chr15

44120564

+IDH3Achr15

78461264

+
intron-3CDSENST00000478130ENST00000441490WDR76chr15

44120564

+IDH3Achr15

78461264

+
intron-3UTRENST00000478130ENST00000558535WDR76chr15

44120564

+IDH3Achr15

78461264

+
intron-intronENST00000478130ENST00000561366WDR76chr15

44120564

+IDH3Achr15

78461264

+

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FusionProtFeatures for WDR76_IDH3A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WDR76

Q9H967

IDH3A

P50213

Specifically binds 5-hydroxymethylcytosine (5hmC),suggesting that it acts as a specific reader of 5hmC.{ECO:0000250}. Catalytic subunit of the enzyme which catalyzes thedecarboxylation of isocitrate (ICT) into alpha-ketoglutarate. Theheterodimer composed of the alpha (IDH3A) and beta (IDH3B)subunits and the heterodimer composed of the alpha (IDH3A) andgamma (IDH3G) subunits, have considerable basal activity but thefull activity of the heterotetramer (containing two subunits ofIDH3A, one of IDH3B and one of IDH3G) requires the assembly andcooperative function of both heterodimers.{ECO:0000269|PubMed:28139779}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WDR76_IDH3A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_WDR76_ENST00000263795_chr15_44120564_+_IDH3A_ENST00000558554_chr15_78461264_+_182aa
MSRSGAAAEKADSRQRPQMKVNEYKENQNIAYVSLRPAQTTVLIKTAKVYLAPFSLSNYQLDQLMCPKSLSEKNSNNEVACKKTKIKKTC
RRIIPPKMKNTSSKAESTLQNSSSAVHTESNKLQPKRTADAMNLSVDVESSQDGDSDEDTTPSLSLTKDLGGNAKCSDFTEEICRRVKDL

>In-frame_WDR76_ENST00000381246_chr15_44120564_+_IDH3A_ENST00000558554_chr15_78461264_+_118aa
MCPKSLSEKNSNNEVACKKTKIKKTCRRIIPPKMKNTSSKAESTLQNSSSAVHTESNKLQPKRTADAMNLSVDVESSQDGDSDEDTTPSL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_WDR76_ENST00000263795_chr15_44120564_+_IDH3A_ENST00000558554_chr15_78461264_+_546nt
ATGTCCAGGTCGGGCGCGGCGGCTGAGAAGGCGGACTCCAGACAGCGACCCCAGATGAAGGTAAATGAATATAAAGAAAATCAAAACATC
GCTTATGTGTCTCTGAGACCAGCACAGACTACAGTTTTAATAAAAACAGCTAAGGTCTATCTTGCCCCCTTTTCACTCAGTAATTACCAG
CTAGACCAGCTTATGTGCCCCAAATCCCTATCAGAAAAGAATTCTAACAATGAAGTGGCGTGTAAGAAGACTAAAATAAAGAAAACTTGC
AGAAGGATTATACCTCCAAAGATGAAAAACACATCTTCCAAGGCAGAATCCACGCTGCAAAATTCATCCTCAGCTGTTCATACTGAAAGT
AACAAGCTACAACCCAAGAGAACGGCAGATGCGATGAATCTCAGTGTTGATGTGGAAAGTAGTCAGGATGGAGACAGTGATGAAGATACC
ACACCATCCCTGAGCTTGACAAAAGATTTGGGAGGCAATGCAAAATGCTCAGACTTCACAGAGGAAATCTGTCGCCGAGTAAAAGATTTA

>In-frame_WDR76_ENST00000381246_chr15_44120564_+_IDH3A_ENST00000558554_chr15_78461264_+_354nt
ATGTGCCCCAAATCCCTATCAGAAAAGAATTCTAACAATGAAGTGGCGTGTAAGAAGACTAAAATAAAGAAAACTTGCAGAAGGATTATA
CCTCCAAAGATGAAAAACACATCTTCCAAGGCAGAATCCACGCTGCAAAATTCATCCTCAGCTGTTCATACTGAAAGTAACAAGCTACAA
CCCAAGAGAACGGCAGATGCGATGAATCTCAGTGTTGATGTGGAAAGTAGTCAGGATGGAGACAGTGATGAAGATACCACACCATCCCTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_WDR76_ENST00000263795_chr15_44120564_+_IDH3A_ENST00000558554_chr15_78461264_+_1171nt
TCGGACCCGCCCCTCCCGGCCTCCCGCCGCAATCTTGGCGGGAAGGCGCCGGCCGCTAAGAAGCCGAAAGATGTCCAGGTCGGGCGCGGC
GGCTGAGAAGGCGGACTCCAGACAGCGACCCCAGATGAAGGTAAATGAATATAAAGAAAATCAAAACATCGCTTATGTGTCTCTGAGACC
AGCACAGACTACAGTTTTAATAAAAACAGCTAAGGTCTATCTTGCCCCCTTTTCACTCAGTAATTACCAGCTAGACCAGCTTATGTGCCC
CAAATCCCTATCAGAAAAGAATTCTAACAATGAAGTGGCGTGTAAGAAGACTAAAATAAAGAAAACTTGCAGAAGGATTATACCTCCAAA
GATGAAAAACACATCTTCCAAGGCAGAATCCACGCTGCAAAATTCATCCTCAGCTGTTCATACTGAAAGTAACAAGCTACAACCCAAGAG
AACGGCAGATGCGATGAATCTCAGTGTTGATGTGGAAAGTAGTCAGGATGGAGACAGTGATGAAGATACCACACCATCCCTGAGCTTGAC
AAAAGATTTGGGAGGCAATGCAAAATGCTCAGACTTCACAGAGGAAATCTGTCGCCGAGTAAAAGATTTAGATTAACACTTCTACAACTG
GCATTTACATCAGTCACTCTAAATGGACACCACATGAACCTCTGTTTAGAATACCTACGTATGTATGCATTGGTTTGCTTGTTTCTTGAC
AGTACATTTTTAGATCTGGCCTTTTCTTAACAAAATCTGTGCAAAAGATGCAGGTGGATGTCCCTAGGTCTGTTTTCAAAGAACTTTTTC
CAAGTGCTTGTTTTATTTATTAAGTGTCTACCTGGTAAATGTTTTTTTTGTAAACTCTGAGTGGACTGTATCATTTGCTATTCTAAACCA
TTTTACACTTAAGTTAAAATAGTTTCTCTTCAGCTGTAAATAACAGGATACAGAATTAACAAGAGAAAATGTCTAACTTTTTAAGAAAAA
CCTTATTTTCTTCGGTTTTTGAAAAACATAATGGAAATAAAACAGGATATTGACATAATAGCACAAAATGACACTCTTCTAAAACTAAAT
GGGCACAAGAGAATTTTCCTGGGAAAGTTCACATCAAAAAGAGTGAATGTGGTATATTTCTAAATGATATGGAAAATAGAGACAGATTTG

>In-frame_WDR76_ENST00000381246_chr15_44120564_+_IDH3A_ENST00000558554_chr15_78461264_+_1180nt
GGCCTCCCGCCGCAATCTTGGCGGGAAGGCGCCGGCCGCTAAGAAGCCGAAAGATGTCCAGGTCGGGCGCGGCGGCTGAGAAGGCGGACT
CCAGACAGCGACCCCAGATGAAGGTGAGAAACGGACTGGTGCTTCCAAGGTAAATGAATATAAAGAAAATCAAAACATCGCTTATGTGTC
TCTGAGACCAGCACAGACTACAGTTTTAATAAAAACAGCTAAGGTCTATCTTGCCCCCTTTTCACTCAGTAATTACCAGCTAGACCAGCT
TATGTGCCCCAAATCCCTATCAGAAAAGAATTCTAACAATGAAGTGGCGTGTAAGAAGACTAAAATAAAGAAAACTTGCAGAAGGATTAT
ACCTCCAAAGATGAAAAACACATCTTCCAAGGCAGAATCCACGCTGCAAAATTCATCCTCAGCTGTTCATACTGAAAGTAACAAGCTACA
ACCCAAGAGAACGGCAGATGCGATGAATCTCAGTGTTGATGTGGAAAGTAGTCAGGATGGAGACAGTGATGAAGATACCACACCATCCCT
GAGCTTGACAAAAGATTTGGGAGGCAATGCAAAATGCTCAGACTTCACAGAGGAAATCTGTCGCCGAGTAAAAGATTTAGATTAACACTT
CTACAACTGGCATTTACATCAGTCACTCTAAATGGACACCACATGAACCTCTGTTTAGAATACCTACGTATGTATGCATTGGTTTGCTTG
TTTCTTGACAGTACATTTTTAGATCTGGCCTTTTCTTAACAAAATCTGTGCAAAAGATGCAGGTGGATGTCCCTAGGTCTGTTTTCAAAG
AACTTTTTCCAAGTGCTTGTTTTATTTATTAAGTGTCTACCTGGTAAATGTTTTTTTTGTAAACTCTGAGTGGACTGTATCATTTGCTAT
TCTAAACCATTTTACACTTAAGTTAAAATAGTTTCTCTTCAGCTGTAAATAACAGGATACAGAATTAACAAGAGAAAATGTCTAACTTTT
TAAGAAAAACCTTATTTTCTTCGGTTTTTGAAAAACATAATGGAAATAAAACAGGATATTGACATAATAGCACAAAATGACACTCTTCTA
AAACTAAATGGGCACAAGAGAATTTTCCTGGGAAAGTTCACATCAAAAAGAGTGAATGTGGTATATTTCTAAATGATATGGAAAATAGAG


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FusionGenePPI for WDR76_IDH3A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WDR76CUL4A, CUL4B, CUL3, HELLS, SRRM2, CCT2, XRCC6, XRCC5, ZC3HAV1, GNB2L1, SUGT1, RPSA, HSP90AA1, PARP1, BAG2, CCT7, CCT8, CCT5, CCT3, PPIB, LRRC59, CCT4, NUDT21, FXR1, C1QBP, HMGB1, RPS23, RPL22, SSRP1, RPS18, RPS25, FEN1, RPS17, SPIN2B, PCGF6, GFOD1, HIST1H2BG, HIST1H3A, CAPZA2, EZH2, MYH9, AP4M1, C10orf12, GAN, CAMK2D, IKZF1, IMPDH1, PARP2, SUPT16H, HIST2H3PS2, XPC, SSSCA1, LIG3IDH3ADMWD, DDA1, PSMD4, TERF1, TERF2, MYC, S100A16, UQCRFS1P1, SUCLA2, ADRB2, MBNL1, RAB4A, STAU1, HUWE1, CUL7, EGFR, IDH3B, RDH13, IDH3G, ABCC1, ABCC3, ACO2, ACTN4, ATP2B1, CCT8, HDHD1, IDH1, ACADM, CAD, CANX, CCT6A, CCT6B, CLTCL1, CS, EPRS, ETFA, IDH2, MDH2, PPP2R1A, PSMC5, RPLP0, RPN1, SLC25A3, SUCLG2, IPO9, PSMD2, UBE2N, UQCRC2, NFATC2, DLD, SDHA, SOD1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WDR76_IDH3A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneIDH3AP50213DB09092XanthinolIsocitrate dehydrogenase [NAD] subunit alpha, mitochondrialsmall moleculeapproved|withdrawn

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RelatedDiseases for WDR76_IDH3A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIDH3AC0029408Degenerative polyarthritis1CTD_human