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Fusion gene ID: 41929 |
FusionGeneSummary for WDR75_RNF212 |
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Fusion gene information | Fusion gene name: WDR75_RNF212 | Fusion gene ID: 41929 | Hgene | Tgene | Gene symbol | WDR75 | RNF212 | Gene ID | 84128 | 285498 |
Gene name | WD repeat domain 75 | ring finger protein 212 | |
Synonyms | NET16|UTP17 | ZHP3 | |
Cytomap | 2q32.2 | 4p16.3 | |
Type of gene | protein-coding | protein-coding | |
Description | WD repeat-containing protein 75U3 small nucleolar RNA-associated protein 17 homologUTP17, small subunit (SSU) processome component, homolog | probable E3 SUMO-protein ligase RNF212probable E3 SUMO-protein transferase RNF212 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q8IWA0 | Q495C1 | |
Ensembl transtripts involved in fusion gene | ENST00000314761, | ENST00000382968, ENST00000433731, ENST00000333673, ENST00000505730, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 2=18 |
# samples | 1 | 3 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: WDR75 [Title/Abstract] AND RNF212 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CB157092 | WDR75 | chr2 | 190306305 | + | RNF212 | chr4 | 1052181 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000314761 | ENST00000382968 | WDR75 | chr2 | 190306305 | + | RNF212 | chr4 | 1052181 | - |
5CDS-intron | ENST00000314761 | ENST00000433731 | WDR75 | chr2 | 190306305 | + | RNF212 | chr4 | 1052181 | - |
5CDS-intron | ENST00000314761 | ENST00000333673 | WDR75 | chr2 | 190306305 | + | RNF212 | chr4 | 1052181 | - |
5CDS-intron | ENST00000314761 | ENST00000505730 | WDR75 | chr2 | 190306305 | + | RNF212 | chr4 | 1052181 | - |
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FusionProtFeatures for WDR75_RNF212 |
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Hgene | Tgene |
WDR75 | RNF212 |
Ribosome biogenesis factor. Involved in nucleolarprocessing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.{ECO:0000269|PubMed:17699751}. | SUMO E3 ligase that acts as a regulator of crossing-overduring meiosis: required to couple chromosome synapsis to theformation of crossover-specific recombination complexes. Localizesto recombination sites and stabilizes meiosis-specificrecombination factors, such as MutS-gamma complex proteins (MSH4and MSH5) and TEX11. May mediate sumoylation of target proteinsMSH4 and/or MSH5, leading to enhance their binding torecombination sites. Acts as a limiting factor for crossoverdesignation and/or reinforcement and plays an antagonist role withCCNB1IP1/HEI10 in the regulation of meiotic recombination (Bysimilarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for WDR75_RNF212 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for WDR75_RNF212 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for WDR75_RNF212 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WDR75_RNF212 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |