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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41830

FusionGeneSummary for WDR33_LRP1B

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR33_LRP1B
Fusion gene ID: 41830
HgeneTgene
Gene symbol

WDR33

LRP1B

Gene ID

55339

53353

Gene nameWD repeat domain 33LDL receptor related protein 1B
SynonymsNET14|WDC146LRP-1B|LRP-DIT|LRPDIT
Cytomap

2q14.3

2q22.1-q22.2

Type of geneprotein-codingprotein-coding
Descriptionpre-mRNA 3' end processing protein WDR33WD repeat-containing protein 33WD repeat-containing protein WDC146low-density lipoprotein receptor-related protein 1BLRP-deleted in tumorslow density lipoprotein receptor related protein-deleted in tumorlow density lipoprotein receptor-related protein 1Blow density lipoprotein-related protein 1B (deleted in tumors)
Modification date2018052320180519
UniProtAcc

Q9C0J8

Q9NZR2

Ensembl transtripts involved in fusion geneENST00000322313, ENST00000393006, 
ENST00000409658, 
ENST00000389484, 
ENST00000486364, 
Fusion gene scores* DoF score6 X 6 X 2=725 X 5 X 4=100
# samples 65
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WDR33 [Title/Abstract] AND LRP1B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-EE-A181-06AWDR33chr2

128520636

-LRP1Bchr2

142567970

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000322313ENST00000389484WDR33chr2

128520636

-LRP1Bchr2

142567970

-
Frame-shiftENST00000322313ENST00000486364WDR33chr2

128520636

-LRP1Bchr2

142567970

-
Frame-shiftENST00000393006ENST00000389484WDR33chr2

128520636

-LRP1Bchr2

142567970

-
Frame-shiftENST00000393006ENST00000486364WDR33chr2

128520636

-LRP1Bchr2

142567970

-
intron-3CDSENST00000409658ENST00000389484WDR33chr2

128520636

-LRP1Bchr2

142567970

-
intron-3CDSENST00000409658ENST00000486364WDR33chr2

128520636

-LRP1Bchr2

142567970

-

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FusionProtFeatures for WDR33_LRP1B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WDR33

Q9C0J8

LRP1B

Q9NZR2

Essential for both cleavage and polyadenylation of pre-mRNA 3' ends. {ECO:0000269|PubMed:19217410}. Potential cell surface proteins that bind andinternalize ligands in the process of receptor-mediatedendocytosis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WDR33_LRP1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WDR33_LRP1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WDR33RNPS1, KAT7, PFN2, UTP14A, SH3GL3, ZHX1, ZBTB16, GIT1, PRMT1, TP53, RBM48, EEF1G, SMARCAD1, ELAVL1, HNRNPA1, ISG15, CPSF1, CPSF2, CPSF3, FIP1L1, ZNF622, MED17, BARD1, MDC1, CDK4, HDAC11, CDK6, DYRK4, CLK2, WWOX, RPA3, RPA2, RPA1, BMI1, TRA2A, CPSF4L, PAPOLA, CPSF4, PCF11, RBBP5, SYMPK, MED4, B9D2, SEC16A, CEP170P1, SNW1, CDC5L, P4HA2, P4HA3, JMJD6, VTN, ZC3H18, LZTS2, HNRNPLL, AHCYL2, SNRNP70, UBCLRP1BARRB1, CUL4B, TAZ, RSPO1, SFRP4, PTPRK, FOXD4L6, ZFP41, EWSR1, LRPAP1, ZNF408, ZNF224, ZNF331, FAM19A3, ZNF563, ZNF517, ZNF169, SCGB1D1, DNAJC10, CHRDL1, OLFM3, EGFL6, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WDR33_LRP1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WDR33_LRP1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLRP1BC0007134Renal Cell Carcinoma1CTD_human
TgeneLRP1BC0025202melanoma1CTD_human