![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 41830 |
FusionGeneSummary for WDR33_LRP1B |
![]() |
Fusion gene information | Fusion gene name: WDR33_LRP1B | Fusion gene ID: 41830 | Hgene | Tgene | Gene symbol | WDR33 | LRP1B | Gene ID | 55339 | 53353 |
Gene name | WD repeat domain 33 | LDL receptor related protein 1B | |
Synonyms | NET14|WDC146 | LRP-1B|LRP-DIT|LRPDIT | |
Cytomap | 2q14.3 | 2q22.1-q22.2 | |
Type of gene | protein-coding | protein-coding | |
Description | pre-mRNA 3' end processing protein WDR33WD repeat-containing protein 33WD repeat-containing protein WDC146 | low-density lipoprotein receptor-related protein 1BLRP-deleted in tumorslow density lipoprotein receptor related protein-deleted in tumorlow density lipoprotein receptor-related protein 1Blow density lipoprotein-related protein 1B (deleted in tumors) | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9C0J8 | Q9NZR2 | |
Ensembl transtripts involved in fusion gene | ENST00000322313, ENST00000393006, ENST00000409658, | ENST00000389484, ENST00000486364, | |
Fusion gene scores | * DoF score | 6 X 6 X 2=72 | 5 X 5 X 4=100 |
# samples | 6 | 5 | |
** MAII score | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: WDR33 [Title/Abstract] AND LRP1B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SKCM | TCGA-EE-A181-06A | WDR33 | chr2 | 128520636 | - | LRP1B | chr2 | 142567970 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000322313 | ENST00000389484 | WDR33 | chr2 | 128520636 | - | LRP1B | chr2 | 142567970 | - |
Frame-shift | ENST00000322313 | ENST00000486364 | WDR33 | chr2 | 128520636 | - | LRP1B | chr2 | 142567970 | - |
Frame-shift | ENST00000393006 | ENST00000389484 | WDR33 | chr2 | 128520636 | - | LRP1B | chr2 | 142567970 | - |
Frame-shift | ENST00000393006 | ENST00000486364 | WDR33 | chr2 | 128520636 | - | LRP1B | chr2 | 142567970 | - |
intron-3CDS | ENST00000409658 | ENST00000389484 | WDR33 | chr2 | 128520636 | - | LRP1B | chr2 | 142567970 | - |
intron-3CDS | ENST00000409658 | ENST00000486364 | WDR33 | chr2 | 128520636 | - | LRP1B | chr2 | 142567970 | - |
Top |
FusionProtFeatures for WDR33_LRP1B |
![]() |
Hgene | Tgene |
WDR33 | LRP1B |
Essential for both cleavage and polyadenylation of pre-mRNA 3' ends. {ECO:0000269|PubMed:19217410}. | Potential cell surface proteins that bind andinternalize ligands in the process of receptor-mediatedendocytosis. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for WDR33_LRP1B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for WDR33_LRP1B |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
WDR33 | RNPS1, KAT7, PFN2, UTP14A, SH3GL3, ZHX1, ZBTB16, GIT1, PRMT1, TP53, RBM48, EEF1G, SMARCAD1, ELAVL1, HNRNPA1, ISG15, CPSF1, CPSF2, CPSF3, FIP1L1, ZNF622, MED17, BARD1, MDC1, CDK4, HDAC11, CDK6, DYRK4, CLK2, WWOX, RPA3, RPA2, RPA1, BMI1, TRA2A, CPSF4L, PAPOLA, CPSF4, PCF11, RBBP5, SYMPK, MED4, B9D2, SEC16A, CEP170P1, SNW1, CDC5L, P4HA2, P4HA3, JMJD6, VTN, ZC3H18, LZTS2, HNRNPLL, AHCYL2, SNRNP70, UBC | LRP1B | ARRB1, CUL4B, TAZ, RSPO1, SFRP4, PTPRK, FOXD4L6, ZFP41, EWSR1, LRPAP1, ZNF408, ZNF224, ZNF331, FAM19A3, ZNF563, ZNF517, ZNF169, SCGB1D1, DNAJC10, CHRDL1, OLFM3, EGFL6, TRIM25 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for WDR33_LRP1B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for WDR33_LRP1B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | LRP1B | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Tgene | LRP1B | C0025202 | melanoma | 1 | CTD_human |