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Fusion gene ID: 4193 |
FusionGeneSummary for BIRC6_MATN3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BIRC6_MATN3 | Fusion gene ID: 4193 | Hgene | Tgene | Gene symbol | BIRC6 | MATN3 | Gene ID | 57448 | 4148 |
| Gene name | baculoviral IAP repeat containing 6 | matrilin 3 | |
| Synonyms | APOLLON|BRUCE | DIPOA|EDM5|HOA|OADIP|OS2 | |
| Cytomap | 2p22.3 | 2p24.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | baculoviral IAP repeat-containing protein 6BIR repeat-containing ubiquitin-conjugating enzymeRING-type E3 ubiquitin transferase BIRC6ubiquitin-conjugating BIR-domain enzyme apollon | matrilin-3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9NR09 | O15232 | |
| Ensembl transtripts involved in fusion gene | ENST00000421745, | ENST00000407540, ENST00000421259, | |
| Fusion gene scores | * DoF score | 16 X 15 X 12=2880 | 1 X 1 X 1=1 |
| # samples | 19 | 1 | |
| ** MAII score | log2(19/2880*10)=-3.92199748799873 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: BIRC6 [Title/Abstract] AND MATN3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-EO-A3KW-01A | BIRC6 | chr2 | 32641231 | + | MATN3 | chr2 | 20206071 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000421745 | ENST00000407540 | BIRC6 | chr2 | 32641231 | + | MATN3 | chr2 | 20206071 | - |
| In-frame | ENST00000421745 | ENST00000421259 | BIRC6 | chr2 | 32641231 | + | MATN3 | chr2 | 20206071 | - |
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FusionProtFeatures for BIRC6_MATN3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BIRC6 | MATN3 |
| Anti-apoptotic protein which can regulate cell death bycontrolling caspases and by acting as an E3 ubiquitin-proteinligase. Has an unusual ubiquitin conjugation system in that itcould combine in a single polypeptide, ubiquitin conjugating (E2)with ubiquitin ligase (E3) activity, forming a chimeric E2/E3ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Actsas an inhibitor of CASP3, CASP7 and CASP9. Important regulator forthe final stages of cytokinesis. Crucial for normal vesicletargeting to the site of abscission, but also for the integrity ofthe midbody and the midbody ring, and its striking ubiquitinmodification. {ECO:0000269|PubMed:14765125,ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369}. | Major component of the extracellular matrix of cartilageand may play a role in the formation of extracellular filamentousnetworks. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | BIRC6 | chr2:32641231 | chr2:20206071 | ENST00000421745 | + | 10 | 74 | 30_36 | 957 | 4858 | Compositional bias | Note=Poly-Ala |
| Hgene | BIRC6 | chr2:32641231 | chr2:20206071 | ENST00000421745 | + | 10 | 74 | 284_358 | 957 | 4858 | Repeat | Note=BIR |
| Tgene | >MATN3 | chr2:32641231 | chr2:20206071 | ENST00000407540 | - | 0 | 8 | 456_480 | 74 | 487 | Coiled coil | Ontology_term=ECO:0000250 |
| Tgene | >MATN3 | chr2:32641231 | chr2:20206071 | ENST00000407540 | - | 0 | 8 | 264_305 | 74 | 487 | Domain | EGF-like 1 |
| Tgene | >MATN3 | chr2:32641231 | chr2:20206071 | ENST00000407540 | - | 0 | 8 | 306_347 | 74 | 487 | Domain | EGF-like 2 |
| Tgene | >MATN3 | chr2:32641231 | chr2:20206071 | ENST00000407540 | - | 0 | 8 | 348_389 | 74 | 487 | Domain | EGF-like 3 |
