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Fusion gene ID: 41802 |
FusionGeneSummary for WDR11_PDLIM1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: WDR11_PDLIM1 | Fusion gene ID: 41802 | Hgene | Tgene | Gene symbol | WDR11 | PDLIM1 | Gene ID | 55717 | 9124 |
| Gene name | WD repeat domain 11 | PDZ and LIM domain 1 | |
| Synonyms | BRWD2|DR11|HH14|SRI1|WDR15 | CLIM1|CLP-36|CLP36|HEL-S-112|hCLIM1 | |
| Cytomap | 10q26.12 | 10q23.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | WD repeat-containing protein 11WD repeat domain 15WD repeat-containing protein 15bromodomain and WD repeat-containing protein 2sensitization to ricin complex subunit 1 | PDZ and LIM domain protein 1LIM domain protein CLP-36carboxyl terminal LIM domain protein 1elfinepididymis secretory protein Li 112 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q9BZH6 | O00151 | |
| Ensembl transtripts involved in fusion gene | ENST00000263461, ENST00000604509, | ENST00000329399, ENST00000477757, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 4 X 4=80 |
| # samples | 1 | 5 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: WDR11 [Title/Abstract] AND PDLIM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-DQ-7593-01A | WDR11 | chr10 | 122664928 | + | PDLIM1 | chr10 | 97031541 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000263461 | ENST00000329399 | WDR11 | chr10 | 122664928 | + | PDLIM1 | chr10 | 97031541 | - |
| 5CDS-intron | ENST00000263461 | ENST00000477757 | WDR11 | chr10 | 122664928 | + | PDLIM1 | chr10 | 97031541 | - |
| 3UTR-3CDS | ENST00000604509 | ENST00000329399 | WDR11 | chr10 | 122664928 | + | PDLIM1 | chr10 | 97031541 | - |
| 3UTR-intron | ENST00000604509 | ENST00000477757 | WDR11 | chr10 | 122664928 | + | PDLIM1 | chr10 | 97031541 | - |
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FusionProtFeatures for WDR11_PDLIM1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| WDR11 | PDLIM1 |
| Cytoskeletal protein that may act as an adapter thatbrings other proteins (like kinases) to the cytoskeleton(PubMed:10861853). Involved in assembly, disassembly anddirectioning of stress fibers in fibroblasts. Required for thelocalization of ACTN1 and PALLD to stress fibers. Required forcell migration and in maintaining cell polarity of fibroblasts (Bysimilarity). {ECO:0000250|UniProtKB:P52944,ECO:0000269|PubMed:10861853}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | WDR11 | chr10:122664928 | chr10:97031541 | ENST00000263461 | + | 26 | 29 | 111_154 | 1097 | 1225 | Repeat | Note=WD 2 |
| Hgene | WDR11 | chr10:122664928 | chr10:97031541 | ENST00000263461 | + | 26 | 29 | 354_393 | 1097 | 1225 | Repeat | Note=WD 3 |
| Hgene | WDR11 | chr10:122664928 | chr10:97031541 | ENST00000263461 | + | 26 | 29 | 471_510 | 1097 | 1225 | Repeat | Note=WD 4 |
| Hgene | WDR11 | chr10:122664928 | chr10:97031541 | ENST00000263461 | + | 26 | 29 | 566_605 | 1097 | 1225 | Repeat | Note=WD 5 |
| Hgene | WDR11 | chr10:122664928 | chr10:97031541 | ENST00000263461 | + | 26 | 29 | 59_108 | 1097 | 1225 | Repeat | Note=WD 1 |
| Hgene | WDR11 | chr10:122664928 | chr10:97031541 | ENST00000263461 | + | 26 | 29 | 708_745 | 1097 | 1225 | Repeat | Note=WD 6 |
| Hgene | WDR11 | chr10:122664928 | chr10:97031541 | ENST00000263461 | + | 26 | 29 | 747_787 | 1097 | 1225 | Repeat | Note=WD 7 |
| Hgene | WDR11 | chr10:122664928 | chr10:97031541 | ENST00000263461 | + | 26 | 29 | 793_831 | 1097 | 1225 | Repeat | Note=WD 8 |
| Hgene | WDR11 | chr10:122664928 | chr10:97031541 | ENST00000263461 | + | 26 | 29 | 893_940 | 1097 | 1225 | Repeat | Note=WD 9 |
| Tgene | >PDLIM1 | chr10:122664928 | chr10:97031541 | ENST00000329399 | - | 0 | 7 | 258_317 | 32 | 330 | Domain | LIM zinc-binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >WDR11 | chr10:122664928 | chr10:97031541 | ENST00000263461 | + | 26 | 29 | 1127_1147 | 1097 | 1225 | Transmembrane | Helical |
| Tgene | PDLIM1 | chr10:122664928 | chr10:97031541 | ENST00000329399 | - | 0 | 7 | 3_85 | 32 | 330 | Domain | PDZ |
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FusionGeneSequence for WDR11_PDLIM1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_WDR11_ENST00000263461_chr10_122664928_+_PDLIM1_ENST00000329399_chr10_97031541_-_1395aa MLPYTVNFKVSARTLTGALNAHNKAAVDWGWQGLIAYGCHSLVVVIDSITAQTLQVLEKHKADVVKVKWARENYHHNIGSPYCLRLASAD VNGKIIVWDVAAGVAQCEIQEHAKPIQDVQWLWNQDASRDLLLAIHPPNYIVLWNADTGTKLWKKSYADNILSFSFDPFDPSHLTLLTSE GIVFISDFSPSKPPSGPGKKVYISSPHSSPAHNKLATATGAKKALNKVKILITQEKPSAEFITLNDCLQLAYLPSKRNHMLLLYPREILI LDLEVNQTVGVIAIERTGVPFLQVIPCFQRDGLFCLHENGCITLRVRRSYNNIFTTSNEEPDPDPVQELTYDLRSQCDAIRVTKTVRPFS MVCCPVNENAAALVVSDGRVMIWELKSAVCNRNSRNSSSGVSPLYSPVSFCGIPVGVLQNKLPDLSLDNMIGQSAIAGEEHPRGSILREV HLKFLLTGLLSGLPAPQFAIRMCPPLTTKNIKMYQPLLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLSFATSTPNNM GLVRNELQLVDLPTGRSIAFRGERGNDESAIEMIKVSHLKQYLAVVFRDKPLELWDVRTCTLLREMSKNFPTITALEWSPSHNLKSLRKK QLATREAMARQTVVSDTELSIVESSVISLLQEAESKSELSQNISAREHFVFTDIDGQVYHLTVEGNSVKDSARIPPDGSMGSITCIAWKG DTLVLGDMDGNLNFWDLKGRVSRGIPTHRSWVRKIRFAPGKGNQKLIAMYNDGAEVWDTKEVQMVSSLRSGRNVTFRILDVDWCTSDKVI LASDDGCIRVLEMSMKSACFRMDEQELTEPVWCPYLLVPRASLALKAFLLHQPWNGQYSLDISHVDYPENEEIKNLLQEQLNSLSNDIKK LLLDPEFTLLQRCLLVSRLYGDESELHFWTVAAHYLHSLSQEKSASTTAPKEAAPRDKLSNPLDICYDVLCENAYFQKFQLERVNLQEVK RSTYDHTRKCTDQLLLLGQTDRAVQLLLETSADNQHYYCDSLKACLVTTVTSSGPSQSTIKLVATNMIANGKLAEGVQLLCLIDKAADAC RYLQTYGEWNRAAWLAKVTPGSKAALANLCIGDVITAIDGENTSNMTHLEAQNRIKGCTDNLTLTVARSEHKVWSPLVTEEGKRHPYKMN LASEPQEVLHIGSAHNRSAMPFTASPASSTTARVITNQYNNPAGLYSSENISNFNNALESKTAASGVEANSRPLDHAQPPSSLVIDKESE VYKMLQEKQELNEPPKQSTSFLVLQEILESEEKGDPNKPSGFRSVKAPVTKVAASIGNAQKLPMCDKCGTGIVGVFVKLRDRHRHPECYV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_WDR11_ENST00000263461_chr10_122664928_+_PDLIM1_ENST00000329399_chr10_97031541_-_4185nt ATGTTGCCCTACACAGTGAACTTCAAGGTGTCGGCGCGCACCCTCACGGGGGCCCTCAACGCCCACAACAAGGCGGCGGTGGACTGGGGC TGGCAAGGTTTAATTGCTTATGGATGTCATTCACTTGTGGTAGTGATTGATTCCATTACTGCCCAAACTCTTCAAGTTTTAGAAAAGCAT AAAGCTGATGTTGTAAAGGTTAAATGGGCCAGGGAAAACTATCACCATAACATTGGCTCACCATATTGCTTACGGTTAGCTTCTGCTGAT GTCAATGGGAAGATCATCGTCTGGGATGTAGCAGCAGGAGTAGCTCAGTGTGAGATCCAAGAGCATGCCAAGCCTATCCAGGATGTTCAG TGGTTGTGGAATCAAGATGCTTCCCGCGATTTACTGCTTGCTATCCACCCGCCAAATTACATTGTGCTCTGGAATGCCGACACTGGCACC AAACTATGGAAGAAGAGCTATGCAGATAACATTCTTTCTTTTTCTTTTGACCCTTTTGATCCCTCACATTTAACTTTGCTTACCAGCGAG GGTATTGTTTTCATCTCAGACTTCTCCCCATCCAAGCCTCCCTCAGGCCCTGGGAAAAAAGTTTACATATCCAGCCCACACTCTAGCCCA GCTCATAACAAGCTGGCCACAGCCACAGGTGCCAAGAAAGCTCTAAATAAAGTAAAAATTTTAATCACTCAAGAGAAACCTAGTGCTGAA TTCATAACTCTCAATGATTGCCTTCAGTTGGCATACCTGCCTTCAAAAAGGAATCACATGTTGTTGCTCTATCCTCGAGAGATTTTAATC CTTGACCTTGAGGTGAATCAGACGGTGGGTGTGATTGCAATAGAACGCACAGGAGTTCCATTTTTACAGGTAATACCCTGCTTTCAGCGT GATGGTTTATTTTGTCTACATGAAAATGGTTGTATAACTTTACGTGTTCGAAGATCTTATAATAACATTTTTACCACTTCAAATGAGGAA CCAGATCCAGATCCAGTTCAGGAGCTTACCTATGATTTACGAAGCCAGTGTGATGCAATCAGGGTGACAAAAACCGTCCGTCCCTTCAGT ATGGTGTGCTGTCCTGTCAATGAGAATGCAGCCGCCCTCGTAGTGAGTGATGGCAGGGTCATGATATGGGAACTCAAGTCTGCAGTTTGT AATCGAAATTCACGGAACAGTAGTTCTGGTGTGTCACCTTTATATTCACCAGTGTCTTTCTGTGGAATTCCTGTAGGAGTGCTACAGAAT AAACTCCCAGACCTTTCCTTAGATAACATGATTGGGCAAAGTGCAATTGCTGGGGAAGAACATCCCAGAGGTTCAATTCTGCGGGAAGTG CACCTCAAGTTCCTGCTGACGGGACTGCTTTCAGGACTGCCCGCACCACAGTTTGCTATTCGTATGTGTCCACCGTTGACCACAAAAAAC ATCAAGATGTATCAGCCACTGCTGGCTGTTGGTACAAGTAATGGTTCTGTCCTGGTGTACCATCTCACCAGTGGTCTGCTACACAAAGAG TTAAGCATCCACTCATGTGAAGTCAAGGGTATTGAATGGACAAGTTTGACTAGTTTTCTTTCTTTTGCTACCTCAACACCAAACAATATG GGATTAGTGAGAAATGAACTTCAACTGGTTGATCTTCCAACAGGTAGGAGCATTGCTTTTCGTGGTGAAAGAGGCAATGATGAATCTGCC ATCGAAATGATTAAAGTATCTCATTTGAAGCAGTATTTGGCAGTCGTATTCAGAGATAAACCCCTGGAGCTATGGGATGTTAGGACTTGT ACCCTTCTTAGAGAGATGTCCAAAAACTTCCCTACAATAACTGCTTTGGAGTGGTCACCATCTCACAACTTGAAGAGCCTGAGAAAGAAG CAACTTGCAACTCGAGAGGCCATGGCCCGCCAGACCGTAGTCTCAGACACAGAGCTGAGTATTGTTGAATCATCTGTGATCAGCTTGCTG CAGGAGGCAGAAAGTAAATCTGAACTTAGTCAGAACATCTCTGCCCGGGAACATTTTGTATTTACCGATATTGATGGCCAAGTGTATCAT CTCACTGTTGAAGGAAACTCAGTAAAAGACAGTGCTCGGATTCCACCAGATGGAAGTATGGGTAGTATTACCTGCATCGCTTGGAAAGGT GATACATTAGTGCTTGGAGATATGGATGGAAATTTAAATTTCTGGGACTTGAAAGGCAGAGTATCCAGAGGAATACCCACACACCGAAGT TGGGTGAGGAAGATTCGTTTTGCTCCTGGTAAAGGAAATCAAAAATTAATAGCAATGTACAATGATGGAGCTGAAGTGTGGGATACTAAA GAGGTTCAGATGGTGAGCAGTTTAAGAAGTGGCAGAAATGTGACCTTTCGTATATTGGATGTGGACTGGTGTACGTCAGATAAAGTGATC TTGGCCTCAGATGATGGGTGCATCAGAGTCCTAGAGATGTCTATGAAGTCTGCGTGCTTTAGAATGGATGAACAAGAGTTAACCGAGCCT GTGTGGTGCCCCTATCTCCTTGTTCCAAGGGCCTCTCTTGCCTTGAAAGCCTTCTTATTACACCAGCCTTGGAATGGACAGTATTCTTTG GACATTTCTCATGTTGACTATCCAGAAAATGAAGAAATAAAGAATCTCCTCCAAGAACAGTTGAATTCATTGTCTAATGACATAAAGAAA CTGTTGCTTGATCCAGAATTCACTCTCTTGCAGAGGTGCCTGCTTGTTTCAAGGCTCTATGGTGATGAATCGGAGCTGCACTTCTGGACT GTCGCTGCCCACTACCTGCACAGCTTATCCCAGGAAAAGTCAGCCAGCACAACAGCTCCTAAAGAAGCTGCTCCTCGAGACAAACTGAGC AACCCACTGGATATATGCTATGACGTGCTCTGTGAAAATGCCTACTTTCAGAAATTTCAGCTAGAAAGGGTTAATCTGCAGGAAGTGAAA CGGTCAACTTATGATCATACAAGGAAATGTACAGACCAGCTACTGCTCTTGGGTCAAACAGACAGAGCTGTGCAGTTGCTGTTGGAAACA AGTGCAGATAACCAGCATTATTACTGTGATTCACTGAAAGCCTGTTTAGTCACTACTGTCACCTCGTCAGGCCCCTCTCAGAGCACCATT AAGTTGGTGGCAACGAATATGATTGCCAATGGCAAATTGGCAGAGGGCGTTCAGTTGCTCTGCCTGATAGATAAGGCTGCAGACGCCTGC CGCTACCTGCAGACATACGGCGAGTGGAATCGGGCTGCATGGCTGGCAAAAGTCACTCCTGGAAGCAAGGCGGCTCTAGCTAATTTATGT ATTGGAGATGTAATCACAGCCATTGATGGGGAAAATACTAGCAATATGACACACTTGGAAGCTCAGAACAGAATCAAAGGCTGCACAGAC AACTTGACTCTCACTGTAGCCAGATCTGAACATAAAGTCTGGTCTCCTCTGGTGACGGAGGAAGGGAAGCGTCATCCATACAAGATGAAT TTAGCCTCTGAACCCCAGGAGGTCCTGCACATAGGAAGCGCCCACAACCGAAGTGCCATGCCCTTTACCGCCTCGCCTGCCTCCAGCACT ACTGCCAGGGTCATCACAAACCAGTACAACAACCCAGCTGGCCTCTACTCTTCTGAAAATATCTCCAACTTCAACAATGCCCTGGAGTCA AAGACTGCTGCCAGCGGGGTGGAGGCGAACAGCAGACCCTTAGACCATGCTCAGCCTCCAAGCAGCCTTGTCATCGACAAAGAATCTGAA GTTTACAAGATGCTTCAGGAGAAACAGGAGTTGAATGAGCCCCCGAAACAGTCCACGTCTTTCTTGGTTTTGCAGGAAATCCTGGAGTCT GAAGAAAAAGGGGATCCCAACAAGCCCTCAGGATTCAGAAGTGTTAAAGCTCCTGTCACTAAAGTGGCTGCGTCGATTGGAAATGCTCAG AAGTTGCCTATGTGTGACAAATGTGGCACTGGGATTGTTGGTGTGTTTGTGAAGCTGCGGGACCGTCACCGCCACCCTGAGTGTTATGTG TGCACTGACTGTGGCACCAACCTGAAACAGAAGGGCCATTTCTTTGTGGAGGATCAAATCTACTGTGAGAAGCATGCCCGGGAGCGAGTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_WDR11_ENST00000263461_chr10_122664928_+_PDLIM1_ENST00000329399_chr10_97031541_-_4784nt AGCACAACCGCCTAAGCGGCGGAACTCTGGAGAGTGCGGAACCTAGGATCCTAGGAAACTGAAGGCAACGGAACCTGGGGGCGATGGAAT CCGGGAGCGGTGGAACCCGGAGCCTGTAGAACTTGAATCTAGAGGAACCTGACAGCGGCGCCGAGGGGGCCACCCGGACTCTGTTTGGAA CGGAAGCACAGTGTCCGCCGCTTCCTGGTTGCGGGTCAGCGCCCAGGTCCTGGGCTGGCCGCCGGGATGTTGCCCTACACAGTGAACTTC AAGGTGTCGGCGCGCACCCTCACGGGGGCCCTCAACGCCCACAACAAGGCGGCGGTGGACTGGGGCTGGCAAGGTTTAATTGCTTATGGA TGTCATTCACTTGTGGTAGTGATTGATTCCATTACTGCCCAAACTCTTCAAGTTTTAGAAAAGCATAAAGCTGATGTTGTAAAGGTTAAA TGGGCCAGGGAAAACTATCACCATAACATTGGCTCACCATATTGCTTACGGTTAGCTTCTGCTGATGTCAATGGGAAGATCATCGTCTGG GATGTAGCAGCAGGAGTAGCTCAGTGTGAGATCCAAGAGCATGCCAAGCCTATCCAGGATGTTCAGTGGTTGTGGAATCAAGATGCTTCC CGCGATTTACTGCTTGCTATCCACCCGCCAAATTACATTGTGCTCTGGAATGCCGACACTGGCACCAAACTATGGAAGAAGAGCTATGCA GATAACATTCTTTCTTTTTCTTTTGACCCTTTTGATCCCTCACATTTAACTTTGCTTACCAGCGAGGGTATTGTTTTCATCTCAGACTTC TCCCCATCCAAGCCTCCCTCAGGCCCTGGGAAAAAAGTTTACATATCCAGCCCACACTCTAGCCCAGCTCATAACAAGCTGGCCACAGCC ACAGGTGCCAAGAAAGCTCTAAATAAAGTAAAAATTTTAATCACTCAAGAGAAACCTAGTGCTGAATTCATAACTCTCAATGATTGCCTT CAGTTGGCATACCTGCCTTCAAAAAGGAATCACATGTTGTTGCTCTATCCTCGAGAGATTTTAATCCTTGACCTTGAGGTGAATCAGACG GTGGGTGTGATTGCAATAGAACGCACAGGAGTTCCATTTTTACAGGTAATACCCTGCTTTCAGCGTGATGGTTTATTTTGTCTACATGAA AATGGTTGTATAACTTTACGTGTTCGAAGATCTTATAATAACATTTTTACCACTTCAAATGAGGAACCAGATCCAGATCCAGTTCAGGAG CTTACCTATGATTTACGAAGCCAGTGTGATGCAATCAGGGTGACAAAAACCGTCCGTCCCTTCAGTATGGTGTGCTGTCCTGTCAATGAG AATGCAGCCGCCCTCGTAGTGAGTGATGGCAGGGTCATGATATGGGAACTCAAGTCTGCAGTTTGTAATCGAAATTCACGGAACAGTAGT TCTGGTGTGTCACCTTTATATTCACCAGTGTCTTTCTGTGGAATTCCTGTAGGAGTGCTACAGAATAAACTCCCAGACCTTTCCTTAGAT AACATGATTGGGCAAAGTGCAATTGCTGGGGAAGAACATCCCAGAGGTTCAATTCTGCGGGAAGTGCACCTCAAGTTCCTGCTGACGGGA CTGCTTTCAGGACTGCCCGCACCACAGTTTGCTATTCGTATGTGTCCACCGTTGACCACAAAAAACATCAAGATGTATCAGCCACTGCTG GCTGTTGGTACAAGTAATGGTTCTGTCCTGGTGTACCATCTCACCAGTGGTCTGCTACACAAAGAGTTAAGCATCCACTCATGTGAAGTC AAGGGTATTGAATGGACAAGTTTGACTAGTTTTCTTTCTTTTGCTACCTCAACACCAAACAATATGGGATTAGTGAGAAATGAACTTCAA CTGGTTGATCTTCCAACAGGTAGGAGCATTGCTTTTCGTGGTGAAAGAGGCAATGATGAATCTGCCATCGAAATGATTAAAGTATCTCAT TTGAAGCAGTATTTGGCAGTCGTATTCAGAGATAAACCCCTGGAGCTATGGGATGTTAGGACTTGTACCCTTCTTAGAGAGATGTCCAAA AACTTCCCTACAATAACTGCTTTGGAGTGGTCACCATCTCACAACTTGAAGAGCCTGAGAAAGAAGCAACTTGCAACTCGAGAGGCCATG GCCCGCCAGACCGTAGTCTCAGACACAGAGCTGAGTATTGTTGAATCATCTGTGATCAGCTTGCTGCAGGAGGCAGAAAGTAAATCTGAA CTTAGTCAGAACATCTCTGCCCGGGAACATTTTGTATTTACCGATATTGATGGCCAAGTGTATCATCTCACTGTTGAAGGAAACTCAGTA AAAGACAGTGCTCGGATTCCACCAGATGGAAGTATGGGTAGTATTACCTGCATCGCTTGGAAAGGTGATACATTAGTGCTTGGAGATATG GATGGAAATTTAAATTTCTGGGACTTGAAAGGCAGAGTATCCAGAGGAATACCCACACACCGAAGTTGGGTGAGGAAGATTCGTTTTGCT CCTGGTAAAGGAAATCAAAAATTAATAGCAATGTACAATGATGGAGCTGAAGTGTGGGATACTAAAGAGGTTCAGATGGTGAGCAGTTTA AGAAGTGGCAGAAATGTGACCTTTCGTATATTGGATGTGGACTGGTGTACGTCAGATAAAGTGATCTTGGCCTCAGATGATGGGTGCATC AGAGTCCTAGAGATGTCTATGAAGTCTGCGTGCTTTAGAATGGATGAACAAGAGTTAACCGAGCCTGTGTGGTGCCCCTATCTCCTTGTT CCAAGGGCCTCTCTTGCCTTGAAAGCCTTCTTATTACACCAGCCTTGGAATGGACAGTATTCTTTGGACATTTCTCATGTTGACTATCCA GAAAATGAAGAAATAAAGAATCTCCTCCAAGAACAGTTGAATTCATTGTCTAATGACATAAAGAAACTGTTGCTTGATCCAGAATTCACT CTCTTGCAGAGGTGCCTGCTTGTTTCAAGGCTCTATGGTGATGAATCGGAGCTGCACTTCTGGACTGTCGCTGCCCACTACCTGCACAGC TTATCCCAGGAAAAGTCAGCCAGCACAACAGCTCCTAAAGAAGCTGCTCCTCGAGACAAACTGAGCAACCCACTGGATATATGCTATGAC GTGCTCTGTGAAAATGCCTACTTTCAGAAATTTCAGCTAGAAAGGGTTAATCTGCAGGAAGTGAAACGGTCAACTTATGATCATACAAGG AAATGTACAGACCAGCTACTGCTCTTGGGTCAAACAGACAGAGCTGTGCAGTTGCTGTTGGAAACAAGTGCAGATAACCAGCATTATTAC TGTGATTCACTGAAAGCCTGTTTAGTCACTACTGTCACCTCGTCAGGCCCCTCTCAGAGCACCATTAAGTTGGTGGCAACGAATATGATT GCCAATGGCAAATTGGCAGAGGGCGTTCAGTTGCTCTGCCTGATAGATAAGGCTGCAGACGCCTGCCGCTACCTGCAGACATACGGCGAG TGGAATCGGGCTGCATGGCTGGCAAAAGTCACTCCTGGAAGCAAGGCGGCTCTAGCTAATTTATGTATTGGAGATGTAATCACAGCCATT GATGGGGAAAATACTAGCAATATGACACACTTGGAAGCTCAGAACAGAATCAAAGGCTGCACAGACAACTTGACTCTCACTGTAGCCAGA TCTGAACATAAAGTCTGGTCTCCTCTGGTGACGGAGGAAGGGAAGCGTCATCCATACAAGATGAATTTAGCCTCTGAACCCCAGGAGGTC CTGCACATAGGAAGCGCCCACAACCGAAGTGCCATGCCCTTTACCGCCTCGCCTGCCTCCAGCACTACTGCCAGGGTCATCACAAACCAG TACAACAACCCAGCTGGCCTCTACTCTTCTGAAAATATCTCCAACTTCAACAATGCCCTGGAGTCAAAGACTGCTGCCAGCGGGGTGGAG GCGAACAGCAGACCCTTAGACCATGCTCAGCCTCCAAGCAGCCTTGTCATCGACAAAGAATCTGAAGTTTACAAGATGCTTCAGGAGAAA CAGGAGTTGAATGAGCCCCCGAAACAGTCCACGTCTTTCTTGGTTTTGCAGGAAATCCTGGAGTCTGAAGAAAAAGGGGATCCCAACAAG CCCTCAGGATTCAGAAGTGTTAAAGCTCCTGTCACTAAAGTGGCTGCGTCGATTGGAAATGCTCAGAAGTTGCCTATGTGTGACAAATGT GGCACTGGGATTGTTGGTGTGTTTGTGAAGCTGCGGGACCGTCACCGCCACCCTGAGTGTTATGTGTGCACTGACTGTGGCACCAACCTG AAACAGAAGGGCCATTTCTTTGTGGAGGATCAAATCTACTGTGAGAAGCATGCCCGGGAGCGAGTCACACCACCTGAGGGTTATGAAGTG GTCACTGTGTTCCCCAAGTGAGCCAGCAGATCTGACCACTGTTCTCCAGCAGGCCTCTGCTGCAGCTTTTTCTCTCAGTGTTCTGGCCCT CTCCTCTCTTGAAAGTTCTCTGCTTACTTTGGTTTTCCCTCTGCTTGTAAAACATTGAGTCCCCTCCCTGCCTTGGTTAATTGACTCACA CCAGCTGTGCGATGCCCGCTTTTACAATTAAAGGAAAACTGTTTTGTTCAGTGTCACCTTGTCAGCAACACTGTGTCCCTTCGCCCCACC GTTCTTCTCTGCTGCATTTGGACATCAGCCAAATTTGAACCCAATCAAATATAACGTGTCTGACACTGATTTTGTTTTTACTCAATAAAT |
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FusionGenePPI for WDR11_PDLIM1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| WDR11 | GABARAPL1, UBXN7, NOTCH1, ZNF397, FAS, HLA-B, C17orf75, ALDH1L2, FBXW11, NAA40, PSMA1, PSMA2, PSMA4, PSMA6, UBA2, XPOT, NTRK1, TMEM17, TMEM216, PPM1H, CDC25A, TPCN2, FGF8, RNF19B, STYX | PDLIM1 | GFAP, VIM, ACTN4, STK35, ACTN2, ACTN1, RLIM, PDLIM1, ESR1, SUPT4H1, RPS6KA5, MAPK6, CLNS1A, IGBP1, PNPT1, ARIH2, HK2, NUBP1, NXF1, CUL7, LUZP4, ACTN3, NUDT12, RANGRF, HSPB1, STMN1, LIMA1, FBXO31, CDH1, SOX2, GORASP2, SCYL2, G3BP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for WDR11_PDLIM1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WDR11_PDLIM1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | WDR11 | C0036341 | Schizophrenia | 1 | CTD_human |
| Hgene | WDR11 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| Hgene | WDR11 | C3540450 | HYPOGONADOTROPIC HYPOGONADISM 14 WITH OR WITHOUT ANOSMIA | 1 | UNIPROT |
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