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Fusion gene ID: 41744 |
FusionGeneSummary for WASF2_IFI6 |
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Fusion gene information | Fusion gene name: WASF2_IFI6 | Fusion gene ID: 41744 | Hgene | Tgene | Gene symbol | WASF2 | IFI6 | Gene ID | 10163 | 2537 |
Gene name | WAS protein family member 2 | interferon alpha inducible protein 6 | |
Synonyms | IMD2|SCAR2|WASF4|WAVE2|dJ393P12.2 | 6-16|FAM14C|G1P3|IFI-6-16|IFI616 | |
Cytomap | 1p36.11 | 1p35.3 | |
Type of gene | protein-coding | protein-coding | |
Description | wiskott-Aldrich syndrome protein family member 2WASP family Verprolin-homologous protein 2WASP family protein member 2WASP family protein member 4protein WAVE-2putative Wiskott-Aldrich syndrome protein family member 4suppressor of cyclic-AMP recepto | interferon alpha-inducible protein 6interferon, alpha-inducible protein clone IFI-6-16interferon-induced protein 6-16 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q9Y6W5 | P09912 | |
Ensembl transtripts involved in fusion gene | ENST00000430629, ENST00000536657, | ENST00000361157, ENST00000339145, ENST00000362020, | |
Fusion gene scores | * DoF score | 9 X 2 X 11=198 | 2 X 2 X 2=8 |
# samples | 23 | 2 | |
** MAII score | log2(23/198*10)=0.216133430864766 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: WASF2 [Title/Abstract] AND IFI6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | ESCA | TCGA-VR-A8EX-01A | WASF2 | chr1 | 27816497 | - | IFI6 | chr1 | 27995857 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-5UTR | ENST00000430629 | ENST00000361157 | WASF2 | chr1 | 27816497 | - | IFI6 | chr1 | 27995857 | - |
5UTR-5UTR | ENST00000430629 | ENST00000339145 | WASF2 | chr1 | 27816497 | - | IFI6 | chr1 | 27995857 | - |
5UTR-5UTR | ENST00000430629 | ENST00000362020 | WASF2 | chr1 | 27816497 | - | IFI6 | chr1 | 27995857 | - |
5UTR-5UTR | ENST00000536657 | ENST00000361157 | WASF2 | chr1 | 27816497 | - | IFI6 | chr1 | 27995857 | - |
5UTR-5UTR | ENST00000536657 | ENST00000339145 | WASF2 | chr1 | 27816497 | - | IFI6 | chr1 | 27995857 | - |
5UTR-5UTR | ENST00000536657 | ENST00000362020 | WASF2 | chr1 | 27816497 | - | IFI6 | chr1 | 27995857 | - |
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FusionProtFeatures for WASF2_IFI6 |
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Hgene | Tgene |
WASF2 | IFI6 |
Downstream effector molecule involved in thetransmission of signals from tyrosine kinase receptors and smallGTPases to the actin cytoskeleton. Promotes formation of actinfilaments. Part of the WAVE complex that regulates lamellipodiaformation. The WAVE complex regulates actin filamentreorganization via its interaction with the Arp2/3 complex.{ECO:0000269|PubMed:10381382, ECO:0000269|PubMed:16275905}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for WASF2_IFI6 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for WASF2_IFI6 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
WASF2 | ACTR3, BAIAP2, RYK, ITSN2, WASL, KLF16, YWHAQ, TCERG1, PRPF40A, APBB1, GAS7, POLD1, ZDHHC17, ABI3, ABI1, ABI2, ZNF511, NCK2, LHX4, CYFIP1, CYFIP2, NCKAP1, NTRK1, CEP19, TMEM17, TCF4, CDH1, TIMM50, NHSL2, AMZ1, CCDC53, CBLC, GJB7, HOMER3, CCDC27, EVL, TRIM25 | IFI6 | ELAVL1, APP |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for WASF2_IFI6 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WASF2_IFI6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | IFI6 | C0000786 | Spontaneous abortion | 1 | CTD_human |
Tgene | IFI6 | C0021400 | Influenza | 1 | CTD_human |