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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41929

FusionGeneSummary for WDR75_RNF212

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR75_RNF212
Fusion gene ID: 41929
HgeneTgene
Gene symbol

WDR75

RNF212

Gene ID

84128

285498

Gene nameWD repeat domain 75ring finger protein 212
SynonymsNET16|UTP17ZHP3
Cytomap

2q32.2

4p16.3

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing protein 75U3 small nucleolar RNA-associated protein 17 homologUTP17, small subunit (SSU) processome component, homologprobable E3 SUMO-protein ligase RNF212probable E3 SUMO-protein transferase RNF212
Modification date2018051920180523
UniProtAcc

Q8IWA0

Q495C1

Ensembl transtripts involved in fusion geneENST00000314761, ENST00000382968, 
ENST00000433731, ENST00000333673, 
ENST00000505730, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 2=18
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: WDR75 [Title/Abstract] AND RNF212 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB157092WDR75chr2

190306305

+RNF212chr4

1052181

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000314761ENST00000382968WDR75chr2

190306305

+RNF212chr4

1052181

-
5CDS-intronENST00000314761ENST00000433731WDR75chr2

190306305

+RNF212chr4

1052181

-
5CDS-intronENST00000314761ENST00000333673WDR75chr2

190306305

+RNF212chr4

1052181

-
5CDS-intronENST00000314761ENST00000505730WDR75chr2

190306305

+RNF212chr4

1052181

-

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FusionProtFeatures for WDR75_RNF212


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WDR75

Q8IWA0

RNF212

Q495C1

Ribosome biogenesis factor. Involved in nucleolarprocessing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.{ECO:0000269|PubMed:17699751}. SUMO E3 ligase that acts as a regulator of crossing-overduring meiosis: required to couple chromosome synapsis to theformation of crossover-specific recombination complexes. Localizesto recombination sites and stabilizes meiosis-specificrecombination factors, such as MutS-gamma complex proteins (MSH4and MSH5) and TEX11. May mediate sumoylation of target proteinsMSH4 and/or MSH5, leading to enhance their binding torecombination sites. Acts as a limiting factor for crossoverdesignation and/or reinforcement and plays an antagonist role withCCNB1IP1/HEI10 in the regulation of meiotic recombination (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WDR75_RNF212


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WDR75_RNF212


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WDR75_RNF212


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WDR75_RNF212


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource