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Fusion gene ID: 41788 |
FusionGeneSummary for WDFY3_KCNIP4 |
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Fusion gene information | Fusion gene name: WDFY3_KCNIP4 | Fusion gene ID: 41788 | Hgene | Tgene | Gene symbol | WDFY3 | KCNIP4 | Gene ID | 23001 | 80333 |
Gene name | WD repeat and FYVE domain containing 3 | potassium voltage-gated channel interacting protein 4 | |
Synonyms | ALFY|BCHS|MCPH18|ZFYVE25 | CALP|KCHIP4 | |
Cytomap | 4q21.23 | 4p15.31-p15.2 | |
Type of gene | protein-coding | protein-coding | |
Description | WD repeat and FYVE domain-containing protein 3autophagy-linked FYVE protein | Kv channel-interacting protein 4Kv channel interacting protein 4a-type potassium channel modulatory protein 4calsenilin-like protein | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q8IZQ1 | Q6PIL6 | |
Ensembl transtripts involved in fusion gene | ENST00000322366, ENST00000295888, ENST00000512267, | ENST00000382148, ENST00000447367, ENST00000382150, ENST00000382152, ENST00000509207, ENST00000382149, ENST00000359001, | |
Fusion gene scores | * DoF score | 7 X 6 X 5=210 | 12 X 7 X 9=756 |
# samples | 7 | 13 | |
** MAII score | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/756*10)=-2.53987461119262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: WDFY3 [Title/Abstract] AND KCNIP4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-C8-A26Y-01A | WDFY3 | chr4 | 85634312 | - | KCNIP4 | chr4 | 21764655 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000322366 | ENST00000382148 | WDFY3 | chr4 | 85634312 | - | KCNIP4 | chr4 | 21764655 | - |
5CDS-intron | ENST00000322366 | ENST00000447367 | WDFY3 | chr4 | 85634312 | - | KCNIP4 | chr4 | 21764655 | - |
5CDS-intron | ENST00000322366 | ENST00000382150 | WDFY3 | chr4 | 85634312 | - | KCNIP4 | chr4 | 21764655 | - |
5CDS-intron | ENST00000322366 | ENST00000382152 | WDFY3 | chr4 | 85634312 | - | KCNIP4 | chr4 | 21764655 | - |
5CDS-intron | ENST00000322366 | ENST00000509207 | WDFY3 | chr4 | 85634312 | - | KCNIP4 | chr4 | 21764655 | - |
5CDS-intron | ENST00000322366 | ENST00000382149 | WDFY3 | chr4 | 85634312 | - | KCNIP4 | chr4 | 21764655 | - |
5CDS-intron | ENST00000322366 | ENST00000359001 | WDFY3 | chr4 | 85634312 | - | KCNIP4 | chr4 | 21764655 | - |
5CDS-intron | ENST00000295888 | ENST00000382148 | WDFY3 | chr4 | 85634312 | - | KCNIP4 | chr4 | 21764655 | - |
5CDS-intron | ENST00000295888 | ENST00000447367 | WDFY3 | chr4 | 85634312 | - | KCNIP4 | chr4 | 21764655 | - |
5CDS-intron | ENST00000295888 | ENST00000382150 | WDFY3 | chr4 | 85634312 | - | KCNIP4 | chr4 | 21764655 | - |
5CDS-intron | ENST00000295888 | ENST00000382152 | WDFY3 | chr4 | 85634312 | - | KCNIP4 | chr4 | 21764655 | - |
5CDS-intron | ENST00000295888 | ENST00000509207 | WDFY3 | chr4 | 85634312 | - | KCNIP4 | chr4 | 21764655 | - |
5CDS-intron | ENST00000295888 | ENST00000382149 | WDFY3 | chr4 | 85634312 | - | KCNIP4 | chr4 | 21764655 | - |
5CDS-intron | ENST00000295888 | ENST00000359001 | WDFY3 | chr4 | 85634312 | - | KCNIP4 | chr4 | 21764655 | - |
intron-intron | ENST00000512267 | ENST00000382148 | WDFY3 | chr4 | 85634312 | - | KCNIP4 | chr4 | 21764655 | - |
intron-intron | ENST00000512267 | ENST00000447367 | WDFY3 | chr4 | 85634312 | - | KCNIP4 | chr4 | 21764655 | - |
intron-intron | ENST00000512267 | ENST00000382150 | WDFY3 | chr4 | 85634312 | - | KCNIP4 | chr4 | 21764655 | - |
intron-intron | ENST00000512267 | ENST00000382152 | WDFY3 | chr4 | 85634312 | - | KCNIP4 | chr4 | 21764655 | - |
intron-intron | ENST00000512267 | ENST00000509207 | WDFY3 | chr4 | 85634312 | - | KCNIP4 | chr4 | 21764655 | - |
intron-intron | ENST00000512267 | ENST00000382149 | WDFY3 | chr4 | 85634312 | - | KCNIP4 | chr4 | 21764655 | - |
intron-intron | ENST00000512267 | ENST00000359001 | WDFY3 | chr4 | 85634312 | - | KCNIP4 | chr4 | 21764655 | - |
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FusionProtFeatures for WDFY3_KCNIP4 |
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Hgene | Tgene |
WDFY3 | KCNIP4 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for WDFY3_KCNIP4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for WDFY3_KCNIP4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
WDFY3 | SQSTM1, MAP1LC3A, ATG5, ATG12, ATG16L1, BAG3, TRAF6, PRMT1, PRMT6, SUV39H1, EEF2K, ZBTB44, TRIM39, CEP76, SHMT2, MOV10, NXF1, HLA-B, HLA-E, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3C, GRB2, RABGAP1L, STAT3, PIK3R3, TENC1, MDFI, DAXX, NFE2L1, RAB5C, S100A4, WEE1, RTEL1, TERF2IP, SGTB, TMEM132A, NEDD1, BAG6, FLCN, DEF8, HERC1, DCAF6, APAF1, ICAM1, CD79B, RHOT2, PDCD1, DMWD, DDX11, P2RX2, WDR60, WDR75, ALG13, SLC2A12, VCAM1, DPYSL4 | KCNIP4 | KCNIP2, PSEN2, PSEN1, APP, KCNIP1, SCGB1D1, MTX1, LACRT, ZG16B, PRR4, HLA-DRA, KLK4, TFPI, ECE2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for WDFY3_KCNIP4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WDFY3_KCNIP4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |