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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41791

FusionGeneSummary for WDFY3_WDFY3

check button Fusion gene summary
Fusion gene informationFusion gene name: WDFY3_WDFY3
Fusion gene ID: 41791
HgeneTgene
Gene symbol

WDFY3

WDFY3

Gene ID

23001

23001

Gene nameWD repeat and FYVE domain containing 3WD repeat and FYVE domain containing 3
SynonymsALFY|BCHS|MCPH18|ZFYVE25ALFY|BCHS|MCPH18|ZFYVE25
Cytomap

4q21.23

4q21.23

Type of geneprotein-codingprotein-coding
DescriptionWD repeat and FYVE domain-containing protein 3autophagy-linked FYVE proteinWD repeat and FYVE domain-containing protein 3autophagy-linked FYVE protein
Modification date2018051920180519
UniProtAcc

Q8IZQ1

Q8IZQ1

Ensembl transtripts involved in fusion geneENST00000322366, ENST00000295888, 
ENST00000512267, 
ENST00000322366, 
ENST00000295888, ENST00000512267, 
Fusion gene scores* DoF score7 X 6 X 5=2104 X 4 X 3=48
# samples 74
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WDFY3 [Title/Abstract] AND WDFY3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA427969WDFY3chr4

85843108

-WDFY3chr4

85844891

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000322366ENST00000322366WDFY3chr4

85843108

-WDFY3chr4

85844891

-
intron-intronENST00000322366ENST00000295888WDFY3chr4

85843108

-WDFY3chr4

85844891

-
intron-intronENST00000322366ENST00000512267WDFY3chr4

85843108

-WDFY3chr4

85844891

-
intron-intronENST00000295888ENST00000322366WDFY3chr4

85843108

-WDFY3chr4

85844891

-
intron-intronENST00000295888ENST00000295888WDFY3chr4

85843108

-WDFY3chr4

85844891

-
intron-intronENST00000295888ENST00000512267WDFY3chr4

85843108

-WDFY3chr4

85844891

-
intron-intronENST00000512267ENST00000322366WDFY3chr4

85843108

-WDFY3chr4

85844891

-
intron-intronENST00000512267ENST00000295888WDFY3chr4

85843108

-WDFY3chr4

85844891

-
intron-intronENST00000512267ENST00000512267WDFY3chr4

85843108

-WDFY3chr4

85844891

-

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FusionProtFeatures for WDFY3_WDFY3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WDFY3

Q8IZQ1

WDFY3

Q8IZQ1


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WDFY3_WDFY3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WDFY3_WDFY3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WDFY3_WDFY3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WDFY3_WDFY3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource