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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 41858

FusionGeneSummary for WDR48_HERC2

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR48_HERC2
Fusion gene ID: 41858
HgeneTgene
Gene symbol

WDR48

HERC2

Gene ID

57599

8924

Gene nameWD repeat domain 48HECT and RLD domain containing E3 ubiquitin protein ligase 2
SynonymsP80|SPG60|UAF1D15F37S1|MRT38|SHEP1|jdf2|p528
Cytomap

3p22.2

15q13.1

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing protein 48USP1 associated factor 1WD repeat endosomal proteintesticular tissue protein Li 224E3 ubiquitin-protein ligase HERC2HECT-type E3 ubiquitin transferase HERC2hect domain and RCC1-like domain-containing protein 2hect domain and RLD 2probable E3 ubiquitin-protein ligase HERC2
Modification date2018052320180523
UniProtAcc

Q8TAF3

O95714

Ensembl transtripts involved in fusion geneENST00000302313, ENST00000418020, 
ENST00000544962, ENST00000396258, 
ENST00000466405, 		ENST00000261609, 
ENST00000563945, 
Fusion gene scores* DoF score3 X 3 X 2=183 X 3 X 3=27
# samples 33
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: WDR48 [Title/Abstract] AND HERC2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWDR48

GO:0016579

protein deubiquitination

18082604|19075014|24145035

TgeneHERC2

GO:0006974

cellular response to DNA damage stimulus

22508508

TgeneHERC2

GO:0016567

protein ubiquitination

20304803


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-XF-AAMG-01AWDR48chr3

39093564

+HERC2chr15

28397976

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000302313ENST00000261609WDR48chr3

39093564

+HERC2chr15

28397976

-
5CDS-intronENST00000302313ENST00000563945WDR48chr3

39093564

+HERC2chr15

28397976

-
5UTR-3CDSENST00000418020ENST00000261609WDR48chr3

39093564

+HERC2chr15

28397976

-
5UTR-intronENST00000418020ENST00000563945WDR48chr3

39093564

+HERC2chr15

28397976

-
In-frameENST00000544962ENST00000261609WDR48chr3

39093564

+HERC2chr15

28397976

-
5CDS-intronENST00000544962ENST00000563945WDR48chr3

39093564

+HERC2chr15

28397976

-
5UTR-3CDSENST00000396258ENST00000261609WDR48chr3

39093564

+HERC2chr15

28397976

-
5UTR-intronENST00000396258ENST00000563945WDR48chr3

39093564

+HERC2chr15

28397976

-
intron-3CDSENST00000466405ENST00000261609WDR48chr3

39093564

+HERC2chr15

28397976

-
intron-intronENST00000466405ENST00000563945WDR48chr3

39093564

+HERC2chr15

28397976

-

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FusionProtFeatures for WDR48_HERC2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WDR48

Q8TAF3

HERC2

O95714


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-68934457_479435824835DomainHECT
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-68933951_400235824835RepeatRCC1 3-1
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-68934004_405635824835RepeatRCC1 3-2
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-68934058_410835824835RepeatRCC1 3-3
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-68934110_416235824835RepeatRCC1 3-4
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-68934164_421435824835RepeatRCC1 3-5
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-68934216_426635824835RepeatRCC1 3-6
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-68934268_431835824835RepeatRCC1 3-7

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDR48chr3:39093564chr15:28397976ENST00000302313+119115_15416678RepeatNote=WD 3
HgeneWDR48chr3:39093564chr15:28397976ENST00000302313+119166_20516678RepeatNote=WD 4
HgeneWDR48chr3:39093564chr15:28397976ENST00000302313+119208_24716678RepeatNote=WD 5
HgeneWDR48chr3:39093564chr15:28397976ENST00000302313+119250_28916678RepeatNote=WD 6
HgeneWDR48chr3:39093564chr15:28397976ENST00000302313+11928_6716678RepeatNote=WD 1
HgeneWDR48chr3:39093564chr15:28397976ENST00000302313+119292_33416678RepeatNote=WD 7
HgeneWDR48chr3:39093564chr15:28397976ENST00000302313+119358_39716678RepeatNote=WD 8
HgeneWDR48chr3:39093564chr15:28397976ENST00000302313+11973_11216678RepeatNote=WD 2
HgeneWDR48chr3:39093564chr15:28397976ENST00000396258+118115_154-40596RepeatNote=WD 3
HgeneWDR48chr3:39093564chr15:28397976ENST00000396258+118166_205-40596RepeatNote=WD 4
HgeneWDR48chr3:39093564chr15:28397976ENST00000396258+118208_247-40596RepeatNote=WD 5
HgeneWDR48chr3:39093564chr15:28397976ENST00000396258+118250_289-40596RepeatNote=WD 6
HgeneWDR48chr3:39093564chr15:28397976ENST00000396258+11828_67-40596RepeatNote=WD 1
HgeneWDR48chr3:39093564chr15:28397976ENST00000396258+118292_334-40596RepeatNote=WD 7
HgeneWDR48chr3:39093564chr15:28397976ENST00000396258+118358_397-40596RepeatNote=WD 8
HgeneWDR48chr3:39093564chr15:28397976ENST00000396258+11873_112-40596RepeatNote=WD 2
HgeneWDR48chr3:39093564chr15:28397976ENST00000544962+111115_15416403RepeatNote=WD 3
HgeneWDR48chr3:39093564chr15:28397976ENST00000544962+111166_20516403RepeatNote=WD 4
HgeneWDR48chr3:39093564chr15:28397976ENST00000544962+111208_24716403RepeatNote=WD 5
HgeneWDR48chr3:39093564chr15:28397976ENST00000544962+111250_28916403RepeatNote=WD 6
HgeneWDR48chr3:39093564chr15:28397976ENST00000544962+11128_6716403RepeatNote=WD 1
HgeneWDR48chr3:39093564chr15:28397976ENST00000544962+111292_33416403RepeatNote=WD 7
HgeneWDR48chr3:39093564chr15:28397976ENST00000544962+111358_39716403RepeatNote=WD 8
HgeneWDR48chr3:39093564chr15:28397976ENST00000544962+11173_11216403RepeatNote=WD 2
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-6893948_98035824835Coiled coilOntology_term=ECO:0000255
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-68931207_128335824835DomainCytochrome b5 heme-binding
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-68931859_193235824835DomainMIB/HERC2
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-68932759_293635824835DomainDOC
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-68932958_300935824835RepeatRCC1 2-1
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-68933010_306435824835RepeatRCC1 2-2
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-68933065_311635824835RepeatRCC1 2-3
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-68933118_316835824835RepeatRCC1 2-4
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-68933171_322235824835RepeatRCC1 2-5
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-68933224_327435824835RepeatRCC1 2-6
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-68933275_332635824835RepeatRCC1 2-7
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-6893415_46135824835RepeatRCC1 1-1
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-6893462_51235824835RepeatRCC1 1-2
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-6893513_56835824835RepeatRCC1 1-3
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-6893569_62035824835RepeatRCC1 1-4
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-6893623_67435824835RepeatRCC1 1-5
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-6893675_72635824835RepeatRCC1 1-6
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-6893728_77835824835RepeatRCC1 1-7
TgeneHERC2chr3:39093564chr15:28397976ENST00000261609-68932702_274935824835Zinc fingerZZ-type


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FusionGeneSequence for WDR48_HERC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_WDR48_ENST00000302313_chr3_39093564_+_HERC2_ENST00000261609_chr15_28397976_-_1269aa
MAAHHRQNTAGRRKVQVADMLLELCVTELEDVATDSQSGRLSSQPVVVESSHPYTDDTSTSGTVKIPGAEGLRVEFDRQCSTERRHDPLT
VMDGVNRIVSVRSGREWSDWSSELRIPGDELKWKFISDGSVNGWGWRFTVYPIMPAAGPKELLSDRCVLSCPSMDLVTCLLDFRLNLASN
RSIVPRLAASLAACAQLSALAASHRMWALQRLRKLLTTEFGQSININRLLGENDGETRALSFTGSALAALVKGLPEALQRQFEYEDPIVR
GGKQLLHSPFFKVLVALACDLELDTLPCCAETHKWAWFRRYCMASRVAVALDKRTPLPRLFLDEVAKKIRELMADSENMDVLHESHDIFK
REQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGR
LGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACV
TAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTG
LGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTT
NAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKPASAGKLPAQVPMEYNHLQEIPIIALRNRLLLLHHLSELFCPCIPMFDLEGSLDET
GLGPSVGFDTLRGILISQGKEAAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMSSFGPDSLLLPHRVW
KVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLSPAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAE
PVWKQLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFTVPSASGQDIQLSSKHTHITLDNRAEYVRLAINYRLHEFDEQV
AAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIEPSASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADF
RGRDFVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDYARIALTGEPAADDSSDDSDNEDVDSFASDS

>In-frame_WDR48_ENST00000544962_chr3_39093564_+_HERC2_ENST00000261609_chr15_28397976_-_1269aa
MAAHHRQNTAGRRKVQVADMLLELCVTELEDVATDSQSGRLSSQPVVVESSHPYTDDTSTSGTVKIPGAEGLRVEFDRQCSTERRHDPLT
VMDGVNRIVSVRSGREWSDWSSELRIPGDELKWKFISDGSVNGWGWRFTVYPIMPAAGPKELLSDRCVLSCPSMDLVTCLLDFRLNLASN
RSIVPRLAASLAACAQLSALAASHRMWALQRLRKLLTTEFGQSININRLLGENDGETRALSFTGSALAALVKGLPEALQRQFEYEDPIVR
GGKQLLHSPFFKVLVALACDLELDTLPCCAETHKWAWFRRYCMASRVAVALDKRTPLPRLFLDEVAKKIRELMADSENMDVLHESHDIFK
REQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGR
LGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACV
TAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTG
LGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTT
NAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKPASAGKLPAQVPMEYNHLQEIPIIALRNRLLLLHHLSELFCPCIPMFDLEGSLDET
GLGPSVGFDTLRGILISQGKEAAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMSSFGPDSLLLPHRVW
KVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLSPAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAE
PVWKQLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFTVPSASGQDIQLSSKHTHITLDNRAEYVRLAINYRLHEFDEQV
AAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIEPSASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADF
RGRDFVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDYARIALTGEPAADDSSDDSDNEDVDSFASDS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_WDR48_ENST00000302313_chr3_39093564_+_HERC2_ENST00000261609_chr15_28397976_-_3807nt
ATGGCGGCCCATCACCGGCAGAACACAGCAGGGCGGAGGAAAGTGCAGGTGGCAGATATGCTGTTGGAGCTCTGTGTCACCGAGTTGGAG
GATGTGGCCACAGACTCGCAGAGCGGCCGCCTCTCTTCTCAGCCTGTGGTGGTGGAGAGTAGCCACCCTTACACCGACGACACCTCCACC
AGTGGCACAGTGAAGATACCAGGTGCAGAAGGACTCAGGGTAGAATTTGACCGGCAGTGCTCCACAGAGAGGCGCCACGACCCTCTCACA
GTCATGGACGGCGTCAACAGGATCGTCTCCGTGCGGTCAGGCCGAGAGTGGTCCGACTGGTCCAGCGAGCTGCGCATCCCAGGGGATGAG
TTAAAGTGGAAGTTCATCAGCGATGGGTCTGTGAATGGCTGGGGCTGGCGCTTCACCGTCTATCCCATCATGCCAGCTGCTGGCCCTAAA
GAACTCCTCTCTGACCGCTGCGTCCTCTCCTGTCCATCCATGGACTTGGTGACGTGTCTGTTAGACTTCCGACTCAACCTTGCCTCTAAC
AGAAGCATCGTCCCTCGCCTTGCGGCCTCGCTGGCAGCTTGTGCACAGCTGAGTGCCCTAGCTGCCAGTCACAGAATGTGGGCCCTTCAG
AGACTGAGGAAGCTGCTTACAACTGAATTTGGGCAGTCAATTAACATAAATAGGCTGCTTGGAGAAAATGATGGGGAAACAAGAGCTTTG
AGTTTTACAGGTAGTGCTCTTGCTGCTTTGGTGAAAGGTCTTCCAGAAGCTTTGCAAAGGCAGTTTGAATATGAAGATCCTATTGTGAGG
GGTGGCAAACAGCTGCTCCACAGCCCATTCTTTAAGGTACTGGTAGCTCTTGCTTGTGACCTGGAGCTGGACACTCTGCCTTGCTGTGCC
GAGACGCACAAGTGGGCCTGGTTCCGGAGGTACTGCATGGCCTCCCGTGTTGCTGTGGCCCTTGACAAAAGAACACCGTTGCCCCGTCTG
TTTCTTGATGAGGTGGCTAAGAAAATTCGTGAATTAATGGCAGACAGCGAAAACATGGATGTTCTGCATGAGAGCCATGACATTTTTAAA
AGAGAGCAAGACGAACAACTTGTGCAGTGGATGAACAGGCGACCAGATGACTGGACTCTCTCTGCTGGTGGCAGTGGAACAATTTATGGA
TGGGGACATAATCACAGGGGCCAGCTCGGGGGCATTGAAGGCGCAAAAGTCAAAGTTCCCACTCCCTGTGAAGCCCTTGCAACTCTCAGA
CCCGTGCAGTTAATCGGAGGGGAACAGACCCTCTTTGCTGTGACGGCTGATGGGAAGCTGTATGCCACTGGGTATGGTGCAGGTGGCAGA
CTAGGCATTGGAGGGACAGAGTCGGTGTCCACCCCAACATTGCTTGAATCCATTCAGCATGTGTTTATTAAGAAAGTAGCTGTGAACTCT
GGAGGAAAGCACTGCCTTGCCCTGTCTTCAGAAGGAGAAGTTTACTCTTGGGGTGAGGCAGAAGATGGGAAGTTGGGGCATGGCAACAGA
AGTCCGTGTGACCGCCCTCGTGTCATCGAGTCTCTGAGAGGAATTGAAGTGGTCGATGTTGCTGCTGGCGGAGCCCACAGCGCCTGTGTC
ACAGCAGCCGGGGACCTCTACACATGGGGCAAAGGCCGCTACGGCCGGCTGGGGCACAGCGACAGTGAGGACCAGCTGAAGCCGAAGCTG
GTGGAGGCGCTGCAGGGCCACCGTGTGGTTGACATCGCCTGTGGCAGTGGAGATGCCCAGACCCTCTGCCTCACAGATGACGACACTGTC
TGGTCCTGGGGGGACGGGGACTACGGCAAGCTCGGCCGGGGAGGCAGCGATGGCTGTAAAGTGCCTATGAAGATTGATTCTCTTACTGGT
CTTGGAGTAGTTAAAGTGGAATGCGGATCCCAGTTTTCTGTTGCCCTTACCAAATCTGGAGCTGTTTATACCTGGGGCAAAGGCGATTAT
CACAGGTTGGGCCATGGATCAGATGACCATGTTCGAAGGCCTCGGCAGGTCCAAGGGTTGCAGGGGAAGAAAGTCATCGCCATCGCCACT
GGCTCCCTGCACTGTGTGTGCTGCACAGAGGATGGTGAGGTTTATACATGGGGCGACAATGATGAGGGACAACTGGGAGACGGAACCACC
AATGCCATCCAGAGGCCTCGGTTGGTAGCTGCCCTTCAGGGTAAGAAGGTCAACCGTGTGGCCTGTGGCTCAGCACATACCCTCGCCTGG
TCGACCAGCAAGCCCGCCAGTGCTGGCAAACTCCCTGCACAGGTCCCCATGGAGTACAATCACCTGCAGGAGATCCCCATCATTGCGCTG
AGGAACCGTCTGCTGCTGCTGCACCACCTCTCCGAGCTCTTCTGCCCCTGCATCCCCATGTTCGACCTGGAAGGCTCGCTCGACGAAACT
GGACTCGGGCCTTCTGTTGGGTTCGACACTCTCCGAGGAATTCTGATATCCCAGGGAAAGGAGGCGGCTTTCCGGAAAGTAGTACAAGCA
ACTATGGTACGCGATCGTCAGCATGGCCCCGTCGTGGAGCTGAACCGCATCCAGGTCAAACGATCAAGGAGCAAAGGCGGGCTGGCCGGC
CCCGACGGCACCAAGTCTGTCTTTGGGCAGATGTGTGCTAAGATGAGCTCGTTTGGTCCCGACAGCCTCCTCCTTCCTCACCGTGTCTGG
AAAGTCAAGTTTGTGGGTGAATCTGTGGATGACTGTGGGGGCGGCTACAGCGAGTCCATAGCTGAGATCTGTGAGGAGCTGCAGAACGGA
CTCACGCCCCTGCTGATCGTGACACCCAACGGGAGGGATGAGTCTGGGGCCAACCGAGACTGCTACCTGCTCAGCCCGGCCGCCAGAGCA
CCCGTGCACAGCAGCATGTTCCGCTTCCTGGGTGTGTTGCTGGGCATTGCCATCCGAACCGGGAGTCCCCTGAGCCTCAACCTTGCCGAG
CCTGTCTGGAAGCAGCTGGCTGGGATGAGCCTCACCATCGCGGACCTCAGTGAGGTTGATAAGGATTTTATTCCTGGACTCATGTACATC
CGAGACAATGAAGCCACCTCAGAGGAGTTTGAAGCCATGAGCCTGCCCTTCACAGTGCCAAGTGCCAGTGGCCAGGACATTCAGTTGAGC
TCCAAGCACACACACATCACCCTGGACAACCGCGCGGAGTACGTGCGGCTGGCGATAAACTATAGACTCCATGAATTTGATGAGCAGGTG
GCTGCTGTTCGGGAAGGAATGGCCCGCGTTGTGCCTGTTCCCCTCCTCTCTCTGTTCACCGGCTACGAACTGGAGACGATGGTGTGTGGC
AGCCCTGACATCCCGCTGCACCTTCTCAAGTCGGTGGCCACCTATAAAGGCATCGAGCCTTCCGCATCGCTGATCCAGTGGTTCTGGGAG
GTGATGGAGTCCTTCTCCAACACAGAGCGCTCTCTTTTCCTTCGCTTCGTCTGGGGCCGGACGAGGCTGCCCAGGACCATCGCCGACTTC
CGGGGCCGAGACTTCGTCATCCAGGTGTTGGATAAATACAACCCTCCAGACCACTTCCTCCCTGAGTCCTACACCTGTTTCTTCTTGCTG
AAGCTGCCCAGGTATTCCTGCAAGCAGGTGCTGGAGGAGAAGCTCAAGTACGCCATCCACTTCTGCAAGTCCATAGACACAGATGACTAC
GCTCGCATCGCACTTACAGGAGAGCCAGCCGCCGACGACAGCAGCGACGATTCAGATAACGAGGATGTCGACTCCTTTGCTTCGGACTCT

>In-frame_WDR48_ENST00000544962_chr3_39093564_+_HERC2_ENST00000261609_chr15_28397976_-_3807nt
ATGGCGGCCCATCACCGGCAGAACACAGCAGGGCGGAGGAAAGTGCAGGTGGCAGATATGCTGTTGGAGCTCTGTGTCACCGAGTTGGAG
GATGTGGCCACAGACTCGCAGAGCGGCCGCCTCTCTTCTCAGCCTGTGGTGGTGGAGAGTAGCCACCCTTACACCGACGACACCTCCACC
AGTGGCACAGTGAAGATACCAGGTGCAGAAGGACTCAGGGTAGAATTTGACCGGCAGTGCTCCACAGAGAGGCGCCACGACCCTCTCACA
GTCATGGACGGCGTCAACAGGATCGTCTCCGTGCGGTCAGGCCGAGAGTGGTCCGACTGGTCCAGCGAGCTGCGCATCCCAGGGGATGAG
TTAAAGTGGAAGTTCATCAGCGATGGGTCTGTGAATGGCTGGGGCTGGCGCTTCACCGTCTATCCCATCATGCCAGCTGCTGGCCCTAAA
GAACTCCTCTCTGACCGCTGCGTCCTCTCCTGTCCATCCATGGACTTGGTGACGTGTCTGTTAGACTTCCGACTCAACCTTGCCTCTAAC
AGAAGCATCGTCCCTCGCCTTGCGGCCTCGCTGGCAGCTTGTGCACAGCTGAGTGCCCTAGCTGCCAGTCACAGAATGTGGGCCCTTCAG
AGACTGAGGAAGCTGCTTACAACTGAATTTGGGCAGTCAATTAACATAAATAGGCTGCTTGGAGAAAATGATGGGGAAACAAGAGCTTTG
AGTTTTACAGGTAGTGCTCTTGCTGCTTTGGTGAAAGGTCTTCCAGAAGCTTTGCAAAGGCAGTTTGAATATGAAGATCCTATTGTGAGG
GGTGGCAAACAGCTGCTCCACAGCCCATTCTTTAAGGTACTGGTAGCTCTTGCTTGTGACCTGGAGCTGGACACTCTGCCTTGCTGTGCC
GAGACGCACAAGTGGGCCTGGTTCCGGAGGTACTGCATGGCCTCCCGTGTTGCTGTGGCCCTTGACAAAAGAACACCGTTGCCCCGTCTG
TTTCTTGATGAGGTGGCTAAGAAAATTCGTGAATTAATGGCAGACAGCGAAAACATGGATGTTCTGCATGAGAGCCATGACATTTTTAAA
AGAGAGCAAGACGAACAACTTGTGCAGTGGATGAACAGGCGACCAGATGACTGGACTCTCTCTGCTGGTGGCAGTGGAACAATTTATGGA
TGGGGACATAATCACAGGGGCCAGCTCGGGGGCATTGAAGGCGCAAAAGTCAAAGTTCCCACTCCCTGTGAAGCCCTTGCAACTCTCAGA
CCCGTGCAGTTAATCGGAGGGGAACAGACCCTCTTTGCTGTGACGGCTGATGGGAAGCTGTATGCCACTGGGTATGGTGCAGGTGGCAGA
CTAGGCATTGGAGGGACAGAGTCGGTGTCCACCCCAACATTGCTTGAATCCATTCAGCATGTGTTTATTAAGAAAGTAGCTGTGAACTCT
GGAGGAAAGCACTGCCTTGCCCTGTCTTCAGAAGGAGAAGTTTACTCTTGGGGTGAGGCAGAAGATGGGAAGTTGGGGCATGGCAACAGA
AGTCCGTGTGACCGCCCTCGTGTCATCGAGTCTCTGAGAGGAATTGAAGTGGTCGATGTTGCTGCTGGCGGAGCCCACAGCGCCTGTGTC
ACAGCAGCCGGGGACCTCTACACATGGGGCAAAGGCCGCTACGGCCGGCTGGGGCACAGCGACAGTGAGGACCAGCTGAAGCCGAAGCTG
GTGGAGGCGCTGCAGGGCCACCGTGTGGTTGACATCGCCTGTGGCAGTGGAGATGCCCAGACCCTCTGCCTCACAGATGACGACACTGTC
TGGTCCTGGGGGGACGGGGACTACGGCAAGCTCGGCCGGGGAGGCAGCGATGGCTGTAAAGTGCCTATGAAGATTGATTCTCTTACTGGT
CTTGGAGTAGTTAAAGTGGAATGCGGATCCCAGTTTTCTGTTGCCCTTACCAAATCTGGAGCTGTTTATACCTGGGGCAAAGGCGATTAT
CACAGGTTGGGCCATGGATCAGATGACCATGTTCGAAGGCCTCGGCAGGTCCAAGGGTTGCAGGGGAAGAAAGTCATCGCCATCGCCACT
GGCTCCCTGCACTGTGTGTGCTGCACAGAGGATGGTGAGGTTTATACATGGGGCGACAATGATGAGGGACAACTGGGAGACGGAACCACC
AATGCCATCCAGAGGCCTCGGTTGGTAGCTGCCCTTCAGGGTAAGAAGGTCAACCGTGTGGCCTGTGGCTCAGCACATACCCTCGCCTGG
TCGACCAGCAAGCCCGCCAGTGCTGGCAAACTCCCTGCACAGGTCCCCATGGAGTACAATCACCTGCAGGAGATCCCCATCATTGCGCTG
AGGAACCGTCTGCTGCTGCTGCACCACCTCTCCGAGCTCTTCTGCCCCTGCATCCCCATGTTCGACCTGGAAGGCTCGCTCGACGAAACT
GGACTCGGGCCTTCTGTTGGGTTCGACACTCTCCGAGGAATTCTGATATCCCAGGGAAAGGAGGCGGCTTTCCGGAAAGTAGTACAAGCA
ACTATGGTACGCGATCGTCAGCATGGCCCCGTCGTGGAGCTGAACCGCATCCAGGTCAAACGATCAAGGAGCAAAGGCGGGCTGGCCGGC
CCCGACGGCACCAAGTCTGTCTTTGGGCAGATGTGTGCTAAGATGAGCTCGTTTGGTCCCGACAGCCTCCTCCTTCCTCACCGTGTCTGG
AAAGTCAAGTTTGTGGGTGAATCTGTGGATGACTGTGGGGGCGGCTACAGCGAGTCCATAGCTGAGATCTGTGAGGAGCTGCAGAACGGA
CTCACGCCCCTGCTGATCGTGACACCCAACGGGAGGGATGAGTCTGGGGCCAACCGAGACTGCTACCTGCTCAGCCCGGCCGCCAGAGCA
CCCGTGCACAGCAGCATGTTCCGCTTCCTGGGTGTGTTGCTGGGCATTGCCATCCGAACCGGGAGTCCCCTGAGCCTCAACCTTGCCGAG
CCTGTCTGGAAGCAGCTGGCTGGGATGAGCCTCACCATCGCGGACCTCAGTGAGGTTGATAAGGATTTTATTCCTGGACTCATGTACATC
CGAGACAATGAAGCCACCTCAGAGGAGTTTGAAGCCATGAGCCTGCCCTTCACAGTGCCAAGTGCCAGTGGCCAGGACATTCAGTTGAGC
TCCAAGCACACACACATCACCCTGGACAACCGCGCGGAGTACGTGCGGCTGGCGATAAACTATAGACTCCATGAATTTGATGAGCAGGTG
GCTGCTGTTCGGGAAGGAATGGCCCGCGTTGTGCCTGTTCCCCTCCTCTCTCTGTTCACCGGCTACGAACTGGAGACGATGGTGTGTGGC
AGCCCTGACATCCCGCTGCACCTTCTCAAGTCGGTGGCCACCTATAAAGGCATCGAGCCTTCCGCATCGCTGATCCAGTGGTTCTGGGAG
GTGATGGAGTCCTTCTCCAACACAGAGCGCTCTCTTTTCCTTCGCTTCGTCTGGGGCCGGACGAGGCTGCCCAGGACCATCGCCGACTTC
CGGGGCCGAGACTTCGTCATCCAGGTGTTGGATAAATACAACCCTCCAGACCACTTCCTCCCTGAGTCCTACACCTGTTTCTTCTTGCTG
AAGCTGCCCAGGTATTCCTGCAAGCAGGTGCTGGAGGAGAAGCTCAAGTACGCCATCCACTTCTGCAAGTCCATAGACACAGATGACTAC
GCTCGCATCGCACTTACAGGAGAGCCAGCCGCCGACGACAGCAGCGACGATTCAGATAACGAGGATGTCGACTCCTTTGCTTCGGACTCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_WDR48_ENST00000302313_chr3_39093564_+_HERC2_ENST00000261609_chr15_28397976_-_4558nt
AAGTGACGTCGGAGTGTCAACATGCAAGATGGCGGCCCATCACCGGCAGAACACAGCAGGGCGGAGGAAAGTGCAGGTGGCAGATATGCT
GTTGGAGCTCTGTGTCACCGAGTTGGAGGATGTGGCCACAGACTCGCAGAGCGGCCGCCTCTCTTCTCAGCCTGTGGTGGTGGAGAGTAG
CCACCCTTACACCGACGACACCTCCACCAGTGGCACAGTGAAGATACCAGGTGCAGAAGGACTCAGGGTAGAATTTGACCGGCAGTGCTC
CACAGAGAGGCGCCACGACCCTCTCACAGTCATGGACGGCGTCAACAGGATCGTCTCCGTGCGGTCAGGCCGAGAGTGGTCCGACTGGTC
CAGCGAGCTGCGCATCCCAGGGGATGAGTTAAAGTGGAAGTTCATCAGCGATGGGTCTGTGAATGGCTGGGGCTGGCGCTTCACCGTCTA
TCCCATCATGCCAGCTGCTGGCCCTAAAGAACTCCTCTCTGACCGCTGCGTCCTCTCCTGTCCATCCATGGACTTGGTGACGTGTCTGTT
AGACTTCCGACTCAACCTTGCCTCTAACAGAAGCATCGTCCCTCGCCTTGCGGCCTCGCTGGCAGCTTGTGCACAGCTGAGTGCCCTAGC
TGCCAGTCACAGAATGTGGGCCCTTCAGAGACTGAGGAAGCTGCTTACAACTGAATTTGGGCAGTCAATTAACATAAATAGGCTGCTTGG
AGAAAATGATGGGGAAACAAGAGCTTTGAGTTTTACAGGTAGTGCTCTTGCTGCTTTGGTGAAAGGTCTTCCAGAAGCTTTGCAAAGGCA
GTTTGAATATGAAGATCCTATTGTGAGGGGTGGCAAACAGCTGCTCCACAGCCCATTCTTTAAGGTACTGGTAGCTCTTGCTTGTGACCT
GGAGCTGGACACTCTGCCTTGCTGTGCCGAGACGCACAAGTGGGCCTGGTTCCGGAGGTACTGCATGGCCTCCCGTGTTGCTGTGGCCCT
TGACAAAAGAACACCGTTGCCCCGTCTGTTTCTTGATGAGGTGGCTAAGAAAATTCGTGAATTAATGGCAGACAGCGAAAACATGGATGT
TCTGCATGAGAGCCATGACATTTTTAAAAGAGAGCAAGACGAACAACTTGTGCAGTGGATGAACAGGCGACCAGATGACTGGACTCTCTC
TGCTGGTGGCAGTGGAACAATTTATGGATGGGGACATAATCACAGGGGCCAGCTCGGGGGCATTGAAGGCGCAAAAGTCAAAGTTCCCAC
TCCCTGTGAAGCCCTTGCAACTCTCAGACCCGTGCAGTTAATCGGAGGGGAACAGACCCTCTTTGCTGTGACGGCTGATGGGAAGCTGTA
TGCCACTGGGTATGGTGCAGGTGGCAGACTAGGCATTGGAGGGACAGAGTCGGTGTCCACCCCAACATTGCTTGAATCCATTCAGCATGT
GTTTATTAAGAAAGTAGCTGTGAACTCTGGAGGAAAGCACTGCCTTGCCCTGTCTTCAGAAGGAGAAGTTTACTCTTGGGGTGAGGCAGA
AGATGGGAAGTTGGGGCATGGCAACAGAAGTCCGTGTGACCGCCCTCGTGTCATCGAGTCTCTGAGAGGAATTGAAGTGGTCGATGTTGC