| Tgene | >MATN3 | chr2:32641231 | chr2:20206071 | ENST00000407540 | - | 0 | 8 | 390_431 | 74 | 487 | Domain | EGF-like 4 |
| Tgene | >MATN3 | chr2:32641231 | chr2:20206071 | ENST00000407540 | - | 0 | 8 | 83_258 | 74 | 487 | Domain | VWFA |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >BIRC6 | chr2:32641231 | chr2:20206071 | ENST00000421745 | + | 10 | 74 | 1660_1668 | 957 | 4858 | Compositional bias | Note=Poly-Ala |
| Hgene | >BIRC6 | chr2:32641231 | chr2:20206071 | ENST00000421745 | + | 10 | 74 | 4576_4704 | 957 | 4858 | Region | Note=Ubiquitin-conjugating |
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FusionGeneSequence for BIRC6_MATN3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_BIRC6_ENST00000421745_chr2_32641231_+_MATN3_ENST00000407540_chr2_20206071_-_1370aa MVTGGGAAPPGTVTEPLPSVIVLSAGRKMAAAAAAASGPGCSSAAGAGAAGVSEWLVLRDGCMHCDADGLHSLSYHPALNAILAVTSRGT IKVIDGTSGATLQASALSAKPGGQVKCQYISAVDKVIFVDDYAVGCRKDLNGILLLDTALQTPVSKQDDVVQLELPVTEAQQLLSACLEK VDISSTEGYDLFITQLKDGLKNTSHETAANHKVAKWATVTFHLPHHVLKSIASAIVNELKKINQNVAALPVASSVMDRLSYLLPSARPEL GVGPGRSVDRSLMYSEANRRETFTSWPHVGYRWAQPDPMAQAGFYHQPASSGDDRAMCFTCSVCLVCWEPTDEPWSEHERHSPNCPFVKG EHTQNVPLSVTLATSPAQFPCTDGTDRISCFGSGSCPHFLAAATKRGKICIWDVSKLMKVHLKFEINAYDPAIVQQLILSGDPSSGVDSR RPTLAWLEDSSSCSDIPKLEGDSDDLLEDSDSEEHSRSDSVTGHTSQKEAMEVSLDITALSILQQPEKLQWEIVANVLEDTVKDLEELGA NPCLTNSKSEKTKEKHQEQHNIPFPCLLAGGLLTYKSPATSPISSNSHRSLDGLSRTQGESISEQGSTDNESCTNSELNSPLVRRTLPVL LLYSIKESDEKAGKIFSQMNNIMSKSLHDDGFTVPQIIEMELDSQEQLLLQDPPVTYIQQFADAAANLTSPDSEKWNSVFPKPGTLVQCL RLPKFAEEENLCIDSITPCADGIHLLVGLRTCPVESLSAINQVEALNNLNKLNSALCNRRKGELESNLAVVNGANISVIQHESPADVQTP LIIQPEQRNVSGGYLVLYKMNYATRIVTLEEEPIKIQHIKDPQDTITSLILLPPDILDNREDDCEEPIEDMQLTSKNGFEREKTSDISTL GHLVITTQGGYVKILDLSNFEILAKVEPPKKEGTEEQDTFVSVIYCSGTDRLCACTKGVCKSRPLDLVFIIDSSRSVRPLEFTKVKTFVS RIIDTLDIGPADTRVAVVNYASTVKIEFQLQAYTDKQSLKQAVGRITPLSTGTMSGLAIQTAMDEAFTVEAGAREPSSNIPKVAIIVTDG RPQDQVNEVAARAQASGIELYAVGVDRADMASLKMMASEPLEEHVFYVETYGVIEKLSSRFQETFCALDPCVLGTHQCQHVCISDGEGKH HCECSQGYTLNADKKTCSALDRCALNTHGCEHICVNDRSGSYHCECYEGYTLNEDRKTCSAQDKCALGTHGCQHICVNDRTGSHHCECYE GYTLNADKKTCSVRDKCALGSHGCQHICVSDGAASYHCDCYPGYTLNEDKKTCSATEEARRLVSTEDACGCEATLAFQDKVSSYLQRLNT >In-frame_BIRC6_ENST00000421745_chr2_32641231_+_MATN3_ENST00000421259_chr2_20206071_-_1328aa MVTGGGAAPPGTVTEPLPSVIVLSAGRKMAAAAAAASGPGCSSAAGAGAAGVSEWLVLRDGCMHCDADGLHSLSYHPALNAILAVTSRGT IKVIDGTSGATLQASALSAKPGGQVKCQYISAVDKVIFVDDYAVGCRKDLNGILLLDTALQTPVSKQDDVVQLELPVTEAQQLLSACLEK VDISSTEGYDLFITQLKDGLKNTSHETAANHKVAKWATVTFHLPHHVLKSIASAIVNELKKINQNVAALPVASSVMDRLSYLLPSARPEL GVGPGRSVDRSLMYSEANRRETFTSWPHVGYRWAQPDPMAQAGFYHQPASSGDDRAMCFTCSVCLVCWEPTDEPWSEHERHSPNCPFVKG EHTQNVPLSVTLATSPAQFPCTDGTDRISCFGSGSCPHFLAAATKRGKICIWDVSKLMKVHLKFEINAYDPAIVQQLILSGDPSSGVDSR RPTLAWLEDSSSCSDIPKLEGDSDDLLEDSDSEEHSRSDSVTGHTSQKEAMEVSLDITALSILQQPEKLQWEIVANVLEDTVKDLEELGA NPCLTNSKSEKTKEKHQEQHNIPFPCLLAGGLLTYKSPATSPISSNSHRSLDGLSRTQGESISEQGSTDNESCTNSELNSPLVRRTLPVL LLYSIKESDEKAGKIFSQMNNIMSKSLHDDGFTVPQIIEMELDSQEQLLLQDPPVTYIQQFADAAANLTSPDSEKWNSVFPKPGTLVQCL RLPKFAEEENLCIDSITPCADGIHLLVGLRTCPVESLSAINQVEALNNLNKLNSALCNRRKGELESNLAVVNGANISVIQHESPADVQTP LIIQPEQRNVSGGYLVLYKMNYATRIVTLEEEPIKIQHIKDPQDTITSLILLPPDILDNREDDCEEPIEDMQLTSKNGFEREKTSDISTL GHLVITTQGGYVKILDLSNFEILAKVEPPKKEGTEEQDTFVSVIYCSGTDRLCACTKGVCKSRPLDLVFIIDSSRSVRPLEFTKVKTFVS RIIDTLDIGPADTRVAVVNYASTVKIEFQLQAYTDKQSLKQAVGRITPLSTGTMSGLAIQTAMDEAFTVEAGAREPSSNIPKVAIIVTDG RPQDQVNEVAARAQASGIELYAVGVDRADMASLKMMASEPLEEHVFYVETYGVIEKLSSRFQETFCALDRCALNTHGCEHICVNDRSGSY HCECYEGYTLNEDRKTCSAQDKCALGTHGCQHICVNDRTGSHHCECYEGYTLNADKKTCSVRDKCALGSHGCQHICVSDGAASYHCDCYP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_BIRC6_ENST00000421745_chr2_32641231_+_MATN3_ENST00000407540_chr2_20206071_-_4110nt ATGGTGACTGGTGGTGGTGCTGCACCTCCCGGGACTGTCACTGAGCCGCTTCCCAGTGTGATTGTGCTGAGCGCAGGCCGGAAGATGGCG GCTGCGGCTGCGGCGGCCTCGGGCCCCGGCTGCTCCTCGGCGGCGGGGGCGGGGGCGGCCGGGGTCTCAGAGTGGCTGGTGCTGCGGGAC GGCTGCATGCACTGCGACGCCGACGGGCTGCACAGCCTGTCCTACCACCCTGCGCTCAACGCCATCCTGGCCGTCACTAGCCGCGGGACC ATCAAAGTCATCGACGGCACCTCGGGGGCCACACTGCAGGCCTCCGCGCTCAGTGCTAAACCAGGTGGACAGGTGAAATGTCAGTATATC TCTGCTGTGGATAAAGTTATATTTGTGGATGATTATGCAGTAGGGTGTAGGAAGGACCTTAATGGAATCTTGTTGTTAGACACTGCTCTG CAAACTCCAGTTTCAAAGCAGGATGATGTGGTTCAGCTTGAATTACCCGTTACAGAGGCACAGCAGCTCTTATCAGCATGTTTAGAAAAG GTAGATATTTCTAGTACAGAGGGTTATGATTTGTTCATCACACAGCTCAAAGATGGTTTAAAAAATACATCTCATGAGACTGCAGCAAAC CACAAAGTTGCTAAGTGGGCCACAGTTACATTTCATCTTCCTCATCATGTGTTGAAGTCCATTGCCAGTGCCATTGTAAATGAACTCAAG AAAATAAATCAAAATGTTGCTGCCTTACCTGTGGCGTCCTCAGTGATGGACAGATTGTCTTACCTCTTACCTAGTGCACGTCCAGAACTC GGAGTGGGGCCAGGCCGTTCTGTAGACAGATCACTGATGTATAGTGAAGCTAACAGACGGGAGACATTTACCTCATGGCCTCATGTAGGC TATAGGTGGGCACAACCAGATCCCATGGCTCAAGCTGGATTTTATCATCAGCCTGCCTCATCTGGAGATGATAGAGCCATGTGTTTTACT TGTAGTGTATGCCTCGTTTGTTGGGAACCTACTGATGAACCTTGGTCTGAACACGAAAGACATTCCCCAAACTGCCCATTTGTGAAAGGT GAGCACACACAGAATGTGCCATTGTCAGTCACTCTTGCAACAAGTCCTGCACAGTTTCCTTGTACGGATGGAACTGACAGAATATCTTGC TTTGGGTCGGGGAGCTGCCCTCATTTTCTAGCTGCTGCAACTAAACGAGGAAAGATCTGCATATGGGATGTTTCCAAACTTATGAAGGTG CACTTAAAGTTTGAAATTAATGCCTATGATCCAGCAATTGTACAACAGCTTATTCTATCAGGAGACCCAAGCTCAGGAGTTGATTCAAGG AGACCAACTTTGGCGTGGCTGGAGGACTCCTCTAGTTGCTCAGATATACCAAAATTGGAAGGAGATAGTGATGATTTACTGGAGGATTCA GACAGTGAAGAGCATTCCAGATCAGATTCTGTGACAGGGCATACATCACAGAAGGAAGCCATGGAAGTAAGCCTTGATATAACAGCACTC AGCATTCTCCAACAGCCAGAAAAACTTCAGTGGGAGATTGTTGCAAATGTGCTTGAAGATACTGTTAAGGATCTTGAAGAACTTGGGGCA AATCCTTGTTTAACAAACTCTAAGAGTGAAAAGACAAAGGAAAAGCACCAGGAGCAACACAACATTCCTTTTCCATGTTTATTAGCTGGA GGTTTATTAACATATAAATCTCCTGCTACCTCACCCATTAGTAGTAATTCTCACAGGTCACTGGATGGTTTAAGCAGAACTCAGGGTGAA AGTATATCAGAACAAGGGTCAACTGACAATGAATCCTGCACTAATTCAGAACTAAATTCTCCTCTGGTAAGGAGGACTTTACCGGTTTTG CTTCTTTATAGCATCAAGGAATCTGATGAGAAAGCAGGAAAGATCTTTTCACAGATGAACAATATTATGAGTAAAAGTTTGCATGATGAT GGTTTTACTGTTCCACAGATTATTGAAATGGAGCTGGATAGTCAGGAGCAGTTGTTATTGCAGGATCCTCCTGTGACTTACATTCAGCAA TTTGCAGATGCAGCAGCCAACCTTACCTCTCCGGATTCTGAGAAGTGGAACTCTGTGTTTCCCAAGCCTGGGACTTTGGTTCAGTGCTTG AGGCTGCCAAAGTTTGCAGAGGAGGAGAATCTTTGTATAGACTCAATAACTCCTTGTGCTGACGGAATTCATTTGTTGGTAGGACTGCGG ACATGCCCTGTTGAATCCTTGAGTGCAATAAATCAAGTAGAGGCCTTGAATAATTTAAATAAATTAAACTCTGCACTATGTAATAGACGG AAAGGTGAGCTGGAATCAAATCTTGCTGTAGTGAATGGTGCAAATATTAGTGTAATCCAACATGAATCACCAGCAGATGTACAGACTCCT TTAATAATTCAGCCTGAGCAGAGGAATGTTAGTGGTGGATATTTAGTGCTTTATAAAATGAATTATGCCACTCGGATAGTGACTTTAGAA GAGGAGCCAATAAAAATACAACATATCAAAGATCCCCAGGACACAATTACCTCGCTCATTTTGCTTCCACCCGATATATTGGATAATCGA GAGGATGACTGTGAGGAACCTATTGAGGACATGCAGTTAACCTCAAAGAATGGTTTTGAGAGAGAAAAAACGTCTGACATTTCTACTCTT GGACACCTGGTAATAACCACTCAGGGAGGATATGTAAAAATACTAGATCTTTCAAACTTTGAAATTTTGGCCAAAGTGGAGCCTCCCAAA AAGGAGGGCACTGAGGAACAGGACACATTTGTTTCTGTGATTTACTGTTCTGGCACAGACAGGCTGTGTGCATGCACCAAAGGTGTTTGC AAGAGCAGACCCTTGGACCTGGTGTTTATCATTGATAGTTCTCGTAGCGTACGGCCCCTGGAATTCACCAAAGTGAAAACTTTTGTCTCC CGGATAATCGACACTCTGGACATTGGGCCAGCCGACACGCGGGTGGCAGTGGTGAACTATGCTAGCACTGTGAAGATCGAGTTCCAACTC CAGGCCTACACAGATAAGCAGTCCCTGAAGCAGGCCGTGGGTCGAATCACACCCTTGTCAACAGGCACCATGTCAGGCCTAGCCATCCAG ACAGCAATGGACGAAGCCTTCACAGTGGAGGCAGGGGCTCGAGAGCCCTCTTCTAACATCCCTAAGGTGGCCATCATTGTTACAGATGGG AGGCCCCAGGACCAGGTGAATGAGGTGGCGGCTCGGGCCCAAGCATCTGGTATTGAGCTCTATGCTGTGGGCGTGGACCGGGCAGACATG GCGTCCCTCAAGATGATGGCCAGTGAGCCCCTAGAGGAGCATGTTTTCTACGTGGAGACCTATGGGGTCATTGAGAAACTTTCCTCTAGA TTCCAGGAAACCTTCTGTGCGCTGGACCCCTGTGTGCTTGGAACACACCAGTGCCAGCACGTCTGCATCAGTGATGGGGAAGGCAAGCAC CACTGTGAGTGTAGCCAAGGATACACCTTGAATGCCGACAAGAAAACGTGTTCAGCTCTTGATAGGTGTGCTCTTAACACCCACGGATGT GAGCACATCTGTGTGAATGACAGAAGTGGCTCTTATCATTGTGAGTGCTATGAAGGTTATACCTTGAATGAAGACAGGAAAACTTGTTCA GCTCAAGATAAATGTGCTTTGGGTACCCATGGGTGTCAGCACATTTGTGTGAATGACAGAACAGGGTCCCATCATTGTGAATGCTATGAG GGCTACACTCTGAATGCAGATAAAAAAACATGTTCAGTCCGTGACAAGTGTGCCCTAGGCTCTCATGGTTGCCAGCACATTTGTGTGAGT GATGGGGCCGCATCCTACCACTGTGATTGCTATCCTGGCTACACCTTAAATGAGGACAAGAAAACATGTTCAGCCACTGAGGAAGCACGA AGACTTGTTTCCACTGAAGATGCTTGTGGATGTGAAGCTACACTGGCATTCCAGGACAAGGTCAGCTCGTATCTTCAAAGACTGAACACT >In-frame_BIRC6_ENST00000421745_chr2_32641231_+_MATN3_ENST00000421259_chr2_20206071_-_3984nt ATGGTGACTGGTGGTGGTGCTGCACCTCCCGGGACTGTCACTGAGCCGCTTCCCAGTGTGATTGTGCTGAGCGCAGGCCGGAAGATGGCG GCTGCGGCTGCGGCGGCCTCGGGCCCCGGCTGCTCCTCGGCGGCGGGGGCGGGGGCGGCCGGGGTCTCAGAGTGGCTGGTGCTGCGGGAC GGCTGCATGCACTGCGACGCCGACGGGCTGCACAGCCTGTCCTACCACCCTGCGCTCAACGCCATCCTGGCCGTCACTAGCCGCGGGACC ATCAAAGTCATCGACGGCACCTCGGGGGCCACACTGCAGGCCTCCGCGCTCAGTGCTAAACCAGGTGGACAGGTGAAATGTCAGTATATC TCTGCTGTGGATAAAGTTATATTTGTGGATGATTATGCAGTAGGGTGTAGGAAGGACCTTAATGGAATCTTGTTGTTAGACACTGCTCTG CAAACTCCAGTTTCAAAGCAGGATGATGTGGTTCAGCTTGAATTACCCGTTACAGAGGCACAGCAGCTCTTATCAGCATGTTTAGAAAAG GTAGATATTTCTAGTACAGAGGGTTATGATTTGTTCATCACACAGCTCAAAGATGGTTTAAAAAATACATCTCATGAGACTGCAGCAAAC CACAAAGTTGCTAAGTGGGCCACAGTTACATTTCATCTTCCTCATCATGTGTTGAAGTCCATTGCCAGTGCCATTGTAAATGAACTCAAG AAAATAAATCAAAATGTTGCTGCCTTACCTGTGGCGTCCTCAGTGATGGACAGATTGTCTTACCTCTTACCTAGTGCACGTCCAGAACTC GGAGTGGGGCCAGGCCGTTCTGTAGACAGATCACTGATGTATAGTGAAGCTAACAGACGGGAGACATTTACCTCATGGCCTCATGTAGGC TATAGGTGGGCACAACCAGATCCCATGGCTCAAGCTGGATTTTATCATCAGCCTGCCTCATCTGGAGATGATAGAGCCATGTGTTTTACT TGTAGTGTATGCCTCGTTTGTTGGGAACCTACTGATGAACCTTGGTCTGAACACGAAAGACATTCCCCAAACTGCCCATTTGTGAAAGGT GAGCACACACAGAATGTGCCATTGTCAGTCACTCTTGCAACAAGTCCTGCACAGTTTCCTTGTACGGATGGAACTGACAGAATATCTTGC TTTGGGTCGGGGAGCTGCCCTCATTTTCTAGCTGCTGCAACTAAACGAGGAAAGATCTGCATATGGGATGTTTCCAAACTTATGAAGGTG CACTTAAAGTTTGAAATTAATGCCTATGATCCAGCAATTGTACAACAGCTTATTCTATCAGGAGACCCAAGCTCAGGAGTTGATTCAAGG AGACCAACTTTGGCGTGGCTGGAGGACTCCTCTAGTTGCTCAGATATACCAAAATTGGAAGGAGATAGTGATGATTTACTGGAGGATTCA GACAGTGAAGAGCATTCCAGATCAGATTCTGTGACAGGGCATACATCACAGAAGGAAGCCATGGAAGTAAGCCTTGATATAACAGCACTC AGCATTCTCCAACAGCCAGAAAAACTTCAGTGGGAGATTGTTGCAAATGTGCTTGAAGATACTGTTAAGGATCTTGAAGAACTTGGGGCA AATCCTTGTTTAACAAACTCTAAGAGTGAAAAGACAAAGGAAAAGCACCAGGAGCAACACAACATTCCTTTTCCATGTTTATTAGCTGGA GGTTTATTAACATATAAATCTCCTGCTACCTCACCCATTAGTAGTAATTCTCACAGGTCACTGGATGGTTTAAGCAGAACTCAGGGTGAA AGTATATCAGAACAAGGGTCAACTGACAATGAATCCTGCACTAATTCAGAACTAAATTCTCCTCTGGTAAGGAGGACTTTACCGGTTTTG CTTCTTTATAGCATCAAGGAATCTGATGAGAAAGCAGGAAAGATCTTTTCACAGATGAACAATATTATGAGTAAAAGTTTGCATGATGAT GGTTTTACTGTTCCACAGATTATTGAAATGGAGCTGGATAGTCAGGAGCAGTTGTTATTGCAGGATCCTCCTGTGACTTACATTCAGCAA TTTGCAGATGCAGCAGCCAACCTTACCTCTCCGGATTCTGAGAAGTGGAACTCTGTGTTTCCCAAGCCTGGGACTTTGGTTCAGTGCTTG AGGCTGCCAAAGTTTGCAGAGGAGGAGAATCTTTGTATAGACTCAATAACTCCTTGTGCTGACGGAATTCATTTGTTGGTAGGACTGCGG ACATGCCCTGTTGAATCCTTGAGTGCAATAAATCAAGTAGAGGCCTTGAATAATTTAAATAAATTAAACTCTGCACTATGTAATAGACGG AAAGGTGAGCTGGAATCAAATCTTGCTGTAGTGAATGGTGCAAATATTAGTGTAATCCAACATGAATCACCAGCAGATGTACAGACTCCT TTAATAATTCAGCCTGAGCAGAGGAATGTTAGTGGTGGATATTTAGTGCTTTATAAAATGAATTATGCCACTCGGATAGTGACTTTAGAA GAGGAGCCAATAAAAATACAACATATCAAAGATCCCCAGGACACAATTACCTCGCTCATTTTGCTTCCACCCGATATATTGGATAATCGA GAGGATGACTGTGAGGAACCTATTGAGGACATGCAGTTAACCTCAAAGAATGGTTTTGAGAGAGAAAAAACGTCTGACATTTCTACTCTT GGACACCTGGTAATAACCACTCAGGGAGGATATGTAAAAATACTAGATCTTTCAAACTTTGAAATTTTGGCCAAAGTGGAGCCTCCCAAA AAGGAGGGCACTGAGGAACAGGACACATTTGTTTCTGTGATTTACTGTTCTGGCACAGACAGGCTGTGTGCATGCACCAAAGGTGTTTGC AAGAGCAGACCCTTGGACCTGGTGTTTATCATTGATAGTTCTCGTAGCGTACGGCCCCTGGAATTCACCAAAGTGAAAACTTTTGTCTCC CGGATAATCGACACTCTGGACATTGGGCCAGCCGACACGCGGGTGGCAGTGGTGAACTATGCTAGCACTGTGAAGATCGAGTTCCAACTC CAGGCCTACACAGATAAGCAGTCCCTGAAGCAGGCCGTGGGTCGAATCACACCCTTGTCAACAGGCACCATGTCAGGCCTAGCCATCCAG ACAGCAATGGACGAAGCCTTCACAGTGGAGGCAGGGGCTCGAGAGCCCTCTTCTAACATCCCTAAGGTGGCCATCATTGTTACAGATGGG AGGCCCCAGGACCAGGTGAATGAGGTGGCGGCTCGGGCCCAAGCATCTGGTATTGAGCTCTATGCTGTGGGCGTGGACCGGGCAGACATG GCGTCCCTCAAGATGATGGCCAGTGAGCCCCTAGAGGAGCATGTTTTCTACGTGGAGACCTATGGGGTCATTGAGAAACTTTCCTCTAGA TTCCAGGAAACCTTCTGTGCTCTTGATAGGTGTGCTCTTAACACCCACGGATGTGAGCACATCTGTGTGAATGACAGAAGTGGCTCTTAT CATTGTGAGTGCTATGAAGGTTATACCTTGAATGAAGACAGGAAAACTTGTTCAGCTCAAGATAAATGTGCTTTGGGTACCCATGGGTGT CAGCACATTTGTGTGAATGACAGAACAGGGTCCCATCATTGTGAATGCTATGAGGGCTACACTCTGAATGCAGATAAAAAAACATGTTCA GTCCGTGACAAGTGTGCCCTAGGCTCTCATGGTTGCCAGCACATTTGTGTGAGTGATGGGGCCGCATCCTACCACTGTGATTGCTATCCT GGCTACACCTTAAATGAGGACAAGAAAACATGTTCAGCCACTGAGGAAGCACGAAGACTTGTTTCCACTGAAGATGCTTGTGGATGTGAA GCTACACTGGCATTCCAGGACAAGGTCAGCTCGTATCTTCAAAGACTGAACACTAAACTTGATGACATTTTGGAGAAGTTGAAAATAAAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_BIRC6_ENST00000421745_chr2_32641231_+_MATN3_ENST00000407540_chr2_20206071_-_5244nt TCCCTGCTTCTCCCCCTCTCCCGTCAGCCTCCCTCCGAGTTTGGCCCCTCCGGCCGGGCGATCGACGTTCCGCGTGCGTGCGGGCGCCTG ACTTCACTTCCGGCTAACGCGCTCGGCTTGCCCCCTGGCCCCGGATGGTGACTGGTGGTGGTGCTGCACCTCCCGGGACTGTCACTGAGC CGCTTCCCAGTGTGATTGTGCTGAGCGCAGGCCGGAAGATGGCGGCTGCGGCTGCGGCGGCCTCGGGCCCCGGCTGCTCCTCGGCGGCGG GGGCGGGGGCGGCCGGGGTCTCAGAGTGGCTGGTGCTGCGGGACGGCTGCATGCACTGCGACGCCGACGGGCTGCACAGCCTGTCCTACC ACCCTGCGCTCAACGCCATCCTGGCCGTCACTAGCCGCGGGACCATCAAAGTCATCGACGGCACCTCGGGGGCCACACTGCAGGCCTCCG CGCTCAGTGCTAAACCAGGTGGACAGGTGAAATGTCAGTATATCTCTGCTGTGGATAAAGTTATATTTGTGGATGATTATGCAGTAGGGT GTAGGAAGGACCTTAATGGAATCTTGTTGTTAGACACTGCTCTGCAAACTCCAGTTTCAAAGCAGGATGATGTGGTTCAGCTTGAATTAC CCGTTACAGAGGCACAGCAGCTCTTATCAGCATGTTTAGAAAAGGTAGATATTTCTAGTACAGAGGGTTATGATTTGTTCATCACACAGC TCAAAGATGGTTTAAAAAATACATCTCATGAGACTGCAGCAAACCACAAAGTTGCTAAGTGGGCCACAGTTACATTTCATCTTCCTCATC ATGTGTTGAAGTCCATTGCCAGTGCCATTGTAAATGAACTCAAGAAAATAAATCAAAATGTTGCTGCCTTACCTGTGGCGTCCTCAGTGA TGGACAGATTGTCTTACCTCTTACCTAGTGCACGTCCAGAACTCGGAGTGGGGCCAGGCCGTTCTGTAGACAGATCACTGATGTATAGTG AAGCTAACAGACGGGAGACATTTACCTCATGGCCTCATGTAGGCTATAGGTGGGCACAACCAGATCCCATGGCTCAAGCTGGATTTTATC ATCAGCCTGCCTCATCTGGAGATGATAGAGCCATGTGTTTTACTTGTAGTGTATGCCTCGTTTGTTGGGAACCTACTGATGAACCTTGGT CTGAACACGAAAGACATTCCCCAAACTGCCCATTTGTGAAAGGTGAGCACACACAGAATGTGCCATTGTCAGTCACTCTTGCAACAAGTC CTGCACAGTTTCCTTGTACGGATGGAACTGACAGAATATCTTGCTTTGGGTCGGGGAGCTGCCCTCATTTTCTAGCTGCTGCAACTAAAC GAGGAAAGATCTGCATATGGGATGTTTCCAAACTTATGAAGGTGCACTTAAAGTTTGAAATTAATGCCTATGATCCAGCAATTGTACAAC AGCTTATTCTATCAGGAGACCCAAGCTCAGGAGTTGATTCAAGGAGACCAACTTTGGCGTGGCTGGAGGACTCCTCTAGTTGCTCAGATA TACCAAAATTGGAAGGAGATAGTGATGATTTACTGGAGGATTCAGACAGTGAAGAGCATTCCAGATCAGATTCTGTGACAGGGCATACAT CACAGAAGGAAGCCATGGAAGTAAGCCTTGATATAACAGCACTCAGCATTCTCCAACAGCCAGAAAAACTTCAGTGGGAGATTGTTGCAA ATGTGCTTGAAGATACTGTTAAGGATCTTGAAGAACTTGGGGCAAATCCTTGTTTAACAAACTCTAAGAGTGAAAAGACAAAGGAAAAGC ACCAGGAGCAACACAACATTCCTTTTCCATGTTTATTAGCTGGAGGTTTATTAACATATAAATCTCCTGCTACCTCACCCATTAGTAGTA ATTCTCACAGGTCACTGGATGGTTTAAGCAGAACTCAGGGTGAAAGTATATCAGAACAAGGGTCAACTGACAATGAATCCTGCACTAATT CAGAACTAAATTCTCCTCTGGTAAGGAGGACTTTACCGGTTTTGCTTCTTTATAGCATCAAGGAATCTGATGAGAAAGCAGGAAAGATCT TTTCACAGATGAACAATATTATGAGTAAAAGTTTGCATGATGATGGTTTTACTGTTCCACAGATTATTGAAATGGAGCTGGATAGTCAGG AGCAGTTGTTATTGCAGGATCCTCCTGTGACTTACATTCAGCAATTTGCAGATGCAGCAGCCAACCTTACCTCTCCGGATTCTGAGAAGT GGAACTCTGTGTTTCCCAAGCCTGGGACTTTGGTTCAGTGCTTGAGGCTGCCAAAGTTTGCAGAGGAGGAGAATCTTTGTATAGACTCAA TAACTCCTTGTGCTGACGGAATTCATTTGTTGGTAGGACTGCGGACATGCCCTGTTGAATCCTTGAGTGCAATAAATCAAGTAGAGGCCT TGAATAATTTAAATAAATTAAACTCTGCACTATGTAATAGACGGAAAGGTGAGCTGGAATCAAATCTTGCTGTAGTGAATGGTGCAAATA TTAGTGTAATCCAACATGAATCACCAGCAGATGTACAGACTCCTTTAATAATTCAGCCTGAGCAGAGGAATGTTAGTGGTGGATATTTAG TGCTTTATAAAATGAATTATGCCACTCGGATAGTGACTTTAGAAGAGGAGCCAATAAAAATACAACATATCAAAGATCCCCAGGACACAA TTACCTCGCTCATTTTGCTTCCACCCGATATATTGGATAATCGAGAGGATGACTGTGAGGAACCTATTGAGGACATGCAGTTAACCTCAA AGAATGGTTTTGAGAGAGAAAAAACGTCTGACATTTCTACTCTTGGACACCTGGTAATAACCACTCAGGGAGGATATGTAAAAATACTAG ATCTTTCAAACTTTGAAATTTTGGCCAAAGTGGAGCCTCCCAAAAAGGAGGGCACTGAGGAACAGGACACATTTGTTTCTGTGATTTACT GTTCTGGCACAGACAGGCTGTGTGCATGCACCAAAGGTGTTTGCAAGAGCAGACCCTTGGACCTGGTGTTTATCATTGATAGTTCTCGTA GCGTACGGCCCCTGGAATTCACCAAAGTGAAAACTTTTGTCTCCCGGATAATCGACACTCTGGACATTGGGCCAGCCGACACGCGGGTGG CAGTGGTGAACTATGCTAGCACTGTGAAGATCGAGTTCCAACTCCAGGCCTACACAGATAAGCAGTCCCTGAAGCAGGCCGTGGGTCGAA TCACACCCTTGTCAACAGGCACCATGTCAGGCCTAGCCATCCAGACAGCAATGGACGAAGCCTTCACAGTGGAGGCAGGGGCTCGAGAGC CCTCTTCTAACATCCCTAAGGTGGCCATCATTGTTACAGATGGGAGGCCCCAGGACCAGGTGAATGAGGTGGCGGCTCGGGCCCAAGCAT CTGGTATTGAGCTCTATGCTGTGGGCGTGGACCGGGCAGACATGGCGTCCCTCAAGATGATGGCCAGTGAGCCCCTAGAGGAGCATGTTT TCTACGTGGAGACCTATGGGGTCATTGAGAAACTTTCCTCTAGATTCCAGGAAACCTTCTGTGCGCTGGACCCCTGTGTGCTTGGAACAC ACCAGTGCCAGCACGTCTGCATCAGTGATGGGGAAGGCAAGCACCACTGTGAGTGTAGCCAAGGATACACCTTGAATGCCGACAAGAAAA CGTGTTCAGCTCTTGATAGGTGTGCTCTTAACACCCACGGATGTGAGCACATCTGTGTGAATGACAGAAGTGGCTCTTATCATTGTGAGT GCTATGAAGGTTATACCTTGAATGAAGACAGGAAAACTTGTTCAGCTCAAGATAAATGTGCTTTGGGTACCCATGGGTGTCAGCACATTT GTGTGAATGACAGAACAGGGTCCCATCATTGTGAATGCTATGAGGGCTACACTCTGAATGCAGATAAAAAAACATGTTCAGTCCGTGACA AGTGTGCCCTAGGCTCTCATGGTTGCCAGCACATTTGTGTGAGTGATGGGGCCGCATCCTACCACTGTGATTGCTATCCTGGCTACACCT TAAATGAGGACAAGAAAACATGTTCAGCCACTGAGGAAGCACGAAGACTTGTTTCCACTGAAGATGCTTGTGGATGTGAAGCTACACTGG CATTCCAGGACAAGGTCAGCTCGTATCTTCAAAGACTGAACACTAAACTTGATGACATTTTGGAGAAGTTGAAAATAAATGAATATGGAC AAATACATCGTTAAATTGCTCCAATTTCTCACCTGAAAATGTGGACAGCTTGGTGTACTTAATACTCATGCATTCTTTTGCACACCTGTT ATTGCCAATGTTCCTGCTAATAATTTGCCATTATCTGTATTAATGCTTGAATATTACTGGATAAATTGTATGAAGATCTTCTGCAGAATC AGCATGATTCTTCCAAGGAAATACATATGCAGATACTTATTAAGAGCAAACTTTAGTGTCTCTAAGTTATGACTGTGAAATGATTGGTAG GAAATAGAATGAAAAGTTTAGTGTTTCTTTATCTACTAATTGAGCCATTTAATTTTTAAATGTTTATATTAGATAACCATATTCACAATG GAAACTTTAGGTCTAGTTTCTTTTGATAGTATTTATAATATAAATCAATCTTATTACTGAGAGTGCAAATTGTACAAGGTATTTACACAT ACAACTTCATATAACTGAGATGAATGTAATTTTGAACTGTTTAACACTTTTTGTTTTTTGCTTATTTTGTTGGAGTATTATTGAAGATGT GATCAATAGATTGTAATACACATATCTAAAAATAGTTAACACAGATCAAGTGAACATTACATTGCCATTTTTAATTCATTCTGGTCTTTG AAAGAAATGTACTACTAAAGAGCACTAGTTGTGAATTTAGGGTGTTAAACTTTTTACCAAGTACAAAAATCCCAAATTCACTTTATTATT TTGCTTCAGGATCCAAGTGACAAAGTTATATATTTATAAAATTGCTATAAATCGACAAAATCTAATGTTGTCTTTTTAATGTTAGTGATC CACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAAAGTCTAACTTTTTTTTACTTATATATTTGATACATATAATTCTTTTG GCTTTGAAACTTGCAACTTTGAGAACAAAACAGTCCTTTAAATTTTGCACTGCTCAATTCTGTTTTTCGTTTGCATTGTCTTTAATATAA >In-frame_BIRC6_ENST00000421745_chr2_32641231_+_MATN3_ENST00000421259_chr2_20206071_-_4192nt TCCCTGCTTCTCCCCCTCTCCCGTCAGCCTCCCTCCGAGTTTGGCCCCTCCGGCCGGGCGATCGACGTTCCGCGTGCGTGCGGGCGCCTG ACTTCACTTCCGGCTAACGCGCTCGGCTTGCCCCCTGGCCCCGGATGGTGACTGGTGGTGGTGCTGCACCTCCCGGGACTGTCACTGAGC CGCTTCCCAGTGTGATTGTGCTGAGCGCAGGCCGGAAGATGGCGGCTGCGGCTGCGGCGGCCTCGGGCCCCGGCTGCTCCTCGGCGGCGG GGGCGGGGGCGGCCGGGGTCTCAGAGTGGCTGGTGCTGCGGGACGGCTGCATGCACTGCGACGCCGACGGGCTGCACAGCCTGTCCTACC ACCCTGCGCTCAACGCCATCCTGGCCGTCACTAGCCGCGGGACCATCAAAGTCATCGACGGCACCTCGGGGGCCACACTGCAGGCCTCCG CGCTCAGTGCTAAACCAGGTGGACAGGTGAAATGTCAGTATATCTCTGCTGTGGATAAAGTTATATTTGTGGATGATTATGCAGTAGGGT GTAGGAAGGACCTTAATGGAATCTTGTTGTTAGACACTGCTCTGCAAACTCCAGTTTCAAAGCAGGATGATGTGGTTCAGCTTGAATTAC CCGTTACAGAGGCACAGCAGCTCTTATCAGCATGTTTAGAAAAGGTAGATATTTCTAGTACAGAGGGTTATGATTTGTTCATCACACAGC TCAAAGATGGTTTAAAAAATACATCTCATGAGACTGCAGCAAACCACAAAGTTGCTAAGTGGGCCACAGTTACATTTCATCTTCCTCATC ATGTGTTGAAGTCCATTGCCAGTGCCATTGTAAATGAACTCAAGAAAATAAATCAAAATGTTGCTGCCTTACCTGTGGCGTCCTCAGTGA TGGACAGATTGTCTTACCTCTTACCTAGTGCACGTCCAGAACTCGGAGTGGGGCCAGGCCGTTCTGTAGACAGATCACTGATGTATAGTG AAGCTAACAGACGGGAGACATTTACCTCATGGCCTCATGTAGGCTATAGGTGGGCACAACCAGATCCCATGGCTCAAGCTGGATTTTATC ATCAGCCTGCCTCATCTGGAGATGATAGAGCCATGTGTTTTACTTGTAGTGTATGCCTCGTTTGTTGGGAACCTACTGATGAACCTTGGT CTGAACACGAAAGACATTCCCCAAACTGCCCATTTGTGAAAGGTGAGCACACACAGAATGTGCCATTGTCAGTCACTCTTGCAACAAGTC CTGCACAGTTTCCTTGTACGGATGGAACTGACAGAATATCTTGCTTTGGGTCGGGGAGCTGCCCTCATTTTCTAGCTGCTGCAACTAAAC GAGGAAAGATCTGCATATGGGATGTTTCCAAACTTATGAAGGTGCACTTAAAGTTTGAAATTAATGCCTATGATCCAGCAATTGTACAAC AGCTTATTCTATCAGGAGACCCAAGCTCAGGAGTTGATTCAAGGAGACCAACTTTGGCGTGGCTGGAGGACTCCTCTAGTTGCTCAGATA TACCAAAATTGGAAGGAGATAGTGATGATTTACTGGAGGATTCAGACAGTGAAGAGCATTCCAGATCAGATTCTGTGACAGGGCATACAT CACAGAAGGAAGCCATGGAAGTAAGCCTTGATATAACAGCACTCAGCATTCTCCAACAGCCAGAAAAACTTCAGTGGGAGATTGTTGCAA ATGTGCTTGAAGATACTGTTAAGGATCTTGAAGAACTTGGGGCAAATCCTTGTTTAACAAACTCTAAGAGTGAAAAGACAAAGGAAAAGC ACCAGGAGCAACACAACATTCCTTTTCCATGTTTATTAGCTGGAGGTTTATTAACATATAAATCTCCTGCTACCTCACCCATTAGTAGTA ATTCTCACAGGTCACTGGATGGTTTAAGCAGAACTCAGGGTGAAAGTATATCAGAACAAGGGTCAACTGACAATGAATCCTGCACTAATT CAGAACTAAATTCTCCTCTGGTAAGGAGGACTTTACCGGTTTTGCTTCTTTATAGCATCAAGGAATCTGATGAGAAAGCAGGAAAGATCT TTTCACAGATGAACAATATTATGAGTAAAAGTTTGCATGATGATGGTTTTACTGTTCCACAGATTATTGAAATGGAGCTGGATAGTCAGG AGCAGTTGTTATTGCAGGATCCTCCTGTGACTTACATTCAGCAATTTGCAGATGCAGCAGCCAACCTTACCTCTCCGGATTCTGAGAAGT GGAACTCTGTGTTTCCCAAGCCTGGGACTTTGGTTCAGTGCTTGAGGCTGCCAAAGTTTGCAGAGGAGGAGAATCTTTGTATAGACTCAA TAACTCCTTGTGCTGACGGAATTCATTTGTTGGTAGGACTGCGGACATGCCCTGTTGAATCCTTGAGTGCAATAAATCAAGTAGAGGCCT TGAATAATTTAAATAAATTAAACTCTGCACTATGTAATAGACGGAAAGGTGAGCTGGAATCAAATCTTGCTGTAGTGAATGGTGCAAATA TTAGTGTAATCCAACATGAATCACCAGCAGATGTACAGACTCCTTTAATAATTCAGCCTGAGCAGAGGAATGTTAGTGGTGGATATTTAG TGCTTTATAAAATGAATTATGCCACTCGGATAGTGACTTTAGAAGAGGAGCCAATAAAAATACAACATATCAAAGATCCCCAGGACACAA TTACCTCGCTCATTTTGCTTCCACCCGATATATTGGATAATCGAGAGGATGACTGTGAGGAACCTATTGAGGACATGCAGTTAACCTCAA AGAATGGTTTTGAGAGAGAAAAAACGTCTGACATTTCTACTCTTGGACACCTGGTAATAACCACTCAGGGAGGATATGTAAAAATACTAG ATCTTTCAAACTTTGAAATTTTGGCCAAAGTGGAGCCTCCCAAAAAGGAGGGCACTGAGGAACAGGACACATTTGTTTCTGTGATTTACT GTTCTGGCACAGACAGGCTGTGTGCATGCACCAAAGGTGTTTGCAAGAGCAGACCCTTGGACCTGGTGTTTATCATTGATAGTTCTCGTA GCGTACGGCCCCTGGAATTCACCAAAGTGAAAACTTTTGTCTCCCGGATAATCGACACTCTGGACATTGGGCCAGCCGACACGCGGGTGG CAGTGGTGAACTATGCTAGCACTGTGAAGATCGAGTTCCAACTCCAGGCCTACACAGATAAGCAGTCCCTGAAGCAGGCCGTGGGTCGAA TCACACCCTTGTCAACAGGCACCATGTCAGGCCTAGCCATCCAGACAGCAATGGACGAAGCCTTCACAGTGGAGGCAGGGGCTCGAGAGC CCTCTTCTAACATCCCTAAGGTGGCCATCATTGTTACAGATGGGAGGCCCCAGGACCAGGTGAATGAGGTGGCGGCTCGGGCCCAAGCAT CTGGTATTGAGCTCTATGCTGTGGGCGTGGACCGGGCAGACATGGCGTCCCTCAAGATGATGGCCAGTGAGCCCCTAGAGGAGCATGTTT TCTACGTGGAGACCTATGGGGTCATTGAGAAACTTTCCTCTAGATTCCAGGAAACCTTCTGTGCTCTTGATAGGTGTGCTCTTAACACCC ACGGATGTGAGCACATCTGTGTGAATGACAGAAGTGGCTCTTATCATTGTGAGTGCTATGAAGGTTATACCTTGAATGAAGACAGGAAAA CTTGTTCAGCTCAAGATAAATGTGCTTTGGGTACCCATGGGTGTCAGCACATTTGTGTGAATGACAGAACAGGGTCCCATCATTGTGAAT GCTATGAGGGCTACACTCTGAATGCAGATAAAAAAACATGTTCAGTCCGTGACAAGTGTGCCCTAGGCTCTCATGGTTGCCAGCACATTT GTGTGAGTGATGGGGCCGCATCCTACCACTGTGATTGCTATCCTGGCTACACCTTAAATGAGGACAAGAAAACATGTTCAGCCACTGAGG AAGCACGAAGACTTGTTTCCACTGAAGATGCTTGTGGATGTGAAGCTACACTGGCATTCCAGGACAAGGTCAGCTCGTATCTTCAAAGAC TGAACACTAAACTTGATGACATTTTGGAGAAGTTGAAAATAAATGAATATGGACAAATACATCGTTAAATTGCTCCAATTTCTCACCTGA |
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FusionGenePPI for BIRC6_MATN3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| BIRC6 | RNF41, KIF23, USP8, DIABLO, CASP9, HTRA2, UBC, VAV2, SIRT7, CASP3, CASP7, BIRC6, CASP8, UBE2D1, CSNK2A1, RASSF2, EPS15L1, GBF1, CCNA2, CDC27, ANAPC11, TEX35, PRSS45, RTBDN, C3orf20, WDR4, DFNA5, FAM175B, CA11, FIGF, MOS, HERC2, CHIA, CLEC11A, INTS4P2, TBC1D22A, FAM58A, MCPH1, TP53, UNK, RPGR, KIF22, LLGL2, PLK1, MYH13, SSH3, AGRP, ANGPTL3, UGGT2, AKAP9, DCAF12, FERMT2, PSMC5, MGST3, CCDC22, OSBPL2, ADAMTS4, HEY1 | MATN3 | MATN1, TCF4, KRTAP10-8, NOTCH2NL, TF, PBLD, GDA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BIRC6_MATN3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BIRC6_MATN3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | MATN3 | C1846843 | EPIPHYSEAL DYSPLASIA, MULTIPLE, 5 | 7 | CTD_human;ORPHANET;UNIPROT |
| Tgene | MATN3 | C1837481 | Spondyloepimetaphyseal Dysplasia, Matrilin-3 Related | 1 | CTD_human;ORPHANET;UNIPROT |
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