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Fusion gene ID: 41903 |
FusionGeneSummary for WDR74_DHTKD1 |
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Fusion gene information | Fusion gene name: WDR74_DHTKD1 | Fusion gene ID: 41903 | Hgene | Tgene | Gene symbol | WDR74 | DHTKD1 | Gene ID | 54663 | 55526 |
Gene name | WD repeat domain 74 | dehydrogenase E1 and transketolase domain containing 1 | |
Synonyms | - | AMOXAD|CMT2Q | |
Cytomap | 11q12.3 | 10p14 | |
Type of gene | protein-coding | protein-coding | |
Description | WD repeat-containing protein 74NOP seven-associated protein 1 | probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrialdehydrogenase E1 and transketolase domain-containing protein 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q6RFH5 | Q96HY7 | |
Ensembl transtripts involved in fusion gene | ENST00000311713, ENST00000278856, ENST00000529106, ENST00000525239, ENST00000525752, ENST00000540620, | ENST00000263035, ENST00000465617, | |
Fusion gene scores | * DoF score | 27 X 13 X 4=1404 | 4 X 4 X 2=32 |
# samples | 28 | 4 | |
** MAII score | log2(28/1404*10)=-2.32604420335959 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: WDR74 [Title/Abstract] AND DHTKD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA440878 | WDR74 | chr11 | 62609077 | - | DHTKD1 | chr10 | 12139775 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000311713 | ENST00000263035 | WDR74 | chr11 | 62609077 | - | DHTKD1 | chr10 | 12139775 | + |
intron-3UTR | ENST00000311713 | ENST00000465617 | WDR74 | chr11 | 62609077 | - | DHTKD1 | chr10 | 12139775 | + |
intron-3CDS | ENST00000278856 | ENST00000263035 | WDR74 | chr11 | 62609077 | - | DHTKD1 | chr10 | 12139775 | + |
intron-3UTR | ENST00000278856 | ENST00000465617 | WDR74 | chr11 | 62609077 | - | DHTKD1 | chr10 | 12139775 | + |
intron-3CDS | ENST00000529106 | ENST00000263035 | WDR74 | chr11 | 62609077 | - | DHTKD1 | chr10 | 12139775 | + |
intron-3UTR | ENST00000529106 | ENST00000465617 | WDR74 | chr11 | 62609077 | - | DHTKD1 | chr10 | 12139775 | + |
intron-3CDS | ENST00000525239 | ENST00000263035 | WDR74 | chr11 | 62609077 | - | DHTKD1 | chr10 | 12139775 | + |
intron-3UTR | ENST00000525239 | ENST00000465617 | WDR74 | chr11 | 62609077 | - | DHTKD1 | chr10 | 12139775 | + |
intron-3CDS | ENST00000525752 | ENST00000263035 | WDR74 | chr11 | 62609077 | - | DHTKD1 | chr10 | 12139775 | + |
intron-3UTR | ENST00000525752 | ENST00000465617 | WDR74 | chr11 | 62609077 | - | DHTKD1 | chr10 | 12139775 | + |
intron-3CDS | ENST00000540620 | ENST00000263035 | WDR74 | chr11 | 62609077 | - | DHTKD1 | chr10 | 12139775 | + |
intron-3UTR | ENST00000540620 | ENST00000465617 | WDR74 | chr11 | 62609077 | - | DHTKD1 | chr10 | 12139775 | + |
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FusionProtFeatures for WDR74_DHTKD1 |
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Hgene | Tgene |
WDR74 | DHTKD1 |
The 2-oxoglutarate dehydrogenase complex catalyzes theoverall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Itcontains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamidesuccinyltransferase (E2) and lipoamide dehydrogenase (E3) (Bysimilarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for WDR74_DHTKD1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for WDR74_DHTKD1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for WDR74_DHTKD1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WDR74_DHTKD1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | WDR74 | C0025202 | melanoma | 1 | CTD_human |
Tgene | DHTKD1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | DHTKD1 | C1859817 | 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA | 1 | ORPHANET;UNIPROT |