TGCTGGCGGAGCCCACAGCGCCTGTGTCACAGCAGCCGGGGACCTCTACACATGGGGCAAAGGCCGCTACGGCCGGCTGGGGCACAGCGA
CAGTGAGGACCAGCTGAAGCCGAAGCTGGTGGAGGCGCTGCAGGGCCACCGTGTGGTTGACATCGCCTGTGGCAGTGGAGATGCCCAGAC
CCTCTGCCTCACAGATGACGACACTGTCTGGTCCTGGGGGGACGGGGACTACGGCAAGCTCGGCCGGGGAGGCAGCGATGGCTGTAAAGT
GCCTATGAAGATTGATTCTCTTACTGGTCTTGGAGTAGTTAAAGTGGAATGCGGATCCCAGTTTTCTGTTGCCCTTACCAAATCTGGAGC
TGTTTATACCTGGGGCAAAGGCGATTATCACAGGTTGGGCCATGGATCAGATGACCATGTTCGAAGGCCTCGGCAGGTCCAAGGGTTGCA
GGGGAAGAAAGTCATCGCCATCGCCACTGGCTCCCTGCACTGTGTGTGCTGCACAGAGGATGGTGAGGTTTATACATGGGGCGACAATGA
TGAGGGACAACTGGGAGACGGAACCACCAATGCCATCCAGAGGCCTCGGTTGGTAGCTGCCCTTCAGGGTAAGAAGGTCAACCGTGTGGC
CTGTGGCTCAGCACATACCCTCGCCTGGTCGACCAGCAAGCCCGCCAGTGCTGGCAAACTCCCTGCACAGGTCCCCATGGAGTACAATCA
CCTGCAGGAGATCCCCATCATTGCGCTGAGGAACCGTCTGCTGCTGCTGCACCACCTCTCCGAGCTCTTCTGCCCCTGCATCCCCATGTT
CGACCTGGAAGGCTCGCTCGACGAAACTGGACTCGGGCCTTCTGTTGGGTTCGACACTCTCCGAGGAATTCTGATATCCCAGGGAAAGGA
GGCGGCTTTCCGGAAAGTAGTACAAGCAACTATGGTACGCGATCGTCAGCATGGCCCCGTCGTGGAGCTGAACCGCATCCAGGTCAAACG
ATCAAGGAGCAAAGGCGGGCTGGCCGGCCCCGACGGCACCAAGTCTGTCTTTGGGCAGATGTGTGCTAAGATGAGCTCGTTTGGTCCCGA
CAGCCTCCTCCTTCCTCACCGTGTCTGGAAAGTCAAGTTTGTGGGTGAATCTGTGGATGACTGTGGGGGCGGCTACAGCGAGTCCATAGC
TGAGATCTGTGAGGAGCTGCAGAACGGACTCACGCCCCTGCTGATCGTGACACCCAACGGGAGGGATGAGTCTGGGGCCAACCGAGACTG
CTACCTGCTCAGCCCGGCCGCCAGAGCACCCGTGCACAGCAGCATGTTCCGCTTCCTGGGTGTGTTGCTGGGCATTGCCATCCGAACCGG
GAGTCCCCTGAGCCTCAACCTTGCCGAGCCTGTCTGGAAGCAGCTGGCTGGGATGAGCCTCACCATCGCGGACCTCAGTGAGGTTGATAA
GGATTTTATTCCTGGACTCATGTACATCCGAGACAATGAAGCCACCTCAGAGGAGTTTGAAGCCATGAGCCTGCCCTTCACAGTGCCAAG
TGCCAGTGGCCAGGACATTCAGTTGAGCTCCAAGCACACACACATCACCCTGGACAACCGCGCGGAGTACGTGCGGCTGGCGATAAACTA
TAGACTCCATGAATTTGATGAGCAGGTGGCTGCTGTTCGGGAAGGAATGGCCCGCGTTGTGCCTGTTCCCCTCCTCTCTCTGTTCACCGG
CTACGAACTGGAGACGATGGTGTGTGGCAGCCCTGACATCCCGCTGCACCTTCTCAAGTCGGTGGCCACCTATAAAGGCATCGAGCCTTC
CGCATCGCTGATCCAGTGGTTCTGGGAGGTGATGGAGTCCTTCTCCAACACAGAGCGCTCTCTTTTCCTTCGCTTCGTCTGGGGCCGGAC
GAGGCTGCCCAGGACCATCGCCGACTTCCGGGGCCGAGACTTCGTCATCCAGGTGTTGGATAAATACAACCCTCCAGACCACTTCCTCCC
TGAGTCCTACACCTGTTTCTTCTTGCTGAAGCTGCCCAGGTATTCCTGCAAGCAGGTGCTGGAGGAGAAGCTCAAGTACGCCATCCACTT
CTGCAAGTCCATAGACACAGATGACTACGCTCGCATCGCACTTACAGGAGAGCCAGCCGCCGACGACAGCAGCGACGATTCAGATAACGA
GGATGTCGACTCCTTTGCTTCGGACTCTACACAAGATTATTTAACAGGACACTAAGATGGGGAAACGTCCTCGTGAGATGAGAGCCTGAG
CCAGGCAGCAGAGCGCTCGCTGCTGTGTAGACTGTAGGCTGCCTGGTGTGTCTGATGAGAAGCGTCCGTCCTCGAGCCAGGCGGGAGGAG
GGAGTGGAGAGACTGACTGGCCGTGATGGGAATGACAGTGAGAAGGTCCGCCTGTGCGCGTGGAACACTGTGGACGCTCGACTTCCAAGG
GTCTTCTCACCCGTAATGCTGCATTACATGTAGGACTGTGTTTACTAAAGTGTGTAAATGTTTATATAAATACCAAATTGCAGCATCCCC
AAAATGAATAAAGCCTTTTTACTTGTGGGTGCAATCGATTTTTTTTCTTTCTCCTTTCTTTCAAGTGTCGTGAGTCGTCTTGATTGTATA
TTGGAAATAACTGTGTAACAAATCGTATTATAAATATTTCAATTAATTTTACTCTGAATTTGTTTATTAAAAGACTTTTGAACATGAAAT
GATTAGTATTACTTGAATGCATCCAGAGGATATTTAAACCAAAATGAAAAACCAGAAGGCCATTTGGTGTCCCCCCTCCCAGGTGTCCCC
TTGTAGCATATGCATTATGTCATCTGAATTGAGGCCTTTCTGTGAACAGCATCATAACTTCTATCATGGAAAGTGTACTATATATAATGT

>In-frame_WDR48_ENST00000544962_chr3_39093564_+_HERC2_ENST00000261609_chr15_28397976_-_4540nt
AACATGCAAGATGGCGGCCCATCACCGGCAGAACACAGCAGGGCGGAGGAAAGTGCAGGTGGCAGATATGCTGTTGGAGCTCTGTGTCAC
CGAGTTGGAGGATGTGGCCACAGACTCGCAGAGCGGCCGCCTCTCTTCTCAGCCTGTGGTGGTGGAGAGTAGCCACCCTTACACCGACGA
CACCTCCACCAGTGGCACAGTGAAGATACCAGGTGCAGAAGGACTCAGGGTAGAATTTGACCGGCAGTGCTCCACAGAGAGGCGCCACGA
CCCTCTCACAGTCATGGACGGCGTCAACAGGATCGTCTCCGTGCGGTCAGGCCGAGAGTGGTCCGACTGGTCCAGCGAGCTGCGCATCCC
AGGGGATGAGTTAAAGTGGAAGTTCATCAGCGATGGGTCTGTGAATGGCTGGGGCTGGCGCTTCACCGTCTATCCCATCATGCCAGCTGC
TGGCCCTAAAGAACTCCTCTCTGACCGCTGCGTCCTCTCCTGTCCATCCATGGACTTGGTGACGTGTCTGTTAGACTTCCGACTCAACCT
TGCCTCTAACAGAAGCATCGTCCCTCGCCTTGCGGCCTCGCTGGCAGCTTGTGCACAGCTGAGTGCCCTAGCTGCCAGTCACAGAATGTG
GGCCCTTCAGAGACTGAGGAAGCTGCTTACAACTGAATTTGGGCAGTCAATTAACATAAATAGGCTGCTTGGAGAAAATGATGGGGAAAC
AAGAGCTTTGAGTTTTACAGGTAGTGCTCTTGCTGCTTTGGTGAAAGGTCTTCCAGAAGCTTTGCAAAGGCAGTTTGAATATGAAGATCC
TATTGTGAGGGGTGGCAAACAGCTGCTCCACAGCCCATTCTTTAAGGTACTGGTAGCTCTTGCTTGTGACCTGGAGCTGGACACTCTGCC
TTGCTGTGCCGAGACGCACAAGTGGGCCTGGTTCCGGAGGTACTGCATGGCCTCCCGTGTTGCTGTGGCCCTTGACAAAAGAACACCGTT
GCCCCGTCTGTTTCTTGATGAGGTGGCTAAGAAAATTCGTGAATTAATGGCAGACAGCGAAAACATGGATGTTCTGCATGAGAGCCATGA
CATTTTTAAAAGAGAGCAAGACGAACAACTTGTGCAGTGGATGAACAGGCGACCAGATGACTGGACTCTCTCTGCTGGTGGCAGTGGAAC
AATTTATGGATGGGGACATAATCACAGGGGCCAGCTCGGGGGCATTGAAGGCGCAAAAGTCAAAGTTCCCACTCCCTGTGAAGCCCTTGC
AACTCTCAGACCCGTGCAGTTAATCGGAGGGGAACAGACCCTCTTTGCTGTGACGGCTGATGGGAAGCTGTATGCCACTGGGTATGGTGC
AGGTGGCAGACTAGGCATTGGAGGGACAGAGTCGGTGTCCACCCCAACATTGCTTGAATCCATTCAGCATGTGTTTATTAAGAAAGTAGC
TGTGAACTCTGGAGGAAAGCACTGCCTTGCCCTGTCTTCAGAAGGAGAAGTTTACTCTTGGGGTGAGGCAGAAGATGGGAAGTTGGGGCA
TGGCAACAGAAGTCCGTGTGACCGCCCTCGTGTCATCGAGTCTCTGAGAGGAATTGAAGTGGTCGATGTTGCTGCTGGCGGAGCCCACAG
CGCCTGTGTCACAGCAGCCGGGGACCTCTACACATGGGGCAAAGGCCGCTACGGCCGGCTGGGGCACAGCGACAGTGAGGACCAGCTGAA
GCCGAAGCTGGTGGAGGCGCTGCAGGGCCACCGTGTGGTTGACATCGCCTGTGGCAGTGGAGATGCCCAGACCCTCTGCCTCACAGATGA
CGACACTGTCTGGTCCTGGGGGGACGGGGACTACGGCAAGCTCGGCCGGGGAGGCAGCGATGGCTGTAAAGTGCCTATGAAGATTGATTC
TCTTACTGGTCTTGGAGTAGTTAAAGTGGAATGCGGATCCCAGTTTTCTGTTGCCCTTACCAAATCTGGAGCTGTTTATACCTGGGGCAA
AGGCGATTATCACAGGTTGGGCCATGGATCAGATGACCATGTTCGAAGGCCTCGGCAGGTCCAAGGGTTGCAGGGGAAGAAAGTCATCGC
CATCGCCACTGGCTCCCTGCACTGTGTGTGCTGCACAGAGGATGGTGAGGTTTATACATGGGGCGACAATGATGAGGGACAACTGGGAGA
CGGAACCACCAATGCCATCCAGAGGCCTCGGTTGGTAGCTGCCCTTCAGGGTAAGAAGGTCAACCGTGTGGCCTGTGGCTCAGCACATAC
CCTCGCCTGGTCGACCAGCAAGCCCGCCAGTGCTGGCAAACTCCCTGCACAGGTCCCCATGGAGTACAATCACCTGCAGGAGATCCCCAT
CATTGCGCTGAGGAACCGTCTGCTGCTGCTGCACCACCTCTCCGAGCTCTTCTGCCCCTGCATCCCCATGTTCGACCTGGAAGGCTCGCT
CGACGAAACTGGACTCGGGCCTTCTGTTGGGTTCGACACTCTCCGAGGAATTCTGATATCCCAGGGAAAGGAGGCGGCTTTCCGGAAAGT
AGTACAAGCAACTATGGTACGCGATCGTCAGCATGGCCCCGTCGTGGAGCTGAACCGCATCCAGGTCAAACGATCAAGGAGCAAAGGCGG
GCTGGCCGGCCCCGACGGCACCAAGTCTGTCTTTGGGCAGATGTGTGCTAAGATGAGCTCGTTTGGTCCCGACAGCCTCCTCCTTCCTCA
CCGTGTCTGGAAAGTCAAGTTTGTGGGTGAATCTGTGGATGACTGTGGGGGCGGCTACAGCGAGTCCATAGCTGAGATCTGTGAGGAGCT
GCAGAACGGACTCACGCCCCTGCTGATCGTGACACCCAACGGGAGGGATGAGTCTGGGGCCAACCGAGACTGCTACCTGCTCAGCCCGGC
CGCCAGAGCACCCGTGCACAGCAGCATGTTCCGCTTCCTGGGTGTGTTGCTGGGCATTGCCATCCGAACCGGGAGTCCCCTGAGCCTCAA
CCTTGCCGAGCCTGTCTGGAAGCAGCTGGCTGGGATGAGCCTCACCATCGCGGACCTCAGTGAGGTTGATAAGGATTTTATTCCTGGACT
CATGTACATCCGAGACAATGAAGCCACCTCAGAGGAGTTTGAAGCCATGAGCCTGCCCTTCACAGTGCCAAGTGCCAGTGGCCAGGACAT
TCAGTTGAGCTCCAAGCACACACACATCACCCTGGACAACCGCGCGGAGTACGTGCGGCTGGCGATAAACTATAGACTCCATGAATTTGA
TGAGCAGGTGGCTGCTGTTCGGGAAGGAATGGCCCGCGTTGTGCCTGTTCCCCTCCTCTCTCTGTTCACCGGCTACGAACTGGAGACGAT
GGTGTGTGGCAGCCCTGACATCCCGCTGCACCTTCTCAAGTCGGTGGCCACCTATAAAGGCATCGAGCCTTCCGCATCGCTGATCCAGTG
GTTCTGGGAGGTGATGGAGTCCTTCTCCAACACAGAGCGCTCTCTTTTCCTTCGCTTCGTCTGGGGCCGGACGAGGCTGCCCAGGACCAT
CGCCGACTTCCGGGGCCGAGACTTCGTCATCCAGGTGTTGGATAAATACAACCCTCCAGACCACTTCCTCCCTGAGTCCTACACCTGTTT
CTTCTTGCTGAAGCTGCCCAGGTATTCCTGCAAGCAGGTGCTGGAGGAGAAGCTCAAGTACGCCATCCACTTCTGCAAGTCCATAGACAC
AGATGACTACGCTCGCATCGCACTTACAGGAGAGCCAGCCGCCGACGACAGCAGCGACGATTCAGATAACGAGGATGTCGACTCCTTTGC
TTCGGACTCTACACAAGATTATTTAACAGGACACTAAGATGGGGAAACGTCCTCGTGAGATGAGAGCCTGAGCCAGGCAGCAGAGCGCTC
GCTGCTGTGTAGACTGTAGGCTGCCTGGTGTGTCTGATGAGAAGCGTCCGTCCTCGAGCCAGGCGGGAGGAGGGAGTGGAGAGACTGACT
GGCCGTGATGGGAATGACAGTGAGAAGGTCCGCCTGTGCGCGTGGAACACTGTGGACGCTCGACTTCCAAGGGTCTTCTCACCCGTAATG
CTGCATTACATGTAGGACTGTGTTTACTAAAGTGTGTAAATGTTTATATAAATACCAAATTGCAGCATCCCCAAAATGAATAAAGCCTTT
TTACTTGTGGGTGCAATCGATTTTTTTTCTTTCTCCTTTCTTTCAAGTGTCGTGAGTCGTCTTGATTGTATATTGGAAATAACTGTGTAA
CAAATCGTATTATAAATATTTCAATTAATTTTACTCTGAATTTGTTTATTAAAAGACTTTTGAACATGAAATGATTAGTATTACTTGAAT
GCATCCAGAGGATATTTAAACCAAAATGAAAAACCAGAAGGCCATTTGGTGTCCCCCCTCCCAGGTGTCCCCTTGTAGCATATGCATTAT
GTCATCTGAATTGAGGCCTTTCTGTGAACAGCATCATAACTTCTATCATGGAAAGTGTACTATATATAATGTTTGTGTCATGTATATGCC


