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Fusion gene ID: 41822 |
FusionGeneSummary for WDR26_RPS14 |
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Fusion gene information | Fusion gene name: WDR26_RPS14 | Fusion gene ID: 41822 | Hgene | Tgene | Gene symbol | WDR26 | RPS14 | Gene ID | 80232 | 6208 |
Gene name | WD repeat domain 26 | ribosomal protein S14 | |
Synonyms | CDW2|GID7|MIP2|SKDEAS | EMTB|S14 | |
Cytomap | 1q42.11-q42.12 | 5q33.1 | |
Type of gene | protein-coding | protein-coding | |
Description | WD repeat-containing protein 26CUL4- and DDB1-associated WDR protein 2GID complex subunit 7 homologmyocardial ischemic preconditioning upregulated protein 2 | 40S ribosomal protein S14emetine resistancesmall ribosomal subunit protein uS11 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q9H7D7 | P62263 | |
Ensembl transtripts involved in fusion gene | ENST00000414423, ENST00000295024, ENST00000366852, ENST00000479727, | ENST00000401695, ENST00000407193, ENST00000312037, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 3 X 3 X 1=9 |
# samples | 2 | 3 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: WDR26 [Title/Abstract] AND RPS14 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | RPS14 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 7867928 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AF116710 | WDR26 | chr1 | 224614528 | + | RPS14 | chr5 | 149829294 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000414423 | ENST00000401695 | WDR26 | chr1 | 224614528 | + | RPS14 | chr5 | 149829294 | - |
intron-5UTR | ENST00000414423 | ENST00000407193 | WDR26 | chr1 | 224614528 | + | RPS14 | chr5 | 149829294 | - |
intron-intron | ENST00000414423 | ENST00000312037 | WDR26 | chr1 | 224614528 | + | RPS14 | chr5 | 149829294 | - |
intron-5UTR | ENST00000295024 | ENST00000401695 | WDR26 | chr1 | 224614528 | + | RPS14 | chr5 | 149829294 | - |
intron-5UTR | ENST00000295024 | ENST00000407193 | WDR26 | chr1 | 224614528 | + | RPS14 | chr5 | 149829294 | - |
intron-intron | ENST00000295024 | ENST00000312037 | WDR26 | chr1 | 224614528 | + | RPS14 | chr5 | 149829294 | - |
intron-5UTR | ENST00000366852 | ENST00000401695 | WDR26 | chr1 | 224614528 | + | RPS14 | chr5 | 149829294 | - |
intron-5UTR | ENST00000366852 | ENST00000407193 | WDR26 | chr1 | 224614528 | + | RPS14 | chr5 | 149829294 | - |
intron-intron | ENST00000366852 | ENST00000312037 | WDR26 | chr1 | 224614528 | + | RPS14 | chr5 | 149829294 | - |
intron-5UTR | ENST00000479727 | ENST00000401695 | WDR26 | chr1 | 224614528 | + | RPS14 | chr5 | 149829294 | - |
intron-5UTR | ENST00000479727 | ENST00000407193 | WDR26 | chr1 | 224614528 | + | RPS14 | chr5 | 149829294 | - |
intron-intron | ENST00000479727 | ENST00000312037 | WDR26 | chr1 | 224614528 | + | RPS14 | chr5 | 149829294 | - |
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FusionProtFeatures for WDR26_RPS14 |
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Hgene | Tgene |
WDR26 | RPS14 |
G-beta-like protein involved in cell signal transduction(PubMed:15378603, PubMed:19446606, PubMed:22065575,PubMed:23625927, PubMed:27098453, PubMed:26895380). Acts as anegative regulator in MAPK signaling pathway (PubMed:15378603).Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequentactivation in leukocytes (PubMed:22065575, PubMed:23625927). Actsas a negative regulator of the canonical Wnt signaling pathwaythrough preventing ubiquitination of beta-catenin CTNNB1 by thebeta-catenin destruction complex, thus negatively regulatingCTNNB1 degradation (PubMed:27098453). Serves as a scaffold tocoordinate PI3K/AKT pathway-driven cell growth and migration(PubMed:26895380). Protects cells from oxidative stress-inducedapoptosis via the down-regulation of AP-1 transcriptional activityas well as by inhibiting cytochrome c release from mitochondria(PubMed:19446606). Protects also cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity).{ECO:0000250|UniProtKB:F1LTR1, ECO:0000269|PubMed:15378603,ECO:0000269|PubMed:19446606, ECO:0000269|PubMed:23625927,ECO:0000269|PubMed:26895380, ECO:0000269|PubMed:27098453}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for WDR26_RPS14 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for WDR26_RPS14 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for WDR26_RPS14 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WDR26_RPS14 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | RPS14 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Tgene | RPS14 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Tgene | RPS14 | C0242184 | Hypoxia | 1 | CTD_human |