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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41807

FusionGeneSummary for WDR17_LTA4H

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR17_LTA4H
Fusion gene ID: 41807
HgeneTgene
Gene symbol

WDR17

LTA4H

Gene ID

116966

4048

Gene nameWD repeat domain 17leukotriene A4 hydrolase
Synonyms--
Cytomap

4q34.2

12q23.1

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing protein 17leukotriene A-4 hydrolaseLTA-4 hydrolasetesticular secretory protein Li 27
Modification date2018040320180523
UniProtAcc

Q8IZU2

P09960

Ensembl transtripts involved in fusion geneENST00000508596, ENST00000393643, 
ENST00000280190, ENST00000507824, 
ENST00000509792, 		ENST00000228740, 
ENST00000552789, ENST00000413268, 
ENST00000548375, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 6 X 3=108
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/108*10)=-1.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WDR17 [Title/Abstract] AND LTA4H [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLTA4H

GO:0019370

leukotriene biosynthetic process

9774412|15078870

TgeneLTA4H

GO:0043171

peptide catabolic process

9774412|15078870|18804029


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-HT-8106-01AWDR17chr4

177017736

+LTA4Hchr12

96413018

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000508596ENST00000228740WDR17chr4

177017736

+LTA4Hchr12

96413018

-
intron-3CDSENST00000508596ENST00000552789WDR17chr4

177017736

+LTA4Hchr12

96413018

-
intron-3CDSENST00000508596ENST00000413268WDR17chr4

177017736

+LTA4Hchr12

96413018

-
intron-intronENST00000508596ENST00000548375WDR17chr4

177017736

+LTA4Hchr12

96413018

-
intron-3CDSENST00000393643ENST00000228740WDR17chr4

177017736

+LTA4Hchr12

96413018

-
intron-3CDSENST00000393643ENST00000552789WDR17chr4

177017736

+LTA4Hchr12

96413018

-
intron-3CDSENST00000393643ENST00000413268WDR17chr4

177017736

+LTA4Hchr12

96413018

-
intron-intronENST00000393643ENST00000548375WDR17chr4

177017736

+LTA4Hchr12

96413018

-
Frame-shiftENST00000280190ENST00000228740WDR17chr4

177017736

+LTA4Hchr12

96413018

-
Frame-shiftENST00000280190ENST00000552789WDR17chr4

177017736

+LTA4Hchr12

96413018

-
Frame-shiftENST00000280190ENST00000413268WDR17chr4

177017736

+LTA4Hchr12

96413018

-
5CDS-intronENST00000280190ENST00000548375WDR17chr4

177017736

+LTA4Hchr12

96413018

-
Frame-shiftENST00000507824ENST00000228740WDR17chr4

177017736

+LTA4Hchr12

96413018

-
Frame-shiftENST00000507824ENST00000552789WDR17chr4

177017736

+LTA4Hchr12

96413018

-
Frame-shiftENST00000507824ENST00000413268WDR17chr4

177017736

+LTA4Hchr12

96413018

-
5CDS-intronENST00000507824ENST00000548375WDR17chr4

177017736

+LTA4Hchr12

96413018

-
intron-3CDSENST00000509792ENST00000228740WDR17chr4

177017736

+LTA4Hchr12

96413018

-
intron-3CDSENST00000509792ENST00000552789WDR17chr4

177017736

+LTA4Hchr12

96413018

-
intron-3CDSENST00000509792ENST00000413268WDR17chr4

177017736

+LTA4Hchr12

96413018

-
intron-intronENST00000509792ENST00000548375WDR17chr4

177017736

+LTA4Hchr12

96413018

-

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FusionProtFeatures for WDR17_LTA4H


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WDR17

Q8IZU2

LTA4H

P09960

Epoxide hydrolase that catalyzes the final step in thebiosynthesis of the proinflammatory mediator leukotriene B4. Hasalso aminopeptidase activity. {ECO:0000269|PubMed:11917124,ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870,ECO:0000269|PubMed:18804029, ECO:0000269|PubMed:1897988,ECO:0000269|PubMed:1975494, ECO:0000269|PubMed:2244921}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WDR17_LTA4H


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WDR17_LTA4H


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WDR17LTA4HGH1, MCC, TMEM62, DDA1, UBA5, HDAC5, ELAVL1, SIRT7, TINF2, SIRT1, ZNF593, ALDOA, FKBP2, GALK2, IDH1, PGM1, PRPF4, SPR, TRAP1, NAPRT, TAGLN2, NTRK1, KRAS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WDR17_LTA4H


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneLTA4HP09960DB01197CaptoprilLeukotriene A-4 hydrolasesmall moleculeapproved

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RelatedDiseases for WDR17_LTA4H


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneWDR17C0023903Liver neoplasms1CTD_human
TgeneLTA4HC0004153Atherosclerosis1CTD_human
TgeneLTA4HC0011570Mental Depression1PSYGENET
TgeneLTA4HC0011581Depressive disorder1PSYGENET
TgeneLTA4HC0023893Liver Cirrhosis, Experimental1CTD_human