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FusionGenePPI for WDR48_HERC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WDR48BCR, BRCA1, CSNK2A1, CSNK2A2, CSNK2B, CTNND1, DKC1, DMWD, POLR2G, POLR2I, PPIB, SET, STK11, SUPT6H, TARBP1, TCOF1, TP53, USP1, WRN, NELFE, CUL4B, EIF3A, EIF3F, EIF3H, ARHGEF10, KDM4A, ZBTB33, PSME3, CRTAP, UNC13B, RAD51AP1, AHCYL1, C11orf58, GPN1, PHLPP2, MYCBP2, PHLPP1, BOP1, AHCYL2, AP3M1, GPN3, ZNF639, UBR5, WDR70, SHQ1, NOP10, PPP1R9A, NHP2, IWS1, YLPM1, USP12, USP46, UIMC1, WDR20, ZBTB2, TRMT11, P3H1, PPP1R9B, NAF1, FAM122B, ATAD5, PCNA, FANCI, PSMA3, ITCH, PAXIP1, FBXL7, CUL3, VSX2, BASP1, YARS, NTRK1, UBC, AR, NFATC1, NFATC2, JMJD6, TSPYL6, RNF19B, USH1C, RAD51HERC2DBNL, MPDU1, ZRANB1, USP19, USP20, USP16, USP42, PMS1, CDC42, BRCA1, RNF8, MDC1, UBE2N, RNF168, SIRT3, CALM1, PIAS4, UBC, UBE3A, SIRT7, ATRIP, CLSPN, CCP110, NEURL4, SSSCA1, ECI2, RPA3, RPA1, CEP170, SRGAP2, TBK1, TANK, SEC23IP, KTN1, HERC2, STK33, UBE2D3, XPA, CDK8, MAPK6, TP53, FBXL5, CEP250, PSMD14, CCDC8, EIF3I, UCHL5, DNAJA1, BIRC6, GET4, FAM63A, RIPK1, RNF115, DNAJB5, HOXD13, CCDC88A, HERC3, HOOK1, RABEP1, FAM83H, RYBP, CCDC151, SPZ1, RNF166, ETFA, INPP4A, MUS81, CCDC22, AGAP3, ARHGEF5, EME1, HERC1, KIF20A, HPS3, HPS5, TUBA1C, KMT2D, RAB34, ZDHHC17, EPHA7, ZBTB5, NUP153, GTF3C2, MLF2, ARNT, RNGTT, CCDC186, TRMT2A, IGHV1OR15-9, FDFT1, ASAH1, MAVS, CST4, SPTLC2, ZG16B, NCCRP1, HLA-A, HM13, VDAC2, KRT80, CSTA, BLMH, PSMB4, PSMD1, PSMD11, PELP1, TEX10, ITPR2, PTPN1, GNA13, FNDC3A, EPCAM, NCOA4, LACTB, NEK11, HLA-E, LMNB2, FTH1, MLEC, LMNA, URI1, PPM1B, COPB2, OBSL1, COPG2, COPG1, COPA, BICD1, BICD2, ZFYVE9, SNAPIN, SLC30A9, PCM1, FHOD3, AKAP9, NIN, NUDCD2, SLC27A4, ASPM, PEX1, ETAA1, PRR14L, RIC8A, PHKG2, SCO2, WDR62, GNAS, PHKB, PHKA2, ENPP1, EIF3H, MIOS, EIF3A, OCRL, MTMR3, EIF3E, PHKA1, WDR59, EIF3B, EIF3L, EIF3M, EIF4G1, EIF3G, EIF3C, EIF3K, EIF3D, CTNNA1, CTNNB1, WDR24, GCC2, LCP1, SELO, SPECC1L, SNX6, ARAF, TUBB3, RAF1, ABR, RER1, TXLNG, CBX2, SENP1, ATP4A, EXD2, SSX2IP, CDC25C, MYO9B, CXorf57, SOGA1, FLII, FASTKD5, CPT1A, AURKB, WDR92, COPZ1, FTL, COPE, PRKAR2B, CEP290, CEP162, CEP104, MARK2, KIFC3, PSMC1, SMC3, GTSE1, CHMP4B, NPRL2, LRRK2, RAB5A, RAB5B, ATOH1, SIRT1, STK11, UBE2D1, EGFR, DUSP26, MAP7D2, CCDC136, PRIMPOL, ZNF286A, APBB1, FAM98A, LGALS3BP, ARID3A, SOST, HSDL2, FARP2, CCDC65, KNOP1, APBA2, ERG, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WDR48_HERC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WDR48_HERC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHERC2C0009324Ulcerative Colitis1CTD_human
TgeneHERC2C0036341Schizophrenia1PSYGENET
TgeneHERC2C0264423Asthma, Occupational1CTD_human
TgeneHERC2C3809753MENTAL RETARDATION, AUTOSOMAL RECESSIVE 381ORPHANET;UNIPROT